RADX controls RAD51 filament dynamics to regulate replication fork stability

Rad54 Drives ATP Hydrolysis-Dependent DNA Sequence Alignment during Homologous Recombination

(2020) J. Brooks Crickard et al.   CELL

RADX condenses single-stranded DNA to antagonize RAD51 loading

(2020) Hongshan Zhang et al.   NUCLEIC ACIDS RESEARCH

Human RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating the anti-recombinase FIGNL1 AAA+ ATPase

(2019) Kenichiro Matsuzaki et al.   Nature Communications

RPA and RAD51: fork reversal, fork protection, and genome stability

(2018) Kamakoti P. Bhat et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RPA and RAD51: fork reversal, fork protection, and genome stability

(2018) Kamakoti P. Bhat et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RADX Modulates RAD51 Activity to Control Replication Fork Protection

(2018) Kamakoti P. Bhat et al.   Cell Reports

RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks

(2017) Huzefa Dungrawala et al.   MOLECULAR CELL

Scipion: A software framework toward integration, reproducibility and validation in 3D electron microscopy

(2016) J.M. de la Rosa-Trevín et al.   JOURNAL OF STRUCTURAL BIOLOGY

Visualizing recombination intermediates with single-stranded DNA curtains

(2016) Zhi Qi et al.   METHODS

The β-isoform of BCCIP promotes ADP release from the RAD51 presynaptic filament and enhances homologous DNA pairing

(2016) Andrew A. Kelso et al.   NUCLEIC ACIDS RESEARCH

Protein dynamics of human RPA and RAD51 on ssDNA during assembly and disassembly of the RAD51 filament

(2016) Chu Jian Ma et al.   NUCLEIC ACIDS RESEARCH

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

(2015) Ralph Zellweger et al.   JOURNAL OF CELL BIOLOGY

An Overview of the Molecular Mechanisms of Recombinational DNA Repair

(2015) Stephen C. Kowalczykowski   Cold Spring Harbor Perspectives in Biology

Replication protein A: Single-stranded DNA's first responder

(2014) Ran Chen et al.   BIOESSAYS

FBH1 Helicase Disrupts RAD51 Filamentsin Vitroand Modulates Homologous Recombination in Mammalian Cells

(2013) Jitka Simandlova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Inhibition of Homologous Recombination by the PCNA-Interacting Protein PARI

(2011) George-Lucian Moldovan et al.   MOLECULAR CELL

Two classes of BRC repeats in BRCA2 promote RAD51 nucleoprotein filament function by distinct mechanisms

(2011) A. Carreira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purified human BRCA2 stimulates RAD51-mediated recombination

(2010) Ryan B. Jensen et al.   NATURE

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA

(2010) Jie Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The BRC Repeats of BRCA2 Modulate the DNA-Binding Selectivity of RAD51

(2009) Aura Carreira et al.   CELL

Regulation of Rad51 Recombinase Presynaptic Filament Assembly via Interactions with the Rad52 Mediator and the Srs2 Anti-recombinase

(2009) Changhyun Seong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Srs2 Disassembles Rad51 Filaments by a Protein-Protein Interaction Triggering ATP Turnover and Dissociation of Rad51 from DNA

(2009) Edwin Antony et al.   MOLECULAR CELL

Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption

(2009) S. Colavito et al.   NUCLEIC ACIDS RESEARCH