Article
Nutrition & Dietetics
Xin Qian, Qian Si, Guopeng Lin, Minmin Zhu, Jingyu Lu, Hao Zhang, Gang Wang, Wei Chen
Summary: This study investigates the relieving effects of two dominant Bifidobacterium species on type 2 diabetes (T2D) and explores the possible mechanisms. The results suggest that B. adolescentis strains are more effective in alleviating T2D symptoms compared to B. bifidum strains. This effect is closely related to the ability of B. adolescentis to restore gut microbiota homeostasis, increase short-chain fatty acid-producing flora, and reduce inflammation.
Article
Biochemistry & Molecular Biology
Xiangnan Zhang, Qiannan Li, Ning Han, Chaofan Song, Yangnan Lin, Liansheng Zhang, Daoyuan Ren, Yan Zhao, Xingbin Yang, Ting Li
Summary: The antidiabetic effects and underlying mechanisms of the polysaccharides extracted from Fu brick tea (FBTP) were investigated in high-fat diet/streptozotocin-induced type 2 diabetes mellitus (T2DM) rats. It was found that FBTP could alleviate dyslipidemia, insulin resistance, and oxidative stress in T2DM rats by reshaping the gut microbiota and regulating intestinal metabolites.
Article
Cardiac & Cardiovascular Systems
Daria Igudesman, Jamie Crandell, Karen D. Corbin, Dessi P. Zaharieva, Ananta Addala, Joan M. Thomas, Cynthia M. Bulik, Brian W. Pence, Richard E. Pratley, Michael R. Kosorok, David M. Maahs, Ian M. Carroll, Elizabeth J. Mayer-Davis
Summary: This study aimed to evaluate the association between disordered eating and gut microbiota-derived short chain fatty acids (SCFA) in individuals with type 1 diabetes. The results showed that disordered eating and insulin restriction were associated with a reduced abundance of gut microbes that produce SCFA.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Maria-Adriana Neag, Anca-Elena Craciun, Andreea-Ioana Inceu, Diana-Elena Burlacu, Cristian-Ioan Craciun, Anca-Dana Buzoianu
Summary: Diabetes mellitus is a multifactorial disease with gastrointestinal symptoms caused by the enteric nervous system, which functions independently of the central nervous system. Short-chain fatty acids (SCFAs), bacterial metabolites of gut microbiota, modulate the enteric nervous system and have beneficial effects on diabetes. However, the specific nutraceuticals to increase SCFAs and achieve these effects are uncertain. Further studies are needed to understand the modulation of gut dysbiosis with SCFAs in diabetes, as well as the interplay between gut microbiota and the enteric nervous system.
Article
Endocrinology & Metabolism
Guo-Chong Chen, Rhonda Arthur, Li-Qiang Qin, Li-Hua Chen, Zhendong Mei, Yan Zheng, Yang Li, Tao Wang, Thomas E. Rohan, Qibin Qi
Summary: The study found that consumption of oily fish, but not nonoily fish, was associated with a lower risk of type 2 diabetes in 392,287 middle-aged and older participants. Additionally, the use of fish oil supplements was also linked to a reduced risk of developing type 2 diabetes, especially with consistent use over time.
Article
Biochemistry & Molecular Biology
Yongcan Jin, Shuang Qi, Bo Jiang, Caoxing Huang
Summary: As the number of diabetes cases continues to rise, there is a growing need for effective management of diabetes and its effects. This study investigated the effects of sulfonated lignin with varying sulfonation degrees on the inhibition of alpha-amylase and alpha-glucosidase and the proliferation of intestinal beneficial bacteria in vitro. The results showed that sulfonated lignin could inhibit the activity of alpha-amylase and alpha-glucosidase and promote the growth of beneficial bacteria, suggesting its potential as a prebiotic for the prevention and treatment of type 2 diabetes mellitus.
Review
Biochemistry & Molecular Biology
Yifeng Fu, Siying Li, Yunhua Xiao, Gang Liu, Jun Fang
Summary: This study explores the importance of microbiota metabolites in type 2 diabetes (T2D), as well as the role of medication and dietary components in reducing the risk of developing diabetes. A deeper understanding of the link between gut microbial metabolites and T2D will enhance our knowledge of the disease and may offer new treatment approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Stephen J. Hierons, Jordan S. Marsh, Dongmei Wu, Claudia A. Blindauer, Alan J. Stewart
Summary: The disruption of HSA-Zn2+ binding by NEFA is a potential mechanism contributing to the prothrombotic milieu in obesity and T2DM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Dominic Salamone, Angela Albarosa Rivellese, Claudia Vetrani
Summary: The gut microbiota and its metabolites can influence various physiological mechanisms related to human health. Dietary fiber may play a key role in modulating the risk of metabolic diseases by affecting gut microbiota activity and SCFA production. Studies have explored the relationship between gut microbiota, short-chain fatty acids, and glucose metabolism, discussing the potential mechanisms behind this association.
ACTA DIABETOLOGICA
(2021)
Article
Nutrition & Dietetics
Daria Igudesman, Jamie L. Crandell, Karen D. Corbin, Julie Hooper, Joan M. Thomas, Cynthia M. Bulik, Brian W. Pence, Richard E. Pratley, Michael R. Kosorok, David M. Maahs, Ian M. Carroll, Elizabeth J. Mayer-Davis
Summary: This study aims to explore whether increased carbohydrate intake is associated with SCFA-producing gut microbes, SCFA, and intestinal microbial diversity in young adults with long-standing type 1 diabetes. The results showed that fiber and carbohydrate intake were positively associated with fecal SCFA and acetate concentrations. Controlled feeding studies should be conducted to determine whether gut microbes and SCFA can be directly manipulated in type 1 diabetes.
JOURNAL OF NUTRITION
(2023)
Article
Multidisciplinary Sciences
Froukje Vanweert, Michael Neinast, Edmundo Erazo Tapia, Tineke van de Weijer, Joris Hoeks, Vera B. Schrauwen-Hinderling, Megan C. Blair, Marc R. Bornstein, Matthijs K. C. Hesselink, Patrick Schrauwen, Zoltan Arany, Esther Phielix
Summary: This study used NaPB to lower plasma BCAA levels in patients with T2D and found that it improved peripheral insulin sensitivity, muscle mitochondrial oxidative capacity, and whole-body insulin-stimulated carbohydrate oxidation while reducing plasma BCAA and glucose levels.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Jiaojiao Han, Ziyan Wang, Chenyang Lu, Jun Zhou, Ye Li, Tinghong Ming, Zhen Zhang, Zaijie Jim Wang, Xiurong Su
Summary: Anserine, a natural carnosine derivative, demonstrates anti-hyperuricaemic and anti-inflammatory effects by inhibiting uric acid biosynthesis and promoting excretion. It also relies on the gut microbiota to alleviate hyperuricaemia, improve intestinal barrier function, and increase short-chain fatty acid production. The protective effects of anserine on hyperuricaemia can be partially mediated by the gut microbiota, making it a new and safe prebiotic material and suggesting potential development of oligopeptides.
Article
Surgery
Maria A. Martinez-Sanchez, Andres Balaguer-Roman, Virginia E. Fernandez-Ruiz, Sonia Almansa-Saura, Victoria Garcia-Zafra, Mercedes Ferrer-Gomez, Maria D. Frutos, Maria I. Queipo-Ortuno, Antonio J. Ruiz-Alcaraz, Maria A. Nunez-Sanchez, Bruno Ramos-Molina
Summary: Obesity has become an epidemic and bariatric surgery is an effective intervention for weight loss. Short-chain fatty acids (SCFA) play a key role in weight control and insulin sensitivity. This study investigated the impact of bariatric surgery on circulating SCFA levels in patients with severe obesity.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Article
Nutrition & Dietetics
Hui-Ju Tsai, Wei-Chun Hung, Wei-Wen Hung, Yen-Jung Lee, Yo-Chia Chen, Chun-Ying Lee, Yi-Chun Tsai, Chia-Yen Dai
Summary: This study aimed to explore the association between short-chain fatty acids (SCFAs) and the severity of non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes mellitus (T2D) patients. The results showed that the circulating levels of isobutyrate and methylbutyrate were negatively correlated with NAFLD severity. This suggests that SCFAs may be related to the severity of NAFLD in T2D patients.
Review
Endocrinology & Metabolism
Phillip J. White, Robert W. McGarrah, Mark A. Herman, James R. Bain, Svati H. Shah, Christopher B. Newgard
Summary: The association of obesity and insulin resistance with increased levels of branched-chain and aromatic amino acids and decreased glycine levels is well-established. Human metabolomics and genetic studies have further confirmed these observations, with preclinical studies identifying mechanisms involved in amino acid homeostasis disruption and its connection to dysregulated glucose and lipid metabolism, particularly in the development of insulin resistance, type 2 diabetes, and cardiovascular diseases.
MOLECULAR METABOLISM
(2021)
Article
Medicine, General & Internal
C. C. Van Olden, A. W. Van de Laar, A. S. Meijnikman, O. Aydin, N. Van Olst, J. B. Hoozemans, L. M. De Brauw, S. C. Bruin, Y. I. Z. Acherman, J. Verheij, J. E. Pyykko, M. Hagedoorn, R. Sanderman, N. C. Bosma, V. Tremaroli, A. Lundqvist, L. E. Olofsson, H. Herrema, D. Lappa, S. Hjorth, J. Nielsen, T. Schwartz, A. K. Groen, M. Nieuwdorp, F. Backhed, V. E. A. Gerdes
Summary: The BARIA study aims to investigate the impact of gut microbiota and their metabolites on metabolism in obese patients, as well as how baseline characteristics affect clinical outcomes after bariatric surgery. Through comprehensive analyses of patient samples using metagenomics and metabolomics, the study hopes to provide insights into the epidemic of obesity-related diseases.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Mark M. Smits, Kristina S. Fluitman, Hilde Herrema, Mark Davids, Mark H. H. Kramer, Albert K. Groen, Clara Belzer, Willem M. de Vos, Djuna L. Cahen, Max Nieuwdorp, Daniel H. van Raalte
Summary: The study aimed to investigate the effects of GLP-1 receptor agonists and DPP-4 inhibitors on the intestinal microbiota in adults with type 2 diabetes. Results showed that these agents did not affect the diversity of the intestinal microbiota, nor were changes in microbial composition related to clinical parameters.
DIABETES & METABOLISM
(2021)
Letter
Gastroenterology & Hepatology
Abraham S. Meijnikman, Sjoerd Bruin, Albert K. Groen, Max Nieuwdorp, Hilde Herrema
JOURNAL OF HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Torsten P. M. Scheithauer, Guido J. Bakker, Maaike Winkelmeijer, Mark Davids, Max Nieuwdorp, Daniel H. van Raalte, Hilde Herrema
Summary: Intestinal immunoglobulins play a crucial role in binding bacteria in the gut and accelerating their transit time, while also preventing the interaction of immunogenic compounds with intestinal immune cells. A study on the impact of vancomycin treatment on gut microbiome composition found that the increase in Gram-negative bacteria coincided with significantly elevated levels of immunogenic bacterial components in the feces. This led to a notable increase in intestinal antibodies, particularly IgA and IgM, which acted as a defense mechanism against pathogen intrusion into systemic sites.
Article
Endocrinology & Metabolism
P. Maria Clemente-Olivo, J. Jayron Habibe, Mariska Vos, Roelof Ottenhoff, Aldo Jongejan, Hilde Herrema, Noam Zelcer, Sander Kooijman, Patrick C. N. Rensen, Daniel H. van Raalte, Max Nieuwdorp, Etto C. Eringa, J. Carlie de Vries
Summary: The study reveals that the FHL2 gene is associated with obesity and energy metabolism. FHL2 deficiency protects mice from high-fat diet-induced weight gain while glucose handling remains normal. Enhanced energy expenditure was observed in multiple tissues.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Nutrition & Dietetics
Pierre Bel Lassen, Ilias Attaye, Solia Adriouch, Mary Nicolaou, Judith Aron-Wisnewsky, Trine Nielsen, Rima Chakaroun, Emmanuelle Le Chatelier, Sofia Forslund, Eugeni Belda, Peer Bork, Fredrik Backhed, Michael Stumvoll, Oluf Pedersen, Hilde Herrema, Albert K. Groen, Sara-Joan Pinto-Sietsma, Aeilko H. Zwinderman, Max Nieuwdorp, Karine Clement
Summary: The study investigates the associations between dietary protein intake, gut microbiota composition, and metabolic status in different ethnicities. Animal protein intake is associated with pre-T2D and T2D status but not with gut microbiota diversity, regardless of ethnicity.
Review
Nutrition & Dietetics
Carlijn A. Wagenaar, Marieke van de Put, Michelle Bisschops, Wendy Walrabenstein, Catharina S. de Jonge, Hilde Herrema, Dirkjan van Schaardenburg
Summary: The study shows that high-fiber plant-based dietary interventions are more effective at reducing disease-specific outcomes and increasing microbiome diversity compared to other diets and fiber supplements, especially in patients with T2DM.
