Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

(2020) Joanna Kalucka et al.   CELL

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

(2019) Dvir Aran et al.   NATURE IMMUNOLOGY

Lysosomal Acid Lipase in Lipid Metabolism and Beyond

(2019) Fang Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Metabolic Pathways Fueling the Endothelial Cell Drive

(2019) Xuri Li et al.   Annual Review of Physiology

SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis

(2019) Linzhang Huang et al.   NATURE

Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data

(2019) Samuel L. Wolock et al.   Cell Systems

DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors

(2019) Christopher S. McGinnis et al.   Cell Systems

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism

(2019) Stephen G. Young et al.   Cell Metabolism

Metabolic regulation through the endosomal system

(2019) Jerome Gilleron et al.   TRAFFIC

Hallmarks of Endothelial Cell Metabolism in Health and Disease

(2019) Xuri Li et al.   Cell Metabolism

Contribution of adipogenesis to healthy adipose tissue expansion in obesity

(2019) Lavanya Vishvanath et al.   JOURNAL OF CLINICAL INVESTIGATION

Brown adipose cross talk in tissue plasticity and human metabolism

(2019) Camilla Scheele et al.   ENDOCRINE REVIEWS

Opportunities and challenges in the therapeutic activation of human energy expenditure and thermogenesis to manage obesity

(2019) Kong Y. Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis

(2018) Madalina Duta-Mare et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice

(2018) Markus Heine et al.   Cell Metabolism

Impact of dietary ω3 polyunsaturated fatty acid supplementation on brown and brite adipocyte function

(2018) Rayane A. Ghandour et al.   JOURNAL OF LIPID RESEARCH

Impaired thermogenesis and sharp increases in plasma triglyceride levels in GPIHBP1-deficient mice during cold exposure

(2018) Mikael Larsson et al.   JOURNAL OF LIPID RESEARCH

The Role of Pyruvate Dehydrogenase Kinase-4 (PDK4) in Bladder Cancer and Chemoresistance

(2018) Benjamin L Woolbright et al.   MOLECULAR CANCER THERAPEUTICS

The Common and Distinct Features of Brown and Beige Adipocytes

(2018) Kenji Ikeda et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Optimal housing temperatures for mice to mimic the thermal environment of humans: An experimental study

(2018) Alexander W. Fischer et al.   Molecular Metabolism

Endothelial cell CD36 optimizes tissue fatty acid uptake

(2018) Ni-Huiping Son et al.   JOURNAL OF CLINICAL INVESTIGATION

The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins

(2018) Alexander W. Fischer et al.   Molecular Metabolism

Intact innervation is essential for diet-induced recruitment of brown adipose tissue

(2018) Alexander W. Fischer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation

(2018) Miroslav Balaz et al.   Cell Metabolism

New Advances in Adaptive Thermogenesis: UCP1 and Beyond

(2018) Edward T. Chouchani et al.   Cell Metabolism

Overexpression of PDK4 is associated with cell proliferation, drug resistance and poor prognosis in ovarian cancer

(2018) Jinghao Wang et al.   Cancer Management and Research

Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis

(2017) Anna Worthmann et al.   NATURE MEDICINE

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

(2017) Matthew D Lynes et al.   NATURE MEDICINE

Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport

(2017) Alexander Bartelt et al.   Nature Communications

Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRα+ adipose progenitors

(2017) Bo Wang et al.   Cell Discovery

Next-generation in vivo optical imaging with short-wave infrared quantum dots

(2017) Oliver T. Bruns et al.   Nature Biomedical Engineering

FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues

(2016) Christian Schlein et al.   Cell Metabolism

Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans

(2016) Maria Chondronikola et al.   Cell Metabolism

Metabolic interplay between white, beige, brown adipocytes and the liver

(2016) Ludger Scheja et al.   JOURNAL OF HEPATOLOGY

High-throughput discovery of novel developmental phenotypes

(2016) Mary E. Dickinson et al.   NATURE

Human 'brite/beige' adipocytes develop from capillary networks and their implantation improves metabolic homeostasis in mice

