Basal Cell Carcinoma: From Pathophysiology to Novel Therapeutic Approaches

Sonidegib and vismodegib in the treatment of patients with locally advanced basal cell carcinoma: a joint expert opinion

(2020) R. Dummer et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Basal cell carcinoma in post-traumatic scar successfully treated with thulium laser and photodynamic therapy

(2020) Santo R. Mercuri et al.   GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers

(2020) Josh Lewis Stern et al.   MOLECULAR CANCER RESEARCH

Coding and noncoding somatic mutations in candidate genes in basal cell carcinoma

(2020) Maria Giovanna Maturo et al.   Scientific Reports

S2k Guidelines for Cutaneous Basal Cell Carcinoma - Part 2: Treatment, Prevention and Follow-up

(2019) Berenice M. Lang et al.   JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT

Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety

(2019) Victoria A. Snaidr et al.   EXPERIMENTAL DERMATOLOGY

Next-Generation Hedgehog/GLI Pathway Inhibitors for Cancer Therapy

(2019) Elisabeth Peer et al.   Cancers

Aging and the treatment of basal cell carcinoma

(2019) Shreya Sreekantaswamy et al.   CLINICS IN DERMATOLOGY

Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened

(2019) Silvia Pietrobono et al.   Frontiers in Genetics

Diagnosis and treatment of basal cell carcinoma: European consensus–based interdisciplinary guidelines

(2019) Ketty Peris et al.   EUROPEAN JOURNAL OF CANCER

p63 Is a Promising Marker in the Diagnosis of Unusual Skin Cancer

(2019) Artem Smirnov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Nicotinamide in Genomic Stability and Skin Cancer Chemoprevention

(2019) Luca Fania et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hedgehog Signaling: An Achilles’ Heel in Cancer

(2019) Madiha Niyaz et al.   Translational Oncology

Molecular testing in metastatic basal cell carcinoma

(2019) Babette J.A. Verkouteren et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

YAP and TAZ are essential for basal and squamous cell carcinoma initiation

(2018) Maud Debaugnies et al.   EMBO REPORTS

CD10, TDAG51, CK20, AR, INSM1, and Nestin Expression in the Differential Diagnosis of Trichoblastoma and Basal Cell Carcinoma

(2018) Cem Leblebici et al.   INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY

Guidelines of care for the management of basal cell carcinoma

(2018) John Y.S. Kim et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Basal Cell Carcinoma, PART II: Contemporary Approaches to Diagnosis, Treatment, and Prevention

(2018) Michael C. Cameron et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Basal cell carcinoma: the utility of in vivo and ex vivo confocal microscopy

(2018) C. Longo et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Antihypertensive drugs and risk of skin cancer

(2018) Nicoletta Cassano et al.   GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

MicroRNA-451a acts as tumor suppressor in cutaneous basal cell carcinoma

(2018) Hui Sun et al.   Molecular Genetics & Genomic Medicine

Sequential treatment of daylight photodynamic therapy and imiquimod 5% cream for the treatment of superficial basal cell carcinoma on sun exposed areas

(2018) Giovanni Paolino et al.   Dermatologic Therapy

Basal Cell Carcinoma Review

(2018) Dennis P. Kim et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Vismodegib in patients with advanced basal cell carcinoma: Primary analysis of STEVIE, an international, open-label trial

(2017) N. Basset-Séguin et al.   EUROPEAN JOURNAL OF CANCER

Understanding the Molecular Genetics of Basal Cell Carcinoma

(2017) Cristina Pellegrini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long-term efficacy and safety of sonidegib in patients with locally advanced and metastatic basal cell carcinoma: 30-month analysis of the randomized phase 2 BOLT study

(2017) J.T. Lear et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond

(2017) Anshika Bakshi et al.   MOLECULAR CARCINOGENESIS

Sun Protection for Preventing Basal Cell and Squamous Cell Skin Cancers

(2017) Kate Rowan-Robinson   PUBLIC HEALTH NURSING

The Epidemiology and Clinicopathological Features of Basal Cell Carcinoma in Patients 80 Years and Older

(2017) Satish F. K. Lubeek et al.   JAMA Dermatology

MicroRNA in non-melanoma skin cancer

(2017) Michael Sand et al.   Cancer Biomarkers

A phase II randomized controlled trial of nicotinamide for skin cancer chemoprevention in renal transplant recipients

(2016) A.C. Chen et al.   BRITISH JOURNAL OF DERMATOLOGY

Accuracy of optical coherence tomography for the diagnosis of superficial basal cell carcinoma: a prospective, consecutive, cohort study of 168 cases

(2016) H.M. Cheng et al.   BRITISH JOURNAL OF DERMATOLOGY

Vismodegib, itraconazole and sonidegib as hedgehog pathway inhibitors and their relative competencies in the treatment of basal cell carcinomas

(2016) Mohd Wahid et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Three-Year Follow-Up Results of Photodynamic Therapy vs. Imiquimod vs. Fluorouracil for Treatment of Superficial Basal Cell Carcinoma: A Single-Blind, Noninferiority, Randomized Controlled Trial

(2016) Marieke H. Roozeboom et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Can oral nonsteroidal antiinflammatory drugs play a role in the prevention of basal cell carcinoma? A systematic review and metaanalysis

(2016) Chiho Muranushi et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Basal Cell Skin Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology

(2016) Christopher K. Bichakjian et al.   Journal of the National Comprehensive Cancer Network

Defining the clonal dynamics leading to mouse skin tumour initiation

(2016) Adriana Sánchez-Danés et al.   NATURE

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma

(2016) Ximena Bonilla et al.   NATURE GENETICS

Long-noncoding RNAs in basal cell carcinoma

(2016) Michael Sand et al.   TUMOR BIOLOGY

Real-time Raman spectroscopy for automatic in vivo skin cancer detection: an independent validation

(2015) Jianhua Zhao et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Échographie cutanée haute résolution dans le diagnostic différentiel entre carcinome basocellulaire nodulaire et hyperplasie sébacée du visage : une étude pilote

(2015) G. Bens et al.   ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE

Digging a hole under Hedgehog: downstream inhibition as an emerging anticancer strategy

(2015) Laura Di Magno et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of nonpigmented basal cell carcinoma: an observational study

(2015) M. Ulrich et al.   BRITISH JOURNAL OF DERMATOLOGY

Systematic review of optical coherence tomography usage in the diagnosis and management of basal cell carcinoma

(2015) H.M. Cheng et al.   BRITISH JOURNAL OF DERMATOLOGY

Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma

(2015) Scott X. Atwood et al.   CANCER CELL

Dermoscopy in the diagnosis and management of basal cell carcinoma

(2015) Aimilios Lallas et al.   Future Oncology

Basal cell carcinoma of the skin (part 1): epidemiology, pathology and genetic syndromes

(2015) Tiago Ribeiro Correia de Sá et al.   Future Oncology

Usefulness of Photodynamic Therapy as a Possible Therapeutic Alternative in the Treatment of Basal Cell Carcinoma

(2015) Paola Savoia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Use of antihypertensive drugs and risk of skin cancer

(2015) S.A.J. Schmidt et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Dermoscopic variability of basal cell carcinoma according to clinical type and anatomic location

(2015) M. Suppa et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial

(2015) Michael R Migden et al.   LANCET ONCOLOGY

Skin Cancer Epidemiology, Detection, and Management

(2015) Sumul Ashok Gandhi et al.   MEDICAL CLINICS OF NORTH AMERICA

A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention

(2015) Andrew C. Chen et al.   NEW ENGLAND JOURNAL OF MEDICINE

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

Frequent DPH3 promoter mutations in skin cancers

(2015) Evgeniya Denisova et al.   Oncotarget

Timing of Subsequent New Tumors in Patients Who Present With Basal Cell Carcinoma or Cutaneous Squamous Cell Carcinoma

(2015) Mackenzie R. Wehner et al.   JAMA Dermatology

Shiny White Streaks: A Sign of Malignancy at Dermoscopy of Pigmented Skin Lesions

(2014) D Shitara et al.   ACTA DERMATO-VENEREOLOGICA

Basal cell carcinomas in a tertiary referral centre: a systematic analysis

(2014) J. Dreier et al.   BRITISH JOURNAL OF DERMATOLOGY

Surgical excision versus Mohs’ micrographic surgery for basal cell carcinoma of the face: A randomised clinical trial with 10year follow-up

(2014) Eva van Loo et al.   EUROPEAN JOURNAL OF CANCER

TERT Promoter Mutations in Skin Cancer: The Effects of Sun Exposure and X-Irradiation

(2014) Helena Pópulo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Topical pharmacotherapy for skin cancer

(2014) Giuseppe Micali et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Classifying distinct basal cell carcinoma subtype by means of dermatoscopy and reflectance confocal microscopy

(2014) Caterina Longo et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Emerging interactions between skin stem cells and their niches

(2014) Ya-Chieh Hsu et al.   NATURE MEDICINE

Das Basalzellkarzinom und seine seltenen Formvarianten

(2014) J. Liersch et al.   PATHOLOGE

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress

(2013) D Mazzà et al.   CELL DEATH AND DIFFERENTIATION

The Role of Reflectance Confocal Microscopy as an Aid in the Diagnosis of Collision Tumors

(2013) Elvira Moscarella et al.   DERMATOLOGY

In vivo Diagnosis of Basal Cell Carcinoma Subtype by Reflectance Confocal Microscopy

(2013) Malou Peppelman et al.   DERMATOLOGY

Risk of subsequent cutaneous malignancy in patients with prior keratinocyte carcinoma: A systematic review and meta-analysis

(2013) Sophie C. Flohil et al.   EUROPEAN JOURNAL OF CANCER

Update on non-melanoma skin cancer and the value of dermoscopy in its diagnosis and treatment monitoring

(2013) Aimilios Lallas et al.   Expert Review of Anticancer Therapy

Chemoprevention of Nonmelanoma Skin Cancer

(2013) Razieh Soltani-Arabshahi et al.   FACIAL PLASTIC SURGERY

Mitochondrial D310 D-Loop instability and histological subtypes in radiation-induced cutaneous basal cell carcinomas

