Mechanistic insights on clearance and inhibition discordance between liver microsomes and hepatocytes when clearance in liver microsomes is higher than in hepatocytes

The Critical Role of Passive Permeability in Designing Successful Drugs

(2020) Li Di et al.   ChemMedChem

Evaluation of the Disconnect between Hepatocyte and Microsome Intrinsic Clearance and In Vitro In Vivo Extrapolation Performance

(2020) Beth Williamson et al.   DRUG METABOLISM AND DISPOSITION

A Novel Unified Approach to Predict Human Hepatic Clearance for Both Enzyme- and Transporter-Mediated Mechanisms Using Suspended Human Hepatocytes

(2019) Keith A. Riccardi et al.   DRUG METABOLISM AND DISPOSITION

A novel in vitro experimental system for the evaluation of drug metabolism: Cofactor-supplemented permeabilized cryopreserved human hepatocytes (MetMax™ Cryopreserved Human Hepatocytes)

(2018) Albert P. Li et al.   DRUG METABOLISM AND DISPOSITION

Comparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell Lines

(2018) Keith Riccardi et al.   DRUG METABOLISM AND DISPOSITION

TREND ANALYSIS OF A DATABASE OF INTRAVENOUS PHARMACOKINETIC PARAMETERS IN HUMANS FOR 1352 DRUG COMPOUNDS

(2018) Franco Lombardo et al.   DRUG METABOLISM AND DISPOSITION

Clearance in Drug Design

(2018) Dennis A. Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS)

(2015) Manthena V. Varma et al.   PHARMACEUTICAL RESEARCH

Permeability Comparison between Hepatocyte and Low Efflux MDCKII Cell Monolayer

(2014) Rui Li et al.   AAPS Journal

The role of drug metabolizing enzymes in clearance

(2014) Li Di   Expert Opinion on Drug Metabolism & Toxicology

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

(2012) Li Di et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of a new permeability assay using low‐efflux MDCKII cells

(2011) Li Di et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humans

(2010) Takao Watanabe et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Modulation of the Partition Coefficient between Octanol and Buffer at pH 7.4 and pKa to Achieve the Optimum Balance of Blood Clearance and Volume of Distribution for a Series of Tetrahydropyran Histamine Type 3 Receptor Antagonists

(2009) T. Hay et al.   DRUG METABOLISM AND DISPOSITION

Selective inhibition of MDR1 (ABCB1) by HM30181 increases oral bioavailability and therapeutic efficacy of paclitaxel

(2009) Jin-Oh Kwak et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Identification of interspecies difference in efflux transporters of hepatocytes from dog, rat, monkey and human

(2008) Meng Li et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES