Review
Biochemistry & Molecular Biology
Laurent Dube, Schohraya Spahis, Karelle Lachaine, Andreanne Lemieux, Hanine Monhem, Sarah-Maude Poulin, Carolane Randoll, Eva Travaillaud, Nour-El-Houda Ould-Chikh, Valerie Marcil, Edgard Delvin, Emile Levy
Summary: Metabolic syndrome is a serious global public health issue with significant health risks, requiring alternative therapeutic options. Recent studies have shown increased interest in specialized pro-resolving lipid mediators in regulating metabolic derangements.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Endocrinology & Metabolism
Ernesto Pena Calderin, Jing-Juan Zheng, Nolan L. Boyd, Lindsey McNally, Timothy N. Audam, Pawel Lorkiewicz, Bradford G. Hill, Jason Hellmann
Summary: This study found that physical activity could enhance the production of proresolving lipid mediators and increase macrophage mitochondrial metabolism, which play a role in anti-inflammatory effects and reducing the risk of cardiovascular diseases.
MOLECULAR METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Kamila P. Liput, Adam Lepczynski, Magdalena Ogluszka, Agata Nawrocka, Ewa Polawska, Agata Grzesiak, Brygida Slaska, Chandra S. Pareek, Urszula Czarnik, Mariusz Pierzchala
Summary: It is recommended to reduce saturated fatty acids (SFA) and increase polyunsaturated fatty acids (PUFAs) n-3 and n-6 in the diet to lower the risk of metabolic disorders. Western-type diet often contains excessive n-6 PUFAs and a high n-6/n-3 ratio. Oxylipins derived from n-3 and n-6 PUFAs play a role in inflammation, while PUFAs have varying effects on cell growth, proliferation, and neoplastic lesion progression, as observed in in vitro studies, animal models, and epidemiological studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Shayna Sandhaus, Andrew G. Swick
Summary: Specialized proresolving mediators (SPMs) are endogenous lipid metabolites that promote the resolution of inflammation. While not yet studied in the context of the novel Coronavirus, SPMs have shown potential in combating infections and inflammatory lung conditions.
Article
Biochemistry & Molecular Biology
Juan Salazar, Daniela Pirela, Manuel Nava, Ana Castro, Lisse Angarita, Heliana Parra, Samuel Duran-Aguero, Diana Marcela Rojas-Gomez, Nestor Galban, Roberto Anez, Maricarmen Chacin, Andrea Diaz, Nelson Villasmil, Juan Bautista De Sanctis, Valmore Bermudez
Summary: Cardiovascular disease (CVD) is a global public health issue with high morbidity, mortality, and economic impact. Specialized proresolving lipid mediators (SPMs), derived from fatty acids, have shown promise in resolving inflammation associated with the pathogenesis of various diseases, particularly CVD. Preclinical and clinical studies have demonstrated the therapeutic impact of SPMs in CVD, suggesting their potential as a new therapeutic alternative. Further large-scale clinical trials are needed to determine their effects in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Mervin Chavez-Castillo, Angel Ortega, Lorena Cudris-Torres, Pablo Duran, Milagros Rojas, Alexander Manzano, Bermary Garrido, Juan Salazar, Aljadis Silva, Diana Marcela Rojas-Gomez, Juan B. De Sanctis, Valmore Bermudez
Summary: Specialized pro-resolving lipid mediators (SPMs) have emerged as a promising alternative for chronic pain management, playing a central role in regulating inflammation and neuroinflammation. Studies have shown that SPMs can inhibit central and peripheral sensitizations associated with chronic pain disorders, providing a potential therapeutic tool for patients with CP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Wheeler Torres, Jose Luis Perez, Maria P. Diaz, Luis D'Marco, Ana Checa-Ros, Ruben Carrasquero, Lisse Angarita, Yosselin Gomez, Maricarmen Chacin, Paola Ramirez, Nelson Villasmil, Samuel Duran-Aguero, Climaco Cano, Valmore Bermudez
Summary: Cancer is a major global health issue characterized by cell mutation, proliferation, invasion, and metastasis. The increasing incidence of cancer highlights the need for new approaches to understand the molecular changes involved in its development, including chronic inflammation. Specialized pro-resolving mediators (SPMs), bioactive lipids derived from polyunsaturated fatty acids (PUFAs), have shown potential as novel anti-inflammatory molecules that could improve anti-tumor immunity. This review aims to explore the effects of SPMs on carcinogenesis and their therapeutic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Geriatrics & Gerontology
Jana Ponce, Arzu Ulu, Corrine Hanson, Erin Cameron-Smith, John Bertoni, Jenna Wuebker, Alfred Fisher, Ka-Chun Siu, Vivien Marmelat, Jiri Adamec, Danish Bhatti
Summary: Alzheimer's disease (AD) and Parkinson's disease (PD) are neurodegenerative disorders that affect millions of individuals worldwide. Neuroinflammation plays a crucial role in the development and progression of these diseases, and polyunsaturated fatty acid (PUFA)-derived mediators called Specialized Pro-resolving Mediators (SPM) have the potential to have anti-inflammatory and pro-resolving effects. However, there is a significant gap in knowledge regarding the effects of these PUFA-derived metabolites in humans.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Joan Claria, Roger Flores-Costa, Marta Duran-Guell, Cristina Lopez-Vicario
Summary: Inflammation is a key feature of liver diseases, presenting from mild to intense stages, impacting organ function and failure. This review focuses on understanding the inflammatory process in non-alcoholic steatohepatitis and acute-on-chronic liver failure, emphasizing the importance of specialized pro-resolving mediators in regulating inflammation resolution.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Multidisciplinary Sciences
Nan Chiang, Xavier de la Rosa, Stephania Libreros, Hui Pan, Jonathan M. Dreyfuss, Charles N. Serhan
Summary: The study found that cysteinyl-specialized proresolving mediators activate key pathways in planaria regeneration, linking inflammation resolution and regeneration. The results demonstrate a crucial role for TRAF3/IL-10 in regulating mammalian phagocyte functions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Melissa Simard, Sophie Morin, Zainab Ridha, Roxane Pouliot
Summary: The skin's barrier function is crucial for maintaining skin homeostasis. Bioactive lipid mediators derived from n-3 and n-6 PUFAs play complex roles in skin diseases, including psoriasis. High intake of n-3 PUFAs has been shown to reduce the severity and frequency of psoriatic plaques.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jessica Zuniga-Hernandez, Veronica Sambra, Francisca Echeverria, Luis A. Videla, Rodrigo Valenzuela
Summary: This article analyzes the influence of n-3 polyunsaturated fatty acids (n-3 PUFAs) and their lipid mediators on the inflammatory response in respiratory diseases, emphasizing their beneficial effects in prevention and treatment. Studies show that EPA and DHA can attenuate the pro-inflammatory response in respiratory diseases and reduce related symptoms.
Review
Biochemistry & Molecular Biology
Jesmond Dalli, Esteban Alberto Gomez, Charlotte Camille Jouvene
Summary: Precision medicine is more effective than the current prescriptive paradigm in treating chronic inflammatory conditions, but its application is hindered by the lack of biomarkers. Lipid mediators, particularly specialized pro-resolving mediators (SPM), play a central role in regulating immune responses and can be potential biomarkers. Recent advances in chromatography and mass spectrometry have improved the identification and quantitation of these mediators.
Article
Nutrition & Dietetics
Kristal M. Maner-Smith, Erin Ferranti, Anne Dunlop, Elizabeth Corwin, Eric A. Ortlund
Summary: African American women have higher rates of maternal morbidity and mortality, especially related to cardiometabolic complications of pregnancy. Changes in lipid levels, specifically docosahexaenoic acid (DHA) and specialized pro-resolving mediators (SPMs), are associated with these complications. In this study, a lipid signature in early pregnancy serum samples of African American women was identified, which has a predictive accuracy of 74% for cardiometabolic complications. These findings suggest that blood-based markers in early pregnancy could potentially help identify at-risk individuals and tailor interventions.
Article
Health Care Sciences & Services
Karina Gonzalez-Becerra, Elisa Barron-Cabrera, Jose F. Munoz-Valle, Nathaly Torres-Castillo, Juan J. Rivera-Valdes, Roberto Rodriguez-Echevarria, Erika Martinez-Lopez
Summary: The study aimed to analyze the effects of n-3 PUFA supplementation on fatty acid profile, biochemical markers, and inflammatory markers in subjects with obesity. The results showed that both the supplementation and placebo groups increased PUFA intake and DHA in red blood cells, but the placebo group had reductions in IL-8 and MCP-1 levels. Regression analysis revealed that increased DHA levels were associated with decreased IL-8 levels in both groups, suggesting the beneficial anti-inflammatory effects of dietary DHA and n-3 supplementation.
Article
Pediatrics
Laura Galante, Clare M. Reynolds, Amber M. Milan, Tanith Alexander, Frank H. Bloomfield, David Cameron-Smith, Shikha Pundir, Mark H. Vickers
Summary: This study found that perinatal factors are associated with human milk composition throughout lactation, impacting long-term infant growth. Further research is needed to investigate the effects of these changes on infant outcomes.
PEDIATRIC RESEARCH
(2021)
Article
Nutrition & Dietetics
Aimee L. Dordevic, Susan L. Coort, Chris T. Evelo, Chiara Murgia, Andrew J. Sinclair, Maxine P. Bonham, Amy E. Larsen, Petra Gran, David Cameron-Smith
Summary: In middle-aged males with MetS, a widespread suppression of the subcutaneous adipose tissue nutrient responsive gene expression suggests an inflexibility in the transcriptomic responsiveness to both high-fat meals.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Aahana Shrestha, Linda M. Samuelsson, Pankaja Sharma, Li Day, David Cameron-Smith, Amber M. Milan
Summary: For female dairy avoiders, sheep milk and cow milk showed similar effects on acute digestive comfort and lactose malabsorption. Despite lower lactose content, sheep milk did not increase adverse digestive symptoms after ingestion, indicating its potential tolerability compared to cow milk.
FRONTIERS IN NUTRITION
(2021)
Article
Physiology
Thomas Bjornsen, Mathias Wernbom, Goran Paulsen, James F. Markworth, Sveinung Berntsen, Randall F. D'Souza, David Cameron-Smith, Truls Raastad
Summary: High-frequency BFRRE training simultaneously stresses both fiber types, with type I fibers being most affected. This training results in changes in heat shock protein responses, protein translocation, and glycogen content.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Nicola A. Gillies, Bernhard Franzke, Barbara Wessner, Barbara Schober-Halper, Marlene Hofmann, Stefan Oesen, Anela Tosevska, Eva-Maria Strasser, Nicole C. Roy, Amber M. Milan, David Cameron-Smith, Karl-Heinz Wagner
Summary: The study found that choline metabolites such as choline, betaine, and dimethylglycine play a central role in the co-regulation of 1C metabolism and cardiometabolic health in older adults. Additionally, changes in some metabolites were associated with improvements in lipid metabolism.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Letter
Nutrition & Dietetics
Vidit V. Satokar, Wayne S. Cutfield, David Cameron-Smith, Benjamin B. Albert
Summary: This manuscript responds to concerns raised by industry-based scientists about the quality and functionality of commercial fish oils, and highlights the importance of independently verifying n-3 PUFA content and oxidation state before using them in clinical trials.
Article
Endocrinology & Metabolism
Caitlin S. Mitchell, Shirmila D. Premaratna, Garth Bennett, Maria Lambrou, Lauren A. Stahl, Markandeya Jois, Elizabeth Barber, Christopher P. Antoniadis, Stephen C. Woods, David Cameron-Smith, Richard S. Weisinger, Denovan P. Begg
Summary: The study demonstrates that ACE inhibition and angiotensin receptor blockade can reduce food intake to produce weight loss, suggesting that the anti-inflammatory effects of ACE inhibition may be independent of weight loss.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Laura Galante, Clare M. Reynolds, Amber M. Milan, Tanith Alexander, Frank H. Bloomfield, Yannan Jiang, Sharin Asadi, Mariana Muelbert, David Cameron-Smith, Shikha Pundir, Mark H. Vickers
Summary: The concentrations of IGF-1 and leptin in breast milk are associated with the growth and body composition of moderate-late preterm infants up to 4 months corrected age, with varying effects observed in boys and girls. This highlights the importance of sex-specific considerations in the nutritional care of preterm infants in order to optimize their growth outcomes.
FRONTIERS IN NUTRITION
(2021)
Article
Behavioral Sciences
Jia Jiet Lim, Ivana R. Sequeira, Wilson C. Y. Yip, Louise W. Lu, Daniel Barnett, David Cameron-Smith, Sally D. Poppitt
Summary: This study aimed to identify biomarkers of appetite response using a whey protein preload intervention. The results showed that most biomarkers changed in response to the intervention, but did not suppress appetite or energy intake. Glycine had the strongest association with appetite response. The use of multiple biomarkers improved the estimation of appetite response.
Article
Endocrinology & Metabolism
Karen Mei-Ling Tan, Mya-Thway Tint, Narasimhan Kothandaraman, Fabian Yap, Keith M. Godfrey, Yung Seng Lee, Kok Hian Tan, Peter D. Gluckman, Yap-Seng Chong, Mary F. F. Chong, Johan G. Eriksson, David Cameron-Smith
Summary: This study found that higher plasma concentrations of KYN pathway metabolites are associated with obesity and increased risk for metabolic syndrome and fatty liver in prepubertal Asian children.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Nutrition & Dietetics
Utpal Kumar Prodhan, Amber Marie Milan, Aahana Shrestha, Mark Hedley Vickers, David Cameron-Smith, Matthew Philip Greig Barnett
Summary: This study found that milk protein digestion is largely unaffected by dairy- and lactose-intolerances.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Physiology
Chantal A. A. Pileggi, Christopher P. P. Hedges, Randall F. F. D'Souza, Brenan R. R. Durainayagam, Nina Zeng, Vandre C. C. Figueiredo, Anthony J. R. Hickey, Cameron J. J. Mitchell, David Cameron-Smith
Summary: Mitochondrial dynamics show limited changes in response to inactivity. Restoration of ambulatory activity can reverse the altered gene expression patterns, while resistance training has little effect on gene expression changes.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
Brenan Durainayagam, Cameron J. J. Mitchell, Amber M. M. Milan, Marlena C. C. Kruger, Nicole C. C. Roy, Karl Fraser, David Cameron-Smith
Summary: The aim of this study was to examine the dynamic responses of plasma metabolome in overweight females in relation to meal glycaemic load (GL). The results showed that participants with Metabolic Syndrome (MetS) had lower concentrations of certain amino acids and metabolites related to energy metabolism after meals. However, the manipulation of meal GL had minimal impact on the postprandial metabolome, indicating that individual metabolic health has a greater influence.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Review
Nutrition & Dietetics
N. Gillies, D. Cameron-Smith, S. Pundir, C. R. Wall, A. M. Milan
Summary: This systematic review investigates the dietary adequacy of folate, riboflavin, vitamins B-6 and B-12 in older adults and found that riboflavin inadequacy increases with age, while folate adequacy varies between studies. Limited evidence and inconsistency were reported for vitamins B-6 and B-12. Further research is needed to better understand changes in micronutrient intake with age and improve recommendations for older adults.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Agriculture, Dairy & Animal Science
Emma N. Bermingham, Michael Agnew, Mariza Gomes Reis, Kevin Taukiri, Arjan Jonker, David Cameron-Smith, Cameron R. Craigie
Summary: The study aimed to compare the lipid composition of beef from pasture-fed Wagyu-cross cattle with traditional beef breeds. Results showed higher concentrations of phospholipids in pasture-fed beef, with differences in fatty acid composition among commercial cuts. Meat from pasture-fed Wagyu x Dairy cross may provide an important source of long-chain omega-3 fatty acids.
ANIMAL PRODUCTION SCIENCE
(2021)
