期刊
BIOMATERIALS
卷 268, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2020.120560
关键词
DNA Nanostructures; DNA Origami; Bioimaging; Cancer Therapy
资金
- National Science Foundation [CCF-1814797]
- Center for Biomedical Research of Missouri ST
- National Natural Science Foundation of China [32001074]
- Natural Science Basic Research Plan in Shaanxi Province of China [2019JQ045]
- Fundamental Research Funds for the Central Universities [JB191201]
DNA, as a molecular carrier of genetic information, can be fabricated into functional nanomaterials with a wide range of attributes and extremely low cytotoxicity. This review summarizes the applications of functionalized DNA nanostructures in bioimaging and tumor therapy, as well as discusses the remaining challenges and prospects.
Deoxyribonucleic acid (DNA) is a molecular carrier of genetic information that can be fabricated into functional nanomaterials in biochemistry and engineering fields. Those DNA nanostructures, synthesized via Watson-Crick base pairing, show a wide range of attributes along with excellent applicability, precise programmability, and extremely low cytotoxicity in vitro and in vivo. In this review, the applications of functionalized DNA nano structures in bioimaging and tumor therapy are summarized. We focused on approaches involving DNA origami nanostructures due to their widespread use in previous and current reports. Non-DNA origami nanostructures such as DNA tetrahedrons are also covered. Finally, the remaining challenges and perspectives regarding DNA nanostructures in the biomedical arena are discussed.
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