Article
Environmental Sciences
Jiake Li, Yishuo Jiang, Mengmeng Zhai, Jiayu Gao, Yutong Yao, Yafang Li
Summary: In this study, a sponge city resilience assessment system is established, and the grey relational analysis method is used to quantify sponge city resilience. A multi-objective optimization model is also established, aiming to ensure that cities effectively reduce flood risk through the optimal configuration of grey-green infrastructure. The study shows that the optimized sponge city resilience level is significantly improved compared to the original scheme, indicating enhanced ability to cope with waterlogging and pollution.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Development Studies
Yongchi Ma, Yong Jiang
Summary: China introduced sponge city development (SCD) to address complex water challenges in urban development under climatic change and rapid urbanization. However, there is a design deficit in policy implementation that negatively affects the effectiveness and long-term impact of SCD. This paper examines the design deficit and proposes the framework of ecosystem services as a tool to address it.
SUSTAINABLE DEVELOPMENT
(2023)
Article
Biotechnology & Applied Microbiology
Meicheng Ji, Xue Bai
Summary: Sponge city is a new generation urban rainwater management concept that aims to achieve multiple goals. Optimizing urban land use structure is crucial for the construction and development of sponge cities. Establishing an operable index system is key to guiding the planning and construction of sponge cities.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Urban Studies
Lei Wang, Ziming Li, Zhang Zhang
Summary: As an inland megacity in central China, Wuhan has experienced rapid economic revival and comprehensive transformation in the past 16 years. Through the use of statistics, data visualization, observations, and surveys, it is evident that political restructuring, pro-growth development strategies, and concerns for livability and crisis mitigation have played crucial roles in organizing resources for sustainable development in Wuhan.
Article
Environmental Sciences
Yu Jiang, Ling Qiu, Tian Gao, Shuoxin Zhang
Summary: In the study, the combination application of LID measures and retention ponds in an urban community was examined for their effectiveness in reducing runoff and outflow in the context of a Sponge City project. It was found that LID measures have significant effects on runoff and outflow reduction, although they are influenced by the return period. Additionally, retention ponds have minimal impact on runoff but can reduce the peak value of outflow, with less sensitivity to return periods. The combination of LID and retention ponds can effectively reduce the peak flow rate and alleviate pressure on the urban drainage system.
Article
Environmental Sciences
Mengxiao Jin, Michele Lancia, Yong Tian, Stefano Viaroli, Charles Andrews, Junguo Liu, Chunmiao Zheng
Summary: Chinese cities and megacities, with their large areas and high population densities, face challenges of extensive impervious surfaces and reliance on pristine water sources. To address flood risk and water scarcity, the Chinese government introduced the concept of Sponge City, which aims to reduce urban runoff and increase water storage through features like permeable pavements and green roofs. This study evaluates the benefits of integrating urban aquifers with Sponge City features and identifies suitable shallow aquifers throughout China.
Article
Green & Sustainable Science & Technology
Yuanyuan Yang, Wenhui Zhang, Zhe Liu, Dengfeng Liu, Qiang Huang, Jun Xia
Summary: In this study, the DTVGM-SWMM model was developed by incorporating the DTVGM into the SWMM, aiming to address storm-related problems in sponge cities. The model was calibrated and validated using measured data and the results of SWMM, and showed reasonable performance in estimating runoff, especially the outflow process in the urban catchment.
Article
Environmental Sciences
Haichao Li, Hiroshi Ishidaira, Yanqi Wei, Kazuyoshi Souma, Jun Magome
Summary: Urban floods pose a common threat to cities' economy and development. Sponge cities, by implementing low-impact development measures, can enhance flood resistance and reduce the occurrence of floods. This study utilized the Strom Water Management Model (SWMM) to investigate urban runoff under various rainfall patterns in Mianyang city, evaluating the flood reduction benefits from different rain patterns. The findings highlight the importance of considering the influence of rainfall patterns on the effectiveness of sponge city measures.
Article
Environmental Sciences
Changmei Liang, Xiang Zhang, Jie Liu, Luguang Liu, Shiyong Tao
Summary: This study established a multi-objective simulation optimization framework for sponge city construction, considering the minimization of runoff control rate, pollutant control rate, and life-cycle cost. The non-dominated sorting genetic algorithm (NSGA-II) was successfully used to complete the simulation-optimization process. The results showed that different sponge city construction schemes led to different runoff control rates and pollutant control rates, and the cost of sponge city construction increased with the increase of rainfall return period. The study also identified a cost-benefit efficient interval for sponge city construction and provided reference for reasonable and effective sponge city construction in Xining, China.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2023)
Article
Environmental Sciences
Yuanyuan Yang, Yanfei Xin, Jiake Li
Summary: Detention ponds are effective for stormwater management in sponge cities. By using BPNN models and non-dominated sorting genetic algorithm-II, the pond size can be optimized to reduce total suspended solids and catchment peak outflow. The results show that the detention ponds can effectively reduce TSS and CPO, and the reduction tends to grow as the pond size increases.
Article
Green & Sustainable Science & Technology
Dirk Helbing, Farzam Fanitabasi, Fosca Giannotti, Regula Haenggli, Carina I. Hausladen, Jeroen van den Hoven, Sachit Mahajan, Dino Pedreschi, Evangelos Pournaras
Summary: The concept of smart cities, driven by digital technologies, improves quality of life but also raises pressing issues related to privacy, ethics and fairness. The current trend towards value-centered design, combined with considerations of ethics, law, and culture, aims to promote a more sustainable urban development.
Article
Green & Sustainable Science & Technology
Jian Wang, Fei Xue, Ruiying Jing, Qiaohui Lu, Yilong Huang, Xiang Sun, Wenbo Zhu
Summary: This paper proposes a regenerative argument for sponge city construction from the urban scale towards the watershed scale by strengthening the urban water resilience and sustainability. An innovative framework is established to address urban water issues and human livability via various indicators and interrelations between different water modules. The research findings have implications for shifting the sponge city practice towards linking urban development with watershed ecological conservation.
Article
Engineering, Environmental
Alhassane Bah, Hongbo Zhang, Alseny Bah, Jufang He, Zhumei Luo
Summary: Urban flooding can be mitigated effectively through the implementation of low impact development (LID) strategies and the concept of Sponge City. The study demonstrated that LID techniques effectively reduce runoff and flooding, with LID-combinations showing better performance than individual LID implementations.
WATER SCIENCE AND TECHNOLOGY
(2023)
Article
Environmental Sciences
Yuqing Tan, Qiming Cheng, Fengwei Lyu, Fei Liu, Linhao Liu, Yihong Su, Shaochun Yuan, Wenyu Xiao, Zhen Liu, Yao Chen
Summary: The exacerbation of global warming, extreme weather events, and rapid urbanization have led to increased flooding in urban areas. China has adopted sponge city as an efficient means of preventing and controlling urban floods. Using a SWMM-FVCOM model, the hydrological reduction and control effect of sponge city construction (SPCC) within a university campus were evaluated. The study found that implementing SPCC effectively mitigates surface runoff and reduces the severity of urban flooding. However, the efficacy of runoff control decreases with longer rainfall return periods.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2024)
Review
Green & Sustainable Science & Technology
Xin Guan, Jiayu Wang, Feipeng Xiao
Summary: China has proposed a novel urban strategy called Sponge City to address frequent urban flood issues, focusing on water resource management and the use of permeable pavement materials. These materials are designed to be porous to meet infiltration, retention, purification, evaporation, and drainage requirements, offering environmental advantages such as water purification, traffic noise reduction, Urban Heat Island mitigation, and waste materials recycling. While the economic benefits of permeable pavements compared to traditional pavements are still controversial, the future development of pavement materials in Sponge City is expected to improve hydrological performance and expand application range.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Cell Biology
Yao Wang, Qian Chen, Fangzhou Jiao, Chunxia Shi, Maohua Pei, Luwen Wang, Zuojiong Gong
Summary: This study demonstrated that HDAC2 plays a regulatory role in pyroptosis levels during acute liver failure by affecting the ULK1-NLRP3-pyroptosis pathway. Inhibition of HDAC2 may reduce pyroptosis by modulating the K68 lysine site of ULK1. The findings suggest a potential therapeutic target for ALF treatment.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Ganxiao Chen, Xun Li, Zuojiong Gong, Hao Xia, Yao Wang, Xuefen Wang, Yan Huang, Hector Barajas-Martinez, Dan Hu
Summary: COVID-19 patients may experience cardiac injury and develop hypertension, with elevated levels of certain markers. Enhanced Ang II signaling from SARS-CoV-2 infection may contribute to the development of hypertension.
Article
Immunology
Yao Wang, Xun Li, Qian Chen, Fangzhou Jiao, Chunxia Shi, Maohua Pei, Luwen Wang, Zuojiong Gong
Summary: This study demonstrated that the HDAC6 inhibitor ACY-1215 can improve the glycolytic pathway of M1 macrophages by regulating DNMT1 and DDX3X/NLRP3 signals, thus alleviating the inflammatory response in acute liver failure (ALF). The results showed that ACY-1215 can reduce activated M1 macrophages and cytokine levels, increase IDH1, MDH1, and ATP levels, promote DDX3X expression, and inhibit NLRP3 and DNMT1 expression. The findings suggest that ACY-1215 is a potential therapeutic target for ALF by modulating M1 macrophage activation and energy metabolism.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Cell Biology
Qian Chen, Yao Wang, Fangzhou Jiao, Pan Cao, Chunxia Shi, Maohua Pei, Luwen Wang, Zuojiong Gong
Summary: The study found that ACY1215 has hepatoprotective effects in acute liver failure by inhibiting the NLRP3 inflammasome and upregulating the ATM/F-actin mediated signaling pathways.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Virology
Yao Wang, Xun Li, Qian Chen, Fangzhou Jiao, Chunxia Shi, Maohua Pei, Luwen Wang, Zuojiong Gong
Summary: This study examined the correlation between liver pathological inflammation degree and pyroptosis in patients with chronic hepatitis B. The expression of NLRP3, GSDMD, caspase1, IL-18, and IL-1 beta was found to be positively correlated with the grade of inflammatory activity in liver tissue. High expression of these molecules may play a role in liver tissue inflammation and damage in CHB patients.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Physiology
Chun-xia Shi, Yao Wang, Fang-zhou Jiao, Qian Chen, Pan Cao, Mao-hua Pei, Lu-yi Zhang, Jin Guo, Wei Deng, Lu-wen Wang, Zuo-jiong Gong
Summary: Chronic liver inflammation is a complex pathological process where stellate cells and macrophages play important roles. Moderate liver inflammation can protect the liver, but excessive inflammation can lead to irreversible damage. Epigenetic regulation is key in liver inflammation, and understanding its impact on stellate cells and macrophages can provide new insights for liver disease treatment.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chunxia Shi, Maohua Pei, Yao Wang, Qian Chen, Pan Cao, Luyi Zhang, Jin Guo, Wei Deng, Luwen Wang, Xun Li, Zuojiong Gong
Summary: This study explored the role of trimethylamine (TMA) in nonalcoholic fatty liver disease (NAFLD) and found that TMA and its metabolite trimethylamine-N-oxide (TMAO) are closely related to NAFLD. The expression of flavin-containing monooxygenase 1 (FMO1) was increased in NAFLD, and FMO1 and its metabolite TMAO were induced by high fat and TMA. However, silencing FMO1 blocked the effects of high fat and TMA on TMAO. Furthermore, TMAO may exert its role in NAFLD through the activation of unfolded protein response (UPR).
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Wenqian Tang, Juan Xue, Lei Luo, Yao Wang, Xin Cai, Yuqing Liu, Dawei Huang, Xiaodong Wang, Tangqing He, Dingbo Lu, Fan Yang
Summary: The study aimed to investigate the role of kangxianruangan granule (KXRG)-containing serum in inhibiting the differentiation of hepatocellular oval cells (HOCs) into hepatocellular carcinoma cells (HCCs) via the Wnt-1/beta-catenin signaling pathway. The results showed that KXRG significantly reduced the expression of HCC-related indicators, suggesting its potential for the prevention of hepatocellular carcinoma.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Cell Biology
Fangzhou Jiao, Yao Wang, Qian Chen, Pan Cao, Chunxia Shi, Maohua Pei, Luwen Wang, Zuojiong Gong
Summary: The study demonstrated that the SIRT1 activator CAY10602 alleviated liver injury and improved neurological decline in TAA-induced HE rats by suppressing microglial activation and the NLRP3 inflammasome, consequently reducing neurotoxicity.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Oncology
Xiaofeng Ruan, Wenyuan Li, Peng Du, Yao Wang
Summary: This study investigated the key targets and signaling pathways of the traditional Chinese medicine Phellodendron and Anemarrhena drug pair (PADP) in the treatment of liver cancer. The study utilized bioinformatics and network pharmacology technologies to analyze differential genes and identify active components and targets of PADP. The results showed that PADP may treat liver cancer through multiple targets and pathways, including p53 signaling pathway, IL-17 signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, etc. Experimental validation demonstrated that PADP could promote apoptosis, inhibit proliferation and invasion of liver cancer cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Physiology
Chunxia Shi, Fangzhou Jiao, Yao Wang, Qian Chen, Luwen Wang, Zuojiong Gong
Summary: This study found that the SIRT3 inhibitor 3-TYP exacerbated liver injury in mice with acute liver failure (ALF), increasing inflammatory responses, oxidative stress, and hepatocyte apoptosis. Activation of SIRT3 could be a potential target for the treatment of ALF.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wenyuan Li, Wei Li, Xun Li, Luwen Wang, Yao Wang
Summary: This study investigated the role of G3BP1 in regulating ferroptosis in hepatocytes during ALF by affecting P53's entry into the nucleus. It was found that promoting G3BP1 expression could inhibit P53 entry by binding to its nuclear localization sequence. Inhibition of P53's binding to the promoter region of the SLC7A11 gene weakened the repression of SLC7A11 transcription. As a result, the SLC7A11-GSH-GPX4 antiferroptotic pathway was activated, leading to inhibition of ferroptosis in ALF hepatocytes.
Article
Gastroenterology & Hepatology
Wen-Yuan Li, Fan Yang, Xun Li, Lu-Wen Wang, Yao Wang
Summary: This study investigated the protective role of stress granules (SGs) in hepatocytes during hypoxia-induced acute liver failure (ALF) by reducing endoplasmic reticulum stress (ERS)-mediated apoptosis. The results showed that the expression of SGs was positively correlated with the duration of hypoxia and could inhibit the increase of HIF-1 alpha, ERS, and apoptosis. Furthermore, intervention experiments using siRNA-ATF4 and anisomycin confirmed the protective effect of SGs.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Immunology
Chunxia Shi, Pan Cao, Yukun Wang, Qingqi Zhang, Danmei Zhang, Yao Wang, Luwen Wang, Zuojiong Gong
Summary: PANoptosis is a newly proposed cell death characterized by the combination of pyroptosis, apoptosis and necroptosis. This review focuses on the relationship between these three modes of cell death, the key molecules involved, the formation of PANoptosome, and the role of PANoptosis in diseases. The aim is to understand the mechanism of PANoptosis and provide a basis for targeted intervention in treating PANoptosis-related diseases.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Wenyuan Li, Zhongyuan Xia, Yao Wang
Summary: This study used bibliometric methods to analyze the research status and hotspots of ferritinophagy in the past eight years. The results showed that China had the highest research output in this field, and the United States maintained a leading position. The main research focus was on cell biology, and tumor research was identified as a potential future direction. The hotspots of research included oxidative stress pathways, cell death methods, and the nuclear receptor co-activator 4 (NCOA4) in ferritinophagy.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Biodiversity Conservation
Yongcui Lan, Jinliang Wang, Qianwei Liu, Fang Liu, Lanfang Liu, Jie Li, Mengjia Luo
Summary: This study focuses on the five major plateau lake basins in central Yunnan, China, and constructs an ecological security pattern using the source-resistance surface-corridor-pinch point framework. The study simulates land use/cover change in the region and identifies early warning regions where future urban expansion poses a threat to current ecological source areas and corridors.
ECOLOGICAL INDICATORS
(2024)
Article
Biodiversity Conservation
Pingping Huang, Feng Zhao, Bailing Zhou, Kuidong Xu
Summary: This study investigates the distribution of benthic microeukaryotes in the China Seas and finds that they can stride over the ecological barrier of 32 degrees N. The study also highlights the significant influence of depth, temperature, and latitude on communities in the China Seas.
ECOLOGICAL INDICATORS
(2024)
Article
Biodiversity Conservation
Federico Morelli, Yanina Benedetti, Jesse Stanford, Leszek Jerzak, Piotr Tryjanowski, Paolo Perna, Riccardo Santolini
Summary: Species distribution models (SDMs) are numerical tools used for predicting species' spatial distribution. This study found that ecological characteristics, such as habitat specialization, play a role in improving the accuracy of SDMs.
ECOLOGICAL INDICATORS
(2024)
Article
Biodiversity Conservation
Xiaoxuan Wu, Hang Liu, Wei Liu
Summary: Global climate change, urbanization, and economic development have increased the need for sustainable human development, urban ecological governance, and low-carbon energy transformation. This study analyzes the green ecological transition in Chengdu based on panel data from 2010 to 2020, exploring its spatiotemporal evolution and key factors. The results show an overall upward trend in Chengdu's green ecological development and positive spatial autocorrelation in certain districts.
ECOLOGICAL INDICATORS
(2024)
Article
Biodiversity Conservation
Castaldi Simona, Formicola Nicola, Mastrocicco Micol, Morales Rodriguez Carmen, Morelli Raffaella, Prodorutti Daniele, Vannini Andrea, Zanzotti Roberto
Summary: Sustainable agricultural practices are increasingly important for global and national environmental policies and economy. This study compared the sustainability of grape production under integrated and organic management using multiple indicators. The results showed that organic management was more beneficial for most environmental aspects of the agroecosystem compared to integrated management, without affecting grape yield.
ECOLOGICAL INDICATORS
(2024)
Article
Biodiversity Conservation
Gaia Vaglio Laurin, Alexander Cotrina-Sanchez, Luca Belelli-Marchesini, Enrico Tomelleri, Giovanna Battipaglia, Claudia Cocozza, Francesco Niccoli, Jerzy Piotr Kabala, Damiano Gianelle, Loris Vescovo, Luca Da Ros, Riccardo Valentini
Summary: Phenology monitoring is important for understanding forest functioning and climate impacts. This research compares the phenological behavior of European beech forests using Tree-Talker (TT+) and Sentinel 2 satellite data. The study finds differences in the information derived by the two sensor types, particularly in terms of season length, phenology changepoints, and leaf period variability. TT+ with its higher temporal resolution demonstrates precision in capturing the phenological changepoints, especially when satellite image availability is limited.
ECOLOGICAL INDICATORS
(2024)
Article
Biodiversity Conservation
Huanhuan Pan, Ziqiang Du, Zhitao Wu, Hong Zhang, Keming Ma
Summary: The land use and cover changes resulting from coal mining activities and ecological restoration have had a significant impact on ecosystem services in mining areas. This study investigates the relationship between ecosystem services and land use intensity in coal mining areas, emphasizing the importance of understanding this interdependence for balanced human-land system development. The research examines the evolving relationship across different reclamation stages in Shanxi, China, using a coupling coordination degree model. The findings suggest the need for timely and judicious reclamation of coalfields, considering the land's bearing capacity.
ECOLOGICAL INDICATORS
(2024)
Article
Biodiversity Conservation
Jingjuan He, Yijun Shi, Lihua Xu, Zhangwei Lu, Mao Feng
Summary: This study examines the spatial interplay between changes in the blue-green spatial distribution and modifications in land surface temperature grades in Shanghai. The findings reveal that the transformation of the blue-green spatial pattern differs between different sectors of the city, and the impact on the thermal environment varies spatially.
ECOLOGICAL INDICATORS
(2024)
Article
Biodiversity Conservation
Yi Xu, Di Zhang, Junqiang Lin, Qidong Peng, Xiaohui Lei, Tiantian Jin, Jia Wang, Ruifang Yuan
Summary: This study analyzed the response relationship between phytoplankton growth and water environmental parameters in the Middle Route of the South-to-North Water Diversion Project in China using long-term monitoring data and machine learning models. The results revealed the differences between monitoring sites and identified the key parameters that affect phytoplankton growth.
ECOLOGICAL INDICATORS
(2024)