Article
Agriculture, Multidisciplinary
Baixi Zhang, Lijuan Ni, Xiaoshu Tang, Xuemei Chen, Bo Hu
Summary: This study achieved a high yield of t10, c12-CLA through genetic modification and reduced its degradation rate. The highest t10, c12-CLA yield reported to date was obtained in a bioreactor using low-cost carbon sources.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Sen Zhang, De-Wen Kong, Guo-Dong Ma, Cheng-di Liu, Yu-Jiao Yang, Shan Liu, Nan Jiang, Zi-Rong Pan, Wen Zhang, Ling-Lei Kong, Guan-Hua Du
Summary: Research has shown that salvianolic acid A (SAA) has neuroprotective effects and promotes neurogenesis in ischemic stroke, possibly through activating the Wnt3a/GSK3 beta/β-catenin signaling pathway. This has important implications for improving the prognosis of stroke patients.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Genetics & Heredity
Ding Ye, Huijun Huang, David J. H. Wu, Wanting Zhang, Feixiang Zhou, Yu Qian, Jusheng Zheng, Yingying Mao
Summary: Genetically predicted circulating LA levels were inversely associated with the risk of IS, especially LAS, with stable results in subgroup and sensitivity analyses. No reverse association between LA and risk of IS or LAS was observed.
FRONTIERS IN GENETICS
(2021)
Article
Food Science & Technology
Milica Fotiric Aksic, Kristina Lazarevic, Sandra Segan, Maja Natic, Tomislav Tosti, Ivanka Ciric, Mekjell Meland
Summary: The study analyzed seeds from 75 apple cultivars grown in Norway for the first time, revealing that HaKonSeple had the highest oil content while defatted seeds of Sureple Gron contained the highest levels of beta-carotene, lycopene, and total tocopherols.
Article
Chemistry, Applied
Rongxue Zhou, Yuan Zhao, Zhongyang Ren, Linfan Shi, Yucang Zhang, Wuyin Weng
Summary: The study investigated the effects of linoleic acid concentration on the physicochemical properties of soybean 7S protein films during emulsion film formation. Increased linoleic acid concentration led to higher viscosity and larger size of oil droplets in the film-forming solution. The number of oil droplets on the film surfaces and the elongation at break of films increased while the tensile strength decreased with increasing linoleic acid concentration.
Article
Biochemistry & Molecular Biology
Hong Wang, Heli Segersvard, Juuso Siren, Sanni Perttunen, Katariina Immonen, Riikka Kosonen, Yu-Chia Chen, Johanna Tolva, Mirjami Laivuori, Mikko Mayranpaa, Petri T. Kovanen, Juha Sinisalo, Mika Laine, Ilkka Tikkanen, Paivi Lakkisto
Summary: This study reveals the potential role of TNKSs in the pathogenesis of ischemic heart failure (IHF) by regulating Wnt/beta-catenin signaling and possibly modulating miRNAs. Inhibition of TNKS activity may have pharmacotherapeutic potential for the prevention of IHF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Helena M. Amaro, Rita Barros, Tania Tavares, Raquel Almeida, Isabel Sousa Pinto, Francisco Xavier Malcata, Ana Catarina Guedes
Summary: This study evaluated the bioactive potential of lipidic extracts obtained from Gloeothece sp., with the HI extract showing potential for antioxidant, anti-inflammatory, and antitumor activities, making it suitable for nutraceutical purposes.
Article
Plant Sciences
Xiaohe Li, Xiaowei Liu, Ruxia Deng, Shaoyan Gao, Qiuyan Jiang, Rui Liu, Hailong Li, Yang Miao, Yunqian Zhai, Shanshan Zhang, Zhenzhen Wang, Yimeng Ren, Wen Ning, Honggang Zhou, Cheng Yang
Summary: Betulinic acid (BA) has shown anti-pulmonary fibrosis effect by suppressing the Wnt/beta-catenin pathway, inhibiting fibroblast activation, and decreasing the expression of Wnt target genes. In both in vitro and in vivo experiments, BA significantly reduced pulmonary fibrosis and myofibroblast activation.
