Article
Medicine, Research & Experimental
Elmira Roshani Asl, Mohammad Amini, Souzan Najafi, Behzad Mansoori, Ahad Mokhtarzadeh, Ali Mohammadi, Parisa Lotfinejad, Mehdi Bagheri, Solmaz Shirjang, Ziba Lotfi, Yousef Rasmi, Behzad Baradaran
Summary: The highly conserved MAPK signal transduction pathway plays a crucial role in cancer progression, while miRNAs act as critical regulators in cancer initiation and progression. The interaction between miRNAs and the MAPK signaling pathway is pivotal in the development of human cancers.
Article
Biochemistry & Molecular Biology
Polash Kumar Biswas, Yeonjoo Kwak, Aram Kim, Jaekwon Seok, Hee Jeong Kwak, Moonjung Lee, Ahmed Abdal Dayem, Kwonwoo Song, Jae-Yong Park, Kyoung Sik Park, Hyun Jin Shin, Ssang-Goo Cho
Summary: This study investigated the role of TTYH3 in bladder cancer and found that high expression of TTYH3 was associated with poor prognosis in bladder cancer patients. Knockdown of TTYH3 in bladder cancer cells resulted in significantly reduced cell proliferation, sphere formation, migration, and invasion, possibly through the downregulation of FGFR1 phosphorylation and subsequent inhibition of the H-Ras/A-Raf/MEK/ERK signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Hyuk Moon, Simon Weonsang Ro
Summary: The MAPK/ERK signaling pathway is frequently activated in liver cancer, with alternative mechanisms other than genetic mutations driving its activation. Recent studies have focused on understanding the cellular and molecular mechanisms involved in the activation of the MAPK/ERK signaling pathway in HCC, suggesting potential therapeutic strategies targeting this pathway.
Article
Oncology
Yeokyung Shin, Hye Yeon Choi, Yeonjoo Kwak, Gwang-Mo Yang, Yeojin Jeong, Tak-Il Jeon, Jaekwon Seok, Eung-Ryoung Lee, Jung-Hyun Kim, Kilsoo Jeon, Ahmed Abdal Dayem, Kyung Min Lim, Ssang-Goo Cho
Summary: This study showed that high expression of TMBIM6 in breast cancer is significantly associated with cancer invasiveness. Knockdown of TMBIM6 reduced proliferation and migration of invasive breast cancer cells by downregulating the MAPK/ERK signaling pathway. Overexpression of TMBIM6, on the other hand, increased cell invasion and migration by up-regulating mesenchymal markers and MMP-9 and enhancing activation of the MAPK/ERK signaling pathway. TMBIM6-induced up-regulation of miR-181a was also observed and was found to play an important role in the modulation of migration and invasion of breast cancer cells.
Article
Environmental Sciences
Ping Kuang, Hengmin Cui, Li Yu
Summary: This study investigated the mechanism of fluorosis on the growth system using qRT-PCR and WB methods. The results showed that NaF inhibited the proliferation and development of splenic cells and activated the Ras-Raf-MEK-ERK signaling pathway. However, it failed to activate ERK, leading to the disruption of cell regulation and suppressed spleen development.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Oncology
Xitao Zhang, Tianlai Liu, Jinlin Huang, Jianping He
Summary: This study revealed that PICALM promotes CRC progression through the ERK/MAPK signaling pathway, highlighting its potential as a therapeutic target in clinical applications.
CANCER CELL INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Jiayu Zhang, Ting Yang, Mei Han, Xiaoxuan Wang, Weiming Yang, Ning Guo, Yong Ren, Wei Cui, Shangxiao Li, Yongshan Zhao, Xin Zhai, Lina Jia, Jingyu Yang, Chunfu Wu, Lihui Wang
Summary: Lung cancer lacks effective therapies, and epigenetic enzyme mutations are closely related to its malignant phenotype. In this study, gain-of-function mutations were identified in the histone methyltransferase DOT1L, with the strongest being R231Q located in the catalytic DOT domain. R231Q enhanced the substrate binding ability of DOT1L and promoted cell growth and drug resistance in lung cancer cells. Mechanistic studies revealed that R231Q specifically activated the MAPK/ERK signaling pathway by regulating H3K79me2 enrichment on the RAF1 promoter and downstream targets. The combination of a DOT1L inhibitor (SGC0946) and a MAPK/ERK axis inhibitor (binimetinib) effectively reversed the R231Q-induced phenomena. These findings highlight gain-of-function mutations in an epigenetic enzyme and provide promising insights for the precise treatment of lung cancer patients.
