Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation

Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation

(2020) Fabian Erdel et al.   MOLECULAR CELL

Lysine 4 of histone H3.3 is required for embryonic stem cell differentiation, histone enrichment at regulatory regions and transcription accuracy

(2020) Maja Gehre et al.   NATURE GENETICS

MLL4 is required after implantation whereas MLL3 becomes essential during late gestation

(2020) Deepthi Ashokkumar et al.   DEVELOPMENT

A central role for canonical PRC1 in shaping the 3D nuclear landscape

(2020) Shelagh Boyle et al.   GENES & DEVELOPMENT

Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation

(2020) Delphine Douillet et al.   NATURE GENETICS

Histone variant H3.3 residue S31 is essential for Xenopus gastrulation regardless of the deposition pathway

(2020) David Sitbon et al.   Nature Communications

Histone H3.3 phosphorylation amplifies stimulation-induced transcription

(2020) Anja Armache et al.   NATURE

Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3

(2020) Adam Burton et al.   NATURE CELL BIOLOGY

A small UTX stabilization domain of Trr is conserved within mammalian MLL3-4/COMPASS and is sufficient to rescue loss of viability in null animals

(2020) Ryan Rickels et al.   GENES & DEVELOPMENT

Lysine 27 of replication-independent histone H3.3 is required for Polycomb target gene silencing but not for gene activation

(2019) Mary Leatham-Jensen et al.   PLoS Genetics

EZHIP / CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma

(2019) Jens-Martin Hübner et al.   NEURO-ONCOLOGY

Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2

(2019) Aaron J. Plys et al.   GENES & DEVELOPMENT

Phosphorylation of histone H3.3 at serine 31 promotes p300 activity and enhancer acetylation

(2019) Sara Martire et al.   NATURE GENETICS

CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

(2019) Andrea Piunti et al.   Science Advances

PRC2 functions in development and congenital disorders

(2019) Orla Deevy et al.   DEVELOPMENT

Histone Modifications Regulate Chromatin Compartmentalization by Contributing to a Phase Separation Mechanism

(2019) Liang Wang et al.   MOLECULAR CELL

HP1 reshapes nucleosome core to promote phase separation of heterochromatin

(2019) S. Sanulli et al.   NATURE

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

(2019) Roberta Ragazzini et al.   Nature Communications

Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression

(2019) Simone Tamburri et al.   MOLECULAR CELL

PRC1 Catalytic Activity Is Central to Polycomb System Function

(2019) Neil P. Blackledge et al.   MOLECULAR CELL

Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas

(2018) Kristian W. Pajtler et al.   ACTA NEUROPATHOLOGICA

Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome

(2018) Brian T. Weinert et al.   CELL

Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin

(2018) Chul-Hwan Lee et al.   MOLECULAR CELL

Capturing the Onset of PRC2-Mediated Repressive Domain Formation

(2018) Ozgur Oksuz et al.   MOLECULAR CELL

MTF2 recruits Polycomb Repressive Complex 2 by helical-shape-selective DNA binding

(2018) Matteo Perino et al.   NATURE GENETICS

Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes

(2018) Simon Poepsel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Enhancer Logic and Mechanics in Development and Disease

(2018) Ryan Rickels et al.   TRENDS IN CELL BIOLOGY

Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes

(2018) Simon Poepsel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An Mll4/COMPASS-Lsd1 epigenetic axis governs enhancer function and pluripotency transition in embryonic stem cells

(2018) Kaixiang Cao et al.   Science Advances

Epigenetic inheritance mediated by coupling of RNAi and histone H3K9 methylation

(2018) Ruby Yu et al.   NATURE

Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability

(2018) Nahid Iglesias et al.   NATURE

Ubiquitination-Independent Repression of PRC1 Targets during Neuronal Fate Restriction in the Developing Mouse Neocortex

(2018) Masafumi Tsuboi et al.   DEVELOPMENTAL CELL

Probing the Function of Metazoan Histones with a Systematic Library of H3 and H4 Mutants

(2018) Weimin Zhang et al.   DEVELOPMENTAL CELL

Histone H3K4 methylation-dependent and -independent functions of Set1A/COMPASS in embryonic stem cell self-renewal and differentiation

