期刊
CANCER LETTERS
卷 496, 期 -, 页码 134-143出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2020.09.028
关键词
CD8(+) cells; Th cells; Tregs; gamma d T cells; Immunosuppressive microenvironment; Immunotherapy
类别
资金
- Jiangsu Natural Science Foundation Youth Project [BK20180277]
- Doctorial Innovation Foundation of Jiangsu Province [KYCX17_1816]
This review discusses the impact of the GBM microenvironment on T-cell subsets and strategies to overcome immunosuppression.
Glioblastoma multiforme (GBM) is a brain tumor with a high mortality rate. Surgical resection combined with radiotherapy and chemotherapy is the standard treatment for GBM patients, but the 5-year survival rate of patients despite this treatment is low. Immunotherapy has attracted increasing attention in recent years. As the pioneer and the main effector cells of immunotherapy, T cells play a key role in tumor immunotherapy. However, the T cells in GBM microenvironment are inhibited by the highly immunosuppressive environment of GBM, posing huge challenges to T cell-based GBM immunotherapy. This review summarizes the effects of the GBM microenvironment on the infiltration and function of different T-cell subsets and the possible strategies to overcome immunosuppression, and thus enhance the effectiveness of GBM immunotherapy.
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