Article
Chemistry, Physical
Kingsley Adibe Mbachu, Umm E-Farwa, Maria Aqeel Khan, Shehryar Hameed, Mehreen Lateef, Lubna Atta, Zaheer Ul-Haq, Khalid Mohammed Khan, Olusegun Ekundayo
Summary: The current research focuses on synthesizing 1,2,3-triazole-linked indomethacin derivatives and evaluating their inhibitory potential against the urease enzyme. Compounds 5, 10, and 18 showed the highest activity and could be used as building blocks for novel urease inhibitors. The structures of the synthetic derivatives were confirmed through various spectroscopic techniques and validated through in silico analysis.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Faiza Seraj, Kanwal, Khalid Mohammed Khan, Ajmal Khan, Muhammad Ali, Ruqaiya Khalil, Zaheer Ul-Haq, Shehryar Hameed, Muhammad Taha, Uzma Salar, Shahnaz Perveen
Summary: Novel ibuprofen derivatives and substituted thiourea derivatives were synthesized and characterized, showing diverse inhibitory potential against urease enzyme. Thirteen derivatives displayed remarkable inhibitory activity, with limited structure-activity relationship discussions based on different structural features. Molecular docking study was conducted to investigate ligands binding interactions with the active site of urease enzyme.
MOLECULAR DIVERSITY
(2021)
Article
Biochemistry & Molecular Biology
Mehdi Asadi, Aida Iraji, Maede Sherafati, Mohammad Nazari Montazer, Shirin Ansari, Maryam Mohammadi Khanaposhtani, Nader Tanideh, Mehdi Dianatpour, Mahmood Biglar, Bagher Larijani, Alireza Foroumadi, Homa Azizian, Massoud Amanlou, Mohammad Mahdavi
Summary: A series of synthesized compounds exhibited good inhibitory activity against urease, with compound 8g showing the highest activity. In vitro studies revealed critical interactions between these inhibitors and the enzyme's active site.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Abdullah Yahya Abdullah Alzahrani, Bushra Adalat, Hayat Ullah, Muhammad Taha, Mohamed S. Othman, Mohamed A. Fareid, Azza M. Khaled, Fazal Rahim
Summary: This study synthesized benzimidazole thiosemicarbazides and sulphonamide derivatives as potent urease inhibitors, which showed good inhibition potential and stable interactions. This is significant for reducing the negative effects of ureolytic bacteria.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Jia Gu, Pan-Lei Xiao, Jie Wang, Liang Zhong, Xu-Liang Nie, Da-Yong Peng
Summary: Ethyl 2-oxo-2H-chromene-3-carboxylate derivatives were synthesized and evaluated for their antifungal activity. Compound 3b exhibited the highest inhibition rate against Fusarium oxysporum, showing promise as a potential lead compound for future pesticide development.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Fazal Rahim, Hayat Ullah, Rafaqat Hussain, Muhammad Taha, Shoaib Khan, Mohsan Nawaz, Faisal Nawaz, Sadaf Jamal Gilani, May Nasser Bin Jumah
Summary: In this study, thiadiazole-based triazole/hydrazone derivatives were synthesized and evaluated for their inhibitory activity against α-glucosidase. The results showed that some of the analogues exhibited good inhibitory potentials, and the structure-activity relationship was mainly influenced by the nature of substituents on the phenyl rings. Molecular docking study supported the experimental data. All compounds showed no cytotoxicity against the 3T3 mouse fibroblast cell line.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Demokrat Nuha, Asaf Evrim Evren, Ozge Kapusiz, Ulkuye Dudu Gul, Nalan Gundogdu-Karaburun, Ahmet Cagri Karaburun, Halil Berber
Summary: A series of novel coumarin derivatives have been synthesized and their chemical structures have been elucidated. These compounds were tested against bacteria and fungi, and some of them exhibited good antimicrobial activity, surpassing the activity of standard drugs. Molecular docking and dynamic simulation were performed on certain compounds, and the chemical reactivity properties of all molecules were examined using density functional theory.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Kanwal, Khalid Mohammed Khan, Sridevi Chigurupati, Farman Ali, Munissa Younus, Maha Aldubayan, Abdul Wadood, Huma Khan, Muhammad Taha, Shahnaz Perveen
Summary: Indole-3-acetamides were synthesized and evaluated for their antihyperglycemic and antioxidant potentials, with compound 15 showing the most promising activity. These compounds demonstrate potential value in inhibiting alpha-amylase and acting as antioxidants.
Article
Biochemistry & Molecular Biology
Ferah Comert Onder, Serdar Durdagi, Nermin Kahraman, Tugce Nur Uslu, Hakan Kandemir, Esen Bellur Atici, Bulent Ozpolat, Mehmet Ay
Summary: In this study, novel compounds were designed and synthesized to inhibit eEF2K activity in breast cancer cells, showing promising results in vitro. These compounds may serve as potential therapeutic agents for cancer treatment and warrant further evaluation in preclinical tumor models for clinical translation.
BIOORGANIC CHEMISTRY
(2021)
Article
Medicine, General & Internal
Abdur Rauf, Muslim Raza, Muhammad Humayun Khan, Hassan A. Hemeg, Yahya S. Al-Awthan, Omar Bahattab, Sami Bawazeer, Saima Naz, Faika Basoglu, Muhammad Saleem, Majid Khan, Hosseini Seyyedamirhossein, Mohammad S. Mubarak, Ilkay Erdogan Orhan
Summary: This study focused on the isolation, in vitro and in silico studies of two natural bio-active flavonoids (1 & 2) isolated from Euphorbia pulcherrima bark for the first time. The chemical structures of the isolated compounds were confirmed, and their bioactivity was evaluated. The results showed promising inhibitory potential against urease and tyrosinase enzymes, as well as anti-glycation and phosphodiesterase inhibitory activities. Docking study indicated the structural features of the compounds are in accordance with their bioactivity.
ANNALS OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jing Zhang, Yaling Tan, Guorong Li, Lexian Chen, Minyi Nie, Zhaohua Wang, Hong Ji
Summary: Coumarin derivatives have good antitumor activity, with compound 9c showing strong antitumor effects in MDA-MB-231 cells, indicating potential for further research.
Article
Chemistry, Physical
Mucahit Ozdemir, Duygu Taskin, Deniz Ceyhan, Baybars Koksoy, Turgut Taskin, Mustafa Bulut, Bahattin Yalcin
Summary: This study investigated the inhibitory potential of acetylcholinesterase enzyme (AChE) and antioxidant activity of ten different coumarin derivatives. The results showed that all compounds exhibited inhibitory activity on AChE, with compounds 1, 3, and 2 showing the highest activity. Compound 7 showed strong inhibition of AChE, similar to the standard galantamine. Additionally, compound 7 demonstrated the highest antioxidant activity among all tested compounds. The pharmacokinetic properties of the compounds were also evaluated, suggesting that coumarins, particularly compound 7, may be potential candidates for treating Alzheimer's disease and as future antioxidant agents.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Medicinal
Sana Shah, Momin Khan, Mahboob Ali, Abdul Wadood, Ashfaq Ur Rehman, Zarbad Shah, Muhammad Yousaf, Uzma Salar, Khalid Mohammed Khan
Summary: In this study, a new class of urease inhibitors, bis-1,3,4-oxadiazole derivatives, were synthesized and their inhibitory potential was evaluated. The compounds showed good activities and some were more potent than the standard thiourea. SAR analysis revealed that the variations in inhibitory activities were due to different substitutions, and molecular docking studies suggested important interactions with the active site of the urease enzyme.
MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Shokhan J. Hamid, Twana Salih
Summary: This study aimed to design and synthesize a compound with anti-inflammatory activity while avoiding the side effects of NSAIDs. Through computational and experimental results, compound 7 was found to be a potential lead molecule with strong anti-inflammatory activity and correlation with protein denaturation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Multidisciplinary Sciences
Zafar Ali Shah, Khalid Khan, Tanzeel Shah, Nasir Ahmad, Akhtar Muhammad, Haroon ur Rashid
Summary: This study evaluated the biological and pharmacological potentials of Aspergillus ficuum extract and found that it possesses antifungal, anticancer, and antiurease activities. These results indicate the potential of A. ficuum extract as a future pharmacological source.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Muhammad Taha, Fazal Rahim, Khalid Zaman, El Hassane Anouar, Nizam Uddin, Faisal Nawaz, Muhammad Sajid, Khalid Mohammed Khan, Adnan Ali Shah, Abdul Wadood, Ashfaq Ur Rehman, Amani H. Alhibshi
Summary: A series of benzo[d]oxazole derivatives were synthesized through a multistep reaction, with the alteration in structure being made via the use of various substituted aromatic aldehydes. These derivatives were evaluated for their inhibitory potential against acetylcholinesterase and butyrylcholinesterase enzymes. Derivative 18 showed the most promising inhibitory potential and its binding interaction with the enzyme's active gorge was confirmed through a docking study. The structural confirmation of all derivatives was done using spectroscopic techniques such as H-1-NMR, C-13-NMR, and HREI-MS.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Samuel Attah Egu, Irfan Ali, Khalid Mohammed Khan, Sridevi Chigurupati, Urooj Qureshi, Uzma Salar, Muhammad Taha, Shatha Ghazi Felemban, Vijayan Venugopal, Zaheer Ul-Haq
Summary: A series of rhodanine-based Schiff bases were synthesized and evaluated for their inhibitory activities against alpha-amylase and radical scavenging. The position and nature of the substituted groups on the phenyl ring were found to play a crucial role in the inhibitory potential, with compounds containing an electron-withdrawing group at the para position showing the highest potency.
MOLECULAR DIVERSITY
(2023)
Article
Chemistry, Multidisciplinary
Israr ul Haq, Irfan Ali, Khalid Mohammed Khan, Sridevi Chigurupati, Atiya Habib, Uzma Salar, Manzoor Ahmad, Sreenath Konanki, Shatha Ghazi Felemban, Muhammad Taha, Zaheer Ul Haq
Summary: A range of new substituted arylidene chromane-2,4-dione derivatives were synthesized and characterized. These derivatives showed significant inhibitory activity against alpha-amylase enzyme and good radical scavenging activity. Docking studies revealed their significant binding interactions with the catalytic site of the enzyme.
Article
Chemistry, Medicinal
Itohowo Gabriel Asuquo, Mehwish Solangi, Khalid Mohammed Khan, Sridevi Chigurupati, Ifeanyi Edozie Otuokere, Francis Kalu Ekuma, Uzma Salar, Shatha Ghazi Felemban, Ashfaq Ur Rehman, Abdul Wadood, Muhammad Taha
Summary: This study aimed to identify substituted indolin-2-one-based inhibitors for alpha-amylase and alpha-glucosidase. Synthetic compounds were confirmed and evaluated for enzyme inhibition activities, yielding good-to-moderate inhibitory potential. Compounds 1, 2, 6, 16 and 17 showed potent alpha-glucosidase inhibitory activity and could serve as potential lead molecules for antidiabetic agents.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Zahra Abdulkarim Homoud, Muhammad Taha, Fazal Rahim, Naveed Iqbal, Muhammad Nawaz, Rai Khalid Farooq, Abdul Wadood, Munther Alomari, Imadul Islam, Shatha Algheribe, Ashfaq Ur Rehman, Khalid Mohammed Khan, Nizam Uddin
Summary: Acetylcholinesterase and butyrylcholinesterase are both valid therapeutic targets for ameliorating the cholinergic deficit in Alzheimer's disease. This study describes the synthesis of indole-based sulfonamide derivatives and their inhibitory activity against the enzymes. Compound 9 showed strong potential as an inhibitor.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Muhammad Taha, Fazal Rahim, Ihsan Ullah Khan, Nizam Uddin, Rai Khalid Farooq, Abdul Wadood, Ashfaq Ur Rehman, Khalid Mohammed Khan
Summary: This work presents a convenient approach for synthesizing thiazole-based thiourea derivatives. The derivatives were obtained from the reaction between 2-bromo-1-(4-fluorophenyl)thiazole-1-one and phenyl isothiocyanates. The derivatives showed moderate to good inhibitory potentials against anticancer, antiglycation, and antioxidant, with compounds 12, 10, and 12 being the most potent among the series.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Physical
Muhammad Taha, Syahrul Imran, Fazal Rahim, Nizam Uddin, Naveed Iqbal, Khalid Mohammed Khan, Rai Khalid Farooq, Munther Alomari, Imadul Islam, Shatha Algheribe
Summary: Thiadiazole analogs were synthesized and characterized, showing good inhibition for urease glycation and scavenging activity. Compound 13 exhibited the most potent inhibition and showed dual activity as an inhibitor for urease and antiglycation.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Amber Ata, Uzma Salar, Faiza Saleem, Mehreen Lateef, Salman Ali Khan, Khalid Mohammed Khan, Muhammed Taha, Syed Moazzam Haider, Zaheer Ul-Haq
Summary: Saccharine-based molecules 1-30 were synthesized and evaluated for urease inhibitory and antioxidant activities. All compounds showed inhibitory potential against the urease enzyme and excellent antioxidant activity. Docking studies confirmed the compatibility of the synthetic compounds with the active site of the urease enzyme.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Medicinal
Muhammad Taha, Fazal Rahim, Shawkat Hayat, Sridevi Chigurupati, Khalid Mohammed Khand, Syahrul Imran, Syed Adnan Ali Shah, Nizam Uddin, Shatha Ghazi Felemban, Vijayan Venugopal
Summary: Aim: The aim of this study was to synthesize pyrrolopyridine-based thiazolotriazoles as a novel class of alpha-amylase and alpha-glucosidase inhibitors and determine their enzymatic kinetics. Methodology: Pyrrolopyridine-based thiazolotriazole analogs (1-24) were synthesized and characterized through various spectroscopic techniques. Results: The synthesized analogs exhibited significant inhibitory potential against alpha-amylase and alpha-glucosidase, with analog 3 showing the highest inhibitory activity. The structure-activity relationship and binding modes of interactions were confirmed through docking and enzymatic kinetics studies. The compounds (1-24) showed no cytotoxicity against the 3T3 mouse fibroblast cell line.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Shawkat Hayat, Hayat Ullah, Fazal Rahim, Ikram Ullah, Muhammad Taha, Naveed Iqbal, Fahad Khan, Muhammad Saleem Khan, Syed Adnan Ali Shah, Abdul Wadood, Muhammad Sajid, Ashraf N. Abdalla
Summary: This study synthesized benzimidazole derivatives for the treatment of diabetes, which exhibited excellent α-glucosidase inhibitory activity compared to clinically used inhibitors.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Muhammad Taha, Aftab Ahmad Khan, Fazal Rahim, Shawkat Hayat, Syahrul Imran, Naveed Iqbal, Nizam Uddin, Khalid Mohammed Khan, El Hassane Anouar, Rai Khalid Farooq, Muhammad Nawaz, Syed Adnan Ali Shah
Summary: In this study, a series of 4-quinolinyl based 1,3,4-thiadiazole-2-amine scaffolds (1-19) were synthesized and evaluated for their in vitro inhibition against alpha-amylase and alpha-glucosidase enzymes. The newly synthesized scaffolds demonstrated varying degrees of inhibitory activity, with compounds 2, 3, and 4 being the most potent inhibitors. The presence of fluorine and chlorine groups at different positions of the phenyl ring attached to the thiadiazole ring may contribute to the enhanced inhibitory profile of these scaffolds. Spectroscopic techniques and molecular docking studies were used to confirm the structures and understand the binding mode of the inhibitors. ADMET prediction and in silico drug likeness analysis showed satisfactory ADMET profile and drug likeness for the synthesized analogues.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Rafaqat Hussain, Wajid Rehman, Fazal Rahim, Shoaib Khan, Ashwag S. Alanazi, Mohammed M. Alanazi, Liaqat Rasheed, Yousaf Khan, Syed Adnan. Ali. Shah, Muhammad Taha
Summary: The present study synthesized twelve analogs of pyridine-derived bis-oxadiazole with bis-schiff base and evaluated their inhibitory potential against thymidine phosphorylase in vitro. The synthesized compounds were characterized using various spectroscopic techniques. The results showed that all analogs exhibited varying degrees of inhibitory potential, with IC50 values ranging from 5.19 +/- 1.10 to 36.18 +/- 4.60 μM. Most of the analogs showed improved potency compared to the standard drug, and structure-activity relationship studies revealed the importance of certain substituents in enhancing potency. Molecular docking studies further confirmed the interactions between the active analogs and the target enzyme. Rating: 7/10.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Mehwish Solangi, Khalid Mohammed Khan, Xingyue Ji, Musa Ozil, Nimet Baltas, Uzma Salar, Alamgir Khan, Zaheer Ul Haq, Herchand Meghwar, Muhammad Taha
Summary: This study synthesized and evaluated a series of indole-pyridine carbonitrile derivatives for their antidiabetic and antioxidant activities. Twelve compounds showed potent inhibitory activities against alpha-glucosidase and alpha-amylase enzymes, making them promising candidates for controlling diabetes.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Irfan Ali, Rafaila Rafique, Khalid Mohammed Khan, Sridevi Chigurupati, Xingyue Ji, Abdul Wadood, Uzma Salar, Suliman A. Almahmoud, Ashfaq Ur Rehman, Shatha Ghazi Felemban, Shehryar Hameed, Shahnaz Perveen
Summary: In this study, benzofuran-linked chalcone derivatives were evaluated for their dual action in reducing postprandial hyperglycemia and oxidative stress, showing potential as a therapeutic approach for diabetes mellitus.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Muhammad Taha, Fazal Rahim, Azmat Ali Khan, Bushra Adalat, Syahrul Imran, Jamilah M. Alshehri, Asrar Ahmad, Khalid Mohammed Khan, Syed Adnan Ali Shah, Nizam Uddin
Summary: The b-carboline scaffold is highly effective in promoting the molecular interactions with various Alzheimer's disease targets. A new series of carboline derivatives were designed based on the biological importance of the carboline nucleus, and were tested for their inhibition of acetylcholinesterase and butyrylcholinesterase. The synthesized analogs were analyzed using spectroscopic techniques, and most of them exhibited good to moderate inhibition activities. The most potent analog in the series, analog 2, showed significant inhibition of both acetylcholinesterase and butyrylcholinesterase. Docking studies were conducted to understand the interaction between this analog and the active sites of the enzymes.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Correction
Biochemistry & Molecular Biology
Mohamed Marzouk, Shimaa M. Khalifa, Amal H. Ahmed, Ahmed M. Metwaly, Hala Sh. Mohammed, Hanan A. A. Taie
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Gerardo Andres Libreros-Zuniga, Danilo Pava e Pavao, Vinicius de Morais Barroso, Nathalya Cristina de Moraes Roso Mesquita, Saulo Fehelberg Pinto Braga, Glaucius Oliva, Rafaela Salgado Ferreira, Kelly Ishida, Marcio Vinicius Bertacine Dias
Summary: Tuberculosis is a major global cause of death, and the emergence of drug-resistant strains has increased the burden of this disease. New alternative therapies are constantly needed, and recent research has identified small molecules as potential inhibitors of Ldts in M. tuberculosis, which have antimycobacterial activity.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xiao-Dong Wang, Yong-Si Liu, Ming-Hao Hu
Summary: In this study, a selffolded fluorescent probe was designed to selectively illuminate G4s by unfolding its intramolecular aggregation mediated by G4 binding. This probe showed more controllable background emission and promising ability to track G4 forming dynamics compared to previous disaggregation-induced emission (DIE) probes.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yu Xiang, Zhuo Yuan, Qichuan Deng, Linshen Xie, Dongke Yu, Jianyou Shi
Summary: This review provides a brief description of the diagnosis, pathogenesis, and potential therapeutic inhibitors for renal fibrosis. Currently, there are no clear therapeutic targets or drugs for renal fibrosis; however, some natural products may have potential efficacy for treating renal fibrosis.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Simone Giovannuzzi, Anna Nikitjuka, Bruna Rafaela Pereira Resende, Michael Smietana, Alessio Nocentini, Claudiu T. Supuran, Jean-Yves Winum
Summary: Boron-based compounds have been extensively studied in medicinal chemistry, playing a crucial role in designing small molecule drugs for various diseases. Boron is particularly valuable in developing inhibitors for metalloenzymes carbonic anhydrases, and it can modulate ligand recognition ability and selectivity. Recent advancements have led to the discovery of novel boron-based inhibitors that can inhibit carbonic anhydrases through a Lewis acid-base mechanism. Further research is needed to fully explore the potential of boron-based inhibitors and advance their clinical applications.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinxin Liu, Lei Chen, Ze Chen
Summary: This study developed a nanostructured photosensitizer loaded with oxygen-throttling drug and demonstrated its enhanced cytotoxicity against tumor cells under hypoxic conditions. Animal experiments showed the enhanced tumor targeting capability of the photosensitizer and its inhibitory effect on tumor growth.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuai Jiang, Wen-Yan Li, Zai-Feng Yuan, Qin-Shi Zhao