(2017) Christie C. Sze et al.   GENES & DEVELOPMENT

A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation

(2017) Marc A.J. Morgan et al.   GENES & DEVELOPMENT

Functional Redundancy of Variant and Canonical Histone H3 Lysine 9 Modification inDrosophila

(2017) Taylor J. R. Penke et al.   GENETICS

Polycomb and Trithorax Group Genes inDrosophila

(2017) Judith A. Kassis et al.   GENETICS

Ezh2 Mutations Found in the Weaver Overgrowth Syndrome Cause a Partial Loss of H3K27 Histone Methyltransferase Activity

(2017) Julian C Lui et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

H3K4 Methyltransferase Activity Is Required for MLL4 Protein Stability

(2017) Younghoon Jang et al.   JOURNAL OF MOLECULAR BIOLOGY

Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation

(2017) Kristel M. Dorighi et al.   MOLECULAR CELL

Phase separation drives heterochromatin domain formation

(2017) Amy R. Strom et al.   NATURE

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability

(2017) Ryan Rickels et al.   NATURE GENETICS

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas

(2017) Andrea Piunti et al.   NATURE MEDICINE

Ten principles of heterochromatin formation and function

(2017) Robin C. Allshire et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polycomb-mediated chromatin loops revealed by a subkilobase-resolution chromatin interaction map

(2017) Kyle P. Eagen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Silencing repetitive DNA

(2017) Nahid Iglesias et al.   eLife

Functional Redundancy of Variant and Canonical Histone H3 Lysine 9 Modification inDrosophila

(2017) Taylor J. R. Penke et al.   GENETICS

Polycomb and Trithorax Group Genes inDrosophila

(2017) Judith A. Kassis et al.   GENETICS

BioEssays 1∕2017

(2016)   BIOESSAYS

Direct interrogation of the role of H3K9 in metazoan heterochromatin function

(2016) Taylor J.R. Penke et al.   GENES & DEVELOPMENT

Mutation of cancer driverMLL2results in transcription stress and genome instability

(2016) Theodoros Kantidakis et al.   GENES & DEVELOPMENT

Histone H3 globular domain acetylation identifies a new class of enhancers

(2016) Madapura M Pradeepa et al.   NATURE GENETICS

Epigenetic balance of gene expression by Polycomb and COMPASS families

(2016) Andrea Piunti et al.   SCIENCE

A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading

(2016) Chun-Min Shan et al.   eLife

Interrogating the Function of Metazoan Histones using Engineered Gene Clusters

(2015) Daniel J. McKay et al.   DEVELOPMENTAL CELL

The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development

(2015) Robert S. Illingworth et al.   GENES & DEVELOPMENT

Transcriptional repression by PRC1 in the absence of H2A monoubiquitylation

(2015) Ana Raquel Pengelly et al.   GENES & DEVELOPMENT

Chromatin signatures of cancer

(2015) Marc A. Morgan et al.   GENES & DEVELOPMENT

Absence of canonical marks of active chromatin in developmentally regulated genes

(2015) Sílvia Pérez-Lluch et al.   NATURE GENETICS

Critical Role of Histone Turnover in Neuronal Transcription and Plasticity

(2015) Ian Maze et al.   NEURON

Epigenetic Regulation of Chromatin States inSchizosaccharomyces pombe

(2015) Robin C. Allshire et al.   Cold Spring Harbor Perspectives in Biology

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

(2014) Neil P. Blackledge et al.   CELL

Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant

(2014) S. Denissov et al.   DEVELOPMENT

The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation

(2014) A. S. Bledau et al.   DEVELOPMENT

Gene Silencing Triggers Polycomb Repressive Complex 2 Recruitment to CpG Islands Genome Wide

(2014) Eva Madi Riising et al.   MOLECULAR CELL

Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression

(2014) Reinhard Kalb et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling

(2014) H.-M. Herz et al.   SCIENCE

Targeting Polycomb to Pericentric Heterochromatin in Embryonic Stem Cells Reveals a Role for H2AK119u1 in PRC2 Recruitment

