期刊
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
卷 72, 期 4, 页码 499-510出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09637486.2020.1849041
关键词
Pomegranate (Punica granatum); high-fat diet; hepatoprotection; non-alcoholic fatty liver disease (NAFLD); anti-neuroinflammation
资金
- University of Rhode Island Council
The phenolic-enriched pomegranate fruit extract showed hepatoprotective and anti-inflammatory effects in mice fed high-fat diets, indicating its potential protective effects against diet-induced hepatic and neurological diseases.
Diets rich in fats are linked to elevated systemic inflammation, which augments the progression of inflammatory-related disorders including non-alcoholic fatty liver disease (NAFLD) and neurodegenerative diseases. A phenolic-enriched pomegranate fruit extract (PE) was investigated for its hepatoprotective and anti-inflammatory effects in male C57BL/6 mice fed either a high-fat diet or a standard rodent diet with or without 1% of PE for 12 weeks. Mouse livers and hippocampi were evaluated for the expression of genes associated with NAFLD and inflammation by multiplexed gene analysis. PE alleviated diet-induced fatty liver and suppressed hepatic lipid regulating genes including Cd36, Fas, Acot2 and Slc27a1. In addition, PE suppressed gene expression of pro-inflammatory cytokines including Il-1 alpha, Il-7, Il-11, Ifn alpha, Tnf alpha and Lepr in the hippocampi. Our findings support the protective effects of PE against high-fat diet-induced hepatic and neurological disease.
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