Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms

Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia

(2020) Hannah J. Uckelmann et al.   SCIENCE

Targeting compensatory MEK/ERK activation increases JAK inhibitor efficacy in myeloproliferative neoplasms

(2019) Simona Stivala et al.   JOURNAL OF CLINICAL INVESTIGATION

Roles of JAK2 in Aging, Inflammation, Hematopoiesis and Malignant Transformation

(2019) Perner et al.   Cells

High-throughput and high-sensitivity phosphoproteomics with the EasyPhos platform

(2018) Sean J. Humphrey et al.   Nature Protocols

Mechanisms of Resistance to JAK2 Inhibitors in Myeloproliferative Neoplasms

(2017) Sara C. Meyer   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

The Functional Impact of Alternative Splicing in Cancer

(2017) Héctor Climente-González et al.   Cell Reports

EventPointer: an effective identification of alternative splicing events using junction arrays

(2016) Juan P. Romero et al.   BMC GENOMICS

Long-term findings from COMFORT-II, a phase 3 study of ruxolitinib vs best available therapy for myelofibrosis

(2016) C N Harrison et al.   LEUKEMIA

COSMIC: somatic cancer genetics at high-resolution

(2016) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

The effect of long-term ruxolitinib treatment on JAK2p.V617F allele burden in patients with myelofibrosis

(2015) M. Deininger et al.   BLOOD

Impact of FLT3-ITD location on sensitivity to TKI-therapy in vitro and in vivo

(2015) P Arreba-Tutusaus et al.   LEUKEMIA

The spliceosome is a therapeutic vulnerability in MYC-driven cancer

(2015) Tiffany Y.-T. Hsu et al.   NATURE

High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics

(2015) Sean J Humphrey et al.   NATURE BIOTECHNOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Epo-induced erythroid maturation is dependent on Plcγ1 signaling

(2014) T M Schnöder et al.   CELL DEATH AND DIFFERENTIATION

Kit Regulates HSC Engraftment across the Human-Mouse Species Barrier

(2014) Kadriye Nehir Cosgun et al.   Cell Stem Cell

Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells

(2014) Nils A Kulak et al.   NATURE METHODS

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML

(2013) Florian H. Heidel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Genetic and Pharmacologic Inhibition of β-Catenin Targets Imatinib-Resistant Leukemia Stem Cells in CML

(2012) Florian H. Heidel et al.   Cell Stem Cell

YB-1 binds to CAUC motifs and stimulates exon inclusion by enhancing the recruitment of U2AF to weak polypyrimidine tracts

(2012) Wen-Juan Wei et al.   NUCLEIC ACIDS RESEARCH

YB-1 (YBX1) does not bind to Y/CCAAT boxes in vivo

(2012) D Dolfini et al.   ONCOGENE

Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms

(2010) A. Quintas-Cardama et al.   BLOOD

Physiological Jak2V617F Expression Causes a Lethal Myeloproliferative Neoplasm with Differential Effects on Hematopoietic Stem and Progenitor Cells

(2010) Ann Mullally et al.   CANCER CELL

Involvement of p53 and Raf/MEK/ERK pathways in hematopoietic drug resistance

(2008) J A McCubrey et al.   LEUKEMIA

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY