DP7-C-modified liposomes enhance immune responses and the antitumor effect of a neoantigen-based mRNA vaccine

Cholesterol-modified DP7 enhances the effect of individualized cancer immunotherapy based on neoantigens

(2020) Rui Zhang et al.   BIOMATERIALS

Self-Amplifying RNA Vaccines for Venezuelan Equine Encephalitis Virus Induce Robust Protective Immunogenicity in Mice

(2019) Marcelo M. Samsa et al.   MOLECULAR THERAPY

Non-viral Delivery of Zinc Finger Nuclease mRNA Enables Highly Efficient In Vivo Genome Editing of Multiple Therapeutic Gene Targets

(2019) Anthony Conway et al.   MOLECULAR THERAPY

Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9

(2019) Hong-Xia Zhang et al.   MOLECULAR THERAPY

The Emerging Role of In Vitro-Transcribed mRNA in Adoptive T Cell Immunotherapy

(2019) Jessica B. Foster et al.   MOLECULAR THERAPY

mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases

(2019) Giulietta Maruggi et al.   MOLECULAR THERAPY

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

(2019) Piotr S. Kowalski et al.   MOLECULAR THERAPY

Immunogenicity and tolerability of personalized mRNA vaccine mRNA-4650 encoding defined neoantigens expressed by the autologous cancer.

(2019) Gal Cafri et al.   JOURNAL OF CLINICAL ONCOLOGY

A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection

(2019) Nurgun Kose et al.   Science Immunology

Personalized neoantigen-pulsed dendritic cell vaccines show superior immunogenicity to neoantigen-adjuvant vaccines in mouse tumor models

(2019) Rui Zhang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Delivery of a Modified mRNA Encoding IL-22 Binding Protein (IL-22BP) for Colon Cancer Gene Therapy

(2018) Rui Zhang et al.   Journal of Biomedical Nanotechnology

Novel self-assembled micelles based on cholesterol-modified antimicrobial peptide (DP7) for safe and effective systemic administration in bacteria-infected animal models

(2018) Rui Zhang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phase 1/2 study of mRNA vaccine therapy + durvalumab (durva) ± tremelimumab (treme) in patients with metastatic non-small cell lung cancer (NSCLC).

(2018) Leena Gandhi et al.   JOURNAL OF CLINICAL ONCOLOGY

Biomedical applications of mRNA nanomedicine

(2018) Qingqing Xiong et al.   Nano Research

Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia

(2018) Ding An et al.   Cell Reports

Phase I clinical trial of an intranodally administered mRNA based therapeutic vaccine against HIV-1 infection

(2018) Lorna Leal et al.   AIDS

mRNA-Based Genetic Reprogramming

(2018) Luigi Warren et al.   MOLECULAR THERAPY

Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy: Restoring the immunogenicity of immunosilent mRNA

(2017) Rein Verbeke et al.   JOURNAL OF CONTROLLED RELEASE

Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell-mediated lipid nanoparticle-associated toxicity leading to the safe and efficacious decrease in the hepatitis B virus

(2017) Yusuke Sato et al.   JOURNAL OF CONTROLLED RELEASE

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

(2017) Ugur Sahin et al.   NATURE

Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

(2017) Norbert Pardi et al.   Nature Communications

Synthetic mRNAs for manipulating cellular phenotypes: an overview

(2015) Elgar Susanne Quabius et al.   New Biotechnology

In VitroandIn VivoActivities of Antimicrobial Peptides Developed Using an Amino Acid-Based Activity Prediction Method

(2014) Xiaozhe Wu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

Therapeutic vaccines for cancer: an overview of clinical trials

(2014) Ignacio Melero et al.   Nature Reviews Clinical Oncology

Single-cell mRNA transfection studies: Delivery, kinetics and statistics by numbers

(2013) Carolin Leonhardt et al.   Nanomedicine-Nanotechnology Biology and Medicine

Translocation mechanisms of chemically functionalised carbon nanotubes across plasma membranes

(2012) Lara Lacerda et al.   BIOMATERIALS

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation

(2010) Ranit Kedmi et al.   BIOMATERIALS

Messenger RNA-based Vaccines With Dual Activity Induce Balanced TLR-7 Dependent Adaptive Immune Responses and Provide Antitumor Activity

(2010) Mariola Fotin-Mleczek et al.   JOURNAL OF IMMUNOTHERAPY

TLR-based immune adjuvants

(2010) Folkert Steinhagen et al.   VACCINE