Article
Biochemistry & Molecular Biology
Zijiao Zhang, Juhan Song, Seung-Hee Kwon, Zhao Wang, Suk-Gyun Park, Xianyu Piao, Je-Hwang Ryu, Nacksung Kim, Ok-Su Kim, Sun-Hun Kim, Jeong-Tae Koh
Summary: This study found that pirfenidone (PFD) can significantly inhibit alveolar bone loss caused by ligature in mice. PFD may be a promising candidate for controlling periodontitis by suppressing osteoclastogenesis and inflammatory cytokine production through inhibiting the NF-kappa B signal pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Saba Bakhshi, Saeedeh Shamsi
Summary: Evidence suggests that NLRP3 is involved in various inflammatory and autoimmune diseases, and inhibition of NLRP3 can be a useful treatment option. MCC950, a small molecule, can specifically inhibit NLRP3 and reduce the production of proinflammatory cytokines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Myung Jin Lee, Hyang Hwa Ryu, Jae Won Hwang, Jung Ryul Kim, Eui-Sic Cho, Jin Kyeong Choi, Young Jae Moon
Summary: Periodontitis is an inflammatory disease that causes destruction of periodontal tissue. Sirt6, a protein, has been found to suppress inflammation and bone resorption, but its role in periodontitis was unclear. By studying mice with Sirt6 overexpression and using a Sirt6 activator called MDL801, the researchers found that Sirt6 activation prevented bone loss in periodontitis. This suggests that a Sirt6 activator could be a potential therapeutic approach for treating periodontitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Yang Li, Junqi Ling, Qianzhou Jiang
Summary: Bone remodeling is tightly controlled by osteoclast-mediated bone resorption and osteoblast-mediated bone formation, and dysregulated inflammasome activation may lead to pathological bone loss in the alveolar bone. This is associated with various diseases and understanding the mechanism of inflammasome activation is crucial in developing therapeutic strategies for alveolar bone loss.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Y. Han, Y. Huang, P. Gao, Q. Yang, L. Jia, Y. Zheng, W. Li
Summary: Periodontitis is an oral chronic inflammatory disease characterized by periodontal pocket formation, loss of attachment, and alveolar bone resorption. Leptin plays a critical role in the pathogenesis of periodontitis by promoting proinflammatory M1 macrophage skewing. Targeting leptin/NLRP3 signaling may be a feasible approach for treating periodontitis.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yael Alippe, Dustin Kress, Biancamaria Ricci, Kai Sun, Tong Yang, Chun Wang, Jianqiu Xiao, Yousef Abu-Amer, Gabriel Mbalaviele
Summary: The lack of NLRP3 or NLRC4 inflammasomes affects bone metabolism and disease, but the tissue appears to function normally upon compound loss of these receptors' assembled inflammasomes.
Article
Immunology
Huiqin Zhou, Wei Zhang, Danxue Qin, Peiqiang Liu, Wenjun Fan, Hao Lv, Lu Tan, Ziang Gao, Yu Xu
Summary: NLRP3 inflammasome activation plays an important role in allergic rhinitis by inducing macrophage pyroptosis and releasing inflammatory mediators to local tissues.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Long Guo, Zhihao Wang, Jun Li, Luying Cui, Junsheng Dong, Xia Meng, Guoqiang Zhu, Jianji Li, Heng Wang
Summary: This study investigated the anti-inflammatory effect of MCC950 in the cornea of dogs infected with Staphylococcus pseudintermedius. The results showed that MCC950 reduced the expression levels of key proteins involved in the inflammatory pathway and inhibited the activation of the NLRP3 inflammasome. Additionally, MCC950 decreased the levels of inflammatory factors and improved the symptoms of canine keratitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Tim Keuler, Karl Gatterdam, Anil Akbal, Marta Lovotti, Michael Marleaux, Matthias Geyer, Eicke Latz, Michael Guetschow
Summary: The study focused on the design, synthesis, and biochemical evaluation of activity-based probes targeting NLRP3. The probes showed affinity to NLRP3 through SPR measurements and cellular activity was confirmed by reducing interleukin 1 beta release. Coumarin probe 2 was highlighted as a suitable tool compound for the analysis of the NLRP3 inflammasome cellular and biochemical properties.
FRONTIERS IN CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Hao Li, Yanling Guan, Bo Liang, Peng Ding, Xin Hou, Wei Wei, Yang Ma
Summary: NOD-like receptor protein 3 (NLRP3) is an important intracellular pattern recognition receptor associated with several human diseases. MCC950, a specific small-molecule inhibitor, blocks activation of the NLRP3 inflammasome. Preclinical and clinical studies have shown promising results for the clinical therapeutic potential of MCC950.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ying Shi, Lili Zhao, Jing Wang, Shan Liu, Yifei Zhang, Qin Qin
Summary: In this study, the researchers found that inhibiting the NLRP3 inflammasome with MCC950 improved cardiac dysfunction induced by ISO, including cardiac fibrosis, hypertrophy, and inflammation. Furthermore, MCC950 also attenuated ISO-induced oxidative stress and cell senescence.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hantao Yao, Yangge Du, Bulin Jiang, Yilin Liao, Yaoyu Zhao, Mengjie Yin, Ting Li, Yue Sheng, Yaoting Ji, Minquan Du
Summary: Inflammatory disorders induce bone loss through osteoclast differentiation. LFS effectively inhibits osteoclast formation by suppressing AKT phosphorylation and promoting NRF2 expression and translocation, thus combating oxidative stress and bone loss. LFS holds promise as a therapeutic agent for oxidative-stress related diseases and bone loss disorders.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Endocrinology & Metabolism
Hyo Jeong Kim, Ka-Young Ryu, Yong-Gun Kim, Myoung Ok Kim, Ji Hye Lee, Min-Kyoung Song, Young-Jin Youn, Nitin Kumar Pohkrel, Sung-Hyun Kim, Jae-Young Kim, Hye-Jin Jung, Woo-Shin Kim, Chang-Won Hong, Hong-Hee Kim, Youngkyun Lee
Summary: The study revealed the crucial role of PTP1B in osteoclast differentiation, with PTP1B deficiency leading to decreased osteoclast number and activity. This highlights the potential of PTP1B as a therapeutic target for bone-lytic diseases.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Guanghui Zheng, Jing Xu, Fenglian He, Juntao Hu, Weiwei Ge, Xianfei Ji, Changsheng Wang, Jennifer L. Bradley, Mary Ann Peberdy, Joseph P. Ornato, Stefano Toldo, Tong Wang, Wanchun Tang
Summary: The study revealed that the NLRP3 inflammasome inhibitor MCC950 has the potential to reduce brain edema, improve cerebral microcirculation, decrease the level of interleukin-1 beta, and enhance the 24-hour survival rate and neurological deficits in a rat model of cardiac arrest.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Carien Dekker, Henri Mattes, Michael Wright, Andreas Boettcher, Alexandra Hinniger, Nicola Hughes, Sandra Kapps-Fouthier, Jorg Eder, Paulus Erbel, Nikolaus Stiefl, Angela Mackay, Christopher J. Farady
Summary: The NLRP3 inflammasome responds to various pathogenic and sterile signals, producing interleukin-1 beta and interleukin-18. Understanding the structure of NLRP3 NACHT domain can provide insights into activation mechanisms and aid in the development of inhibitors for inflammatory diseases. Stabilizing the auto-inhibited form of the NACHT domain is an effective strategy to inhibit NLRP3 and could be beneficial in future therapeutic approaches.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
H. Wang, C. Lv, Y. Gu, Q. Li, L. Xie, H. Zhang, D. Miao, W. Sun
JOURNAL OF DENTAL RESEARCH
(2018)
Article
Rheumatology
Wensheng Wang, Xi Lin, Hao Xu, Wen Sun, Echoe M. Bouta, Michael J. Zuscik, Di Chen, Edward M. Schwarz, Lianping Xing
ARTHRITIS & RHEUMATOLOGY
(2019)
Article
Endocrinology & Metabolism
