Identification and characterization of human nucleus pulposus cell specific serotypes of adeno-associated virus for gene therapeutic approaches of intervertebral disc disorders

On the Horizon From the ORS

(2016) Howard S. An et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

Adeno-associated virus-mediated BMP-7 and SOX9 in vitro co-transfection of human degenerative intervertebral disc cells

(2015) X.F. Ren et al.   GENETICS AND MOLECULAR RESEARCH

Imbalanced Protein Expression Patterns of Anabolic, Catabolic, Anti-Catabolic and Inflammatory Cytokines in Degenerative Cervical Disc Cells: New Indications for Gene Therapeutic Treatments of Cervical Disc Diseases

(2014) Demissew S. Mern et al.   PLoS One

Co-transfection of adeno-associated virus-mediated human vascular endothelial growth factor165 and transforming growth factor-β1 into annulus fibrosus cells of rabbit degenerative intervertebral discs

(2013) Y.M. Xi et al.   GENETICS AND MOLECULAR RESEARCH

A Combinatorial Relative Mass Value Evaluation of Endogenous Bioactive Proteins in Three-Dimensional Cultured Nucleus Pulposus Cells of Herniated Intervertebral Discs: Identification of Potential Target Proteins for Gene Therapeutic Approaches

(2013) Demissew S. Mern et al.   PLoS One

A Novel Method for the Quantification of Adeno-Associated Virus Vectors for RNA Interference Applications Using Quantitative Polymerase Chain Reaction and Purified Genomic Adeno-Associated Virus DNA as a Standard

(2013) Anke Wagner et al.   Human Gene Therapy Methods

Enhancing human nucleus pulposus cells for biological treatment approaches of degenerative intervertebral disc diseases: a systematic review

(2012) Demissew Shenegelegn Mern et al.   Journal of Tissue Engineering and Regenerative Medicine

Tissue Engineering for Intervertebral Disk Degeneration

(2011) Victor Y.L. Leung et al.   ORTHOPEDIC CLINICS OF NORTH AMERICA

In Vitro and in Vivo Testing of a Novel Regulatory System for Gene Therapy for Intervertebral Disc Degeneration

(2011) Gwendolyn Sowa et al.   SPINE

Rapid Construction of Adeno-Associated Virus Vectors Expressing Multiple Short Hairpin RNAs with High Antiviral Activity Against Echovirus 30

(2010) Diana Rothe et al.   OLIGONUCLEOTIDES

Age-Related Variation in Cell Density of Human Lumbar Intervertebral Disc

(2010) Thomas Liebscher et al.   SPINE

The Rising Prevalence of Chronic Low Back Pain

(2009) Janet K. Freburger et al.   ARCHIVES OF INTERNAL MEDICINE

Biologic Response of Human Intervertebral Disc Cells to Gene Therapy Cocktail

(2009) Seong-Hwan Moon et al.   SPINE

Costs of back pain in Germany

(2008) Christina M. Wenig et al.   EUROPEAN JOURNAL OF PAIN

Tissue engineering and the intervertebral disc: the challenges

(2008) Rita Kandel et al.   EUROPEAN SPINE JOURNAL

Cardiac-targeted RNA interference mediated by an AAV9 vector improves cardiac function in coxsackievirus B3 cardiomyopathy

(2008) Henry Fechner et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Fas ligand expression on human nucleus pulposus cells decreases with disc degeneration processes

(2008) Shuichi Kaneyama et al.   JOURNAL OF ORTHOPAEDIC SCIENCE

Self-complementary AAV Vectors; Advances and Applications

(2008) Douglas M McCarty   MOLECULAR THERAPY

Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc

(2008) J. A. Hoyland et al.   RHEUMATOLOGY

Safety Assessment of Intradiscal Gene Therapy II

(2008) Eric A. Levicoff et al.   SPINE

Regenerative treatment strategies in spinal surgery

(2007) Aldemar Andres Hegewald   Frontiers in Bioscience-Landmark

The effects of recombinant human bone morphogenetic protein-2, recombinant human bone morphogenetic protein-12, and adenoviral bone morphogenetic protein-12 on matrix synthesis in human annulus fibrosis and nucleus pulposus cells

(2007) Lars Gilbertson et al.   Spine Journal