Optogenetic control of small GTPases reveals RhoA mediates intracellular calcium signaling

Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms

(2020) Peng Jin et al.   Annual Review of Neuroscience

Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy

(2019) Craig A Nash et al.   eLife

Calcium signaling and the therapeutic targeting of cancer cells

(2018) Alice H.L. Bong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Membrane Flow Drives an Adhesion-Independent Amoeboid Cell Migration Mode

(2018) Patrick R. O'Neill et al.   DEVELOPMENTAL CELL

G protein βγ subunits directly interact with and activate phospholipase Cϵ

(2018) Jerry C. Madukwe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optogenetic dissection of Rac1 and Cdc42 gradient shaping

(2018) S. de Beco et al.   Nature Communications

RalB directly triggers invasion downstream Ras by mobilizing the Wave complex

(2018) Giulia Zago et al.   eLife

PI3K class II α regulates δ-opioid receptor export from the trans-Golgi network

(2017) Daniel J. Shiwarski et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanical stretch triggers rapid epithelial cell division through Piezo1

(2017) S. A. Gudipaty et al.   NATURE

Optogenetic control of cellular forces and mechanotransduction

(2017) Léo Valon et al.   Nature Communications

Local RhoA activation induces cytokinetic furrows independent of spindle position and cell cycle stage

(2016) Elizabeth Wagner et al.   JOURNAL OF CELL BIOLOGY

Rho kinase activity governs arteriolar myogenic depolarization

(2016) Yao Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Subcellular optogenetic activation of Cdc42 controls local and distal signaling to drive immune cell migration

(2016) Patrick R. O’Neill et al.   MOLECULAR BIOLOGY OF THE CELL

Optogenetic Control of Protein Function: From Intracellular Processes to Tissue Morphogenesis

(2016) Giorgia Guglielmi et al.   TRENDS IN CELL BIOLOGY

Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

(2016) Charles D. Cox et al.   Nature Communications

G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway

(2015) S. Malik et al.   MOLECULAR BIOLOGY OF THE CELL

Light generation of intracellular Ca2+ signals by a genetically encoded protein BACCS

(2015) Tomohiro Ishii et al.   Nature Communications

Illuminating cell signalling with optogenetic tools

(2014) Doug Tischer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins

(2014) Gurkan Guntas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using Optogenetics to Interrogate the Dynamic Control of Signal Transmission by the Ras/Erk Module

(2013) Jared E. Toettcher et al.   CELL

Phospholipase Cε Hydrolyzes Perinuclear Phosphatidylinositol 4-Phosphate to Regulate Cardiac Hypertrophy

(2013) Lianghui Zhang et al.   CELL

Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission

(2013) Matthew K. Martz et al.   MOLECULAR BIOLOGY OF THE CELL

Optogenetic Control of PIP3: PIP3 Is Sufficient to Induce the Actin-Based Active Part of Growth Cones and Is Regulated via Endocytosis

(2013) Toshiyuki Kakumoto et al.   PLoS One

Role of phospholipase Cε in physiological phosphoinositide signaling networks

(2012) Alan V. Smrcka et al.   CELLULAR SIGNALLING

A Fluorogenic Red Fluorescent Protein Heterodimer

(2012) Spencer C. Alford et al.   CHEMISTRY & BIOLOGY

Activity of PLC  contributes to chemotaxis of fibroblasts towards PDGF

(2012) M. Martins et al.   JOURNAL OF CELL SCIENCE

TULIPs: tunable, light-controlled interacting protein tags for cell biology

(2012) Devin Strickland et al.   NATURE METHODS

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Optogenetic control of phosphoinositide metabolism

(2012) O. Idevall-Hagren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The contractile ring

(2011) Ann L. Miller   CURRENT BIOLOGY

Development of an optimized backbone of FRET biosensors for kinases and GTPases

(2011) Naoki Komatsu et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of Constitutive Cargo Transport from thetrans-Golgi Network to Plasma Membrane by Golgi-localized G Protein βγ Subunits

(2010) Roshanak Irannejad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The promise of optogenetics in cell biology: interrogating molecular circuits in space and time

(2010) Jared E Toettcher et al.   NATURE METHODS

Rapid blue-light–mediated induction of protein interactions in living cells

(2010) Matthew J Kennedy et al.   NATURE METHODS

Making the Cut: The Chemical Biology of Cytokinesis

(2009) G. Ekin Atilla-Gokcumen et al.   ACS Chemical Biology

Spatiotemporal control of cell signalling using a light-switchable protein interaction

(2009) Anselm Levskaya et al.   NATURE

A genetically encoded photoactivatable Rac controls the motility of living cells

(2009) Yi I. Wu et al.   NATURE

Dual Activation of Phospholipase C-ϵ by Rho and Ras GTPases

(2008) Jason P. Seifert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase C isozymes as effectors of Ras superfamily GTPases

(2008) T. Kendall Harden et al.   JOURNAL OF LIPID RESEARCH

Regulation of cytokinesis by Rho GTPase flux

(2008) Ann L. Miller et al.   NATURE CELL BIOLOGY

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY