Article
Cell Biology
Yuan Dong, Wenhong Xu, Da Qi, Huinan Qu, Qiu Jin, Minghao Sun, Xudong Wang, Chengshi Quan
Summary: This study found that low expression of CLDN6 in colorectal cancer (CRC) patients was associated with pathological grade and prognosis, and CLDN6 inhibited CRC proliferation through the PTEN/AKT/MDM2 pathway by regulating ubiquitination to enhance p53 stability and nuclear import. These findings enrich the theoretical basis for CLDN6 as a potential biomarker for diagnosis, therapy, and prognosis of CRC.
CELLULAR SIGNALLING
(2023)
Article
Multidisciplinary Sciences
Boyang Fan, Chaojing Zheng, Ning Wang, Zewen Chang, Yunxiao Liu, Chunlin Wang, Jun Xiang, Yangbao Tao, Guiyu Wang, Qian Zhang
Summary: The study identifies a novel circRNA, circSTK3, which is significantly upregulated in colorectal cancer (CRC) tissues and is associated with decreased survival. Functional assays show that circSTK3 promotes cell migration and invasion, and gene expression analysis reveals its involvement in CRC metastasis. The study also uncovers that CTCF transcriptionally regulates circSTK3. These findings highlight the functional and prognostic roles of circSTK3 and demonstrate the importance of circRNAs in metastasis.
Article
Biotechnology & Applied Microbiology
Jun-Hong Hu, Hong-Na Tang, Yu-Hang Wang
Summary: This study reveals that CAFs-exo promotes EMT progression and chemoresistance in CRC cells by secreting LINC00355. Further investigation demonstrates that CAFs-exo-derived LINC00355 enhances the expression of CRKL by inhibiting miR-34b-5p, thereby enhancing chemoresistance and promoting EMT in CRC cells.
CANCER GENE THERAPY
(2023)
Article
Multidisciplinary Sciences
Laura Sole, Teresa Lobo-Jarne, Daniel Alvarez-Villanueva, Josune Alonso-Maranon, Yolanda Guillen, Marta Guix, Irene Sangrador, Catalina Rozalen, Anna Vert, Antonio Barbachano, Joan Lop, Marta Salido, Beatriz Bellosillo, Raquel Garcia-Romero, Marta Garrido, Jessica Gonzalez, Maria Martinez-Iniesta, Erika Lopez-Arribillaga, Ramon Salazar, Clara Montagut, Ferran Torres, Mar Iglesias, Toni Celia-Terrassa, Alberto Munoz, Alberto Villanueva, Anna Bigas, Lluis Espinosa
Summary: This study reveals that sub-lethal dose of chemotherapy induces a quiescence-like phenotype and a YAP-dependent fetal-like intestinal stem cell state in wild-type p53 colorectal cancers, which is associated with higher metastatic activity and poor prognosis in patients.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Andrew J. Schwartz, Joshua W. Goyert, Sumeet Solanki, Samuel A. Kerk, Brandon Chen, Cristina Castillo, Peggy P. Hsu, Brian T. Do, Rashi Singhal, Michael K. Dame, Ho-Joon Lee, Jason R. Spence, Samira Lakhal-Littleton, Matthew G. Vander Heiden, Costas A. Lyssiotis, Xiang Xue, Yatrik M. Shah
Summary: The study reveals that ectopic expression of hepcidin in colorectal cancer plays a critical role in sequestering iron to maintain the nucleotide pool and support cell proliferation. The findings suggest that tumors may modulate local iron handling mechanisms to sustain growth, and deficiency of hepcidin can inhibit tumor development.
