Phenanthrene impacts zebrafish cardiomyocyte excitability by inhibiting IKr and shortening action potential duration

Inhibition of hERG Potassium Channels by the Polycylic Aromatic Hydrocarbon Phenanthrene

(2020) Ehab Al-Moubarak et al.   BIOPHYSICAL JOURNAL

The hERG channel activator, RPR260243, enhances protective IKr current early in the refractory period reducing arrhythmogenicity in zebrafish hearts

(2020) Yu Patrick Shi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Polycyclic aromatic hydrocarbons phenanthrene and retene modify the action potential via multiple ion currents in rainbow trout Oncorhynchus mykiss cardiac myocytes

(2019) Eeva-Riikka Vehniäinen et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization

(2019) Matthew D Perry et al.   CARDIOVASCULAR RESEARCH

Understanding the cardiac toxicity of the anthropogenic pollutant phenanthrene on the freshwater indicator species, the brown trout (Salmo trutta): From whole heart to cardiomyocytes

(2019) Martins Oshioriamhe Ainerua et al.   CHEMOSPHERE

Polyaromatic hydrocarbons in pollution: a heart‐breaking matter

(2019) C. R. Marris et al.   JOURNAL OF PHYSIOLOGY-LONDON

Transcripts of Kv7.1 and MinK channels and slow delayed rectifier K+ current (IKs) are expressed in zebrafish (Danio rerio) heart

(2018) Denis V. Abramochkin et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

A Novel Cardiotoxic Mechanism for a Pervasive Global Pollutant

(2017) Fabien Brette et al.   Scientific Reports

Effects of crude oil on in situ cardiac function in young adult mahi–mahi ( Coryphaena hippurus )

(2016) Derek Nelson et al.   AQUATIC TOXICOLOGY

Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations

(2016) Matthew D. Perry et al.   JOURNAL OF PHYSIOLOGY-LONDON

Phenanthrene exposure induces cardiac hypertrophy via reducing miR-133a expression by DNA methylation

(2016) Lixing Huang et al.   Scientific Reports

Air Pollution and Cardiovascular Disease

(2015) Barry A. Franklin et al.   CURRENT PROBLEMS IN CARDIOLOGY

Getting to the heart of hERG K+channel gating

(2015) Matthew D. Perry et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Sarcoplasmic Reticulum and the Evolution of the Vertebrate Heart

(2014) Holly A. Shiels et al.   PHYSIOLOGY

PNAS Plus: From the Cover: Deepwater Horizon crude oil impacts the developing hearts of large predatory pelagic fish

(2014) J. P. Incardona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crude Oil Impairs Cardiac Excitation-Contraction Coupling in Fish

(2014) F. Brette et al.   SCIENCE

An evaluation of background levels and sources of polycyclic aromatic hydrocarbons in naturally spawned embryos of Pacific herring (Clupea pallasii) from Puget Sound, Washington, USA

(2014) James E. West et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling

(2013) Youyu Zhang et al.   AQUATIC TOXICOLOGY

Slow Delayed Rectifier Potassium Current Blockade Contributes Importantly to Drug-Induced Long QT Syndrome

(2013) Christiaan C. Veerman et al.   Circulation-Arrhythmia and Electrophysiology

Global association of air pollution and heart failure: a systematic review and meta-analysis

(2013) Anoop SV Shah et al.   LANCET

Levels of Polycyclic Aromatic Hydrocarbons, Polychlorinated Biphenyls, and Organochlorine Pesticides in Various Tissues of White-Backed Vulture in India

(2013) V. Dhananjayan et al.   Biomed Research International

Comparative study of polycyclic aromatic hydrocarbons (PAHs) in plasma of Eastern Atlantic juvenile and adult nesting loggerhead sea turtles (Caretta caretta)

(2012) María Camacho et al.   MARINE POLLUTION BULLETIN

hERG K+ Channels: Structure, Function, and Clinical Significance

(2012) Jamie I. Vandenberg et al.   PHYSIOLOGICAL REVIEWS

Cardiac ventricular repolarization reserve: a principle for understanding drug-related proarrhythmic risk

(2011) András Varró et al.   BRITISH JOURNAL OF PHARMACOLOGY

The impact of aromatic ring count on compound developability: further insights by examining carbo- and hetero-aromatic and -aliphatic ring types

(2010) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Acidosis Impairs the Protective Role of hERG K+ Channels Against Premature Stimulation

(2010) CHUN YUN DU et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Adult zebrafish heart as a model for human heart? An electrophysiological study

(2009) Petros Nemtsas et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

hERG1 channel activators: A new anti-arrhythmic principle

(2009) Morten Grunnet et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Characterization of isolated ventricular myocytes from adult zebrafish (Danio rerio)

(2008) Fabien Brette et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cardiac Arrhythmia Is the Primary Response of Embryonic Pacific Herring (Clupea pallasi) Exposed to Crude Oil during Weathering

(2008) John P. Incardona et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The hERG potassium channel and hERG screening for drug-induced torsades de pointes

(2008) Jules C. Hancox et al.   PHARMACOLOGY & THERAPEUTICS

Evaluation of zebrafish embryos as a model for assessing inhibition of hERG

(2007) S.W. Mittelstadt et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS