Epigenetic Reader BRD4 (Bromodomain-Containing Protein 4) Governs Nucleus-Encoded Mitochondrial Transcriptome to Regulate Cardiac Function

The BET Bromodomain Inhibitor I-BET-151 Induces Structural and Functional Alterations of the Heart Mitochondria in Healthy Male Mice and Rats

(2019) Jérôme Piquereau et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer

(2019) Gianluca Civenni et al.   Cell Metabolism

YY1 regulates skeletal muscle regeneration through controlling metabolic reprogramming of satellite cells

(2019) Fengyuan Chen et al.   EMBO JOURNAL

Polycystin-1 Assembles with Kv Channels to Govern Cardiomyocyte Repolarization and Contractility

(2019) Francisco Altamirano et al.   CIRCULATION

PAN-INTACT enables direct isolation of lineage-specific nuclei from fibrous tissues

(2019) Samadrita Bhattacharyya et al.   PLoS One

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

(2019) Daehwan Kim et al.   NATURE BIOTECHNOLOGY

CEMiTool: a Bioconductor package for performing comprehensive modular co-expression analyses

(2018) Pedro S. T. Russo et al.   BMC BIOINFORMATICS

Down Syndrome Critical Region 1 Gene,Rcan1, Helps Maintain a More Fused Mitochondrial NetworkNovelty and Significance

(2018) Valentina Parra et al.   CIRCULATION RESEARCH

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

GENCODE reference annotation for the human and mouse genomes

(2018) Adam Frankish et al.   NUCLEIC ACIDS RESEARCH

The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes

(2017) Ryan J. Conrad et al.   MOLECULAR CELL

Ensembl 2018

(2017) Daniel R Zerbino et al.   NUCLEIC ACIDS RESEARCH

Super-enhancers define a proliferative PGC-1α-expressing melanoma subgroup sensitive to BET inhibition

(2017) K A Gelato et al.   ONCOGENE

Oxidative Stress in Metabolic Disorders and Drug-Induced Injury: The Potential Role of Nrf2 and PPARs Activators

(2017) Ayman M. Mahmoud et al.   Oxidative Medicine and Cellular Longevity

BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure

(2017) Qiming Duan et al.   Science Translational Medicine

Mitochondrial Metabolism in Aging Heart

(2016) Edward J. Lesnefsky et al.   CIRCULATION RESEARCH

Epigenetic regulation in heart failure

(2016) Soo Young Kim et al.   CURRENT OPINION IN CARDIOLOGY

Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations

(2016) Joeva J. Barrow et al.   MOLECULAR CELL

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA

(2016) Matthew S. Stratton et al.   Cell Reports

Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice

(2016) Yuzhi Jia et al.   PLoS One

Readers, Writers, and Erasers

(2015) Thomas G. Gillette et al.   CIRCULATION RESEARCH

Critical role of YY1 in cardiac morphogenesis

(2015) Ilimbek Beketaev et al.   DEVELOPMENTAL DYNAMICS

Estrogen-Related Receptor α (ERRα) and ERRγ Are Essential Coordinators of Cardiac Metabolism and Function

(2015) Ting Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones

(2014) Tomohiko Kanno et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure

(2013) Priti Anand et al.   CELL

BET acetyl-lysine binding proteins control pathological cardiac hypertrophy

(2013) Jessica I. Spiltoir et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondrial dynamics in heart disease

(2012) Gerald W. Dorn   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Differential analysis of gene regulation at transcript resolution with RNA-seq

(2012) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Two-pronged Binding with Bromodomain-containing Protein 4 Liberates Positive Transcription Elongation Factor b from Inactive Ribonucleoprotein Complexes

(2011) Sebastian Schröder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

An improved spectrophotometric method for a more specific and accurate assay of mitochondrial complex III activity

(2008) Cheng Luo et al.   CLINICA CHIMICA ACTA