Article
Biochemical Research Methods
Zhuoru He, Zhongqiu Liu, Lingzhi Gong
Summary: This study revealed the pathogenesis of rheumatoid arthritis through metabolomics, constructed a biomarker panel for accurate prediction, and identified dysregulated metabolic pathways associated with RA.
Article
Immunology
Hongxing Wang, Nanyang Zhang, Kehua Fang, Xiaotian Chang
Summary: This study investigated the metabolic regulatory mechanism of glycolysis in collagen-induced arthritis (CIA) by treating rats with 2-deoxy-D-glucose (2-DG), an inhibitor of glycolysis. The analysis revealed significant changes in metabolic pathways in the plasma, liver, and spleen during the CIA process, with opposite changes following 2-DG treatment. The involvement of spleen and liver metabolism in CIA under the control of glycolysis was suggested.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Tugba Alisik, Murat Alisik, Baris Nacir, Fikriye Figen Ayhan, Hakan Genc, Ozcan Erel
Summary: Higher MPO/PON1 ratio in rheumatoid arthritis (RA) patients may be associated with increased cardiovascular disease (CVD) risk. The dysfunction of HDL in RA patients, as indicated by the MPO/PON1 ratio, suggests potential implications for assessing cardiovascular risk and monitoring treatment effectiveness in this population.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Review
Immunology
Jiahui Yan, Sisi Yang, Liang Han, Xin Ba, Pan Shen, Weiji Lin, Tingting Li, Ruiyuan Zhang, Ying Huang, Yao Huang, Kai Qin, Yu Wang, Shenghao Tu, Zhe Chen
Summary: This article describes the unique lipid profile of RA, explores the mechanisms underlying lipid changes, and investigates the impact of lipid changes on cardiovascular disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Aditya Gupta, Reena Sharma, Kaushik Kuche, Sanyog Jain
Summary: Lipoproteins, especially HDL, are efficient carriers for cholesterol transportation in the body and show promise for drug delivery due to their antioxidant potential and receptor affinity. rHDL, as an endogenously present vehicle, is capable of targeted delivery for various diseases with the potential for enhanced drug delivery through stimuli sensitivity and pH dependent methods. Further research is needed to explore the full potential of rHDL in clinical applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Lei Liu, Taiping Li, Hui Dong, Xijun Wang
Summary: The mechanism of action and potential targets of Paeoniae Radix Alba (Baishao, B) in the treatment of adjuvant-induced arthritis (AIA) rats were explained using metabolomics and network pharmacology techniques, enriching the research evidence for the development of anti-rheumatoid arthritis (RA) drugs.
Review
Immunology
Lingxia Xu, Cen Chang, Ping Jiang, Kai Wei, Runrun Zhang, Yehua Jin, Jianan Zhao, Linshuai Xu, Yiming Shi, Shicheng Guo, Dongyi He
Summary: Rheumatoid arthritis is an autoimmune disease characterized by metabolic alterations. Metabolomics technology can provide insights into the metabolic profiles of patients with rheumatoid arthritis, helping to understand the pathogenesis and treatment response of the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Christina Charles-Schoeman, Jennifer Wang, Ani Shahbazian, Holly Wilhalme, Jenny Brook, Gurjit S. Kaeley, Buzand Oganesian, Ami Ben-Artzi, David A. Elashoff, Veena K. Ranganath
Summary: Active rheumatoid arthritis (RA) is associated with increased cardiovascular risk and impaired function of high-density lipoprotein (HDL). The study evaluated the association between synovial power doppler ultrasound signal (PDUS) and HDL function and structure. Patients with higher baseline PDUS scores had worse HDL function, and treatment with tocilizumab or abatacept led to improvements in HDL function. These findings support previous research suggesting a direct link between joint inflammation and abnormal HDL function.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Leszek Roszkowski, Bozena Jaszczyk, Magdalena Plebanczyk, Marzena Ciechomska
Summary: This study aimed to investigate the regulation of pro-inflammatory mediators, especially S100 proteins, in rheumatoid arthritis (RA) and identify potential biomarkers of high disease activity. Through RNA sequencing analysis, it was found that RA monocytes exhibited significantly increased expression of S100 proteins, TNF, and IL-8 genes. Moreover, S100A8, S100A11, and S100A12 proteins were significantly upregulated in RA patients, especially in early RA, and could serve as better biomarkers of disease activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Yonghong Luo, Xiaolei Ren, Shuwei Weng, Chunhui Yan, Qiaoxia Mao, Daoquan Peng
Summary: Anti-TNF therapies lead to significant increases in total cholesterol (TC) and high-density lipoprotein (HDL) levels in RA patients, as well as short-term and mid-term elevations in low-density lipoprotein (LDL) and apolipoprotein A1 (ApoA1), but not in the long-term. Ratios of proatherosclerotic indexes tend to decrease in the short and mid-term, but return to baseline levels in the long term after TNF inhibition.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Rheumatology
Marzena Ciechomska, Bartosz Wojtas, Krzysztof Bonek, Leszek Roszkowski, Piotr Gluszko, Vladimir Benes, Wlodzimierz Maslinski
Summary: In this study, 20 specific miRNA candidates in rheumatoid arthritis monocytes were predicted to silence inflammatory mediators. The miRNA-146b was found to negatively regulate the anti-inflammatory RARA transcript and correlate with clinical parameters in RA patients.