Article
Chemistry, Medicinal
Dongdong Luo, Zhikun Guo, Xuecui Zhao, Lijuan Wu, Xiaochun Liu, Yingzhi Zhang, Yuhang Zhang, Zirong Deng, Xianjun Qu, Shuxiang Cui, Shengbiao Wan
Summary: Sphingosine-1-phosphate receptor 2 (S1PR2) has been identified as a new GPCR target for designing antagonists to reverse 5-FU resistance. Compound 9d, a potent S1PR2 antagonist, could inhibit DPD expression to reverse 5-FU resistance with acceptable selectivity and pharmacokinetic properties. Compound 9d shows promising potential to reverse 5-FU resistance for colorectal cancer therapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Dongdong Luo, Xiaochun Liu, Leilei Jiang, Zhikun Guo, Yan Lv, Xiaochen Tian, Xiaoyan Wang, Shuxiang Cui, Shengbiao Wan, Xianjun Qu, Ximing Xu, Xiaoyang Li
Summary: In this study, 38 novel S1PR2 antagonists were synthesized and their structure-activity relationship investigated. Compound 43 showed the strongest interaction with S1PR2 and exhibited potent 5-FU resensitizing activity in 5-FU-resistant tumor cells.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Tao Yang, Huibing Wang, Meng Li, Linqi Yang, Yu Han, Chao Liu, Baowen Zhang, Mingfa Wu, Gang Wang, Zhenya Zhang, Wenqi Zhang, Jianming Huang, Huaxing Zhang, Ting Cao, Pingping Chen, Wei Zhang
Summary: This study found that CD151 plays a significant role in promoting colorectal cancer malignancy by impacting various signaling pathways and regulating the expression of key genes such as TGF-β1, CEACAM6, and LGR5. The suppression of CEACAM6, LGR5, and Wnt pathway by CD151 silencing was shown to be mediated through TGF-β1 regulation, offering insight into potential targeted therapies against CD151-based signaling in colorectal cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Genetics & Heredity
Carli M. King, Olivia M. Marx, Wei Ding, Walter A. Koltun, Gregory S. Yochum
Summary: Mutations in Wnt/beta-catenin signaling pathway components drive colorectal cancer by deregulating gene expression controlled by TCF family transcription factors. TCF7L1 plays a significant role in this process by repressing LGR5 expression through binding to a novel WRE at the LGR5 gene locus. This modulation governs spheroid formation potential of CRC cells.
Article
Oncology
Lin Zhu, Jing Wu, Hong Liu
Summary: HERC proteins, including HERC5, act as E3 ligases to ubiquitinate CtBP1 and inhibit apoptosis in colorectal cancer cells. The downregulation of HERC5 attenuates the ubiquitination of CtBP1, leading to the accumulation of CtBP1 and suppression of proapoptotic gene expression, promoting tumourigenesis. Targeting CtBP1 may be a promising strategy for colorectal cancer chemotherapy.
Article
Anatomy & Morphology
Yongbo Hu, Yiming He, Wei Liu, Shun Yu, Yabing Wei, Shaohua Bai, Yu Su, Bin Xiao
Summary: SIAH2 acts as an oncogene in colorectal cancer, promoting tumor proliferation, migration, and invasion. It activates the PI3K/AKT signaling pathway and is regulated by PTEN loss.
Article
Cell Biology
Lianjie Hou, Xiong Tong, Shuyun Lin, Mingfang Yu, Wen-Chu Ye, Meiying Xie
Summary: The study showed that Deoxynivalenol (Don) downregulated miR-221/222 in intestinal epithelial cells, leading to apoptosis and proliferation inhibition. Exosome treatment reversed the effect and targeted Phosphatase and tensin homolog (PTEN) to alleviate Don-induced damage in intestinal epithelial cells. This research expands the understanding of how miR-221/222 and PTEN regulate intestinal epithelial cells defending against Don-induced damage and offers a new approach to protect intestinal development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Maria C. Heinz, Niek A. Peters, Koen C. Oost, Rik G. H. Lindeboom, Lisa van Voorthuijsen, Arianna Fumagalli, Mirjam C. van der Net, Gustavo de Medeiros, Joris H. Hageman, Ingrid Verlaan-Klink, Inne H. M. Borel Rinkes, Prisca Liberali, Martijn Gloerich, Jacco van Rheenen, Michiel Vermeulen, Onno Kranenburg, Hugo J. G. Snippert
Summary: Study on early colorectal cancer liver metastases reveals that micrometastatic lesions lack cancer stem cells (CSC), but the development of overt metastases involves the emergence of de novo CSCs through cellular plasticity at a multicellular stage. Cellular heterogeneity is crucial for continuous growth.
