Review
Cell Biology
Ji-Yong Sung, Jae-Ho Cheong
Summary: Immunometabolism is an emerging discipline in cancer immunotherapy that focuses on the metabolic competition between tumor cells and immune cells for limited nutrients. This competition influences the anticancer immune response and understanding it can aid in developing novel therapeutic approaches for cancer.
Review
Immunology
Sonia Aristin Revilla, Onno Kranenburg, Paul J. Coffer
Summary: Colorectal cancer is a heterogeneous disease with a high incidence and mortality rate worldwide. Tumor-infiltrating lymphocytes (TILs), particularly regulatory T (Treg) cells, play an important role in anti-tumor immunity. Increased numbers of Treg cells in colorectal tumors are associated with tumor development, immunotherapy failure, and a poorer prognosis. Targeting Treg cells is a potential strategy to improve cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Filippo Torrisi, Simona D'Aprile, Simona Denaro, Anna Maria Pavone, Cristiana Alberghina, Agata Zappala, Rosario Giuffrida, Lucia Salvatorelli, Giuseppe Broggi, Gaetano Giuseppe Magro, Vittorio Calabrese, Nunzio Vicario, Rosalba Parenti
Summary: The central nervous system is a complex environment where glioblastoma skillfully adapts and unleashes mechanisms for its development and diffusion. Gene expression changes, epigenetic events, metabolic reprogramming, and stress responses in the tumor microenvironment contribute to genomic instability and immunosuppression that make glioblastoma invincible against immune cells and current therapies. Understanding the cellular mechanisms underlying glioblastoma resistance is crucial for planning effective therapeutic strategies.
Article
Oncology
Siyu Zhang, Wenbei Peng, Haolei Wang, Xuan Xiang, Linlin Ye, Xiaoshan Wei, Zihao Wang, Qianqian Xue, Long Chen, Yuan Su, Qiong Zhou
Summary: This study reveals the immune suppressive mechanism of C1q(+) TAMs and suggests that targeting C1q(+) TAMs effectively alleviates immunosuppression and enhances the efficacy of immune checkpoint blockade (ICB) therapy. The researchers also found that inhibition of FABP5 can weaken the anti-tumor effects of TAMs and improve the effectiveness of ICB therapy, indicating that C1q(+) TAMs have great potential as a therapeutic target for cancer immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Immunology
Hamid Aria, Marzieh Rezaei, Shima Nazem, Abdolreza Daraei, Ghasem Nikfar, Behnam Mansoori, Maryam Bahmanyar, Alireza Tavassoli, Mohammad Kazem Vakil, Yaser Mansoori
Summary: ATP and other nucleoside phosphates, through purinergic receptors and ectonucleotidases, play a crucial role in regulating signaling pathways in the tumor microenvironment. They affect tumor cell metabolism and contribute to therapy resistance.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Liang Li, Si-Rui Ma, Zi-Li Yu
Summary: This article introduces the lipid metabolism of tumor-associated macrophages (TAMs) and its important role in tumorigenesis and immunotherapy. The origins and classifications of TAMs are summarized, and the currently available drugs and interventions are discussed, along with the challenges and possible solutions.
Article
Immunology
Carsten Geiss, Claudius Witzler, Gernot Poschet, Wolfram Ruf, Anne Regnier-Vigouroux
Summary: A study found that ONC201 affects the metabolism and pro-inflammatory state of macrophages, reactivating their anti-tumor activity; however, this effect does not increase toxicity to the tumor cells.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Liang Yan, Yanlian Tan, Guo Chen, Jun Fan, Jun Zhang
Summary: Metabolic reprogramming plays a critical role in cancer and immune cell function, particularly within the tumor microenvironment. Understanding the impact of metabolic reprogramming on both tumor and immune cells and their interaction is essential for effectively modulating the tumor immune microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Melissa Garcia-Caballero, Liliana Sokol, Anne Cuypers, Peter Carmeliet
Summary: The dynamic crosstalk between different components of the tumor microenvironment plays a critical role in cancer progression and metastasis. Angiogenesis is crucial for tumor growth, but abnormal blood vessels can lead to hypoxia and acidosis in the tumor microenvironment. Cancer and stromal cells can alter their metabolism to meet high energy demands and promote tumor proliferation. Recent studies have shown that the metabolism of tumor endothelial cells is reprogrammed and targeting these metabolic pathways can affect blood vessel formation. Therefore, metabolic antiangiogenic therapies combined with immunotherapies offer a clinical opportunity for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Claire Y. Li, Hyeung Ju Park, Jinyeon Shin, Jung Eun Baik, Babak J. Mehrara, Raghu P. Kataru