Article
Chemistry, Applied
Ahmad Nasrollahzadeh, Samaneh Mollaei Tavani, Edris Arjeh, Seid Mahdi Jafari
Summary: Conjugated linoleic acid (CLA) has gained significant attention as a health-promoting compound. Microbial biosynthesis of CLA is a practical and controllable method for commercial production, and understanding the interplay of different factors is essential in optimizing its quantity and composition.
Article
Neurosciences
Ming-Yue Zhou, Ya-Jie Zhang, Hong-Mei Ding, Wei-Feng Wu, Wei-Wei Cai, Yan-Qiang Wang, De-Qin Geng
Summary: In this study, it was found that Diprotin A TFA can protect blood vessels by inhibiting the cleavage of beta-catenin and reducing VE-cadherin disruption. Mice injected with Diprotin A TFA showed reduced cerebral infarction volume, increased vascular area and length, upregulated expression of BBB tight junction proteins, and improved BBB permeability.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Food Science & Technology
Miria B. D. Berteli, Olavo B. Q. Oliveira Filho, Janyeli D. S. Freitas, Wanessa C. Bortolucci, Gustavo R. Silva, Zilda C. Gazim, Francislaine A. R. Livero, Evellyn C. W. Lovato, Juliana S. Silveira, Giani A. Linde, Lilian Barros, Filipa S. Reis, Isabel C. F. R. Ferreira, Luzia D. Paccola-Meirelles, Nelson B. Colauto
Summary: The study determined and evaluated the chemical composition, cytotoxicity, and antioxidant activity of L. crinitus pileus and stipe separately, revealing differences in nutritional composition and active substances between them.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fen Ji, Chao Feng, Jie Qin, Chong Wang, Dongming Zhang, Libo Su, Wenwen Wang, Mengtian Zhang, Hong Li, Longbing Ma, Weicheng Lu, Changmei Liu, Zhaoqian Teng, Baoyang Hu, Fengzeng Jian, Jingdun Xie, Jianwei Jiao
Summary: The deletion of Pd1 in the brain leads to abnormal cortical neurogenesis and depressive-like behaviors. Pd1 regulates neurogenesis by targeting Pax3 through the β-catenin signaling pathway. Furthermore, Pd1 also plays a similar role in the proliferation and differentiation of human neural progenitor cells (hNPCs).
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Immunology
Qun Dong, Jing Tian, Weiwei Zheng, Qiuxiang Fan, Xiaoyong Wu, Yanli Tang, Tao Liu, Hui Yin
Summary: Peripheral vascular disease often results in vascular injury and inflammation. This study investigates the role of IL-33 in hindlimb ischemic injury and its potential mechanisms. The findings suggest that IL-33 promotes blood flow restoration and enhances repair in ischemic hindlimb by modulating the proangiogenic function of endothelial cells through the Akt/eNOS pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yidan Sun, Xiyu Ying, Ruomei Li, Mengjia Weng, Jiajun Shi, Zhenqi Chen
Summary: The study revealed that FGF9 promotes HAS2 expression through the Wnt/β-catenin/TCF7L2 pathway. TCF7L2 binds to the Has2 promoter, leading to transcriptional activation of Has2. Deletion of FGF9 resulted in cleft palate and significant reduction in TCF7L2 expression.
Article
Biochemistry & Molecular Biology
Hong Zhe Zhang, Dong-Sik Chae, Sung-Whan Kim
Summary: This study investigated the synergistic angiogenic properties of adipose tissue-derived mesenchymal stem cells (ASCs) and stromal vascular fraction (SVF) cells. The results showed that A+S cell transplantation had synergistic angiogenic therapeutic effects and could be an alternative therapeutic strategy for treating ischemic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Divya Sekar, Christina Dillmann, Evelyn Sirait-Fischer, Annika F. Fink, Aleksandra Zivkovic, Natalie Baum, Elisabeth Strack, Stephan Klatt, Sven Zukunft, Stefan Wallner, Arnaud Descot, Catherine Olesch, Priscila da Silva, Andreas von Knethen, Tobias Schmid, Sabine Groesch, Rajkumar Savai, Nerea Ferreiros, Ingrid Fleming, Sourav Ghosh, Carla Rothlin, Holger Stark, Hind Medyouf, Bernhard Bruene, Andreas Weigert
Summary: Increased levels of ether-phosphatidylserine (ePS) in tumors are associated with tumor-associated macrophage (TAM) expansion and tumor growth. Inhibiting the production of ePS by targeting phosphatidylserine synthase PTDSS1 reduces tumor growth and TAM infiltration.
