Radix Polygalae extract exerts antidepressant effects in behavioral despair mice and chronic restraint stress-induced rats probably by promoting autophagy and inhibiting neuroinflammation

Curcumin in antidepressant treatments: An overview of potential mechanisms, pre‐clinical/clinical trials and ongoing challenges

(2020) Yinfeng Zhang et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Antidepressant-Like Effects of Chaihu Shugan Powder (柴胡疏肝散) on Rats Exposed to Chronic Unpredictable Mild Stress through Inhibition of Endoplasmic Reticulum Stress-Induced Apoptosis

(2020) Ke-huan Sun et al.   Chinese Journal of Integrative Medicine

Silymarin and silymarin nanoparticles guard against chronic unpredictable mild stress induced depressive-like behavior in mice: involvement of neurogenesis and NLRP3 inflammasome

(2019) Aya Ashraf et al.   JOURNAL OF PSYCHOPHARMACOLOGY

A-Kinase Anchoring Protein 150-PKA Complex in the Basolateral Amygdala Contributes to Depressive-like Behaviors Induced by Chronic Restraint Stress

(2019) Hai-Yun Zhou et al.   BIOLOGICAL PSYCHIATRY

Neuroinflammation caused by mental stress: the effect of chronic restraint stress and acute repeated social defeat stress in mice

(2019) Yuequan Zhu et al.   NEUROLOGICAL RESEARCH

Hippocampus Metabolic Disturbance and Autophagy Deficiency in Olfactory Bulbectomized Rats and the Modulatory Effect of Fluoxetine

(2019) Yunfeng Zhou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Urinary metabolic disturbance in the olfactory bulbectomized rats and the modulatory effects of fluoxetine

(2019) Yun-Feng Zhou et al.   LIFE SCIENCES

Autophagy and Inflammation

(2018) Yu Matsuzawa-Ishimoto et al.   Annual Review of Immunology

The antidepressant effects of ɑ-tocopherol are related to activation of autophagy via the AMPK/mTOR pathway

(2018) Xiaoyan Huang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Extract of Euryale ferox Salisb exerts antidepressant effects and regulates autophagy through the adenosine monophosphate-activated protein kinase-UNC-51-like kinase 1 pathway

(2018) Zhiheng Huang et al.   IUBMB LIFE

OBscure but not OBsolete: Perturbations of the frontal cortex in common between rodent olfactory bulbectomy model and major depression

(2018) Ramamoorthy Rajkumar et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Panax ginseng exerts antidepressant-like effects by suppressing neuroinflammatory response and upregulating nuclear factor erythroid 2 related factor 2 signaling in the amygdala

(2018) Jong Hee Choi et al.   Journal of Ginseng Research

Senegenin exerts anti-depression effect in mice induced by chronic un-predictable mild stress via inhibition of NF-κB regulating NLRP3 signal pathway

(2017) Hongwei Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response

(2017) Vishnu N. Thakare et al.   PHYSIOLOGY & BEHAVIOR

Autophagy Receptors and Neurodegenerative Diseases

(2017) Zhiqiang Deng et al.   TRENDS IN CELL BIOLOGY

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

(2017) Ismail Sergin et al.   Nature Communications

miR-16 and Fluoxetine Both Reverse Autophagic and Apoptotic Change in Chronic Unpredictable Mild Stress Model Rats

(2017) Yang Yang et al.   Frontiers in Neuroscience

The identification of metabolic disturbances in the prefrontal cortex of the chronic restraint stress rat model of depression

(2016) Lanxiang Liu et al.   BEHAVIOURAL BRAIN RESEARCH

Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor

(2016) Masaaki Iwata et al.   BIOLOGICAL PSYCHIATRY

NLRP3 inflammasome activation mediates estrogen deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice

(2016) Yongjun Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

Molecular network of neuronal autophagy in the pathophysiology and treatment of depression

(2015) Jack Jia et al.   Neuroscience Bulletin

Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats

(2014) Ying Pan et al.   BRAIN BEHAVIOR AND IMMUNITY

Environmental enrichment enhances autophagy signaling in the rat hippocampus

(2014) Tomohisa Takahashi et al.   BRAIN RESEARCH

NEUROBIOLOGY OF STRESS, DEPRESSION, AND RAPID ACTING ANTIDEPRESSANTS: REMODELING SYNAPTIC CONNECTIONS

(2014) Ronald S. Duman   DEPRESSION AND ANXIETY

Ultrastructural analysis of autophagosome organization using mammalian autophagy-deficient cells

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An anti-immobility effect of spermine in the forced swim test in mice

(2014) Sylwia Wośko et al.   Pharmacological Reports

Microglial activation, increased TNF and SERT expression in the prefrontal cortex define stress-altered behaviour in mice susceptible to anhedonia

(2013) Yvonne Couch et al.   BRAIN BEHAVIOR AND IMMUNITY

Analysis and detection of the chemical constituents of Radix Polygalae and their metabolites in rats after oral administration by ultra high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry

(2013) Yun Ling et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Electroconvulsive seizures enhance autophagy signaling in rat hippocampus

(2013) Hiroyuki Otabe et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

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(2012) Masaaki Iwata et al.   BRAIN BEHAVIOR AND IMMUNITY

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(2012) Richard M. Ransohoff et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuronal Stimulation Induces Autophagy in Hippocampal Neurons That Is Involved in AMPA Receptor Degradation after Chemical Long-Term Depression

(2012) M. Shehata et al.   JOURNAL OF NEUROSCIENCE

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

(2012) Hyo Jung Kang et al.   NATURE MEDICINE

Autophagy and Neuronal Cell Death in Neurological Disorders

(2012) R. A. Nixon et al.   Cold Spring Harbor Perspectives in Biology

Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

(2011) Nanxin Li et al.   BIOLOGICAL PSYCHIATRY

Possible mechanism of the antidepressant effect of 3,6′-disinapoyl sucrose fromPolygala tenuifoliaWilld

(2011) Yuan Hu et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

Rodent models in depression research: Classical strategies and new directions

(2010) Daniela D. Pollak et al.   ANNALS OF MEDICINE

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Antidepressant effects of the extract YZ-50 fromPolygala tenuifoliain chronic mild stress treated rats and its possible mechanisms

(2010) Yuan Hu et al.   PHARMACEUTICAL BIOLOGY

Antioxidant activity of oligosaccharide ester extracted fromPolygala tenuifoliaroots in senescence-accelerated mice

(2010) Ping Liu et al.   PHARMACEUTICAL BIOLOGY

Potential antidepressant properties of Radix Polygalae (Yuan Zhi)

(2010) P. Liu et al.   PHYTOMEDICINE

Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors

(2008) Mounira Banasr et al.   BIOLOGICAL PSYCHIATRY

Antidepressive-like effects of rapamycin in animal models: Implications for mTOR inhibition as a new target for treatment of affective disorders

(2008) C. Cleary et al.   BRAIN RESEARCH BULLETIN

The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

(2008) Michael Maes et al.   METABOLIC BRAIN DISEASE

Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide

(2006) Johann Steiner et al.   JOURNAL OF PSYCHIATRIC RESEARCH