Steroid‐dependent switch of OvoL/Shavenbaby controls self‐renewal versus differentiation of intestinal stem cells

Fitness trade-offs incurred by ovary-to-gut steroid signalling in Drosophila

(2020) Sara Mahmoud H. Ahmed et al.   NATURE

Ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the PPARγ-homolog Eip75B in Drosophila

(2020) Lisa Zipper et al.   eLife

The Septate Junction Protein Tsp2A Restricts Intestinal Stem Cell Activity via Endocytic Regulation of aPKC and Hippo Signaling

(2019) Chiwei Xu et al.   Cell Reports

OVOL1 Influences the Determination and Expansion of iPSC Reprogramming Intermediates

(2019) Harunobu Kagawa et al.   Stem Cell Reports

The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning

(2019) Suparna Ray et al.   eLife

OVOL2 induces mesenchymal-to-epithelial transition in fibroblasts and enhances cell-state reprogramming towards epithelial lineages

(2019) Kazuhide Watanabe et al.   Scientific Reports

Comprehensive Analysis of a cis -Regulatory Region Reveals Pleiotropy in Enhancer Function

(2018) Ella Preger-Ben Noon et al.   Cell Reports

Temporospatial induction of homeodomain gene cut dictates natural lineage reprogramming

(2018) Ke Xu et al.   eLife

Wnt Signalling in Intestinal Stem Cells: Lessons from Mice and Flies

(2018) Jessica Perochon et al.   Genes

The POU/Oct Transcription Factor Nubbin Controls the Balance of Intestinal Stem Cell Maintenance and Differentiation by Isoform-Specific Regulation

(2018) Xiongzhuo Tang et al.   Stem Cell Reports

An Ovol2‐Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation

(2018) Daniel Haensel et al.   EMBO REPORTS

Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis

(2018) Jérôme Bohère et al.   Nature Communications

An alternative mode of epithelial polarity in the Drosophila midgut

(2018) Jia Chen et al.   PLOS BIOLOGY

Ovol2 gene inhibits the Epithelial-to-Mesenchymal Transition in lung adenocarcinoma by transcriptionally repressing Twist1

(2017) Zhi-Hai Wang et al.   GENE

Conserved role of Ovo in germline development in mouse and Drosophila

(2017) Makoto Hayashi et al.   Scientific Reports

Autosomal-Dominant Corneal Endothelial Dystrophies CHED1 and PPCD1 Are Allelic Disorders Caused by Non-coding Mutations in the Promoter of OVOL2

(2016) Alice E. Davidson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Evolved Repression Overcomes Enhancer Robustness

(2016) Ella Preger-Ben Noon et al.   DEVELOPMENTAL CELL

Gastrointestinal stem cells in health and disease: from flies to humans

(2016) Hongjie Li et al.   Disease Models & Mechanisms

OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors

(2016) Guo-Dong Ye et al.   GASTROENTEROLOGY

A tetraspanin regulates septate junction formation inDrosophilamidgut

(2016) Yasushi Izumi et al.   JOURNAL OF CELL SCIENCE

Wnt signaling in cancer

(2016) T Zhan et al.   ONCOGENE

Expression of OVOL2 is related to epithelial characteristics and shows a favorable clinical outcome in hepatocellular carcinoma

(2016) Hua Guo et al.   OncoTargets and Therapy

OVOL2 Maintains the Transcriptional Program of Human Corneal Epithelium by Suppressing Epithelial-to-Mesenchymal Transition

(2016) Koji Kitazawa et al.   Cell Reports

Low Affinity Binding Site Clusters Confer Hox Specificity and Regulatory Robustness

(2015) Justin Crocker et al.   CELL

Enteroendocrine cells are generated from stem cells through a distinct progenitor in the adult Drosophila posterior midgut

(2015) X. Zeng et al.   DEVELOPMENT

Robust intestinal homeostasis relies on cellular plasticity in enteroblasts mediated by miR-8-Escargot switch

(2015) Z. A. Antonello et al.   EMBO JOURNAL

Discovery and characterization of smORF-encoded bioactive polypeptides

(2015) Alan Saghatelian et al.   Nature Chemical Biology

Pri sORF peptides induce selective proteasome-mediated protein processing

(2015) J. Zanet et al.   SCIENCE

Bidirectional Notch signaling regulates Drosophila intestinal stem cell multipotency