Summary: This study suggests that lymphatic endothelial cells (LECs) can act as immunosuppressive cells in the tumor microenvironment (TME) in an MHC-II dependent manner. LECs in the TME increase MHC-II expression and co-inhibitory signals, suppressing the immune response. This finding highlights the importance of understanding the role of LECs in tumor immunity and opens up new avenues for therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Veronica Finisguerra, Tereza Dvorakova, Matteo Formenti, Pierre Van Meerbeeck, Lionel Mignion, Bernard Gallez, Benoit J. van den Eynde
Summary: Despite limitations in certain tumor types and patients, immunotherapies have achieved revolutionary success in cancer treatment. However, the efficacy of immunotherapies is dependent on the viability and functionality of tumor antigen-specific CD8 T cells within the immunosuppressive tumor microenvironment, where oxygen levels are often low. This study reveals that the antidiabetic drug metformin can improve CD8 T cell fitness in hypoxia, increasing their proliferation and cytokine production, and enhancing their infiltration and survival in hypoxic tumor areas. This presents a promising strategy to overcome resistance to immunotherapy in hypoxic and immunosuppressive tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Immunology
Ming Zhang, Tingju Wei, Xiaodan Zhang, Danfeng Guo
Summary: The tumor microenvironment (TME) plays a critical role in tumor development and immunocyte function. This review focuses on the recent progress in understanding the lipid metabolism reprogramming in immunocytes within the TME. It discusses the potential target molecules, pathways, and genes involved, as well as the impact of hypoxia on abnormal lipid metabolism in immune cells. Furthermore, the review explores the current immunotherapies that mediate the lipid metabolism of immunocytes and proposes new strategies for cancer therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Deepak Kumar Kaushik, Voon Wee Yong
Summary: Metabolism and immune activation are closely connected in a field known as immunometabolism. Immune cells undergo metabolic reprogramming to execute their functions, with potential therapeutic implications for conditions like multiple sclerosis. The relationship between metabolic changes and immune activation remains a topic of ongoing research.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Medicine, Research & Experimental
Zhenzhen Li, Chanjun Sun, Zhihai Qin
Summary: Cancer cells adapt their metabolism to proliferate and survive in harsh environments, with a close relationship between tumor microenvironment and cancer-associated fibroblasts (CAFs) playing key roles in tumor growth and metastasis. CAFs act as major regulators in shaping tumor metabolism, especially through dysregulation of metabolic pathways, influencing cancer cell behavior and response to therapy. The interaction and crosstalk between cancer cells and CAFs contribute to metabolic reprogramming that impacts cancer cell growth and progression.
Review
Cell Biology
Hamid Aria, Farhoodeh Ghaedrahmati, Mazdak Ganjalikhani-Hakemi
Summary: The term immunometabolism refers to intracellular metabolic changes within immune cells, influencing immune responses and being a key feature in immune cell activation and cancer cell progression. Due to its significance in immunotherapy, studying the immunometabolic situation of cells and understanding cancer cell metabolism can lead to innovative cancer treatment strategies.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Plant Sciences
Kaitlyn M. Faries, Claire E. Kohout, Grace Xiyu Wang, Deborah K. Hanson, Dewey Holten, Philip D. Laible, Christine Kirmaier
PHOTOSYNTHESIS RESEARCH
(2019)
Article
Engineering, Biomedical
Zhuolong Zhou, Kevin Van der Jeught, Yuanzhang Fang, Tao Yu, Yujing Li, Zheng Ao, Sheng Liu, Lu Zhang, Yang Yang, Haniyeh Eyvani, Mary L. Cox, Xiyu Wang, Xiaoming He, Guang Ji, Bryan P. Schneider, Feng Guo, Jun Wan, Xinna Zhang, Xiongbin Lu
Summary: High-throughput screening in breast tumour organoids can identify epigenetic inhibitors that promote antigen presentation and enhance T-cell-mediated cytotoxicity.
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Yuri Nagaoka, Kotone Oshiro, Yuta Yoshino, Toshiyuki Matsunaga, Satoshi Endo, Akira Ikari
Summary: This study investigated the effect of intercellular adhesion molecule CLDN1 on the anticancer drug sensitivity of small-cell lung cancer (SCLC) cells. It was found that overexpression of CLDN1 decreased the sensitivity of SCLC cells to anticancer drugs and enhanced their migratory capacity through the activation of the TGF-81/EMT signaling pathway. Treatment with EMT inhibitors showed potential in overcoming the reduced sensitivity to anticancer drugs in CLDN1-overexpressing SCLC cells.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2024)