Article
Medicine, Research & Experimental
Guoshu Bi, Yunyi Bian, Jiaqi Liang, Jiacheng Yin, Runmei Li, Mengnan Zhao, Yiwei Huang, Tao Lu, Cheng Zhan, Hong Fan, Qun Wang
Summary: This study analyzed the metabolic characteristics of glycolysis and oxidative phosphorylation in 9668 patients across 33 tumor types, identifying four metabolic subtypes. Patients with high glycolysis and low oxidative phosphorylation were consistently associated with worse prognosis. Common dysregulated molecular features were found between different metabolic subgroups, with their mutual interfering relationships investigated.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Allergy
Alexandra Goretzki, Yen-Ju Lin, Stefan Schulke
Summary: This review highlights the metabolic changes in immune cells during allergic responses, with a focus on key cell types involved in allergy. Different immune cell types exhibit distinct metabolic phenotypes upon activation, indicating the relevance of immune metabolism in allergic diseases. Further understanding of immune cell metabolism could potentially lead to new treatment targets/strategies for allergic diseases.
Review
Oncology
Giulia Bononi, Samuele Masoni, Valeria Di Bussolo, Tiziano Tuccinardi, Carlotta Granchi, Filippo Minutolo
Summary: This article discusses the phenomenon of tumors rewiring their metabolism to promote their growth, known as the Warburg effect. Extensive research has been conducted on the Warburg effect and its importance in various scientific fields.
SEMINARS IN CANCER BIOLOGY
(2022)
Letter
Oncology
Yi Xu, Christopher Hino, David J. Baylink, Jeffrey Xiao, Mark E. Reeves, Jiang F. Zhong, Saied Mirshahidi, Huynh Cao
Summary: This study demonstrates the successful use of vitamin D gene therapy to treat AML mouse models. The researchers found that 1,25VD3 treatment affected the expression of 17,757 genes, with a significant increase in fructose-bisphosphatase 1 (FBP1) expression. Additionally, 1,25VD3 was found to regulate various metabolic processes in AML. The results suggest that targeting FBP1 overexpression induced by 1,25VD3 could be a novel therapeutic approach to reduce energy production in AML blasts.
BIOMARKER RESEARCH
(2022)
Review
Oncology
Adrian Casas-Benito, Sonia Martinez-Herrero, Alfredo Martinez
Summary: Approximately a century ago, Otto Warburg discovered that cancer cells use a different metabolism called aerobic glycolysis or the Warburg effect. This metabolism allows cancer cells to produce more ATP and promotes cancer progression. Succinate, a Krebs cycle intermediate, has been found to have protumoral functions in cancer and could be a potential target for cancer therapy. However, further research is needed to explore its potential in cancer prevention and treatment.
Review
Immunology
Yen-Ju Lin, Alexandra Goretzki, Stefan Schuelke
Summary: Allergic disorders have been on the rise in recent decades, prompting the emergence of a new research field called immune metabolism. It has been found that metabolic changes in T and B cells may play a role in the development and maintenance of allergies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Annika-Ricarda Kuhn, Marc van Bilsen
Summary: Heart failure is associated with changes in cardiac intermediary metabolism, but the role of metabolic remodeling in heart failure remains unclear. Recent research in cancer has shown that metabolic rewiring directly affects cellular phenotype and function, and similar functions may be served by the rewiring of cardiac cellular metabolism in heart failure. This review discusses the impact of metabolic pathways on cellular phenotype in different cell types of the heart and evaluates their relevance for cardiac pathogenesis and therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Anna Kubicka, Karolina Matczak, Magdalena Labieniec-Watala
Summary: The differences in metabolism between cancer cells and normal cells lead to increased proliferation and abnormal differentiation of cancer cells, while the focus of anti-cancer therapy development is on reprogramming cellular metabolic pathways to halt uncontrolled proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Andrea Cunha, Patricia M. A. Silva, Bruno Sarmento, Odilia Queiros
Summary: The Warburg effect is a metabolic shift that leads to acidification of the tumor microenvironment and increased drug resistance. The metabolic differences between cancer and normal cells provide a strategy for new therapies, and nanodrug delivery systems can overcome multidrug resistance.
Review
Biochemistry & Molecular Biology
Russel Reiter, Ramaswamy Sharma, Sergio Rosales-Corral, Walter Manucha, Luiz Gustavo de Almeida Chuffa, Debora Aparecida Pires de Campos Zuccari
Summary: Melatonin is synthesized in the pineal gland at night, playing a crucial role in cells' glucose metabolism. In pathological cells, exclusion of pyruvate from mitochondria leads to insufficient acetyl-CoA for melatonin synthesis, but supplementation of melatonin can help restore normal cellular metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Serena Castelli, Fabio Ciccarone, Pamela De Falco, Maria Rosa Ciriolo
Summary: Alterations in lipid catabolism have specific effects on cancer cell proliferation and survival. This study found that the antioxidant adaptation of cancer cells to increased fatty acid oxidation is predictive of their proliferative outcome. Mitochondrial fatty acid oxidation has antitumor effects in cancer cells with efficient ROS buffering, while increased ROS levels promote proliferation in cells with an imbalanced antioxidant response.
Article
Biochemistry & Molecular Biology
Suphachai Charoensin, Suwatsak Dansakda
Summary: Oxidative stress triggers changes in cellular energy metabolism and adaptive responses, but the polyphenol antioxidant rosmarinic acid can modulate these effects induced by hydrogen peroxide (H2O2). It reduces reactive oxygen species (ROS) levels, glucose consumption, lactate production, and enhances ATP production and glutathione production through the pentose phosphate pathway. Furthermore, rosmarinic acid downregulates glycolytic enzymes and upregulates antioxidant enzymes, protecting dermal fibroblasts from oxidative damage.
Article
Biochemistry & Molecular Biology
Mingyu Kang, Joon H. H. Kang, In A. Sim, Do Y. Seong, Suji Han, Hyonchol Jang, Ho Lee, Sang W. Kang, Soo-Youl Kim
Summary: Previous work has shown that cancer cells rely on fatty acid oxidation rather than glycolysis for ATP production. However, this study found that some cancer cells undergo cell death when deprived of glucose, resulting in a decrease in ATP production. The response to glucose deprivation was different between glucose insensitive cancer cells (GIC) and glucose sensitive cancer cells (GSC). Glucose deprivation induced cell death in GSC, but not GIC, indicating that GIC have a higher tolerance for decreased NADPH levels. The findings suggest that glucose deprivation-induced cancer cell death is independent of ATP depletion, but rather caused by a failure of ROS regulation by the antioxidant system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kimberly M. Stanke, Carrick Wilson, Srivatsan Kidambi
Summary: The study revealed up-regulation of metabolic target genes in GBM patients, which was significantly associated with an elevated risk for developing GBM. High expression of glycolysis-related genes and low expression of mitochondrial metabolism genes were correlated with poor patient survival.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Oncology
Seyedeh Sahar Mortazavi Farsani, Vivek Verma
Summary: New research reveals that not only cancer cells but also other cell types, including immune cells, exhibit the Warburg effect, converting glucose to lactate even in the presence of sufficient oxygen. Lactate plays a crucial role in metabolism and cell signaling, but high levels can inhibit immune cell function.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)