Hua Wang, Zixuan Hu, Jun Wu, Yukun Mei, Qian Zhang, Hengwei Zhang, Dengshun Miao, Wen Sun
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Article
Cell & Tissue Engineering
Guangpei Chen, Ying Zhang, Shuxiang Yu, Wen Sun, Dengshun Miao
Article
Endocrinology & Metabolism
Hua Wang, Hengwei Zhang, Venkat Srinivasan, Jianguo Tao, Wen Sun, Xi Lin, Tao Wu, Brendan F. Boyce, Frank H. Ebetino, Robert K. Boeckman, Lianping Xing
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Cell Biology
Shuting Zhang, Hanwen Zhang, Zhichun Jin, Siyu Wang, Yan Wang, Linlin Zhu, Wen Sun, Bin Yan
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Cell Biology
Wenlei Li, Jing Zhao, Jialu Wang, Lian Sun, Haiyang Xu, Wen Sun, Yongchu Pan, Hua Wang, Wei-Bing Zhang
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Oncology
Hua Wang, Yuyi Chen, Wenlei Li, Lian Sun, Hongyu Chen, Qiudong Yang, Hang Zhang, Weibing Zhang, Hua Yuan, Hengwei Zhang, Lianping Xing, Wen Sun
JOURNAL OF PATHOLOGY
(2020)
Article
Education, Scientific Disciplines
Wen Sun, Hongyu Chen, Yi Zhong, Wei Zhang, Fengqing Chu, Lin Li, Yue Chen, Xiang Wang, Qirui Wang, Yuxin Wang, Yongyue Wei, Laikui Liu, Yan Xu
Summary: A study introduced an online dental learning platform with 3D tooth models based on micro-computed tomography, and found that the use of this platform had a positive impact on dental anatomy education according to a cohort study. Participants in the Digital group showed improved scores and positive attitudes towards the 3D models.
ANATOMICAL SCIENCES EDUCATION
(2022)
Article
Biochemistry & Molecular Biology
Jun Wu, Rong Wang, Xuechun Kan, Jinghan Zhang, Wen Sun, David Goltzman, Dengshun Miao
Summary: This study reveals that the activation of the Shh-Gli-Bmi1 signaling pathway plays a critical role in the bone anabolic action induced by p27 deficiency. Bmi1 may be an important therapeutic target for treating osteoporosis caused by the activation of p27 signaling or inactivation of sonic hedgehog signaling.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Qiudong Yang, Wenhua Zhao, Yuyi Chen, Yue Chen, Jiali Shi, Ran Qin, Hua Wang, Ruixia Wang, Hua Yuan, Wen Sun
Summary: The study reveals that the RelA/miR-30a/NLRP3 signaling axis is involved in rheumatoid arthritis by regulating the NLRP3 inflammasome in macrophages.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Yue Chen, Hua Wang, Qiudong Yang, Wenhua Zhao, Yuyi Chen, Qiaoqi Ni, Wenlei Li, Jiali Shi, Wei Zhang, Lu Li, Yan Xu, Hengwei Zhang, Dengshun Miao, Lianping Xing, Wen Sun
Summary: This study comprehensively revealed the complexities of the molecular components in the osteoimmunology microenvironment of periodontal tissues at the single-cell level using scRNA-seq. Differences in specific cell types were observed in patients with periodontitis, with significant differentiation characteristics observed in certain cell types after initial periodontal therapy.
Article
Biochemistry & Molecular Biology
Jinbo Li, Xing Li, Wen Sun, Jiao Zhang, Quanquan Yan, Jun Wu, Jianliang Jin, Ruinan Lu, Dengshun Miao
Summary: This study reveals the mechanism of regulating bone-building and hematopoiesis-supportive activities. It highlights the importance of the Bmi1/Sirt1 signaling pathway and explores the potential of pharmacological activation to promote bone-building and hematopoiesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wenlei Li, Jing Zhao, Wen Sun, Hua Wang, Yongchu Pan, Lin Wang, Wei-Bing Zhang
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2020)