Review
Cardiac & Cardiovascular Systems
Dimitris Tousoulis, Tomasz Guzik, Teresa Padro, Dirk J. Duncker, Giuseppe De Luca, Etto Eringa, Marija Vavlukis, Alexios S. Antonopoulos, Themistoklis Katsimichas, Edina Cenko, Ana Djordjevic-Dikic, Ingrid Fleming, Olivia Manfrini, Danijela Trifunovic, Charalambos Antoniades, Filippo Crea
Summary: The human gut microbiota plays a crucial role in gastrointestinal function and host physiology, and is linked to the pathogenesis of cardiovascular disease. Compositional and functional alterations of the gut microbiota may be associated with atherosclerosis and coronary artery disease. Targeting the gut microbiota through interventions holds potential for therapeutic strategies.
CARDIOVASCULAR RESEARCH
(2022)
Article
Peripheral Vascular Disease
Pedro Felipe Malacarne, Corina Ratiu, Anna Gajos-Draus, Niklas Mueller, Melina Lopez, Beatrice Pflueger-Mueller, Xinxin Ding, Timothy Warwick, James Oo, Mauro Siragusa, Carlo Angioni, Stefan Guenther, Andreas Weigert, Gerd Geisslinger, Dieter Luetjohann, Wolf-Hagen Schunck, Ingrid Fleming, Ralf P. Brandes, Flavia Rezende
Summary: This study found that POR expression in endothelial cells maintains eNOS activity, and loss of POR leads to overactivation of the vasoconstrictor prostanoid system, resulting in vascular dysfunction and hypertension.
Article
Physiology
Zumer Naeem, Sven Zukunft, Stephan Guenther, Stefan Liebner, Andreas Weigert, Bruce D. Hammock, Timo Froemel, Ingrid Fleming
Summary: This study investigates the role of polyunsaturated fatty acid metabolites in regulating the hair follicle cycle. The results show that metabolites generated by the cytochrome P450/soluble epoxide hydrolase pathway can delay the transition of the hair follicle to the growth phase and promote hair growth. The activity of soluble epoxide hydrolase changes with the cell cycle and significantly affects levels of specific fatty acids. The findings suggest that soluble epoxide hydrolase activity influences the hair follicle stem cells and matrix cells, thereby affecting the transition from the resting phase to the growth phase and hair growth.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Valentina Vellecco, Elisabetta Panza, Sofia-Iris Bibli, Gian Marco Casillo, Federica Raucci, Onorina Laura Manzo, Martina Smimmo, Romolo Villani, Maria Rosaria Cavezza, Ingrid Fleming, Roberta D'Emmanuele di Villa Bianca, Francesco Maione, Giuseppe Cirino, Mariarosaria Bucci
Summary: This study demonstrates that the S-sulfhydration of PDEs modulates human SKM contractility in both physiological and pathological conditions, representing an advancement in understanding the physiopathology of SKM.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Cell Biology
Ueruen Ukan, Fredy Delgado Lagos, Sebastian Kempf, Stefan Gunther, Mauro Siragusa, Beate Fisslthaler, Ingrid Fleming
Summary: Macrophages polarization induced by thrombin results in an anti-inflammatory, M2-like phenotype and promotes oxLDL phagocytosis by macrophages. Secreted modular Ca2+-binding protein 1 (SMOC1) plays a vital role in thrombin-induced macrophage polarization by regulating phagocytosis and TGF-beta signaling-related genes expression.