Article
Oncology
Wei-Kun Shi, Yun-Hao Li, Xue-Shan Bai, Guo-Le Lin
Summary: This study used bioinformatics to search for genes associated with the prognosis of colorectal cancer (CRC), and identified several genes that may be important for CRC prognosis. Further experiments confirmed the role of one of these genes, CDKN2A, in colorectal cancer cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Huihui Wang, Hao Zhang, Zhirong Sun, Wankun Chen, Changhong Miao
Summary: The research showed that GABABR1 inhibits the migration and invasion of CRC cells by suppressing EMT and the Hippo/YAP1 pathway, indicating that GABABR1 could be a potential therapeutic target for CRC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Ester Pagano, Barbara Romano, Donatella Cicia, Fabio A. Iannotti, Tommaso Venneri, Giuseppe Lucariello, Maria Francesca Nani, Fabio Cattaneo, Paola De Cicco, Maria D'Armiento, Marcello De Luca, Ruggiero Lionetti, Stefania Lama, Paola Stiuso, Pietro Zoppoli, Geppino Falco, Silvia Marchiano, Stefano Fiorucci, Raffaele Capasso, Vincenzo Di Marzo, Francesca Borrelli, Angelo A. Izzo
Summary: TRPM8 is overexpressed in colorectal cancer and its high expression is associated with lower survival rate of patients and hyperactivation of related signaling pathways. TRPM8 may serve as a prognostic marker and potential drug target for colorectal cancer.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Letter
Gastroenterology & Hepatology
A. Garcia-Granero, G. Pellino, A. Spinelli, X. Gonzalez-Argente
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Article
Oncology
Bernhard Mlecnik, Alessandro Lugli, Gabriela Bindea, Florence Marliot, Carlo Bifulco, Jiun-Kae Jack Lee, Inti Zlobec, Tilman T. Rau, Martin D. Berger, Iris D. Nagtegaal, Elisa Vink-Borger, Arndt Hartmann, Carol Geppert, Julie Kolwelter, Susanne Merkel, Robert Grutzmann, Marc Van den Eynde, Anne Jouret-Mourin, Alex Kartheuser, Daniel Leonard, Christophe Remue, Julia Wang, Prashant Bavi, Michael H. A. Roehrl, Pamela S. Ohashi, Linh T. Nguyen, SeongJun Han, Heather L. MacGregor, Sara Hafezi-Bakhtiari, Bradly G. Wouters, Giuseppe Masucci, Emilia K. Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Tessa Fredriksen, Benedicte Buttard, Lucie Lafontaine, Pauline Maby, Amine Majdi, Assia Hijazi, Carine El Sissy, Amos Kirilovsky, Anne Berger, Christine Lagorce, Christopher Paustian, Carmen Ballesteros-Merino, Jeroen Dijkstra, Carlijn van de Water, Shannon Van Lent-van Vliet, Nikki Knijn, Ana-Maria Musing, Dragos-Viorel Scripcariu, Boryana Popivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Toshihiko Torigoe, Noriyuki Sato, Tomohisa Furuhata, Ichiro Takemasa, Prabhu Patel, Hemangini H. Vora, Birva Shah, Jayendrakumar B. Patel, Kruti N. Rajvik, Shashank J. Pandya, Shilin N. Shukla, Yili Wang, Guanjun Zhang, Yutaka Kawakami, Francesco M. Marincola, Paolo A. Ascierto, Bernard A. Fox, Franck Pages, Jerome Galon
Summary: This study found that the immune system status is a better predictor of prognosis in early-stage colon cancer patients than tumor cell-related parameters. The consensus Immunoscore accurately identifies early-stage colon cancer patients with different clinical outcomes, regardless of treatment bias.
Article
Oncology
Andrea Vittorio Emanuele Lisa, Marzia Salgarello, Alessandra Huscher, Fabio Corsi, Daniele Piovani, Federica Rubbino, Stefania Andreoletti, Giovanni Papa, Francesco Klinger, Corrado Tinterri, Alberto Testori, Marta Scorsetti, Paolo Veronesi, Maria Cristina Leonardi, Mario Rietjens, Umberto Cortinovis, Valeria Summo, Emanuele Rampino Cordaro, Pier Camillo Parodi, Paolo Persichetti, Mauro Barone, Giorgio De Santis, Matteo Murolo, Michele Riccio, Angelica Aquinati, Francesco Cavaliere, Nicola Vaia, Giulia Pagura, Erica Dalla Venezia, Franco Bassetto, Vincenzo Vindigni, Luigi Ciuffreda, Maria Alessandra Bocchiotti, Alberto Sciarillo, Nadia Renzi, Graziano Meneghini, Tajna Kraljic, Andrea Loreti, Lucio Fortunato, Valentina Pino, Valeriano Vinci, Marco Klinger
Summary: In this national multicenter study, the impact of postmastectomy radiotherapy (PMRT) on breast reconstruction was analyzed. The study found that patients receiving PMRT had a significantly increased risk of complications, especially capsular contracture in direct-to-implant (DTI) and tissue expander/immediate (TE/I) reconstruction. Autologous reconstruction was found to be the least impacted by PMRT.