Article
Chemistry, Applied
Gerardo Nunez-Lillo, Excequel Ponce, Camila Arancibia-Guerra, Sebastien Carpentier, Alegria Carrasco-Pancorbo, Lucia Olmo-Garcia, Rosana Chirinos, David Campos, Reinaldo Campos-Vargas, Claudio Meneses, Romina Pedreschi
Summary: This study aims to understand the mechanisms behind the color and softening of avocado exocarp. By integrating omics datasets, including transcriptomics, proteomics, and metabolomics, the researchers identified transcription factors and potential biomarkers associated with color and softening control in avocados.
Article
Biochemistry & Molecular Biology
Tong Rong, Bo Wei, Meiying Ao, Haonan Zhao, Yuanfang Li, Yang Zhang, Ying Qin, Jinhua Zhou, Fenfen Zhou, Yong Chen
Summary: The study demonstrated that exogenous GM3 can be targeted to atherosclerosis via reconstituted high-density lipoprotein (rHDL) and has anti-atherosclerotic effects. Furthermore, GM3 packed in HDL nanoparticles (GM3-rHDL) showed enhanced anti-atherosclerotic efficacy and a reduced effective dose of GM3, with pH-responsive GM3 release from the nanoparticles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Samantha Rodriguez-Muguruza, Antonio Altuna-Coy, Veronica Arreaza-Gil, Marina Mendieta-Homs, Sonia Castro-Oreiro, Maria Jose Poveda-Elices, Nuria del Castillo-Pinol, Ramon Fontova-Garrofe, Matilde R. Chacon
Summary: This study identified new serum biomarkers for ERA using metabolomics and constructed a biomarker panel composed of glyceric acid, lactic acid, and 3-hydroxisovaleric acid, which shows potential for improving the early clinical diagnosis of RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Franziska Bottger, Andrea Valles-Marti, Loraine Cahn, Connie R. Jimenez
Summary: Vitamin C has potential as a potent anti-cancer agent when administered intravenously and in high doses. It demonstrates multi-targeting effects as a cancer-specific, pro-oxidative cytotoxic agent, anti-cancer epigenetic regulator, and immune modulator. Despite lacking strong clinical data and phase III studies, there is a need for more awareness and utilization of this promising, non-toxic cancer treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
David Abasiwani Alagpulinsa, Shmuel Yaccoby, Srinivas Ayyadevara, Robert Joseph Shmookler Reis
CANCER BIOLOGY & THERAPY
(2015)
Article
Oncology
David A. Alagpulinsa, Srinivas Ayyadevara, Shmuel Yaccoby, Robert J. Shmookler Reis
MOLECULAR CANCER THERAPEUTICS
(2016)
Meeting Abstract
Oncology
David A. Alagpulinsa, Shmuel Yaccoby, Srinivas Ayyadevara, Robert J. S. Reis
Review
Pharmacology & Pharmacy
David A. Alagpulinsa, Jenny J. L. Cao, Don Sobell, Mark C. Poznansky
PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Oncology
David A. Alagpulinsa, Srinivas Ayyadevare, Robert Joseph Shmookler Reis
FRONTIERS IN ONCOLOGY
(2014)
Article
Surgery
David A. Alagpulinsa, Jenny J. L. Cao, Riley K. Driscol, Ruxandra F. Sirbulescu, Madeline F. E. Penson, Marinko Sremac, Elise N. Engquist, Timothy A. Brauns, James F. Markmann, Douglas A. Melton, Mark C. Poznansky
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Review
Biochemistry & Molecular Biology
David A. Alagpulinsa, Mabel P. Toribio, Iad Alhallak, Robert J. Shmookler Reis
Summary: HSCs are polyfunctional and can regenerate all blood cells throughout life. CH is strongly associated with aging and some diseases, and serves as an independent risk factor for hematologic malignancies, cardiovascular disease, and adverse disease outcomes. Understanding the molecular mechanisms of CH can provide a framework for interventions in healthy aging and disease treatment.
TRENDS IN MOLECULAR MEDICINE
(2022)
Review
Oncology
David A. Alagpulinsa, Raphael E. Szalat, Mark C. Poznansky, Robert J. Shmookler Reis
Article
Hematology
David A. Alagpulinsa, Subodh Kumar, Srikanth Talluri, Purushothama Nanjappa, Leutz Buon, Chandraditya Chakraborty, Mehmet K. Samur, Raphael Szalat, Masood A. Shammas, Nikhil C. Munshi
Meeting Abstract
Hematology
Masood A. Shammas, Leutz Buon, Subodh Kumar, Mehmet K. Samur, David Alagpulinsa, Purushothama Nanjappa, Nikhil C. Munshi
Meeting Abstract
Hematology
Masood A. Shammas, Leutz Buon, Jianhong Lin, Mehmet K. Samur, Jaymin M. Patel, Ankit Vahia, Purushothama Nanjappa, Subodh Kumar, Ahsun Bajwa, Humza Ahmad, David Alagpulinsa, Giovanni Parmigiani, Florence Magrangeas, Stephane Minvielle, Herve Avet-Loiseau, Nikhil C. Munshi
Meeting Abstract
Hematology
David Alagpulinsa, Srinivas Ayyadevara, Shmuel Yaccoby, Robert Shmookler Reis
Meeting Abstract
Hematology
David Alagpulinsa, Srinivas Ayyadevara, Shmuel Yaccoby, Robert Shmookler Reis
Article
Pharmacology & Pharmacy
Eric Woode, David Abasiwani Alagpulinsa, Wonder Kofi Mensah Abotsi
AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY
(2011)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.