Article
Immunology
Antonia Katsouda, Dimitrios Valakos, Vasilios S. Dionellis, Sofia-Iris Bibli, Ioannis Akoumianakis, Sevasti Karaliota, Karim Zuhra, Ingrid Fleming, Noriyuki Nagahara, Sophia Havaki, Vassilis G. Gorgoulis, Dimitris Thanos, Charalambos Antoniades, Csaba Szabo, Andreas Papapetropoulos
Summary: This study found that levels of MPST are downregulated in white adipose tissue in obesity. Deletion of the MPST gene leads to fat accumulation in mice fed a high-fat diet. MPST deficiency also affects mitochondrial protein import as well as metabolic reactions such as the TCA cycle, oxidative phosphorylation, and fatty acid oxidation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Correction
Multidisciplinary Sciences
ShengPeng Wang, Shuang Cao, Malika Arhatte, Dahui Li, Yue Shi, Sabrina Kurz, Jiong Hu, Lei Wang, Jingchen Shao, Ann Atzberger, Zheng Wang, Changhe Wang, Weijin Zang, Ingrid Fleming, Nina Wettschureck, Eric Honore, Stefan Offermanns
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Stefan Kuhnert, Siavash Mansouri, Michael A. Rieger, Rajkumar Savai, Edibe Avci, Gabriela Diaz-Pina, Manju Padmasekar, Mario Looso, Stefan Hadzic, Till Acker, Stephan Klatt, Jochen Wilhelm, Ingrid Fleming, Natascha Sommer, Norbert Weissmann, Claus Vogelmeier, Robert Bals, Andreas Zeiher, Stefanie Dimmeler, Werner Seeger, Soni S. Pullamsetti
Summary: This study found an increased incidence of CHIP mutations in COPD patients, which are associated with hypomethylation of PLD5, leading to elevated levels of glycerol phosphocholine, pro-inflammatory cytokines, and deteriorating lung function.
Editorial Material
Cardiac & Cardiovascular Systems
Ingrid Fleming
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Jiong Hu, Matthias S. Leisegang, Mario Looso, Maria-Kyriaki Drekolia, Janina Wittig, Janina Mettner, Christina Karantanou, Anastasia Kyselova, Gabrjela Dumbovic, Xiaoming Li, Yuanyuan Li, Stefan Guenther, David John, Mauro Siragusa, Sven Zukunft, James A. Oo, Ilka Wittig, Susanne Hille, Andreas Weigert, Stefan Knapp, Ralf P. Brandes, Oliver J. Mueller, Andreas Papapetropoulos, Fragiska Sigala, Gergana Dobreva, Baktybek Kojonazarov, Ingrid Fleming, Sofia-Iris Bibli
Summary: Aging leads to p53-mediated reprogramming, suppression of glycolysis, and reduced telomerase assembly in endothelial cells. The loss of the vasoprotective enzyme CSE contributes to enhanced p53 activity and premature endothelial senescence, impacting vascular repair after injury. Restoring CSE function helps maintain endothelial cell metabolism and prevent senescence.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Zhou Zhou, Min Zhang, Chengcheng Zhao, Xu Gao, Zheng Wen, Junfang Wu, Chen Chen, Ingrid Fleming, Jiong Hu, Dao Wen Wang
Summary: Myocarditis is a challenging inflammatory disease of the heart, and EETs and sEH inhibitors can prevent the progression of coxsackie B3 virus-induced myocarditis and promote viral resistance by increasing IFN production.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Charalambos Antoniades, Dimitris Tousoulis, Marija Vavlukis, Ingrid Fleming, Dirk J. Duncker, Etto Eringa, Olivia Manfrini, Alexios S. Antonopoulos, Evangelos Oikonomou, Teresa Padro, Danijela Trifunovic-Zamaklar, Giuseppe De Luca, Tomasz Guzik, Edina Cenko, Ana Djordjevic-Dikic, Filippo Crea
Summary: This article reviews the heterogeneity of adipose tissue depots in humans and emphasizes the interactions between perivascular adipose tissue (PVAT) and the vascular wall. It highlights the potential therapeutic target of PVAT in cardiovascular diseases and its role as a clinically important source of diagnostic and prognostic biomarkers of vascular function. It also discusses recent imaging technologies that visualize PVAT in clinical practice and the integration of PVAT information into prognostic models using artificial intelligence and machine learning technologies.
EUROPEAN HEART JOURNAL
(2023)