Article
Chemistry, Medicinal
Yan Lan, Yu-Kun Zheng, Liu-Yi Wu, Zi-Jun Zhou, Ruo-Xin Guan, Heng Xu, Ji-Yuan Tu, Xin Gu, Rui Wang, Nan Jiang, Yuan Wu, Cheng-Ren Shu, Zhong-Shi Zhou
Summary: The alcohol extract of Polygonum cuspidatum (PC) has been found to have anti-inflammatory and analgesic effects, potentially through the inhibition of the MAPK/ERK signaling pathway in the spinal cord.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Plant Sciences
Ying Wei, Sichen Ren, Jian Wang, Yanling Wang, Yanfei Cui, Miao Tian, Ruilin Wang, Honghong Liu, Yanling Zhao
Summary: DHE alleviated dyspepsia, inflammatory infiltration, and tissue damage induced by IDO through the ERK and p38 signaling pathways rather than the JNK pathway.
Article
Medicine, Research & Experimental
Hsin-Yu Ho, Chia-Chieh Lin, Yi-Ching Chuang, Yu-Sheng Lo, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: Dehydrocrenatidine has been shown to induce apoptosis in human oral cancer cells through both extrinsic and intrinsic pathways, involving various proteins. Co-treatment with MAPK inhibitors suggests that dehydrocrenatidine induces apoptosis via activation of ERK and JNK signaling pathways. These findings shed light on the potential of dehydrocrenatidine in molecular regulation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Hongxv Wang, Danyu Du, Jianwen Huang, Shuai Wang, Xv He, Shengtao Yuan, Jing Xiao
Summary: This study reveals the role of GPR27 in hepatocellular carcinoma (HCC) progression. The results demonstrate that downregulation of GPR27 inhibits cell proliferation and colony formation, while overexpression of GPR27 has the opposite effect. Furthermore, GPR27 expression affects the activation of the MAPK/ERK signaling pathway in HCC cells, thereby modulating cell proliferation.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Oncology
Da Wang, Fei Xiong, Guanhua Wu, Wenzheng Liu, Bing Wang, Yongjun Chen
Summary: The study found that in cholangiocarcinoma, miR-155-5p targets the 3' UTR of SOX1, activating the RAF/MEK/ERK pathway and promoting cancer progression.
CANCER CELL INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Xiaomin Wen, Lindi Jiao, Hong Tan
Summary: Damage to organs can cause dysfunction and be life-threatening. Some vertebrates, like zebrafish, salamanders, and chicks, are better at regenerating organs than mammals. The MAPK/ERK signaling pathway plays a central role in organ regeneration by regulating various cellular events such as survival, migration, and proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Chong-Yi Yang, Jie Wang, Jian-Qiu Zhang, Hong-miao Cai
Summary: This study investigated the role of human circular RNA circTXNDC11 in the progression of renal cell carcinoma (RCC), revealing that circTXNDC11 is overexpressed in RCC tissues and cells and associated with advanced cancer stages. Functional studies showed that circTXNDC11 promotes RCC growth and invasion by activating the MAPK/ERK pathway, suggesting circTXNDC11 as a potential therapeutic target for RCC treatment.
Article
Plant Sciences
Xingyu Lv, Yuqi Lin, Xi Zhu, Xiujun Cai
Summary: In this study, it was found that Isoalantolactone (IAL), a compound derived from Inula helenium L., has inhibitory effects on gallbladder cancer (GBC). IAL can inhibit the proliferation, migration, and invasion of GBC cells, promote cell apoptosis, and exert its effects by inhibiting the ERK signaling pathway. Animal experiments also confirmed that IAL can suppress the growth of gallbladder tumors.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Pathology
Lina Moallemi-Rad, Amin Ghorbani, Maryam Dadyar, Bashdar Mahmud Hussen, Mohammed Fatih Rasul, Solat Eslami, Mohammad Taheri, Elena Jamali, Soudeh Ghafouri-Fard
Summary: This study evaluated the expression of five Treg-related long non-coding RNAs in breast cancer tissues. The results showed significantly higher expression levels of RMRP, TH2-LCR, MAFTRR, and GATA3-AS1 in breast cancer samples compared to non-tumoral tissues. Positive associations were found between the expression levels of RMRP and MAFTRR genes in tumor tissues and certain tumor characteristics. Additionally, differences in FLICR expression were observed among tumors with different levels of the HER2/neu receptor. These findings suggest that Treg-associated lncRNAs may contribute to the pathogenesis of breast cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Soudeh Ghafouri-Fard, Arian Askari, Bashdar Mahmud Hussen, Mohammed Fatih Rasul, Mohammad Taheri, Arda Kiani
Summary: LINC00152 is an important lncRNA in human disorders and is mainly considered as a tumor-promoting lncRNA. It acts as a molecular sponge for multiple miRNAs and regulates the activity of various signaling pathways. This review summarizes the role of LINC00152 in tumor development and progression, as well as its potential as a diagnostic or prognostic tumor marker and therapeutic target.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Soudeh Ghafouri-Fard, Arash Safarzadeh, Bashdar Mahmud Hussen, Mohammed Fatih Rasul, Mohammad Taheri, Nader Akbari Dilmaghani
Summary: Long intergenic non-protein coding RNA 173 (LINC00173) is a long non-coding RNA that plays a significant role in tumorigenesis. While most studies support its oncogenic role in various cancers, exceptions exist in B-cell precursor acute lymphoblastic leukemia, cervical cancer, pancreatic cancer, and gastric cancer. In breast and lung cancers, LINC00173 has been reported to have both oncogenic and tumor suppressor roles. It acts as a molecular sponge for miRNAs, regulating various miRNA/mRNA axes involved in cancer progression. This review summarizes the current understanding of LINC00173 in these cancers.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Soudeh Ghafouri-Fard, Ashkan Pourtavakoli, Bashdar Mahmud Hussen, Mohammad Taheri, Arda Kiani
Summary: LINC-ROR is a long non-coding RNA that plays diverse roles in human disorders, including cancer and autoimmune and neurodegenerative disorders. It contributes to disease development by altering gene expression, affecting cancer-related signaling pathways, and sequestering tumor suppressor miRNAs. Understanding the functions of LINC-ROR holds potential for developing therapeutic strategies against cancer and related diseases.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Soudeh Ghafouri-Fard, Arian Askari, Bashdar Mahmud Hussen, Aria Baniahmad, Mohammad Taheri, Majid Mokhtari
Summary: Recent decades have witnessed significant progress in understanding the role of different long non-coding RNAs (lncRNAs) in human diseases. ADAMTS9-AS2 is a notable lncRNA with diverse roles in various disorders. While it is generally recognized as a tumor suppressor lncRNA in different cancers, it has been found to be up-regulated in tongue squamous cell carcinoma, salivary adenoid cystic carcinoma, and glioblastoma. Additionally, ADAMTS9-AS2 may play a role in the pathoetiology of pulpitis, acute ischemic stroke, type 2 diabetes, and its complications. This review aims to summarize the role of ADAMTS9-AS2 in different diseases, particularly focusing on its diagnostic and prognostic values.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Mohammad Taheri, Arian Askari, Kimia Behzad Moghadam, Bashdar Mahmud Hussen, Soudeh Ghafouri-Fard, Arda Kiani
Summary: NCK1-AS1 is a lncRNA that promotes carcinogenesis and has been verified in multiple types of cancer. It acts as a sponge for several microRNAs. In this review, we summarize the functions of NCK1-AS1 in malignant conditions and atherosclerosis.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Soudeh Ghafouri-Fard, Atefeh Harsij, Bashdar Mahmud Hussen, Mohammad Taheri, Seyed Abdulmajid Ayatollahi
Summary: Small nucleolar RNA host gene 8 (SNHG8) is a long non-coding RNA that plays vital roles in epithelial and muscle satellite cells and is over-expressed in various cancer cell lines. It acts as a molecular sponge for multiple miRNAs, regulating the expression of their target genes in cancer and influencing the pathogenesis of several disorders, including atherosclerosis, chronic cerebral ischemia, acute gouty arthritis, ischemic stroke, and myocardial infarction. This review aims to summarize the role of SNHG8 in diverse human disorders.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Soudeh Ghafouri-Fard, Hamed Shoorei, Peixin Dong, Yadollah Poornajaf, Bashdar Mahmud Hussen, Mohammad Taheri, Nader Akbari Dilmaghani
Summary: Exosomes are extracellular vesicles that transfer biomolecules and facilitate cell-cell communication. The content, particularly miRNA, in exosomes reflects disease-specific patterns and can be used as diagnostic and prognostic markers. Exosomal miRNAs enter recipient cells and regulate gene expression. They have great potential in detecting disorders, especially cancers. However, standardization, large-scale clinical studies, and consistent experimental settings are challenges that need to be addressed.
NON-CODING RNA RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Soudeh Ghafouri-Fard, Hamed Shoorei, Shahram Dabiri Oskuei, Bashdar Mahmud Hussen, Snur Rasool Abdullah, Mohammad Taheri, Elena Jamali
Summary: Toxic agents exist widely in the environment, households, and workplaces. Their contamination in food and drinking water leads to their entry into the body, where they interact with microRNAs (miRNAs), influencing the etiology of various disorders. These agents can alter redox status, release inflammatory cytokines, and affect mitochondrial function. Dysregulation of miRNA expression is implicated in the development of pathological conditions and signaling pathways, while also playing a role in environmental adaptation. Therefore, the interactions between miRNAs and toxic materials contribute to the detrimental effects on human health.
NON-CODING RNA RESEARCH
(2023)
Article
Multidisciplinary Sciences
Mahnaz Zarein, Asghar Zarban, Hamed Shoorei, Mehdi Gharekhani, Mohammadmehdi Hassanzadeh-Taheri
Summary: The study aimed to examine the effects of the antioxidant hesperidin on ovarian damage and toxicity caused by malathion. The results showed that malathion exposure led to abnormalities in ovarian architecture and reduced follicular counts, while hesperidin mitigated the negative effects of malathion on ovarian tissues.
Article
Biochemistry & Molecular Biology
Bashdar Mahmud Hussen, Khozga Hazhar Abdullah, Snur Rasool Abdullah, Nasik Mahmood Majeed, Sayran Mohamadtahr, Mohammed Fatih Rasul, Peixin Dong, Mohammad Taheri, Majid Samsami
Summary: miRNAs play critical roles in the development and metastasis of breast cancer brain metastases. Certain miRNAs are overexpressed and promote tumor growth and metastasis, while others are downregulated and act as tumor suppressors. Strategies to modulate miRNA expression hold promise for treating breast cancer brain metastases.
NON-CODING RNA RESEARCH
(2023)
Article
Biochemical Research Methods
Soudeh Ghafouri-Fard, Arian Askari, Alireza Zangooie, Hamed Shoorei, Hasan Pourmoshtagh, Mohammad Taheri
Summary: This review provides a comprehensive examination of the role of different non-coding RNAs in the activity and development of NK cells, highlighting the detrimental effects of dysregulated non-coding RNAs on NK cell function and the potential contribution to diverse disorders.
MOLECULAR AND CELLULAR PROBES
(2023)
Article
Biochemical Research Methods
Bashdar Mahmud Hussen, Safeen Jasim Saleem, Snur Rasool Abdullah, Sayran Mohamadtahr, Hazha Jamal Hidayat, Mohammed Fatih Rasul, Mohammad Taheri, Arda Kiani
Summary: Lung cancer is the leading cause of cancer-related deaths globally, and the TGF-beta family of growth factors and miRNA play critical roles in its development. Recent research suggests that TGF-beta signaling directly affects the synthesis of miRNA, ultimately influencing the fate of cancer cells. Understanding the key functions of miRNA in lung cancer progression and its impact on the TGF-beta signaling pathway can help identify potential therapeutic targets for improving lung cancer treatment.
MOLECULAR AND CELLULAR PROBES
(2023)
Review
Biochemistry & Molecular Biology
Mohammad Taheri, Reyhane Eghtedarian, Soudeh Ghafouri-Fard, Mir Davood Omrani
Summary: Certain miRNAs and lncRNAs play important roles in the pathogenesis of type 2 diabetes and can be used as markers or therapeutic molecules.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
