Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects

Energy-stress-mediated AMPK activation inhibits ferroptosis

(2020) Hyemin Lee et al.   NATURE CELL BIOLOGY

Periostin aggravates NLRP3 inflammasome-mediated pyroptosis in myocardial ischemia-reperfusion injury

(2020) Lei Yao et al.   MOLECULAR AND CELLULAR PROBES

Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases

(2020) Xiaohua Song et al.   Frontiers in Neuroscience

Metformin, resveratrol, and exendin-4 inhibit high phosphate-induced vascular calcification via AMPK-RANKL signaling

(2020) Jinmi Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Diabetes and calcification: The potential role of anti-diabetic drugs on vascular calcification regression

(2020) Sounak Ghosh et al.   PHARMACOLOGICAL RESEARCH

The BRD7-P53-SLC25A28 axis regulates ferroptosis in hepatic stellate cells

(2020) Zili Zhang et al.   Redox Biology

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction

(2019) Francesca Vinchi et al.   EUROPEAN HEART JOURNAL

Calcification biomarkers and vascular dysfunction in obesity and type 2 diabetes: influence of oral hypoglycemic agents

(2019) Francesca Schinzari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The regulation of inflammation-related genes after palmitic acid and DHA treatments is not mediated by DNA methylation

(2019) Mirian Samblas et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Periostin Promotes Cell Proliferation and Macrophage Polarization to Drive Repair after AKI

(2019) Raphaёl Kormann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Ferroptosis Affects the Progression of Nonalcoholic Steatohepatitis via the Modulation of Lipid Peroxidation–Mediated Cell Death in Mice

(2019) Jing Qi et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness

(2018) Andrew L Durham et al.   CARDIOVASCULAR RESEARCH

The tumor suppressor protein p53 and the ferroptosis network

(2018) Rui Kang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tumor suppression effect of targeting periostin with siRNA in a nude mouse model of human laryngeal squamous cell carcinoma

(2018) Dong Ye et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Metformin prevents the development of severe chronic kidney disease and its associated mineral and bone disorder

(2018) Ellen Neven et al.   KIDNEY INTERNATIONAL

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

(2018) Amy Tarangelo et al.   Cell Reports

Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration

(2018) Moataz Abdalkader et al.   Frontiers in Neuroscience

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

(2018) Shashank Masaldan et al.   Redox Biology

Inhibition of Vascular Calcification

(2018) Lipei Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

Restoring mitochondrial biogenesis with metformin attenuates β-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis

(2018) Wen-Qi Ma et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Periostin: The bone and beyond

(2017) L Idolazzi et al.   European Journal of Internal Medicine

Metformin-like antidiabetic, cardio-protective and non-glycemic effects of naringenin: Molecular and pharmacological insights

(2017) Ntsoaki Annah Nyane et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Adenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compounds

(2017) Fabiola Marín-Aguilar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

(2017) Yangchun Xie et al.   Cell Reports

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

NFκB-Induced Periostin Activates Integrin-β3 Signaling to Promote Renal Injury in GN

(2016) Niki Prakoura et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Periostin expression induced by oxidative stress contributes to myocardial fibrosis in a rat model of high salt-induced hypertension

(2016) HAN WU et al.   Molecular Medicine Reports

Metformin alleviates vascular calcification induced by vitamin D3 plus nicotine in rats via the AMPK pathway

(2016) Xinyu Zhang et al.   VASCULAR PHARMACOLOGY

Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

(2016) Shang-Jui Wang et al.   Cell Reports

Deletion of Periostin Protects Against Atherosclerosis in Mice by Altering Inflammation and Extracellular Matrix Remodeling

(2015) Jennifer A. Schwanekamp et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vascular calcification: from pathophysiology to biomarkers

(2015) Séverine Evrard et al.   CLINICA CHIMICA ACTA

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Vascular calcification: Mechanisms of vascular smooth muscle cell calcification

(2015) Jane A. Leopold   TRENDS IN CARDIOVASCULAR MEDICINE

Has Our Understanding of Calcification in Human Coronary Atherosclerosis Progressed?

(2014) Fumiyuki Otsuka et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammatory, Metabolic, and Genetic Mechanisms of Vascular Calcification

(2014) Linda L. Demer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Epithelial cell-derived periostin functions as a tumor suppressor in gastric cancer through stabilizing p53 and E-cadherin proteins via the Rb/E2F1/p14ARF/Mdm2 signaling pathway

(2014) Hongjun Lv et al.   CELL CYCLE

Palmitic acid exerts pro-inflammatory effects on vascular smooth muscle cells by inducing the expression of C-reactive protein, inducible nitric oxide synthase and tumor necrosis factor-α

(2014) DI WU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARα

(2014) Yan Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin Inhibits Vascular Calcification in Female Rat Aortic Smooth Muscle Cells via the AMPK-eNOS-NO Pathway

(2013) Xiaorui Cao et al.   ENDOCRINOLOGY

Palmitic Acid Increases Medial Calcification by Inducing Oxidative Stress

(2013) Mathieu R. Brodeur et al.   JOURNAL OF VASCULAR RESEARCH

Palmitic Acid Induces Osteoblastic Differentiation in Vascular Smooth Muscle Cells through ACSL3 and NF-κB, Novel Targets of Eicosapentaenoic Acid

(2013) Aiko Kageyama et al.   PLoS One

Advanced glycation end-product Nɛ-carboxymethyl-Lysine accelerates progression of atherosclerotic calcification in diabetes

(2012) Zhongqun Wang et al.   ATHEROSCLEROSIS

P53 negatively regulates the osteogenic differentiation of vascular smooth muscle cells in mice with chronic kidney disease

(2012) K.L. Li et al.   Cardiovascular Journal of Africa

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents

(2010) Daihiko Hakuno et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulatory mechanisms in vascular calcification

(2010) Andrew P. Sage et al.   Nature Reviews Cardiology

Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition

(2009) Ritsuko Nakano-Kurimoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Periostin mediates vascular smooth muscle cell migration through the integrins ανβ3 and ανβ5 and focal adhesion kinase (FAK) pathway

(2009) Guohong Li et al.   ATHEROSCLEROSIS

Palmitate increases superoxide production through mitochondrial electron transport chain and NADPH oxidase activity in skeletal muscle cells

(2008) Rafael Herling Lambertucci et al.   JOURNAL OF CELLULAR PHYSIOLOGY