Review
Gastroenterology & Hepatology
A. Spinelli, F. M. Carrano, M. E. Laino, M. Andreozzi, G. Koleth, C. Hassan, A. Repici, M. Chand, V. Savevski, G. Pellino
Summary: Artificial intelligence has the potential to revolutionize surgery in the coming years. This review assessed the role of AI in colorectal surgery and identified various potential applications in the preoperative, intraoperative, and postoperative phases. However, more research is needed as AI in colorectal surgery is still in its early stages.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Article
Surgery
Jasper P. Sijberden, Giuseppe Zimmitti, Simone Conci, Nadia Russolillo, Michele Masetti, Federica Cipriani, Jacopo Lanari, Burak Goergec, Andrea Benedetti Cacciaguerra, Fernando Rotellar, Mathieu D'Hondt, Bjorn Edwin, Robert P. Sutcliffe, Ibrahim Dagher, Mikhail Efanov, Santi Lopez-Ben, John N. Primrose, Felice Giuliante, Antonino Spinelli, Manish Chand, Salud Alvarez, Serena Langella, Simone Nicosia, Andrea Ruzzenente, Marco Vivarelli, Umberto Cillo, Luca Aldrighetti, Elio Jovine, Alessandro Ferrero, Alfredo Guglielmi, Marc G. Besselink, Mohammad Abu Hilal
Summary: This retrospective cohort study aimed to compare the outcomes of simultaneous resection (SIMR) for synchronous colorectal liver metastases (sCRLM) in different settings and identify factors associated with unfavorable outcomes. The results showed that SIMR was feasible for patients requiring minor or technically major liver resection. Compared to major resections, minor and technically major resections had lower complication rates and shorter hospital stays. Factors independently associated with an increased risk of severe morbidity included higher American Society of Anesthesiologists grades (>= 3) and undergoing a major liver resection, while undergoing a left-sided colectomy was associated with a decreased risk.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Review
Genetics & Heredity
Luana Greco, Federica Rubbino, Arianna Dal Buono, Luigi Laghi
Summary: Microsatellite instability (MSI), a key feature of defective DNA mismatch repair (MMR) system, is found in 15-20% of colorectal cancers (CRC). It has been established as a unique and pivotal biomarker in the diagnosis, prognosis, and treatment of CRC. MSI tumor cells exhibit strong lymphocytic activation and a shift toward a tumor microenvironment that restrains metastasis and shows high responsiveness to immunotherapy.
Article
Hematology
Kevin Talboom, Wernard A. A. Borstlap, Sapho X. Roodbeen, Emma R. J. Bruns, Christianne J. Buskens, Roel Hompes, Kristien M. A. J. Tytgat, Jurriaan B. Tuynman, Esther C. J. Consten, Gijsbert Heuff, Teaco Kuiper, Anna A. W. van Geloven, Gerrit J. Veldhuis, Joost A. B. van der Hoeven, Michael F. Gerhards, Colin Sietses, Antonino Spinelli, Anthony W. H. van de Ven, Edwin S. van der Zaag, Marinke Westerterp, Henderik L. van Westreenen, Marcel L. Dijkgraaf, Nicole P. Juffermans, Wilhelmus A. Bemelman
Summary: This study compared the efficacy of preoperative intravenous and oral iron supplementation in patients with colorectal cancer and iron deficiency anaemia. The results showed that intravenous iron treatment significantly improved the haemoglobin levels in patients, while oral iron treatment did not.
LANCET HAEMATOLOGY
(2023)
Review
Medicine, General & Internal
Virginia Solitano, Arianna Dal Buono, Roberto Gabbiadini, Marek Wozny, Alessandro Repici, Antonino Spinelli, Stefania Vetrano, Alessandro Armuzzi
Summary: Fibro-stenosing Crohn's disease (CD) is a common disease presentation that leads to impaired quality of life and often requires endoscopic treatments or surgery. Currently, there are no existing imaging techniques that can accurately quantify the amount of fibrosis within a stricture, and managing patients is challenging, requiring a multidisciplinary team.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Arianna Dal Buono, Laura Poliani, Luana Greco, Paolo Bianchi, Monica Barile, Valentina Giatti, Cristiana Bonifacio, Silvia Carrara, Alberto Malesci, Luigi Laghi
Summary: This study investigated the prevalence of germline mutations in cancer predisposition genes in patients with pancreatic ductal adenocarcinoma (PDAC) or suspected related hereditary syndromes. The results showed that 20.1% of the tested subjects carried at least one pathogenic variant in the genes of interest. Therefore, the incorporation of genetic testing and multiple-gene panels in the management of pancreatic cancer would be beneficial.
Editorial Material
Surgery
Antonino Spinelli, Michele Carvello
Article
Surgery
Marcos Gomez Ruiz, Eloy Espin-Basany, Antonino Spinelli, Carmen Cagigas Fernandez, Jesus Bollo Rodriguez, Jose Maria Enriquez Navascues, Tero Rautio, Mindaugas Tiskus
Summary: This study compared intracorporeal and extracorporeal anastomosis as well as laparoscopic and robot-assisted surgery in right hemicolectomies. The results showed that the method of anastomosis and surgical technique did not significantly affect surgical wound infections and severe postoperative complications within 30 days.
BRITISH JOURNAL OF SURGERY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
R. Gabbiadini, P. Spaggiari, A. Dal Buono, M. Iuzzolino, F. Furfaro, F. D'Amico, A. Repici, A. Spinelli, A. Armuzzi
JOURNAL OF CROHNS & COLITIS
(2023)