A CRISPR/Cas13a-powered catalytic electrochemical biosensor for successive and highly sensitive RNA diagnostics

CRISPR-powered electrochemical microfluidic multiplexed biosensor for target amplification-free miRNA diagnostics

(2021) Richard Bruch et al.   BIOSENSORS & BIOELECTRONICS

Sensitive detection of a bacterial pathogen using allosteric probe-initiated catalysis and CRISPR-Cas13a amplification reaction

(2020) Jinjin Shen et al.   Nature Communications

Hydrogel-Based Colorimetric Assay for Multiplexed MicroRNA Detection in a Microfluidic Device

(2020) Hyewon Lee et al.   ANALYTICAL CHEMISTRY

Microfluidic chip for multiple detection of miRNA biomarkers in breast cancer based on three-segment hybridization

(2020) Yakun Gao et al.   AIP Advances

Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers

(2019) Chao Liu et al.   Nature Biomedical Engineering

CRISPR/Cas Powered Multiplexed Biosensing

(2019) Richard Bruch et al.   TRENDS IN BIOTECHNOLOGY

Rolling circle amplification and graphene-based sensor-on-a-chip for sensitive detection of serum circulating miRNAs

(2019) Kiatnida Treerattrakoon et al.   ANALYTICAL BIOCHEMISTRY

Unamplified gene sensing via Cas9 on graphene

(2019) Richard Bruch et al.   Nature Biomedical Engineering

CRISPR/Cas13a‐Powered Electrochemical Microfluidic Biosensor for Nucleic Acid Amplification‐Free miRNA Diagnostics

(2019) Richard Bruch et al.   ADVANCED MATERIALS

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

(2018) Janice S. Chen et al.   SCIENCE

Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6

(2018) Jonathan S. Gootenberg et al.   SCIENCE

Profiling of 179 miRNA Expression in Blood Plasma of Lung Cancer Patients and Cancer-Free Individuals

(2018) Ivan A. Zaporozhchenko et al.   Scientific Reports

DNA-Coded Fluorescence for Color Painting RNAs

(2018) Jiaming Hu et al.   Chem

CRISPR-Cas12a-assisted nucleic acid detection

(2018) Shi-Yuan Li et al.   Cell Discovery

Overhang molecular beacons encapsulated in tethered cationic lipoplex nanoparticles for detection of single-point mutation in extracellular vesicle-associated RNAs

(2018) Jiaming Hu et al.   BIOMATERIALS

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

Programmed DNA destruction by miniature CRISPR-Cas14 enzymes

(2018) Lucas B. Harrington et al.   SCIENCE

Nucleic acid detection with CRISPR-Cas13a/C2c2

(2017) Jonathan S. Gootenberg et al.   SCIENCE

Multiplexed Point-of-Care Testing – xPOCT

(2017) Can Dincer et al.   TRENDS IN BIOTECHNOLOGY

A signal-amplifiable biochip quantifies extracellular vesicle-associated RNAs for early cancer detection

(2017) Jiaming Hu et al.   Nature Communications

Extracellular mRNA Detected by Tethered Lipoplex Nanoparticle Biochip for Lung Adenocarcinoma Detection

(2016) L. James Lee et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Programmable RNA Tracking in Live Cells with CRISPR/Cas9

(2016) David A. Nelles et al.   CELL

Dual-Reporter Drift Correction To Enhance the Performance of Electrochemical Aptamer-Based Sensors in Whole Blood

(2016) Hui Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection

(2016) Alexandra East-Seletsky et al.   NATURE

MiR-21 and MiR-155 promote non-small cell lung cancer progression by downregulating SOCS1, SOCS6, and PTEN

(2016) Xinying Xue et al.   Oncotarget

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

Control of mammalian gene expression by selective mRNA export

(2015) Vihandha O. Wickramasinghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reagentless, Ratiometric Electrochemical DNA Sensors with Improved Robustness and Reproducibility

(2014) Yan Du et al.   ANALYTICAL CHEMISTRY

A Reusable Electrochemical Proximity Assay for Highly Selective, Real-Time Protein Quantitation in Biological Matrices

(2014) Jiaming Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

(2014) Shengdar Q Tsai et al.   NATURE BIOTECHNOLOGY

Identification and consequences of miRNA–target interactions — beyond repression of gene expression

(2014) Jean Hausser et al.   NATURE REVIEWS GENETICS

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

Fabrication of magneto-controlled moveable architecture to develop reusable electrochemical biosensors

(2014) Xiaoli Zhu et al.   Scientific Reports

Real-Time, Aptamer-Based Tracking of Circulating Therapeutic Agents in Living Animals

(2013) B. S. Ferguson et al.   Science Translational Medicine

Quantitation of Femtomolar Protein Levels via Direct Readout with the Electrochemical Proximity Assay

(2012) Jiaming Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Prognostic significance of serum miR-17-5p in lung cancer

(2012) Qun Chen et al.   MEDICAL ONCOLOGY

DNA sensing by electrocatalysis with hemoglobin

(2012) C. G. Pheeney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Point of Care Diagnostics: Status and Future

(2011) Vladimir Gubala et al.   ANALYTICAL CHEMISTRY

Transcriptome to proteome and back to genome

(2011) Mary Muers   NATURE REVIEWS GENETICS

The MicroRNA Spectrum in 12 Body Fluids

(2010) J. A. Weber et al.   CLINICAL CHEMISTRY

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

A molecular-imprint nanosensor for ultrasensitive detection of proteins

(2010) Dong Cai et al.   Nature Nanotechnology

Electrochemical Glucose Sensors and Their Applications in Diabetes Management

(2008) Adam Heller et al.   CHEMICAL REVIEWS

Cancer biomarker profiling with microRNAs

(2008) Stefanie S Jeffrey   NATURE BIOTECHNOLOGY