Cytochrome P450-derived linoleic acid metabolites EpOMEs and DiHOMEs: a review of recent studies

Linoleic Acid Metabolite DiHOME Decreases Post-ischemic Cardiac Recovery in Murine Hearts

(2019) Marwin Bannehr et al.   Cardiovascular Toxicology

Elevated faecal 12,13-diHOME concentration in neonates at high risk for asthma is produced by gut bacteria and impedes immune tolerance

(2019) Sophia R. Levan et al.   Nature Microbiology

α-Linolenic acid-enriched butter attenuated high fat diet-induced insulin resistance and inflammation by promoting bioconversion of n-3 PUFA and subsequent oxylipin formation

(2019) Rong Fan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Mass spectrometry profiling reveals altered plasma levels of monohydroxy fatty acids and related lipids in healthy humans after controlled exposure to biodiesel exhaust

(2018) Sandra Gouveia-Figueira et al.   ANALYTICA CHIMICA ACTA

The oxidized linoleic acid metabolite 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain

(2018) Béla Zimmer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake

(2018) Kristin I. Stanford et al.   Cell Metabolism

Prospective for cytochrome P450 epoxygenase cardiovascular and renal therapeutics

(2018) John D. Imig   PHARMACOLOGY & THERAPEUTICS

Obesity is positively associated with arachidonic acid-derived 5- and 11-hydroxyeicosatetraenoic acid (HETE)

(2017) Charles Austin Pickens et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

(2017) Matthew D Lynes et al.   NATURE MEDICINE

Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice

(2017) Poonamjot Deol et al.   Scientific Reports

Epoxy fatty acids mediate analgesia in murine diabetic neuropathy

(2016) K. Wagner et al.   EUROPEAN JOURNAL OF PAIN

Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD

(2016) David Balgoma et al.   EUROPEAN RESPIRATORY JOURNAL

Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation

(2016) Kei E Fujimura et al.   NATURE MEDICINE

Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain

(2016) Marco Sisignano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persistent Nociception Triggered by Nerve Growth Factor (NGF) Is Mediated by TRPV1 and Oxidative Mechanisms

(2015) M. A. Eskander et al.   JOURNAL OF NEUROSCIENCE

Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain

(2015) Bora Inceoglu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Omeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE2 induced pain model

(2015) Sumanta Kumar Goswami et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid and linoleic acid metabolite responses to 75-km cycling

(2014) David C. Nieman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

PPAR agonists stimulate adipogenesis at the expense of osteoblast differentiation while inhibiting osteoclast formation and activity

(2014) Jessal J. Patel et al.   CELL BIOCHEMISTRY AND FUNCTION

Brown adipose tissue and its therapeutic potential

(2014) M. E. Lidell et al.   JOURNAL OF INTERNAL MEDICINE

Functional characterization of cytochrome P450-derived epoxyeicosatrienoic acids in adipogenesis and obesity

(2014) Weibin Zha et al.   JOURNAL OF LIPID RESEARCH

Soluble Epoxide Hydrolase Inhibition Is Antinociceptive in a Mouse Model of Diabetic Neuropathy

(2014) Karen Wagner et al.   JOURNAL OF PAIN

Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides

(2014) Cristina López-Vicario et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum Metabolic Signatures Induced By a Three-Day Intensified Exercise Period Persist After 14 h of Recovery in Runners

(2013) David C. Nieman et al.   JOURNAL OF PROTEOME RESEARCH

Treatment of mice with 2,3,7,8-Tetrachlorodibenzo-p-dioxin markedly increases the levels of a number of cytochrome P450 metabolites of omega-3 polyunsaturated fatty acids in the liver and lung

(2013) Jun Yang et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis

(2013) P. Sirish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linoleic Acid

(2013) Jay Whelan et al.   Advances in Nutrition

Metabolomics reveals increased isoleukotoxin diol (12,13-DHOME) in human plasma after acute Intralipid infusion

(2012) Lindsay M. Edwards et al.   JOURNAL OF LIPID RESEARCH

Soluble epoxide hydrolase regulates hematopoietic progenitor cell function via generation of fatty acid diols

(2012) T. Fromel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential effects of soluble epoxide hydrolase inhibition and CYP2J2 overexpression on postischemic cardiac function in aged mice

(2012) Ketul R. Chaudhary et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century

(2011) Tanya L Blasbalg et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Diet-Induced Metabolic Syndrome in Rats

(2011) Abishek Iyer et al.   Experimental Diabetes Research

Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart

(2011) Matthew L. Edin et al.   FASEB JOURNAL

Asthmatics Exhibit Altered Oxylipin Profiles Compared to Healthy Individuals after Subway Air Exposure

(2011) Susanna L. Lundström et al.   PLoS One

Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance

(2011) A. Luria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epoxygenated Fatty Acids and Soluble Epoxide Hydrolase Inhibition: Novel Mediators of Pain Reduction

(2010) Karen Wagner et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents

(2010) Amol M. Patwardhan et al.   JOURNAL OF CLINICAL INVESTIGATION

5-Lipoxygenase Activating Protein Signals Adipose Tissue Inflammation and Lipid Dysfunction in Experimental Obesity

(2010) R. Horrillo et al.   JOURNAL OF IMMUNOLOGY

Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids

(2010) Christophe Morisseau et al.   JOURNAL OF LIPID RESEARCH

Thematic Review Series: Proteomics.An integrated omics analysis of eicosanoid biology,

(2009) Matthew W. Buczynski et al.   JOURNAL OF LIPID RESEARCH

Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation

(2009) Yangmei Deng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Expression and Regulation of Soluble Epoxide Hydrolase in Adipose Tissue

(2009) Bart M. De Taeye et al.   Obesity

Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia

(2009) A. M. Patwardhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antinociception Produced by 14,15-Epoxyeicosatrienoic Acid Is Mediated by the Activation of  -Endorphin and Met-Enkephalin in the Rat Ventrolateral Periaqueductal Gray

(2008) M. Terashvili et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS