Oleic acid restores suppressive defects in tissue-resident FOXP3 Tregs from patients with multiple sclerosis

Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function

(2019) Will Bailis et al.   NATURE

Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function

(2019) Cameron S. Field et al.   Cell Metabolism

Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-κB) signaling in cancer cells

(2018) Shogo Senga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

(2018) Elham Azizi et al.   CELL

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis

(2018) Ajit S. Divakaruni et al.   Cell Metabolism

CK2 Controls Th17 and Regulatory T Cell Differentiation Through Inhibition of FoxO1

(2018) Sara A. Gibson et al.   JOURNAL OF IMMUNOLOGY

The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations

(2018) Roddy S. O’Connor et al.   Scientific Reports

Induction and maintenance of regulatory T cells by transcription factors and epigenetic modifications

(2017) Mana Iizuka-Koga et al.   JOURNAL OF AUTOIMMUNITY

Protein Kinase CK2 Controls the Fate between Th17 Cell and Regulatory T Cell Differentiation

(2017) Sara A. Gibson et al.   JOURNAL OF IMMUNOLOGY

High density lipoproteins selectively promote the survival of human regulatory T cells

(2017) Cesar M. Rueda et al.   JOURNAL OF LIPID RESEARCH

Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS

(2017) Milena A. Gianfrancesco et al.   NEUROLOGY

Tissue Tregs

(2016) Marisella Panduro et al.   Annual Review of Immunology

Atherosclerosis-Driven Treg Plasticity Results in Formation of a Dysfunctional Subset of Plastic IFNγ + Th1/TregsNovelty and Significance

(2016) Matthew J. Butcher et al.   CIRCULATION RESEARCH

Redundant roles of the phosphatidate phosphatase family in triacylglycerol synthesis in human adipocytes

(2016) Ana Temprano et al.   DIABETOLOGIA

AKT isoforms modulate Th1‐like Treg generation and function in human autoimmune disease

(2016) Alexandra Kitz et al.   EMBO REPORTS

The AMP analog AICAR modulates the Treg/Th17 axis through enhancement of fatty acid oxidation

(2016) Guido A. Gualdoni et al.   FASEB JOURNAL

The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements

(2016) Claudio Procaccini et al.   IMMUNITY

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells

(2016) Marco De Simone et al.   IMMUNITY

Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer

(2016) George Plitas et al.   IMMUNITY

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells

(2016) Wilson Kuswanto et al.   IMMUNITY

Differential effects of palmitoleic acid on human lymphocyte proliferation and function

(2016) M. E. P. Passos et al.   Lipids in Health and Disease

Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

(2016) Valerie A Gerriets et al.   NATURE IMMUNOLOGY

Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers

(2016) Takuro Saito et al.   NATURE MEDICINE

Instability of Helios-deficient Tregs is associated with conversion to a T-effector phenotype and enhanced antitumor immunity

(2016) Hidetoshi Nakagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

(2016) M. Peng et al.   SCIENCE

Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells

(2016) Mulki Angela et al.   Nature Communications

Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival

(2015) Ulf H. Beier et al.   FASEB JOURNAL

Smad2 and Smad3 Inversely Regulate TGF-β Autoinduction in Clostridium butyricum-Activated Dendritic Cells

(2015) Ikkou Kashiwagi et al.   IMMUNITY

A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes

(2015) Tiffany C. Scharschmidt et al.   IMMUNITY

Regulatory T Cell Reprogramming toward a Th2-Cell-like Lineage Impairs Oral Tolerance and Promotes Food Allergy

(2015) Magali Noval Rivas et al.   IMMUNITY

Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis

(2015) Ruili Yang et al.   IMMUNITY

Regulatory T cells produce profibrotic cytokines in the skin of patients with systemic sclerosis

(2015) Katherine G. MacDonald et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Foxp3 lacking exons 2 and 7 is unable to confer suppressive ability to regulatory T cells in vivo

(2015) Anne-Laure Joly et al.   JOURNAL OF AUTOIMMUNITY

Drugs that reverse disease transcriptomic signatures are more effective in a mouse model of dyslipidemia

(2015) A. Wagner et al.   Molecular Systems Biology

Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants

(2015) Veronica De Rosa et al.   NATURE IMMUNOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Long-chain acyl-CoA esters in metabolism and signaling: Role of acyl-CoA binding proteins

(2015) Ditte Neess et al.   PROGRESS IN LIPID RESEARCH

Individual intestinal symbionts induce a distinct population of ROR + regulatory T cells

(2015) E. Sefik et al.   SCIENCE

Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus

(2014) Yongqiang Feng et al.   CELL

Tetraspanins CD9 and CD151 at the immune synapse support T-cell integrin signaling

(2014) Vera Rocha-Perugini et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

(2014) Valerie A. Gerriets et al.   JOURNAL OF CLINICAL INVESTIGATION

Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver

(2014) Cynthia Moffat et al.   JOURNAL OF LIPID RESEARCH

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

(2014) Luciana Berod et al.   NATURE MEDICINE

Appearance and disappearance of the mRNA signature characteristic of Tregcells in visceral adipose tissue: Age, diet, and PPARγ effects

(2014) Daniela Cipolletta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy

(2014) S. A. Villalta et al.   Science Translational Medicine

Post-translational modification networks regulating FOXP3 function

(2014) Jorg van Loosdregt et al.   TRENDS IN IMMUNOLOGY

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Diversity and history of the long-chain acyl-CoA synthetase (Acsl) gene family in vertebrates

(2013) Mónica Lopes-Marques et al.   BMC EVOLUTIONARY BIOLOGY

A Special Population of Regulatory T Cells Potentiates Muscle Repair

(2013) Dalia Burzyn et al.   CELL

Mitochondrial and cytosolic roles of PINK1 shape induced regulatory T-cell development and function

(2013) Gavin I. Ellis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Relationship between central and peripheral fatty acids in humans

(2013) Jade Guest et al.   Lipids in Health and Disease

Acyltransferases and transacylases that determine the fatty acid composition of glycerolipids and the metabolism of bioactive lipid mediators in mammalian cells and model organisms

(2013) Atsushi Yamashita et al.   PROGRESS IN LIPID RESEARCH

Isolation of Adipose Tissue Immune Cells

(2013) Jeb S. Orr et al.   Jove-Journal of Visualized Experiments

Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism

(2012) W. Yi et al.   SCIENCE

PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation

(2011) Tamas Varga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes

(2011) Stephanie A. McClymont et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

Foxp3+ Regulatory T Cells of Psoriasis Patients Easily Differentiate into IL-17A-Producing Cells and Are Found in Lesional Skin

(2011) H. Jorn Bovenschen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Effects of n-3 PUFAs on breast cancer cells through their incorporation in plasma membrane

(2011) Paola A Corsetto et al.   Lipids in Health and Disease

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

(2011) Margarita Dominguez-Villar et al.   NATURE MEDICINE

Visceral Adipose Inflammation in Obesity Is Associated with Critical Alterations in Tregulatory Cell Numbers

(2011) Jeffrey Deiuliis et al.   PLoS One

Two modes of immune suppression by Foxp3+ regulatory T cells under inflammatory or non-inflammatory conditions

(2011) Tomoyuki Yamaguchi et al.   SEMINARS IN IMMUNOLOGY

SIRT4 Regulates Fatty Acid Oxidation and Mitochondrial Gene Expression in Liver and Muscle Cells

(2010) Nargis Nasrin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose transporters in the 21st Century

(2009) Bernard Thorens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Cutaneous manifestations of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome

(2008) M. Halabi-Tawil et al.   BRITISH JOURNAL OF DERMATOLOGY

A Two-Step Process for Thymic Regulatory T Cell Development

(2008) Chan-Wang Joaquim Lio et al.   IMMUNITY

Foxp3+regulatory T cells maintain immune homeostasis in the skin

(2008) Jan C. Dudda et al.   JOURNAL OF EXPERIMENTAL MEDICINE