Article
Microbiology
Annefleur M. Koopen, Eduardo L. Almeida, Ilias Attaye, Julia J. Witjes, Elena Rampanelli, Soumia Majait, Marleen Kemper, Johannes H. M. Levels, Alinda W. M. Schimmel, Hilde Herrema, Torsten P. M. Scheithauer, Werner Frei, Lars Dragsted, Bolette Hartmann, Jens J. Holst, Paul W. O'Toole, Albert K. Groen, Max Nieuwdorp
Summary: Recent study investigated the potential synergistic effects of combining a Mediterranean diet with lean donor fecal microbiota transplantation (FMT) in metabolic syndrome subjects. The results showed no significant synergistic effects on insulin sensitivity, although the Mediterranean diet led to reductions in body weight, HOMA-IR, and lipid levels. Further trials are needed to explore the combination of other microbial interventions and diets in metabolic syndrome.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Endocrinology & Metabolism
Guido J. Bakker, Abraham S. Meijnikman, Torsten P. Scheithauer, Mark Davids, Omrum Aydin, Thomas C. C. Boerlage, L. Maurits de Brauw, Arnold W. van de Laar, Victor E. Gerdes, Albert K. Groen, Daniel H. van Raalte, Hilde Herrema, Max Nieuwdorp
Summary: The study found that fecal microbiota transplantation did not change the visceral bacterial DNA content or inflammation levels in obese individuals, suggesting that bacterial translocation may not be the main driver of visceral adipose tissue inflammation in obesity.
OBESITY SCIENCE & PRACTICE
(2022)
Article
Gastroenterology & Hepatology
Ilias Attaye, Moritz Warmbrunn, Aureline N. A. F. Boot, Suze C. van der Wolk, Barbara A. Hutten, Joost G. Daams, Hilde Herrema, Max Nieuwdorp
Summary: Dietary interventions can modulate gut microbiota composition, blood pressure, and circulating triglycerides. However, current studies have high methodological heterogeneity and risk of bias. Well-designed and controlled studies are necessary to better understand the complex interaction between diet, microbiome, and cardiometabolic diseases.
Article
Gastroenterology & Hepatology
Torsten P. M. Scheithauer, Mark Davids, Maaike Winkelmeijer, Xanthe Verdoes, Omrum Aydin, Maurits de Brauw, Arnold van de Laar, Abraham S. Meijnikman, Victor E. A. Gerdes, Daniel van Raalte, Hilde Herrema, Max Nieuwdorp
Summary: Obesity and type 2 diabetes are growing burdens for individuals and the healthcare system. Bariatric surgery has been found to effectively reduce body weight, normalize glucose values, and reduce low-grade inflammation. This study investigated the effect of bariatric surgery on gut microbiome and antibody response in obese individuals with and without T2D. The findings suggest that bariatric surgery leads to an expansion of pro-inflammatory bacteria in the gut, but also enhances the antibody response, which may help reduce systemic inflammation and improve intestinal barrier function.
Editorial Material
Gastroenterology & Hepatology
Moritz V. Warmbrunn, Ilias Attaye, Hilde Herrema, Max Nieuwdorp
Article
Microbiology
Koen Wortelboer, Guido J. Bakker, Maaike Winkelmeijer, Natal van Riel, Evgeni Levin, Max Nieuwdorp, Hilde Herrema, Mark Davids
Summary: The gut microbiota and secreted miRNAs have an interaction, and changes in the microbiota can affect the composition of secreted miRNAs.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Pilar Manrique, Yifan Zhu, John van der Oost, Hilde Herrema, Max Nieuwdorp, Willem M. de Vos, Mark Young
Summary: Metabolic Syndrome (MetS) poses a global public health concern, increasing the risk of cardiovascular diseases and type 2 diabetes. Fecal microbiota transplantation (FMT) for MetS can impact the gut bacteriophage community, with better clinical outcomes associated with similarity to healthy donors. Identified bacteriophage groups may help explain differences in treatment response.
Review
Gastroenterology & Hepatology
Abraham Stijn Meijnikman, Hilde Herrema, Torsten Pascal Marcel Scheithauer, Jeffrey Kroon, Max Nieuwdorp, Albert Kornelis Groen
Summary: Cellular senescence is a state of irreversible cell cycle arrest with important physiological functions, but it is also associated with ageing and various pathological conditions. Senescent cells are characterized by short telomeres, enlarged nuclear area, and damaged DNA. The secretion of proinflammatory proteins is a key feature of senescent cells that is thought to contribute to their disease-inducing properties.