(2014) Sarah Cooper et al.   Cell Reports

SAM Domain Polymerization Links Subnuclear Clustering of PRC1 to Gene Silencing

(2013) Kyoichi Isono et al.   DEVELOPMENTAL CELL

Spp1 at the crossroads of H3K4me3 regulation and meiotic recombination

(2013) Laurent Acquaviva et al.   Epigenetics

The MLL3/MLL4 Branches of the COMPASS Family Function as Major Histone H3K4 Monomethylases at Enhancers

(2013) D. Hu et al.   MOLECULAR AND CELLULAR BIOLOGY

The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells

(2013) Deqing Hu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

(Poly)Combing the Pediatric Cancer Genome for Answers

(2013) M. A. Morgan et al.   SCIENCE

A Histone Mutant Reproduces the Phenotype Caused by Loss of Histone-Modifying Factor Polycomb

(2013) A. R. Pengelly et al.   SCIENCE

Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma

(2013) P. W. Lewis et al.   SCIENCE

SET for life: biochemical activities and biological functions of SET domain-containing proteins

(2013) Hans-Martin Herz et al.   TRENDS IN BIOCHEMICAL SCIENCES

The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis

(2012) Ali Shilatifard   Annual Review of Biochemistry

Roles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombination

(2012) Jeremy A. Daniel et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

RYBP-PRC1 Complexes Mediate H2A Ubiquitylation at Polycomb Target Sites Independently of PRC2 and H3K27me3

(2012) Lígia Tavares et al.   CELL

Transcription in the Absence of Histone H3.2 and H3K4 Methylation

(2012) Martina Hödl et al.   CURRENT BIOLOGY

Different means, same end—heterochromatin formation by RNAi and RNAi-independent RNA processing factors in fission yeast

(2012) Francisca E Reyes-Turcu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4

(2012) H.-M. Herz et al.   GENES & DEVELOPMENT

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

(2012) Gang Wu et al.   NATURE GENETICS

Perceiving the epigenetic landscape through histone readers

(2012) Catherine A Musselman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Two Distinct Repressive Mechanisms for Histone 3 Lysine 4 Methylation through Promoting 3′-End Antisense Transcription

(2012) Thanasis Margaritis et al.   PLoS Genetics

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

(2012) Anca M Farcas et al.   eLife

Deletion of KDM6A, a Histone Demethylase Interacting with MLL2, in Three Patients with Kabuki Syndrome

(2011) Damien Lederer et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The double face of the histone variant H3.3

(2011) Emmanuelle Szenker et al.   CELL RESEARCH

A mutation in the E(Z) methyltransferase that increases trimethylation of histone H3 lysine 27 and causes inappropriate silencing of active Polycomb target genes

(2011) Vincent A. Stepanik et al.   DEVELOPMENTAL BIOLOGY

Compaction of chromatin by diverse Polycomb group proteins requires localized regions of high charge

(2011) D. J. Grau et al.   GENES & DEVELOPMENT

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Histone modification: cause or cog?

(2011) Steven Henikoff et al.   TRENDS IN GENETICS

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

(2010) D. B. Yap et al.   BLOOD

Ring1B Compacts Chromatin Structure and Represses Gene Expression Independent of Histone Ubiquitination

(2010) Ragnhild Eskeland et al.   MOLECULAR CELL

The Methyltransferase Activity of Clr4Suv39h Triggers RNAi Independently of Histone H3K9 Methylation

(2010) Erica L. Gerace et al.   MOLECULAR CELL

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

(2010) Ryan D Morin et al.   NATURE GENETICS

Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome

(2010) Sarah B Ng et al.   NATURE GENETICS

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

(2010) P. W. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

(2010) C. J. Sneeringer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone H3K27ac separates active from poised enhancers and predicts developmental state

(2010) M. P. Creyghton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone modifications at human enhancers reflect global cell-type-specific gene expression

(2009) Nathaniel D. Heintzman et al.   NATURE

Role of the polycomb protein EED in the propagation of repressive histone marks

(2009) Raphael Margueron et al.   NATURE

Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin

(2008) Ke Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY