Interferons in cancer immunoediting: sculpting metastasis and immunotherapy response

Cancer Genome Evolutionary Trajectories in Metastasis

(2020) Nicolai J. Birkbak et al.   CANCER CELL

Tumor Immunology and Tumor Evolution: Intertwined Histories

(2020) Jérôme Galon et al.   IMMUNITY

Top 10 Challenges in Cancer Immunotherapy

(2020) Priti S. Hegde et al.   IMMUNITY

Regenerative lineages and immune-mediated pruning in lung cancer metastasis

(2020) Ashley M. Laughney et al.   NATURE MEDICINE

Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells

(2020) Jason B. Williams et al.   Nature Communications

Comparison of Immune Microenvironment Between Colon and Liver Metastatic Tissue in Colon Cancer Patients with Liver Metastasis

(2020) Su-Na Zhou et al.   DIGESTIVE DISEASES AND SCIENCES

Prostate cancer cell‐intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone

(2020) Katie L Owen et al.   EMBO REPORTS

Loss of ELF5–FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling

(2020) Snahlata Singh et al.   NATURE CELL BIOLOGY

Molecular mechanisms and cellular functions of cGAS–STING signalling

(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours

(2020) Ellen Brenner et al.   Nature Communications

Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia

(2020) Jayakumar Vadakekolathu et al.   Science Translational Medicine

Activation of STING by cGAMP Regulates MDSCs to Suppress Tumor Metastasis via Reversing Epithelial-Mesenchymal Transition

(2020) Hao Cheng et al.   Frontiers in Oncology

Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts

(2019) Maartje van der Heijden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferons α and β in cancer: therapeutic opportunities from new insights

(2019) Ernest C. Borden   NATURE REVIEWS DRUG DISCOVERY

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

(2019) Timothy F. Cloughesy et al.   NATURE MEDICINE

Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells

(2019) Yuxuan Miao et al.   CELL

Shared and Distinct Functions of Type I and Type III Interferons

(2019) Helen M. Lazear et al.   IMMUNITY

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

(2019) David W. Vredevoogd et al.   CELL

Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade

(2019) Joseph L. Benci et al.   CELL

Type I IFN protects cancer cells from CD8+ T cell–mediated cytotoxicity after radiation

(2019) Jianzhou Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Tracing the Equilibrium Phase of Cancer Immunoediting in Epidermal Neoplasms via Longitudinal, Intravital Imaging

(2019) Bradley J. Kubick et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cancer Stem Cells and Epithelial-to-Mesenchymal Transition in Cancer Metastasis

(2019) Toni Celià-Terrassa et al.   Cold Spring Harbor Perspectives in Medicine

Interferon target-gene expression and epigenomic signatures in health and disease

(2019) Franck J. Barrat et al.   NATURE IMMUNOLOGY

Immune effector monocyte–neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer

(2019) Catharina Hagerling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer

(2018) Matthew D. Hellmann et al.   CANCER CELL

Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer

(2018) Allen W. Zhang et al.   CELL

LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

(2018) Wanqiang Sheng et al.   CELL

NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis

(2018) Ariella Glasner et al.   IMMUNITY

Epithelial-mesenchymal transition leads to NK cell–mediated metastasis-specific immunosurveillance in lung cancer

(2018) Peter J. Chockley et al.   JOURNAL OF CLINICAL INVESTIGATION

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

(2018) Peter Savas et al.   NATURE MEDICINE

Induction of oligoclonal CD8 T cell responses against pulmonary metastatic cancer by a phospholipid-conjugated TLR7 agonist

(2018) Tadashi Hosoya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing

(2018) Deng Pan et al.   SCIENCE

Extended release of perioperative immunotherapy prevents tumor recurrence and eliminates metastases

(2018) Chun Gwon Park et al.   Science Translational Medicine

IFN-γ Induces Gastric Cancer Cell Proliferation and Metastasis Through Upregulation of Integrin β3-Mediated NF-κB Signaling

(2018) Yuan-Hua Xu et al.   Translational Oncology

Interferon γ and Its Important Roles in Promoting and Inhibiting Spontaneous and Therapeutic Cancer Immunity

(2018) Elise Alspach et al.   Cold Spring Harbor Perspectives in Biology

Immunological differences between primary and metastatic breast cancer

(2018) B Szekely et al.   ANNALS OF ONCOLOGY

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

(2018) Livnat Jerby-Arnon et al.   CELL

Evolution of Metastases in Space and Time under Immune Selection

(2018) Mihaela Angelova et al.   CELL

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

(2018) Moshe Sade-Feldman et al.   CELL

Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade

(2018) Jeffrey J. Ishizuka et al.   NATURE

Cancer immunoediting and resistance to T cell-based immunotherapy

(2018) Jake S. O’Donnell et al.   Nature Reviews Clinical Oncology

IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

(2017) Mark Ayers et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial Interferon Regulatory Factor 1 Regulates Lipopolysaccharide-Induced VCAM-1 Expression Independent of NFκB

(2017) Rui Yan et al.   Journal of Innate Immunity

Accelerated tumour metastasis due to interferon-γ receptor-mediated dissociation of perivascular cells from blood vessels

(2017) Chen Ni et al.   JOURNAL OF PATHOLOGY

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

(2017) Felipe de Sousa e Melo et al.   NATURE

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

(2017) Louise van der Weyden et al.   NATURE

T-cell invigoration to tumour burden ratio associated with anti-PD-1 response

(2017) Alexander C. Huang et al.   NATURE

Identification of essential genes for cancer immunotherapy

(2017) Shashank J. Patel et al.   NATURE

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

(2017) Robert T. Manguso et al.   NATURE

Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a–LCOR axis

(2017) Toni Celià-Terrassa et al.   NATURE CELL BIOLOGY

Overexpression of Interferon Regulatory Factor 7 (IRF7) Reduces Bone Metastasis of Prostate Cancer Cells in Mice

(2017) Yang Zhao et al.   ONCOLOGY RESEARCH

Interferon-beta represses cancer stem cell properties in triple-negative breast cancer

(2017) Mary R. Doherty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions

(2017) Antje Sucker et al.   Nature Communications

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

Neoadjuvant Interferons: Critical for Effective PD-1–Based Immunotherapy in TNBC

(2017) Natasha K. Brockwell et al.   Cancer Immunology Research

Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy

(2016) Jianjun Gao et al.   CELL

Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

(2016) Joseph L. Benci et al.   CELL

Combination Cancer Therapies with Immune Checkpoint Blockade: Convergence on Interferon Signaling

(2016) Andy J. Minn et al.   CELL

Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma

(2016) Y. Lou et al.   CLINICAL CANCER RESEARCH

Distinctive properties of metastasis-initiating cells

(2016) Toni Celià-Terrassa et al.   GENES & DEVELOPMENT

Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

(2016) Qing Chen et al.   NATURE

Circulating and disseminated tumour cells — mechanisms of immune surveillance and escape

(2016) Malte Mohme et al.   Nature Reviews Clinical Oncology

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance

(2016) David H. Munn et al.   TRENDS IN IMMUNOLOGY

Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models

(2016) Alessia Bottos et al.   Nature Communications

Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations

(2016) Daniel Sanghoon Shin et al.   Cancer Discovery

Metastatic Melanoma Cells Evade Immune Detection by Silencing STAT1

(2015) JoDi Osborn et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multiple Structural and Epigenetic Defects in the Human Leukocyte Antigen Class I Antigen Presentation Pathway in a Recurrent Metastatic Melanoma Following Immunotherapy

(2015) Chien-Chung Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interferons and the Immunogenic Effects of Cancer Therapy

(2015) Andy J. Minn   TRENDS IN IMMUNOLOGY

Adaptive Immune Resistance: How Cancer Protects from Immune Attack

(2015) A. Ribas   Cancer Discovery

Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer

(2015) J. Rautela et al.   Cancer Immunology Research

Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways

(2014) Mirjam C. Boelens et al.   CELL

IFNγ-responsiveness of endothelial cells leads to efficient angiostasis in tumours involving down-regulation of Dll4

(2014) Jingjing Deng et al.   JOURNAL OF PATHOLOGY

Perforin-dependent direct cytotoxicity in natural killer cells induces considerable knockdown of spontaneous lung metastases and computer modelling-proven tumor cell dormancy in a HT29 human colon cancer xenograft mouse model

(2014) Tobias Brodbeck et al.   Molecular Cancer

MDSCs Mediate Angiogenesis and Predispose Canine Mammary Tumor Cells for Metastasis via IL-28/IL-28RA (IFN-λ) Signaling

(2014) Joanna Mucha et al.   PLoS One

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

(2014) Limo Chen et al.   Nature Communications

Immune Cell-Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation

(2014) T. Bald et al.   Cancer Discovery

CCL2 increases αvβ3 integrin expression and subsequently promotes prostate cancer migration

(2013) Tien-Huang Lin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-  in a murine model of polycythemia vera

(2013) A. Mullally et al.   BLOOD

Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer

(2013) Gabriela Bindea et al.   IMMUNITY

Cytotoxic T cells induce proliferation of chronic myeloid leukemia stem cells by secreting interferon-γ

(2013) Christian Schürch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T-helper-1-cell cytokines drive cancer into senescence

(2013) Heidi Braumüller et al.   NATURE

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

(2013) R. J. Thapa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells

(2013) S. Spranger et al.   Science Translational Medicine

TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma

(2012) Pengyuan Yang et al.   CANCER CELL

Impaired IFN-  Production by Plasmacytoid Dendritic Cells Favors Regulatory T-cell Expansion That May Contribute to Breast Cancer Progression

(2012) V. Sisirak et al.   CANCER RESEARCH

Cancer immunoediting by the innate immune system in the absence of adaptive immunity

(2012) Timothy O’Sullivan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD8 T Cell Priming in the Presence of IFN-  Renders CTLs with Improved Responsiveness to Homeostatic Cytokines and Recall Antigens: Important Traits for Adoptive T Cell Therapy

(2012) S. Hervas-Stubbs et al.   JOURNAL OF IMMUNOLOGY

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

(2012) Hirokazu Matsushita et al.   NATURE

Expression of tumour-specific antigens underlies cancer immunoediting

(2012) Michel DuPage et al.   NATURE

Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape

(2012) Bradley N Bidwell et al.   NATURE MEDICINE

Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice

(2011) B. L. Mundy-Bosse et al.   CANCER RESEARCH

CpG Blocks Immunosuppression by Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

(2011) C. Zoglmeier et al.   CLINICAL CANCER RESEARCH

IRF7: activation, regulation, modification and function

(2011) S Ning et al.   GENES AND IMMUNITY

Host type I IFN signals are required for antitumor CD8+T cell responses through CD8α+dendritic cells

(2011) Mercedes B. Fuertes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Intratumoral T cell infiltration, MHC class I and STAT1 as biomarkers of good prognosis in colorectal cancer

(2010) J. A. D. Simpson et al.   GUT

Type 1 T Helper Cells Induce the Accumulation of Myeloid-Derived Suppressor Cells in the Inflamed Tgfb1 Knockout Mouse Liver

(2010) James G. Cripps et al.   HEPATOLOGY

Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma

(2010) Jo Eyles et al.   JOURNAL OF CLINICAL INVESTIGATION

Interferon- -triggered indoleamine 2,3-dioxygenase competence in human monocyte-derived dendritic cells induces regulatory activity in allogeneic T cells

(2009) B. Jurgens et al.   BLOOD

Interferon-γ reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages

(2009) Dorothée Duluc et al.   INTERNATIONAL JOURNAL OF CANCER

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Responsiveness of Stromal Fibroblasts to IFN-  Blocks Tumor Growth via Angiostasis

(2009) Y. Lu et al.   JOURNAL OF IMMUNOLOGY

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

Tumor-Targeted Interferon-α Delivery by Tie2-Expressing Monocytes Inhibits Tumor Growth and Metastasis

(2008) Michele De Palma et al.   CANCER CELL

TNFR1 Signaling and IFN-γ Signaling Determine whether T Cells Induce Tumor Dormancy or Promote Multistage Carcinogenesis

(2008) Nele Müller-Hermelink et al.   CANCER CELL

Critical role for constitutive type I interferon signaling in the prevention of cellular transformation

(2008) Hui-min Chen et al.   CANCER SCIENCE

Regulation of apoptosis by type III interferons

(2008) W. Li et al.   CELL PROLIFERATION

Epigenetic disruption of interferon-γ response through silencing the tumor suppressor interferon regulatory factor 8 in nasopharyngeal, esophageal and multiple other carcinomas

(2008) K Y Lee et al.   ONCOGENE

An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer

(2008) R. R. Weichselbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA