CD4+ T cells engineered with FVIII-CAR and murine Foxp3 suppress anti-factor VIII immune responses in hemophilia a mice

A Treg-Selective IL-2 Mutein Prevents the Formation of Factor VIII Inhibitors in Hemophilia Mice Treated With Factor VIII Gene Therapy

(2020) Alex C. Chen et al.   Frontiers in Immunology

CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD

(2020) Yuki Imura et al.   JCI Insight

Antigen‐specific in vitro expansion of factor VIII‐specific regulatory T cells induces tolerance in hemophilia A mice

(2019) Bryn M. Smith et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Chimeric antigen receptor (CAR) T cells targeting a pathogenic MHC class II:peptide complex modulate the progression of autoimmune diabetes

(2018) Li Zhang et al.   JOURNAL OF AUTOIMMUNITY

Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity

(2017) Arnab Ghosh et al.   NATURE MEDICINE

Antigen-specific regulatory T cells: are police CARs the answer?

(2017) Nicholas A.J. Dawson et al.   Translational Research

CAR T-Cell Therapy: Progress and Prospects

(2017) Olivia Wilkins et al.   Human Gene Therapy Methods

FVIII-specific human chimeric antigen receptor T-regulatory cells suppress T- and B-cell responses to FVIII

(2016) Jeongheon Yoon et al.   BLOOD

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor

(2016) Katherine G. MacDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

Development of Third-generation Cocal Envelope Producer Cell Lines for Robust Lentiviral Gene Transfer into Hematopoietic Stem Cells and T-cells

(2016) Olivier Humbert et al.   MOLECULAR THERAPY

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

(2016) C. T. Ellebrecht et al.   SCIENCE

Toxicity and management in CAR T-cell therapy

(2016) Challice L Bonifant et al.   Molecular Therapy-Oncolytics

How antigen specificity directs regulatory T-cell function: self, foreign and engineered specificity

(2016) R. E. Hoeppli et al.   HLA

CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia

(2015) S S Kenderian et al.   LEUKEMIA

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse

(2014) M. F. Martelli et al.   BLOOD

Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses

(2014) Y. C. Kim et al.   BLOOD

Long-term tolerance to factor VIII is achieved by administration of interleukin-2/interleukin-2 monoclonal antibody complexes and low dosages of factor VIII

(2014) C. L. Liu et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Chimeric Antigen Receptor Therapy for Cancer

(2013) David M. Barrett et al.   Annual Review of Medicine

Late immune tolerance induction in haemophilia A patients

(2013) S. L. Meeks et al.   HAEMOPHILIA

Immune tolerance induction in haemophilia A patients with inhibitors by treatment with recombinant factor VIII: a retrospective non-interventional study

(2013) G. E. Rivard et al.   HAEMOPHILIA

Clinical application of regulatory T cells in type 1 diabetes

(2013) Natalia Marek-Trzonkowska et al.   PEDIATRIC DIABETES

How we choose factor VIII to treat hemophilia

(2012) P. M. Mannucci et al.   BLOOD

Promoting transplantation tolerance; adoptive regulatory T cell therapy

(2012) N. Safinia et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

In Vivo Expansion of Regulatory T cells With IL-2/IL-2 mAb Complexes Prevents Anti-factor VIII Immune Responses in Hemophilia A Mice Treated With Factor VIII Plasmid-mediated Gene Therapy

(2011) Chao-Lien Liu et al.   MOLECULAR THERAPY

B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia

(2010) H. M. Kerns et al.   BLOOD

Human Antigen-Specific Regulatory T Cells Generated by T Cell Receptor Gene Transfer

(2010) Todd M. Brusko et al.   PLoS One

Immunomodulation for inhibitors in hemophilia A: the important role of Treg cells

(2010) Carol H Miao   Expert Review of Hematology

Retronectin enhances lentivirus-mediated gene delivery into hematopoietic progenitor cells

(2009) Hyun-Joo Lee et al.   BIOLOGICALS

CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice

(2009) C. H. Miao et al.   BLOOD

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells

(2009) Piotr Trzonkowski et al.   CLINICAL IMMUNOLOGY

Factor VIII Inhibitors: Risk Factors and Methods for Prevention and Immune Modulation

(2009) Ai Hong Zhang et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Regulatory T cells: how do they suppress immune responses?

(2009) S. Sakaguchi et al.   INTERNATIONAL IMMUNOLOGY

The molecular mechanisms of immunomodulation and tolerance induction to factor VIII

(2009) B. WATERS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Cocal-pseudotyped Lentiviral Vectors Resist Inactivation by Human Serum and Efficiently Transduce Primate Hematopoietic Repopulating Cells

(2009) Grant D Trobridge et al.   MOLECULAR THERAPY

Towards a Clinically Relevant Lentiviral Transduction Protocol for Primary Human CD34+ Hematopoietic Stem/Progenitor Cells

(2009) Michelle Millington et al.   PLoS One

Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice

(2008) Julia Yuen-Shan Tsang et al.   JOURNAL OF CLINICAL INVESTIGATION