(2015) Z. Guo et al.   SCIENCE

Coupling the modules of EMT and stemness: A tunable ‘stemness window’ model

(2015) Mohit Kumar Jolly et al.   Oncotarget

EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes

(2015) Yinhua Jin et al.   PLoS Genetics

Recent progress in understanding the role of ecdysteroids in adult insects: Germline development and circadian clock in the fruit fly Drosophila melanogaster

(2015) Outa Uryu et al.   Zoological Letters

Mammary Morphogenesis and Regeneration Require the Inhibition of EMT at Terminal End Buds by Ovol2 Transcriptional Repressor

(2014) Kazuhide Watanabe et al.   DEVELOPMENTAL CELL

Regulation ofDrosophilaintestinal stem cell maintenance and differentiation by the transcription factor Escargot

(2014) Mariano A Loza‐Coll et al.   EMBO JOURNAL

Escargotmaintains stemness and suppresses differentiation inDrosophilaintestinal stem cells

(2014) Jerome Korzelius et al.   EMBO JOURNAL

Pri peptides are mediators of ecdysone for the temporal control of development

(2014) Hélène Chanut-Delalande et al.   NATURE CELL BIOLOGY

Slit/Robo Signaling Regulates Cell Fate Decisions in the Intestinal Stem Cell Lineage of Drosophila

(2014) Benoît Biteau et al.   Cell Reports

Integration of UPRER and Oxidative Stress Signaling in the Control of Intestinal Stem Cell Proliferation

(2014) Lifen Wang et al.   PLoS Genetics

Transcription Factors OVOL1 and OVOL2 Induce the Mesenchymal to Epithelial Transition in Human Cancer

(2013) Hernan Roca et al.   PLoS One

Morphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila

(2013) Nicolas Buchon et al.   Cell Reports

Genome-wide analyses of Shavenbaby target genes reveals distinct features of enhancer organization

(2013) Delphine Menoret et al.   GENOME BIOLOGY

Transcriptome Analysis of the Planarian Eye Identifies ovo as a Specific Regulator of Eye Regeneration

(2012) Sylvain W. Lapan et al.   Cell Reports

EGF signaling regulates the proliferation of intestinal stem cells in Drosophila

(2011) B. Biteau et al.   DEVELOPMENT

Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine

(2011) C. N. Perdigoto et al.   DEVELOPMENT

Tarsal-less peptides control Notch signalling through the Shavenbaby transcription factor

(2011) Jose I. Pueyo et al.   DEVELOPMENTAL BIOLOGY

Morphological evolution caused by many subtle-effect substitutions in regulatory DNA

(2011) Nicolás Frankel et al.   NATURE

EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila

(2010) Huaqi Jiang et al.   Cell Stem Cell

Transcriptional control of stem cell maintenance in the Drosophila intestine

(2010) A. J. Bardin et al.   DEVELOPMENT

Zona Pellucida Domain Proteins Remodel the Apical Compartment for Localized Cell Shape Changes

(2010) Isabelle Fernandes et al.   DEVELOPMENTAL CELL

Characterization of midgut stem cell- and enteroblast-specific Gal4 lines in drosophila

(2010) Xiankun Zeng et al.   GENESIS

Phenotypic robustness conferred by apparently redundant transcriptional enhancers

(2010) Nicolás Frankel et al.   NATURE

Small Peptides Switch the Transcriptional Activity of Shavenbaby During Drosophila Embryogenesis

(2010) T. Kondo et al.   SCIENCE

Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila

(2010) Benoît Biteau et al.   PLoS Genetics

Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut

(2009) Huaqi Jiang et al.   CELL

EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors

(2009) H. Jiang et al.   DEVELOPMENT

JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage

(2009) Katherine Beebe et al.   DEVELOPMENTAL BIOLOGY

Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila

(2009) N. Buchon et al.   GENES & DEVELOPMENT

JNK Activity in Somatic Stem Cells Causes Loss of Tissue Homeostasis in the Aging Drosophila Gut

(2008) Benoît Biteau et al.   Cell Stem Cell

Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells

(2008) Guonan Lin et al.   NATURE