Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission

The RhoGAP Domain of CYK-4 Has an Essential Role in RhoA Activation

(2012) Andy Loria et al.   CURRENT BIOLOGY

Molecular control of animal cell cytokinesis

(2012) Juan Pablo Fededa et al.   NATURE CELL BIOLOGY

LARG links histamine-H1-receptor-activated Gq to Rho-GTPase-dependent signaling pathways

(2011) Mariana Pfreimer et al.   CELLULAR SIGNALLING

Targeting of the RhoGEF Ect2 to the Equatorial Membrane Controls Cleavage Furrow Formation during Cytokinesis

(2011) Kuan-Chung Su et al.   DEVELOPMENTAL CELL

The regulation of abscission by multi-protein complexes

(2011) H. Neto et al.   JOURNAL OF CELL SCIENCE

Citron kinase controls abscission through RhoA and anillin

(2011) Marta Gai et al.   MOLECULAR BIOLOGY OF THE CELL

Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis

(2011) Daphné Dambournet et al.   NATURE CELL BIOLOGY

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

(2011) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Dynamics of endosomal sorting complex required for transport (ESCRT) machinery during cytokinesis and its role in abscission

(2011) N. Elia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingosine 1-Phosphate Receptor 2 Signals Through Leukemia-Associated RhoGEF (LARG), to Promote Smooth Muscle Cell Differentiation

(2010) Matt D. Medlin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Defects in nuclear pore assembly lead to activation of an Aurora B–mediated abscission checkpoint

(2010) Douglas R. Mackay et al.   JOURNAL OF CELL BIOLOGY

Distinct roles of septins in cytokinesis: SEPT9 mediates midbody abscission

(2010) Mathew P. Estey et al.   JOURNAL OF CELL BIOLOGY

Evidence that Mitotic Exit Is a Better Cancer Therapeutic Target Than Spindle Assembly

(2009) Hsiao-Chun Huang et al.   CANCER CELL

Aurora B-Mediated Abscission Checkpoint Protects against Tetraploidization

(2009) Patrick Steigemann et al.   CELL

A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells

(2009) Mohamed Aittaleb et al.   CELLULAR SIGNALLING

The mDial Formin Is Required for Neutrophil Polarization, Migration, and Activation of the LARG/RhoA/ROCK Signaling Axis during Chemotaxis

(2009) Y. Shi et al.   JOURNAL OF IMMUNOLOGY

Centrosome/Spindle Pole–associated Protein Regulates Cytokinesis via Promoting the Recruitment of MyoGEF to the Central Spindle

(2009) Michael Asiedu et al.   MOLECULAR BIOLOGY OF THE CELL

Cytokinetic abscission: cellular dynamics at the midbody

(2009) Patrick Steigemann et al.   TRENDS IN CELL BIOLOGY

Polo-Like Kinase 1 Directs Assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF Complex to Initiate Cleavage Furrow Formation

(2009) Benjamin A. Wolfe et al.   PLOS BIOLOGY

ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA

(2008) Shuh-hei Fujishiro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Final Stages of Cytokinesis and Midbody Ring Formation Are Controlled by BRUCE

(2008) Christian Pohl et al.   CELL

GEF-H1 Couples Nocodazole-induced Microtubule Disassembly to Cell Contractility via RhoA

(2008) Yuan-Chen Chang et al.   MOLECULAR BIOLOGY OF THE CELL

Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B

(2008) Dong Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

LARG and mDia1 Link Gα12/13 to Cell Polarity and Microtubule Dynamics

(2007) Polyxeni Goulimari et al.   MOLECULAR BIOLOGY OF THE CELL