Article
Biochemistry & Molecular Biology
Ciliang Guo, Yeqing Wang, Shihai Zhang, Xiuqi Zhang, Zhenyun Du, Meixia Li, Kan Ding
Summary: This study found that the polysaccharide HAW1-2 from hawthorn can alleviate colitis in mice by regulating inflammatory cytokines and inhibiting related molecular pathways. Additionally, HAW1-2 can modify the composition of gut microbiota, promoting the proliferation of beneficial bacteria and generating beneficial short-chain fatty acids to inhibit colitis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Li Cui, Xueneng Guan, Wenbo Ding, Yi Luo, Wei Wang, Weiquan Bu, Jie Song, Xiaobin Tan, E. Sun, Qing Ning, Guoguang Liu, Xiaobin Jia, Liang Feng
Summary: SP2-1 polysaccharide from Scutellaria baicalensis Georgi shows protective effects against ulcerative colitis by improving pathological damage, reducing weight loss, and repairing intestinal barrier. Additionally, it significantly increases beneficial bacteria and inhibits the growth of harmful bacteria.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Bing Pang, Han Jin, Ning Liao, Junjun Li, Chunmei Jiang, Junling Shi
Summary: Vitamin A supplementation significantly ameliorated ulcerative colitis by regulating gut microbiota, increasing short-chain fatty acid production, and restoring intestinal barrier and inhibiting inflammation.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Food Science & Technology
Jiao Yu, Junwei Zhao, Huiqun Xie, Ming Cai, Liang Yao, Jinmiao Li, Lan Han, Weidong Chen, Nianjun Yu, Daiyin Peng
Summary: The therapeutic effect of Dendrobium huoshanense polysaccharides (DHP) on ulcerative colitis (UC) is confirmed in this study. Through metabolomics and gut flora analysis, it was found that DHP alleviates UC symptoms by improving colonic mucosal barrier function, reducing inflammation, and modulating the composition of gut microbiota.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Cell Biology
Yusuke Yoshimatsu, Tomohisa Sujino, Kentaro Miyamoto, Yosuke Harada, Shun Tanemoto, Keiko Ono, Satoko Umeda, Kosuke Yoshida, Toshiaki Teratani, Takahiro Suzuki, Yohei Mikami, Nobuhiro Nakamoto, Nobuo Sasaki, Kaoru Takabayashi, Naoki Hosoe, Haruhiko Ogata, Kazuaki Sawada, Takeshi Imamura, Akihiko Yoshimura, Takanori Kanai
Summary: CD4(+) Foxp3(+) regulatory T cells (Tregs) play a crucial role in the homeostasis of the colon, but the mechanism controlling their localization is still unclear. This study demonstrates that indigo naturalis (IN), an aryl hydrocarbon receptor (AhR) agonist, increases the numbers of Helios+ Tregs and MHC class II+ epithelial cells (ECs) in the colon. Additionally, IN treatment leads to an increase in CD25(+) T cells near the surface of ECs in ulcerative colitis (UC) patients compared to other therapies.
Article
Food Science & Technology
Zhengyu Ren, Zhenzhen Xu, William Kwame Amakye, Wei Liu, Zikuan Zhao, Li Gao, Min Wang, Jiaoyan Ren
Summary: This study validates the occurrence of spontaneous UC in cynomolgus monkeys and explores the potential of Hericium erinaceus mycelium-derived polysaccharide in reversing UC pathologies.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Yingchun Zhang, Dan Feng, Yue Zeng, Hanyu Zhang, Xiaohong Du, Yang Fu, Xinhui Wang, Dingyue Lian, Ruikang Wang, Hongyu Xiao, Ning Wei, Fuqiang Zhai, Hanru Liu
Summary: This study investigates the preventive effects of Xuedan sustained release pellets (XSPs) on ulcerative colitis (UC) rats and the underlying mechanisms. XSP treatment significantly reduced inflammation and improved gut microbiota composition and short-chain fatty acid production in UC rats.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jhih-Yi Yang, Sheng-Yi Chen, Yen-Hsien Wu, Yi-Lun Liao, Gow-Chin Yen
Summary: This study evaluated the ameliorative effects of buckwheat polysaccharides on TNBS-induced colitis, showing that prefeeding with these polysaccharides decreased inflammatory cytokines and increased antioxidant enzyme levels. It also improved the intestinal inflammation-associated signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Medicinal
Kangjia Jiang, Duo Wang, Le Su, Xinli Liu, Qiulin Yue, Song Zhang, Lin Zhao
Summary: This study evaluated the anti-inflammatory effects of tamarind seed polysaccharide hydrolysate (TSPH) in colitis mice. TSPH restored colon pathology, inhibited pro-inflammatory cytokines secretion, and altered gut microbiota structure. These findings suggest that TSPH has the potential to be a functional food against colitis.
Article
Food Science & Technology
Hanyu Lu, Mingyue Shen, Yi Chen, Qiang Yu, Ting Chen, Jianhua Xie
Summary: This study explored the therapeutic effects and underlying mechanisms of Cyclocarya paliurus polysaccharide (CP) and Chinese yam polysaccharide (CY) on dextran sulfate sodium (DSS)-induced mice colitis model. CP and CYP improved colitis symptoms, enhanced IL-10 production, inhibited cytokines (IL-1 beta, TNF-alpha), and reduced MPO activity. They also maintained intestinal integrity, reduced LBP and ET levels, and modulated gut microbiota composition and metabolism. These findings suggest that polysaccharides may alleviate colitis development and have implications for further research.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Chemistry, Applied
Kexue Zhu, Haofei Fan, Shunjiang Zeng, Shaoping Nie, Yanjun Zhang, Lehe Tan, Chuan Li, Fei Xu, Qibing Liu, Gang Wu
Summary: The study found that JFP-Ps significantly influenced the levels of intestinal bacteria in mice and increased the production of short-chain fatty acids, benefiting gut health.
Review
Food Science & Technology
Qianqian Song, Yikun Wang, Lixing Huang, Mingyue Shen, Yue Yu, Qiang Yu, Yi Chen, Jianhua Xie
Summary: Intestinal flora plays a crucial role in maintaining the balance of the human body's ecosystem. By interacting with polysaccharides, the gut microbiota can be regulated to improve health and prevent disease. Polysaccharides, as prebiotics, have the potential to enhance human health by modulating the composition of gut microbiota.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Zuoting Yu, Dinggang Li, Hongxiang Sun
Summary: This study investigated the protective effect of Herba Origani on dextran sodium sulfate (DSS)-induced ulcerative colitis in mice. The results showed that Herba Origani alleviated colitis symptoms, inflammation, and pathological injury, and repaired intestinal barrier function. It also restored gut microbiota dysbiosis, regulated bile acids metabolism, and adjusted short-chain fatty acids (SCFAs). These findings suggest that Herba Origani has the potential to be used for the treatment of inflammatory intestinal diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Chunyi Xu, Linxian Zhao, Weiling Zhou, Yanyan Li, Huiling Hu, Zhanguo Wang
Summary: This study demonstrates the significant therapeutic effects of berberine hydrochloride and dehydrocostus lactone in combination for the treatment of ulcerative colitis. The co-administration of these two drugs regulates gut microbiota, protects the intestinal barrier, and reduces inflammatory damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jae Gon Lee, Jiyoung Lee, A-reum Lee, Su Vin Jo, Chan Hyuk Park, Dong Soo Han, Chang Soo Eun
Summary: Supplementation of SCFAs did not lead to a significant reduction in colon inflammation, but it did increase the expression of regulatory T cells and IL-17-producing T cells, as well as promote both protective and aggressive gut microbiota.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)