Klotho Deficiency Causes Heart Aging via Impairing the Nrf2-GR Pathway

Epigenetic Regulation of KL (Klotho) via H3K27me3 (Histone 3 Lysine [K] 27 Trimethylation) in Renal Tubule Cells

(2020) Xiaobin Han et al.   HYPERTENSION

In vivo AAV delivery of glutathione reductase gene attenuates anti-aging gene klotho deficiency-induced kidney damage

(2020) Diansa Gao et al.   Redox Biology

Secreted Klotho Attenuates Inflammation-Associated Aortic Valve Fibrosis in Senescence-Accelerated Mice P1Novelty and Significance

(2018) Jianglei Chen et al.   HYPERTENSION

AAV Delivery of Endothelin-1 shRNA Attenuates Cold-Induced Hypertension

(2017) Peter Gin-Fu Chen et al.   HUMAN GENE THERAPY

Bioenergetics of the aging heart and skeletal muscles: Modern concepts and controversies

(2016) Kersti Tepp et al.   AGEING RESEARCH REVIEWS

Mechanical Regulation of Cardiac Aging in Model Systems

(2016) Ayla O. Sessions et al.   CIRCULATION RESEARCH

The role of glutathione reductase and related enzymes on cellular redox homoeostasis network

(2016) Narciso Couto et al.   FREE RADICAL BIOLOGY AND MEDICINE

Safe Oral Triiodo-L-Thyronine Therapy Protects from Post-Infarct Cardiac Dysfunction and Arrhythmias without Cardiovascular Adverse Effects

(2016) Viswanathan Rajagopalan et al.   PLoS One

Antiaging GeneKlothoAttenuates Pancreatic β-Cell Apoptosis in Type 1 Diabetes

(2015) Yi Lin et al.   DIABETES

Haplodeficiency ofKlothoGene Causes Arterial Stiffening via Upregulation of Scleraxis Expression and Induction of AutophagyNovelty and Significance

(2015) Kai Chen et al.   HYPERTENSION

The aging heart, endothelin-1 and the senescent cardiac fibroblast

(2015) Randy T. Cowling   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Soluble serum Klotho levels in healthy subjects. Comparison of two different immunoassays

(2013) Lise Pedersen et al.   CLINICAL BIOCHEMISTRY

Aberrant differentiation of fibroblast progenitors contributes to fibrosis in the aged murine heart: role of elevated circulating insulin levels

(2013) Katarzyna A. Cieslik et al.   FASEB JOURNAL

Klotho gene delivery suppresses Nox2 expression and attenuates oxidative stress in rat aortic smooth muscle cells via the cAMP-PKA pathway

(2012) Yuhong Wang et al.   AGING CELL

Vascular Klotho Deficiency Potentiates the Development of Human Artery Calcification and Mediates Resistance to Fibroblast Growth Factor 23

(2012) Kenneth Lim et al.   CIRCULATION

Oxidative stress and heart failure

(2011) Hiroyuki Tsutsui et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Klotho protein diminishes endothelial apoptosis and senescence via a mitogen-activated kinase pathway

(2011) Yoshihiro Maekawa et al.   Geriatrics & Gerontology International

Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects

(2010) Yuji Yamazaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glutathione reductase plays an anti-apoptotic role against oxidative stress in human hepatoma cells

(2010) Su-Jung Kim et al.   BIOCHIMIE

High-titre retroviral vector system for efficient gene delivery into human and mouse cells of haematopoietic and lymphocytic lineages

(2010) C. Wu et al.   JOURNAL OF GENERAL VIROLOGY

The Aging Heart and Post-Infarction Left Ventricular Remodeling

(2010) Henry Shih et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiac Aging in Mice and Humans: The Role of Mitochondrial Oxidative Stress

(2010) Dao-Fu Dai et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Klotho Gene Delivery Prevents the Progression of Spontaneous Hypertension and Renal Damage

(2009) Yuhong Wang et al.   HYPERTENSION

Current understanding of klotho

(2008) Yuhong Wang et al.   AGEING RESEARCH REVIEWS

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

(2008) C.J. Harvey et al.   FREE RADICAL BIOLOGY AND MEDICINE