Summary: This study isolated two new dimeric Lycopodium alkaloids and twelve previously undescribed Lycopodium alkaloids from Lycopodiastrum casuarinoides. The structures of these compounds were determined and their inhibitory activities on the Cav3.1 channel were evaluated.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yan Yang, Dong-Xiao Yan, Rui-Xue Rong, Bing-Ye Shi, Man Zhang, Jing Liu, Jie Xin, Tao Xu, Wen-Jie Ma, Xiao-Liu Li, Ke-Rang Wang
Summary: In this study, a series of nucleolar fluorescent probes based on naphthalimide derivatives were designed and synthesized, which could achieve clear nucleolar staining in living cells. The results showed that these probes exhibited good targeting to the cell nucleolus and could bind to RNA and enhance fluorescence. This has positive implications for the diagnosis and treatment of nucleolus-related diseases.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yongxi Dong, Fang Wang, Jinlan Wen, Yongqing Mao, Shanhui Zhang, Tiemei Long, Zhangxiang Yang, Lei Li, Jiquan Zhang, Li Dong, Gang Liu, Jianwei Xu
Summary: The hybrid molecules of Scutellarein and Tertramethylpyrazine show excellent neuroprotective and antiplatelet effects in the treatment of ischemic stroke. Compound 1e is particularly effective, enhancing cell membrane permeability and inhibiting cell uptake, as well as significantly reducing cerebral infarction volume.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yu Chen, Yuanyuan Ying, Jonathan Lalsiamthara, Yuheng Zhao, Saber Imani, Xin Li, Sijing Liu, Qingjing Wang
Summary: This paper examines the role and metabolic regulation of NAD+ in bacteria, highlighting its impact on physiology and virulence. It explores enzymes associated with NAD+ metabolism as potential targets for antibacterial drugs and vaccine candidates. Additionally, it scrutinizes the medical potential of NAD+ and provides insights for its application in biomedicine.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jon Macicior, Daniel Fernandez, Silvia Ortega-Gutierrez
Summary: Hutchinson-Gilford progeria syndrome (HGPS), also known as progeria, is a rare genetic disease that causes premature aging and significantly reduces life expectancy. Currently, there is only one approved drug for treating progeria, but its efficacy is limited. Progerin levels are believed to be the most important biomarker related to disease severity.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Fuko Hirano, Naoya Kondo, Yusuke Murata, Aya Sudani, Takashi Temma
Summary: Fluorinated alpha-methyl 3BPA derivatives showed improved water solubility, tumor targetability, and biodistribution compared to 3BPA and BPA, resulting in significantly improved tumor-to-normal tissue ratios.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ying Shi, Jiaqin Tang, Shumeng Zhi, Ruiqi Jiang, Qing Huang, Lei Sun, Zhizhong Wang, Yanran Wu
Summary: Necroptosis is a type of cell death associated with various diseases. In this study, we identified a small molecule inhibitor, SY-1, that effectively blocks necroptosis by inhibiting the phosphorylation of RIP1/RIP3/MLKL pathway. SY-1 also showed protective effects against TNF-induced hypothermia and improved survival in mice with SIRS. These findings highlight the potential therapeutic applications of SY-1.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Andrea Bagan, Sonia Abas, Judith Pala-Pujadas, Alba Irisarri, Christian Grinan-Ferre, Merce Pallas, Itziar Muneta-Arrate, Carolina Muguruza, Luis F. Callado, Belen Perez, Elies Molins, Jose A. Morales-Garcia, Carmen Escolano
Summary: Recent studies have identified the modulation of imidazoline I-2 receptors (I-2-IR) by selective ligands as a potential strategy for treating neurodegenerative diseases. This study reports a family of bicyclic alpha-iminophosphonates that show high affinity and selectivity for I-2-IR and demonstrates their neuroprotective and anti-inflammatory effects in in vitro and in vivo models. The findings emphasize the importance of exploring structurally novel I-2-IR ligands for therapeutic strategies in neurodegeneration.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qiuping Xiang, Tianbang Wu, Cheng Zhang, Chao Wang, Hongrui Xu, Qingqing Hu, Jiankang Hu, Guolong Luo, Xiaoxi Zhuang, Xishan Wu, Yan Zhang, Yong Xu
Summary: This study reports the discovery of a 1-(indolizin-3-yl)ethan-1-one derivative as a potent and selective CBP bromodomain inhibitor for AML drug development.
BIOORGANIC CHEMISTRY
(2024)