Physical ‘strength’ of the multi‐protein chain connecting immune cells: Does the weakest link limit antibody affinity maturation?

T cell receptors, mechanosensors, catch bonds and immunotherapy

(2020) Jia-huai Wang   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses

(2020) Bénédict Fallet et al.   Cell Reports

Fc-mediated effector function contributes to the in vivo antiviral effect of an HIV neutralizing antibody

(2020) Mangaiarkarasi Asokan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations

(2020) Jacob T. Martin et al.   npj Vaccines

Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo

(2020) Yu Kato et al.   IMMUNITY

Early exposure to broadly neutralizing antibodies may trigger a dynamical switch from progressive disease to lasting control of SHIV infection

(2020) Rajat Desikan et al.   PLoS Computational Biology

Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses

(2020) Xiancai Ma et al.   IMMUNITY

Pre-existing resistance in the latent reservoir can compromise VRC01 therapy during chronic HIV-1 infection

(2020) Ananya Saha et al.   PLoS Computational Biology

Mutually assured destruction: the cold war between viruses and natural killer cells

(2019) Ayad Ali et al.   Current Opinion in Virology

Towards multiscale modeling of the CD8+ T cell response to viral infections

(2019) Subhasish Baral et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Broadly Neutralizing Antibodies against HIV: Back to Blood

(2019) Amir Dashti et al.   TRENDS IN MOLECULAR MEDICINE

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus

(2019) Jessica Marcandalli et al.   CELL

B Cell Responses: Cell Interaction Dynamics and Decisions

(2019) Jason G. Cyster et al.   CELL

Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic

(2019) Marina Caskey et al.   NATURE MEDICINE

Mutational pathway maps and founder effects define the within-host spectrum of hepatitis C virus mutants resistant to drugs

(2019) Rubesh Raja et al.   PLoS Pathogens

B cell signaling in context

(2019) Kihyuck Kwak et al.   NATURE IMMUNOLOGY

Mechanosensing through immunoreceptors

(2019) Cheng Zhu et al.   NATURE IMMUNOLOGY

A dynamical motif comprising the interactions between antigens and CD8 T cells may underlie the outcomes of viral infections

(2019) Subhasish Baral et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Injection of Antibodies against Immunodominant Epitopes Tunes Germinal Centers to Generate Broadly Neutralizing Antibodies

(2019) Michael Meyer-Hermann   Cell Reports

Preferential Presentation of High-Affinity Immune Complexes in Germinal Centers Can Explain How Passive Immunization Improves the Humoral Response

(2019) Amar K. Garg et al.   Cell Reports

B cells extract antigens at Arp2/3-generated actin foci interspersed with linear filaments

(2019) Sophie I Roper et al.   eLife

Modeling how reversal of immune exhaustion elicits cure of chronic hepatitis C after the end of treatment with direct-acting antiviral agents

(2018) Subhasish Baral et al.   IMMUNOLOGY AND CELL BIOLOGY

Steered Molecular Dynamics Simulation in Rational Drug Design

(2018) Phuc-Chau Do et al.   Journal of Chemical Information and Modeling

The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen

(2018) Colin Havenar-Daughton et al.   Science Translational Medicine

Modelling how responsiveness to interferon improves interferon-free treatment of hepatitis C virus infection

(2018) Vishnu Venugopal et al.   PLoS Computational Biology

Dissecting FcγR Regulation through a Multivalent Binding Model

(2018) Ryan A. Robinett et al.   Cell Systems

Interferon at the cellular, individual, and population level in hepatitis C virus infection: Its role in the interferon-free treatment era

(2018) Rubesh Raja et al.   IMMUNOLOGICAL REVIEWS

Poly- and autoreactivity of HIV-1 bNAbs: implications for vaccine design

(2018) Joel Finney et al.   Retrovirology

Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

(2018) Talar Tokatlian et al.   SCIENCE

Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem

(2017) Colin Havenar-Daughton et al.   IMMUNOLOGICAL REVIEWS

Early antibody therapy can induce long-lasting immunity to SHIV

(2017) Yoshiaki Nishimura et al.   NATURE

Next generation antibody drugs: pursuit of the 'high-hanging fruit'

(2017) Paul J. Carter et al.   NATURE REVIEWS DRUG DISCOVERY

The microanatomic segregation of selection by apoptosis in the germinal center

(2017) Christian T. Mayer et al.   SCIENCE

Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller

(2017) Natalia T. Freund et al.   Science Translational Medicine

What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination?

(2017) Kai-Michael Toellner et al.   Cold Spring Harbor Perspectives in Biology

Predicting HIV-1 transmission and antibody neutralization efficacy in vivo from stoichiometric parameters

(2017) Oliver F. Brandenberg et al.   PLoS Pathogens

Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

(2016) Mattia Bonsignori et al.   CELL

Immunoregulatory functions of immune complexes in vaccine and therapy

(2016) Yu‐mei Wen et al.   EMBO Molecular Medicine

Complex Antigens Drive Permissive Clonal Selection in Germinal Centers

(2016) Masayuki Kuraoka et al.   IMMUNITY

Regulation of germinal center B-cell differentiation

(2016) Yang Zhang et al.   IMMUNOLOGICAL REVIEWS

B cell antigen extraction is regulated by physical properties of antigen-presenting cells

(2016) Katelyn M. Spillane et al.   JOURNAL OF CELL BIOLOGY

Models for recovering the energy landscape of conformational transitions from single-molecule pulling experiments

(2016) Gaurav Arya   MOLECULAR SIMULATION

Membranome: a database for proteome-wide analysis of single-pass membrane proteins

(2016) Andrei L. Lomize et al.   NUCLEIC ACIDS RESEARCH

Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination

(2016) Hok Hei Tam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualizing antibody affinity maturation in germinal centers

(2016) J. M. J. Tas et al.   SCIENCE

HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1

(2016) T. Schoofs et al.   SCIENCE

Influence of recombination on acquisition and reversion of immune escape and compensatory mutations in HIV-1

(2016) Pradeep Nagaraja et al.   Epidemics

Host-Pathogen Coevolution and the Emergence of Broadly Neutralizing Antibodies in Chronic Infections

(2016) Armita Nourmohammad et al.   PLoS Genetics

Multi-epitope Models Explain How Pre-existing Antibodies Affect the Generation of Broadly Protective Responses to Influenza

(2016) Veronika I. Zarnitsyna et al.   PLoS Pathogens

Manipulating the Selection Forces during Affinity Maturation to Generate Cross-Reactive HIV Antibodies

(2015) Shenshen Wang et al.   CELL

The SPL7013 dendrimer destabilizes the HIV-1 gp120–CD4 complex

(2015) Bidisha Nandy et al.   Nanoscale

Competitive exclusion by autologous antibodies can prevent broad HIV-1 antibodies from arising

(2015) Shishi Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-treatment control of HIV infection

(2015) Jessica M. Conway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyreactivity and Autoreactivity among HIV-1 Antibodies

(2014) Mengfei Liu et al.   JOURNAL OF VIROLOGY

Enhanced neonatal Fc receptor function improves protection against primate SHIV infection

(2014) Sung-Youl Ko et al.   NATURE

Identification and characterization of the constituent human serum antibodies elicited by vaccination

(2014) Jason J. Lavinder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virulence and Pathogenesis of HIV-1 Infection: An Evolutionary Perspective

(2014) C. Fraser et al.   SCIENCE

Emergent properties of the interferon-signalling network may underlie the success of hepatitis C treatment

(2014) Pranesh Padmanabhan et al.   Nature Communications

Theory of rapid force spectroscopy

(2014) Jakob T. Bullerjahn et al.   Nature Communications

Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation

(2014) Thomas B. Kepler et al.   Frontiers in Immunology

Simulations reveal that the HIV-1 gp120-CD4 complex dissociates via complex pathways and is a potential target of the polyamidoamine (PAMAM) dendrimer

(2013) Bidisha Nandy et al.   JOURNAL OF CHEMICAL PHYSICS

Germinal center B cells govern their own fate via antibody feedback

(2013) Yang Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer

(2013) James D Mellor et al.   Journal of Hematology & Oncology

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

(2013) Hua-Xin Liao et al.   NATURE

SAbDab: the structural antibody database

(2013) James Dunbar et al.   NUCLEIC ACIDS RESEARCH

Engineered antibody Fc variant with selectively enhanced Fc RIIb binding over both Fc RIIaR131 and Fc RIIaH131

(2013) F. Mimoto et al.   PROTEIN ENGINEERING DESIGN & SELECTION

B Cells Use Mechanical Energy to Discriminate Antigen Affinities

(2013) E. Natkanski et al.   SCIENCE

Estimating the fraction of progeny virions that must incorporate APOBEC3G for suppression of productive HIV-1 infection

(2013) Pulari U. Thangavelu et al.   VIROLOGY

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Antiretroviral dynamics determines HIV evolution and predicts therapy outcome

(2012) Daniel I S Rosenbloom et al.   NATURE MEDICINE

Ideal, catch, and slip bonds in cadherin adhesion

(2012) S. Rakshit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stochastic Simulations Suggest that HIV-1 Survives Close to Its Error Threshold

(2012) Kushal Tripathi et al.   PLoS Computational Biology

Whole Genome Deep Sequencing of HIV-1 Reveals the Impact of Early Minor Variants Upon Immune Recognition During Acute Infection

(2012) Matthew R. Henn et al.   PLoS Pathogens

Polarized Secretion of Lysosomes at the B Cell Synapse Couples Antigen Extraction to Processing and Presentation

(2011) Maria-Isabel Yuseff et al.   IMMUNITY

Natural killer cells act as rheostats modulating antiviral T cells

(2011) Stephen N. Waggoner et al.   NATURE

Taking Multiple Infections of Cells and Recombination into Account Leads to Small Within-Host Effective-Population-Size Estimates of HIV-1

(2011) Rajesh Balagam et al.   PLoS One

Estimating the Threshold Surface Density of Gp120-CCR5 Complexes Necessary for HIV-1 Envelope-Mediated Cell-Cell Fusion

(2011) Shiva Naresh Mulampaka et al.   PLoS One

A Crystal Structure of the Complex Between Human Complement Receptor 2 and Its Ligand C3d

(2011) J. M. H. van den Elsen et al.   SCIENCE

Mathematical Model of Viral Kinetics In Vitro Estimates the Number of E2-CD81 Complexes Necessary for Hepatitis C Virus Entry

(2011) Pranesh Padmanabhan et al.   PLoS Computational Biology

Estimating Frequencies of Minority Nevirapine-Resistant Strains in Chronically HIV-1-Infected Individuals Naive to Nevirapine by Using Stochastic Simulations and a Mathematical Model

(2010) S. Gadhamsetty et al.   JOURNAL OF VIROLOGY

A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates

(2009) J. C. Y. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Timing the Emergence of Resistance to Anti-HIV Drugs with Large Genetic Barriers

(2009) Pankhuri Arora et al.   PLoS Computational Biology

Measuring Diffusion and Binding Kinetics by Contact Area FRAP

(2008) Timothy P. Tolentino et al.   BIOPHYSICAL JOURNAL

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

Recombination increases human immunodeficiency virus fitness, but not necessarily diversity

(2008) N. N. V. Vijay et al.   JOURNAL OF GENERAL VIROLOGY