Targeting human leukocyte antigen G with chimeric antigen receptors of natural killer cells convert immunosuppression to ablate solid tumors

First immunotherapeutic CAR-T cells against the immune checkpoint protein HLA-G

(2021) François Anna et al.   Journal for ImmunoTherapy of Cancer

Engineering Chimeric Antigen Receptor T cells Against Immune Checkpoint Inhibitors PD-1/PD-L1 for Treating Pancreatic Cancer

(2020) Ching-Yao Yang et al.   Molecular Therapy-Oncolytics

Phase I Trial of Expanded, Activated Autologous NK-cell Infusions with Trastuzumab in Patients with HER2-positive Cancers

(2020) Soo-Chin Lee et al.   CLINICAL CANCER RESEARCH

Targeting PD-L1 in non-small cell lung cancer using CAR T cells

(2020) Ming Liu et al.   Oncogenesis

CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape

(2020) Alba Rodriguez-Garcia et al.   Frontiers in Immunology

HLA-G Neo-Expression on Tumors

(2020) Maria Loustau et al.   Frontiers in Immunology

Chimeric antigen receptor T cells targeting PD-L1 suppress tumor growth

(2020) Le Qin et al.   Biomarker Research

Targeted Natural Killer Cell–Based Adoptive Immunotherapy for the Treatment of Patients with NSCLC after Radiochemotherapy: A Randomized Phase II Clinical Trial

(2020) Gabriele Multhoff et al.   CLINICAL CANCER RESEARCH

Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study

(2020) Jeremy S Abramson et al.   LANCET

HLA-G Expressing Immune Cells in Immune Mediated Diseases

(2020) P. Contini et al.   Frontiers in Immunology

CAR-NK cells: A promising cellular immunotherapy for cancer

(2020) Guozhu Xie et al.   EBioMedicine

Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy

(2020) Ahmet Yilmaz et al.   Journal of Hematology & Oncology

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

(2019) Xianjie Jiang et al.   Molecular Cancer

Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells

(2019) Hongwei Du et al.   CANCER CELL

Immune-related Adverse Events Associated With Checkpoint Inhibition in the Setting of CAR T Cell Therapy: A Case Series

(2019) Swetha Kambhampati et al.   Clinical Lymphoma Myeloma & Leukemia

Immunogenic chemotherapy: Dose and schedule dependence and combination with immunotherapy

(2018) Junjie Wu et al.   CANCER LETTERS

Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity

(2018) Ye Li et al.   Cell Stem Cell

CART Targeting of Solid Tumors: More Pieces to the Puzzle

(2018) Michael Kalos   CLINICAL CANCER RESEARCH

Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward

(2018) Jian Li et al.   Journal of Hematology & Oncology

DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer

(2018) Na Luo et al.   Nature Communications

PD-L1

(2017) Anthousa Kythreotou et al.   JOURNAL OF CLINICAL PATHOLOGY

Human M2 Macrophages Limit NK Cell Effector Functions through Secretion of TGF-β and Engagement of CD85j

(2017) Sol Y. Nuñez et al.   JOURNAL OF IMMUNOLOGY

Can we predict protein from mRNA levels?

(2017) Nikolaus Fortelny et al.   NATURE

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

(2017) Sattva S. Neelapu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibiting DNA methylation activates cancer testis antigens and expression of the antigen processing and presentation machinery in colon and ovarian cancer cells

(2017) Cornelia Siebenkäs et al.   PLoS One

The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments

(2017) John P. Veluchamy et al.   Frontiers in Immunology

Prospects for combined use of oncolytic viruses and CAR T-cells

(2017) Adam Ajina et al.   Journal for ImmunoTherapy of Cancer

The untold story of IFN-γ in cancer biology

(2016) M. Alper Kursunel et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Natural Killer Cell Adoptive Transfer Therapy

(2015) Zachary B. Davis et al.   CANCER JOURNAL

B7H6-specific chimeric antigen receptors lead to tumor elimination and host antitumor immunity

(2015) M-R Wu et al.   GENE THERAPY

Alternative Antigen Processing for MHC Class I: Multiple Roads Lead to Rome

(2015) Cláudia C. Oliveira et al.   Frontiers in Immunology

Epigenetic regulations in the IFNγ signalling pathway: IFNγ-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes

(2015) Veronika Vlková et al.   Oncotarget

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular Pathways: Human Leukocyte Antigen G (HLA-G)

(2013) G. Curigliano et al.   CLINICAL CANCER RESEARCH

Treatment of Metastatic Renal Cell Carcinoma With CAIX CAR-engineered T cells: Clinical Evaluation and Management of On-target Toxicity

(2013) Cor HJ Lamers et al.   MOLECULAR THERAPY

CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

(2013) R. J. Brentjens et al.   Science Translational Medicine

Melanoma cells become resistant to NK-cell-mediated killing when exposed to NK-cell numbers compatible with NK-cell infiltration in the tumor

(2012) Mirna Balsamo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NK cytolysis is dependent on the proportion of HLA-G expression

(2012) Bao-Guo Chen et al.   HUMAN IMMUNOLOGY

Gemcitabine reactivates epigenetically silenced genes and functions as a DNA methyltransferase inhibitor

(2012) STEVEN G. GRAY et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Protein L: a novel reagent for the detection of Chimeric Antigen Receptor (CAR) expression by flow cytometry

(2012) Zhili Zheng et al.   Journal of Translational Medicine

Evaluating tumor heterogeneity in immunohistochemistry-stained breast cancer tissue

(2012) Steven J Potts et al.   LABORATORY INVESTIGATION

Immune parameters affecting the efficacy of chemotherapeutic regimens

(2011) Laurence Zitvogel et al.   Nature Reviews Clinical Oncology

Beyond the increasing complexity of the immunomodulatory HLA-G molecule

(2008) E. D. Carosella et al.   BLOOD

Sunitinib Reverses Type-1 Immune Suppression and Decreases T-Regulatory Cells in Renal Cell Carcinoma Patients

(2008) J. H. Finke et al.   CLINICAL CANCER RESEARCH

Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine

(2008) Carlo Stresemann et al.   INTERNATIONAL JOURNAL OF CANCER