The role of glycogen synthase kinase 3 beta in multiple sclerosis

NRF2 as a Therapeutic Target in Neurodegenerative Diseases

(2020) Mikah S. Brandes et al.   ASN Neuro

Glycogen synthase kinase‐3 promotes T helper type 17 differentiation by promoting interleukin‐9 production

(2020) Dongmei Han et al.   IMMUNOLOGY

GSK3: A Kinase Balancing Promotion and Resolution of Inflammation

(2020) Leonie Hoffmeister et al.   Cells

Wnt/β-catenin Signaling in Tissue Self-Organization

(2020) Kelvin W. Pond et al.   Genes

An expanding GSK3 network: implications for aging research

(2019) Dylan C. Souder et al.   GeroScience

A partnership with the proteasome; the destructive nature of GSK3

(2018) Holly Robertson et al.   BIOCHEMICAL PHARMACOLOGY

The role of Nrf2 signaling in counteracting neurodegenerative diseases

(2018) Albena T. Dinkova-Kostova et al.   FEBS Journal

Modulation of GSK3β autoinhibition by Thr-7 and Thr-8

(2018) Yixin Tong et al.   FEBS LETTERS

Targeting glycogen synthase kinase-3 for oxidative stress and neuroinflammation: Opportunities, challenges and future directions for cerebral stroke management

(2018) Anil Kumar Rana et al.   NEUROPHARMACOLOGY

Crosstalk Between Peroxisome Proliferator-Activated Receptor Gamma and the Canonical WNT/β-Catenin Pathway in Chronic Inflammation and Oxidative Stress During Carcinogenesis

(2018) Alexandre Vallée et al.   Frontiers in Immunology

Targeting GSK3 signaling as a potential therapy of neurodegenerative diseases and aging

(2018) Przemysław Duda et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Indole and 2,4-Thiazolidinedione conjugates as potential anticancer modulators

(2018) Domenica M. Corigliano et al.   PeerJ

Anti-inflammatory effects of isoalantolactone on LPS-stimulated BV2 microglia cells through activating GSK-3β-Nrf2 signaling pathway

(2018) Min Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Transcription factor 7 like 2 promotes oligodendrocyte differentiation and remyelination

(2017) Chao Weng et al.   Molecular Medicine Reports

Stressed and Inflamed, Can GSK3 Be Blamed?

(2017) Richard S. Jope et al.   TRENDS IN BIOCHEMICAL SCIENCES

The GSK3 kinase inhibitor lithium produces unexpected hyperphosphorylation of β-catenin, a GSK3 substrate, in human glioblastoma cells

(2017) Ata ur Rahman Mohammed Abdul et al.   Biology Open

Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis

(2017) Eva María Medina-Rodríguez et al.   Scientific Reports

In vivo regulation of glycogen synthase kinase 3β activity in neurons and brains

(2017) Ambika Krishnankutty et al.   Scientific Reports

Glycogen synthase kinase 3β in Toll-like receptor signaling

(2016) Ryeojin Ko et al.   BMB Reports

Intracellular signaling pathway regulation of myelination and remyelination in the CNS

(2016) Jenna M. Gaesser et al.   EXPERIMENTAL NEUROLOGY

Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015)

(2016) Valle Palomo et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation

(2016) Bin Ma et al.   Frontiers in Immunology

Modulation of Inflammatory Responses by Wnt/β-Catenin Signaling in Dendritic Cells: A Novel Immunotherapy Target for Autoimmunity and Cancer

(2016) Amol Suryawanshi et al.   Frontiers in Immunology

GSK-3β controls NF-kappaB activity via IKKγ/NEMO

(2016) Senad Medunjanin et al.   Scientific Reports

Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus

(2015) Ana Maria Marques Orellana et al.   Aging-US

Canonical Wnt signaling in the oligodendroglial lineage-puzzles remain

(2015) Fuzheng Guo et al.   GLIA

Loss of GSK-3 Causes Abnormal Astrogenesis and Behavior in Mice

(2015) Eui-Man Jung et al.   MOLECULAR NEUROBIOLOGY

Prostaglandin E2 promotes human cholangiocarcinoma cell proliferation, migration and invasion through the upregulation of β-catenin expression via EP3-4 receptor

(2015) MINGZHAN DU et al.   ONCOLOGY REPORTS

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

(2015) Eleonore Beurel et al.   PHARMACOLOGY & THERAPEUTICS

Dysregulation of the IGF-I/PI3K/AKT/mTOR signaling pathway in autism spectrum disorders

(2014) Jianling Chen et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

GSK-3 - at the crossroads of cell death and survival

(2014) U. Maurer et al.   JOURNAL OF CELL SCIENCE

TLR2-Dependent Activation of β-Catenin Pathway in Dendritic Cells Induces Regulatory Responses and Attenuates Autoimmune Inflammation

(2014) Indumathi Manoharan et al.   JOURNAL OF IMMUNOLOGY

Role of ERK1/2 MAPK Signaling in the Maintenance of Myelin and Axonal Integrity in the Adult CNS

(2014) A. Ishii et al.   JOURNAL OF NEUROSCIENCE

GSK3β Promotes the Differentiation of Oligodendrocyte Precursor Cells via β-Catenin-Mediated Transcriptional Regulation

(2014) Liang Zhou et al.   MOLECULAR NEUROBIOLOGY

Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer

(2014) Stephen P J Fancy et al.   NATURE NEUROSCIENCE

Inactive GSK3β is disturbed in the spinal cord during experimental autoimmune encephalomyelitis, but rescued by stem cell therapy

(2014) A. Parvaneh Tafreshi et al.   NEUROSCIENCE

Mycobacteria Bypass Mucosal NF-kB Signalling to Induce an Epithelial Anti-Inflammatory IL-22 and IL-10 Response

(2014) Nataliya Lutay et al.   PLoS One

Circadian rhythms, Wnt/beta-catenin pathway and PPAR alpha/gamma profiles in diseases with primary or secondary cardiac dysfunction

(2014) Yves Lecarpentier et al.   Frontiers in Physiology

The role of the non-canonical Wnt–planar cell polarity pathway in neural crest migration

(2013) Roberto Mayor et al.   BIOCHEMICAL JOURNAL

Glycogen synthase kinase-3 (GSK-3) regulates TGF-β1-induced differentiation of pulmonary fibroblasts

(2013) Hoeke A Baarsma et al.   BRITISH JOURNAL OF PHARMACOLOGY

Design of Glycogen Synthase Kinase-3 Inhibitors: An Overview on Recent Advancements

(2013) Minhajul Arfeen et al.   CURRENT PHARMACEUTICAL DESIGN

Glycogen synthase kinase 3 substrates in mood disorders and schizophrenia

(2013) Adam R. Cole   FEBS Journal

Fas Signal Promotes the Immunosuppressive Function of Regulatory Dendritic Cells via the ERK/β-Catenin Pathway

(2013) Cheng Qian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Th1 Cells and Experimental Autoimmune Encephalomyelitis by Glycogen Synthase Kinase-3

(2013) E. Beurel et al.   JOURNAL OF IMMUNOLOGY

Wnt Signaling in Remyelination in Multiple Sclerosis: Friend or Foe?

(2013) Chong Xie et al.   MOLECULAR NEUROBIOLOGY

Brain Inflammation and Microglia: Facts and Misconceptions

(2013) Hey-Kyeong Jeong et al.   Experimental Neurobiology

Glycogen synthase kinase-3β activation mediates rotenone-induced cytotoxicity with the involvement of microtubule destabilization

(2012) Haruyuki Hongo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Beta-catenin-NF-κB interactions in murine hepatocytes: A complex to die for

(2012) Kari Nejak-Bowen et al.   HEPATOLOGY

Protein Kinase C δ (PKCδ)-Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling Cascade Regulates Glycogen Synthase Kinase-3 (GSK-3) Inhibition-mediated Interleukin-10 (IL-10) Expression in Lipopolysaccharide (LPS)-induced Endotoxemia

(2012) Kyung Tae Noh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt Signaling in the Pathogenesis of Multiple Sclerosis-Associated Chronic Pain

(2012) Subo Yuan et al.   Journal of Neuroimmune Pharmacology

Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways

(2012) Jian Huang et al.   NATURE MEDICINE

GSK-3 mediates the release of IL-1β, TNF-α and IL-10 from cortical glia

(2012) Holly F. Green et al.   NEUROCHEMISTRY INTERNATIONAL

Glycogen synthase kinase 3-specific inhibitor AR-A014418 decreases neuropathic pain in mice: Evidence for the mechanisms of action

(2012) L. Mazzardo-Martins et al.   NEUROSCIENCE

p53 is a major component of the transcriptional and apoptotic program regulated by PI 3-kinase/Akt/GSK3 signaling

(2012) G Nayak et al.   Cell Death & Disease

Tcf7l2 is Tightly Controlled During Myelin Formation

(2011) Hui Fu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Inhibition of glycogen synthase kinase-3 enhances the differentiation and reduces the proliferation of adult human olfactory epithelium neural precursors

(2011) Aziza P. Manceur et al.   EXPERIMENTAL CELL RESEARCH

Adenomatous Polyposis Coli (APC) Regulates Multiple Signaling Pathways by Enhancing Glycogen Synthase Kinase-3 (GSK-3) Activity

(2011) Alexander J. Valvezan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Molecular Regulation of Glycogen Synthase Kinase-3α Isozyme Controlled by Its N-terminal Region

(2011) Inbar Azoulay-Alfaguter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SRY-Box Containing Gene 17 Regulates the Wnt/ -Catenin Signaling Pathway in Oligodendrocyte Progenitor Cells

(2011) L.-J. Chew et al.   JOURNAL OF NEUROSCIENCE

Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination

(2011) Stephen P J Fancy et al.   NATURE NEUROSCIENCE

TGF-β Suppresses β-Catenin-Dependent Tolerogenic Activation Program in Dendritic Cells

(2011) Bryan Vander Lugt et al.   PLoS One

Functions of GSK-3 Signaling in Development of the Nervous System

(2011) Woo-Yang Kim et al.   Frontiers in Molecular Neuroscience

Regulation by glycogen synthase kinase-3 of inflammation and T cells in CNS diseases

(2011) Eléonore Beurel   Frontiers in Molecular Neuroscience

Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination

(2010) Emily P. Harrington et al.   ANNALS OF NEUROLOGY

Allosteric Regulation of Glycogen Synthase Kinase 3β: A Theoretical Study

(2010) Idit Buch et al.   BIOCHEMISTRY

GSK3β: role in therapeutic landscape and development of modulators

(2010) S Phukan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glycogen synthase kinase 3: A point of convergence for the host inflammatory response

(2010) Huizhi Wang et al.   CYTOKINE

Astrocyte-Restricted Ablation of Interleukin-17-Induced Act1-Mediated Signaling Ameliorates Autoimmune Encephalomyelitis

(2010) Zizhen Kang et al.   IMMUNITY

The Role of Glycogen Synthase Kinase 3 in Regulating IFN- -Mediated IL-10 Production

(2010) H. Wang et al.   JOURNAL OF IMMUNOLOGY

Glycogen Synthase Kinase-3 Is an Early Determinant in the Differentiation of Pathogenic Th17 Cells

(2010) E. Beurel et al.   JOURNAL OF IMMUNOLOGY

Elevated Phosphatidylinositol 3,4,5-Trisphosphate in Glia Triggers Cell-Autonomous Membrane Wrapping and Myelination

(2010) S. Goebbels et al.   JOURNAL OF NEUROSCIENCE

The Antinociceptive Effects of AR-A014418, a Selective Inhibitor of Glycogen Synthase Kinase-3 Beta, in Mice

(2010) Daniel F. Martins et al.   JOURNAL OF PAIN

APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex

(2010) Yutaka Shimomura et al.   NATURE

GSK3 signalling in neural development

(2010) Eun-Mi Hur et al.   NATURE REVIEWS NEUROSCIENCE

Is Glycogen Synthase Kinase-3 a Central Modulator in Mood Regulation?

(2010) Xiaohua Li et al.   NEUROPSYCHOPHARMACOLOGY

Glycogen synthase kinase-3 regulates inflammatory tolerance in astrocytes

(2010) E. Beurel et al.   NEUROSCIENCE

Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis

(2010) Ranjan Dutta et al.   PROGRESS IN NEUROBIOLOGY

Towards an integrated view of Wnt signaling in development

(2009) R. van Amerongen et al.   DEVELOPMENT

Reciprocal Requirements for EDA/EDAR/NF-κB and Wnt/β-Catenin Signaling Pathways in Hair Follicle Induction

(2009) Yuhang Zhang et al.   DEVELOPMENTAL CELL

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

(2009) S. P.J. Fancy et al.   GENES & DEVELOPMENT

Glycogen synthase kinase-3 negatively regulates anti-inflammatory interleukin-10 for lipopolysaccharide-induced iNOS/NO biosynthesis and RANTES production in microglial cells

(2009) Wei-Ching Huang et al.   IMMUNOLOGY

Glycogen Synthase Kinase-3  Facilitates IFN- -Induced STAT1 Activation by Regulating Src Homology-2 Domain-Containing Phosphatase 2

(2009) C.-C. Tsai et al.   JOURNAL OF IMMUNOLOGY

Lymphoid Enhancer Binding Factor 1 Regulates Transcription through Gene Looping

(2009) K. Yun et al.   JOURNAL OF IMMUNOLOGY

Akt Signals through the Mammalian Target of Rapamycin Pathway to Regulate CNS Myelination

(2009) S. P. Narayanan et al.   JOURNAL OF NEUROSCIENCE

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction

(2009) Feng Ye et al.   NATURE NEUROSCIENCE

Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3)

(2009) Eléonore Beurel et al.   TRENDS IN IMMUNOLOGY

Effect of mutation K85R on GSK-3β: Molecular dynamics simulation

(2008) Hao Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential Regulation of STAT Family Members by Glycogen Synthase Kinase-3

(2008) Eléonore Beurel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion

(2008) R. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt-mediated self-renewal of neural stem/progenitor cells

(2008) M. Y. S. Kalani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3  Inactivation

(2008) T. M. Thornton et al.   SCIENCE

A Role for PPARγin the Regulation of Cytokines in Immune Cells and Cancer

(2008) Xiao Yi Yang et al.   PPAR Research