(2016) So Yun Min et al.   NATURE MEDICINE

Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat

(2016) Takahiro Seki et al.   Nature Communications

Leptin Raises Defended Body Temperature without Activating Thermogenesis

(2016) Alexander W. Fischer et al.   Cell Reports

Regulation of Hypoxia-Inducible Factor-1a by Reactive Oxygen Species : New Developments in an Old Debate

(2015) Shahrzad Movafagh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

(2015) Jimmy F. P. Berbée et al.   Nature Communications

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

(2015) Wieneke Dijk et al.   eLife

Adipose tissue angiogenesis: Impact on obesity and type-2 diabetes

(2013) Silvia Corvera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Adipose Vascular Endothelial Growth Factor Regulates Metabolic Homeostasis through Angiogenesis

(2013) Hoon-Ki Sung et al.   Cell Metabolism

Vascular endothelial growth factor is important for brown adipose tissue development and maintenance

(2013) Mandrita Bagchi et al.   FASEB JOURNAL

Biochemistry and pathophysiology of intravascular and intracellular lipolysis

(2013) S. G. Young et al.   GENES & DEVELOPMENT

Cholesteryl ester storage disease: Review of the findings in 135 reported patients with an underdiagnosed disease

(2013) Donna L. Bernstein et al.   JOURNAL OF HEPATOLOGY

Bi-directional interconversion of brite and white adipocytes

(2013) Matthias Rosenwald et al.   NATURE CELL BIOLOGY

Compact high-quality CdSe–CdS core–shell nanocrystals with narrow emission linewidths and suppressed blinking

(2013) Ou Chen et al.   NATURE MATERIALS

Adipose tissue browning and metabolic health

(2013) Alexander Bartelt et al.   Nature Reviews Endocrinology

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

(2013) Irina G. Shabalina et al.   Cell Reports

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

(2012) Haruya Ohno et al.   Cell Metabolism

Zfp423 Expression Identifies Committed Preadipocytes and Localizes to Adipose Endothelial and Perivascular Cells

(2012) Rana K. Gupta et al.   Cell Metabolism

The Vascular Endothelium of the Adipose Tissue Gives Rise to Both White and Brown Fat Cells

(2012) Khanh-Van Tran et al.   Cell Metabolism

Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance

(2012) I. Elias et al.   DIABETES

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

(2012) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue

(2012) Florian W Kiefer et al.   NATURE MEDICINE

Dichotomous effects of VEGF-A on adipose tissue dysfunction

(2012) K. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eicosanoids and other lipid mediators and the tumor hypoxic microenvironment

(2011) Sriram Krishnamoorthy et al.   CANCER AND METASTASIS REVIEWS

The spatiotemporal development of adipose tissue

(2011) J. Han et al.   DEVELOPMENT

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

Adipose Tissue-specific Inhibition of Hypoxia-inducible Factor 1α Induces Obesity and Glucose Intolerance by Impeding Energy Expenditure in Mice

(2010) Xinmei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thiadiazole Carbamates: Potent Inhibitors of Lysosomal Acid Lipase and Potential Niemann−Pick Type C Disease Therapeutics

(2010) Anton I. Rosenbaum et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes

(2010) A. Vegiopoulos et al.   SCIENCE

Chylomicronemia With a Mutant GPIHBP1 (Q115P) That Cannot Bind Lipoprotein Lipase

(2009) Anne P. Beigneux et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation

(2009) Yuan Xue et al.   Cell Metabolism

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

(2009) Natasa Petrovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals

(2009) Oliver T. Bruns et al.   Nature Nanotechnology

Positive and Negative Modulation of Angiogenesis by VEGFR1 Ligands

(2009) Y. Cao   Science Signaling

Thermogenically competent nonadrenergic recruitment in brown preadipocytes by a PPARγ agonist

(2008) Natasa Petrovic et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Enhanced angiogenesis in obesity and in response to PPARγ activators through adipocyte VEGF and ANGPTL4 production

(2008) Olga Gealekman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells

(2008) Seung-Nam Jung et al.   CARCINOGENESIS

Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways: Fig. 1.

(2008) Ira J. Goldberg et al.   JOURNAL OF LIPID RESEARCH

White Fat Progenitor Cells Reside in the Adipose Vasculature

(2008) W. Tang et al.   SCIENCE