(2013) Paula Boaventura et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Mutational Landscape of Basal Cell Carcinomas by Whole-Exome Sequencing

(2013) Shyam S. Jayaraman et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Fractionated 5-aminolevulinic acid photodynamic therapy after partial debulking versus surgical excision for nodular basal cell carcinoma: A randomized controlled trial with at least 5-year follow-up

(2013) Marieke H. Roozeboom et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial

(2013) Aimée HMM Arits et al.   LANCET ONCOLOGY

Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinoma

(2013) Glynis A Scott et al.   MODERN PATHOLOGY

Imiquimod directly inhibits Hedgehog signalling by stimulating adenosine receptor/protein kinase A-mediated GLI phosphorylation

(2013) F Wolff et al.   ONCOGENE

TERT Promoter Mutations Are Frequent in Cutaneous Basal Cell Carcinoma and Squamous Cell Carcinoma

(2013) Klaus G. Griewank et al.   PLoS One

Positive compared with negative margins in a single-centre retrospective study on 3957 consecutive excisions of basal cell carcinomas. Associated risk factors and preferred surgical management

(2013) D. Codazzi et al.   Journal of Plastic Surgery and Hand Surgery

Adenoid basal cell carcinoma and its mimics

(2013) Sujata Jetley et al.   INDIAN JOURNAL OF DERMATOLOGY

A possible chemopreventive role for photodynamic therapy in Gorlin syndrome: a report of basal cell carcinoma reduction and review of literature

(2012) Christopher M. Wolfe et al.   AUSTRALASIAN JOURNAL OF DERMATOLOGY

Expression of microRNAs in basal cell carcinoma

(2012) M. Sand et al.   BRITISH JOURNAL OF DERMATOLOGY

Real-time Raman Spectroscopy for In Vivo Skin Cancer Diagnosis

(2012) H. Lui et al.   CANCER RESEARCH

Confocal Microscopy Insights into the Treatment and Cellular Immune Response of Basal Cell Carcinoma to Photodynamic Therapy

(2012) Caterina Longo et al.   DERMATOLOGY

NF-κB and the link between inflammation and cancer

(2012) Joseph A. DiDonato et al.   IMMUNOLOGICAL REVIEWS

Hedgehog pathway inhibition and the race against tumor evolution

(2012) Scott X. Atwood et al.   JOURNAL OF CELL BIOLOGY

Oral Nicotinamide Reduces Actinic Keratoses in Phase II Double-Blinded Randomized Controlled Trials

(2012) Devita Surjana et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

In Vivo Confocal Microscopy for Diagnosis of Melanoma and Basal Cell Carcinoma Using a Two-Step Method: Analysis of 710 Consecutive Clinically Equivocal Cases

(2012) Pascale Guitera et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Introduction to Confocal Microscopy

(2012) Adaobi Nwaneshiudu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The risk of squamous cell and basal cell cancer associated with psoralen and ultraviolet A therapy: A 30-year prospective study

(2012) Robert S. Stern   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

LGR5 Interacts and Cointernalizes with Wnt Receptors To Modulate Wnt/ -Catenin Signaling

(2012) K. S. Carmon et al.   MOLECULAR AND CELLULAR BIOLOGY

Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma

(2012) Aleksandar Sekulic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Silencing of Diphthamide Synthesis 3 (Dph3) Reduces Metastasis of Murine Melanoma

(2012) Lei Wang et al.   PLoS One

Indoor tanning and non-melanoma skin cancer: systematic review and meta-analysis

(2012) M. R. Wehner et al.   BMJ-British Medical Journal

Correlation of Global MicroRNA Expression With Basal Cell Carcinoma Subtype

(2012) Christopher Heffelfinger et al.   G3-Genes Genomes Genetics

MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma

(2012) E Sonkoly et al.   Oncogenesis

Keratin 15-Positive Stem Cells Give Rise to Basal Cell Carcinomas in Irradiated Ptch1+/− Mice

(2011) John T. Seykora et al.   CANCER CELL

Basal Cell Carcinomas Arise from Hair Follicle Stem Cells in Ptch1+/− Mice

(2011) Grace Ying Wang et al.   CANCER CELL

Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations

(2011) Marina Grachtchouk et al.   JOURNAL OF CLINICAL INVESTIGATION

The Mechanisms of UV Mutagenesis

(2011) Hironobu IKEHATA et al.   JOURNAL OF RADIATION RESEARCH

Confocal features of equivocal facial lesions on severely sun-damaged skin: Four case studies with dermatoscopic, confocal, and histopathologic correlation

(2011) Elisabeth M.T. Wurm et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Indoor tanning and risk of early-onset basal cell carcinoma

(2011) Leah M. Ferrucci et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Giant basal cell carcinoma of the skin: literature review and personal experience

(2011) G. Zoccali et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin

(2011) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Risk Factors for Single and Multiple Basal Cell Carcinomas

(2010) Ville Kiiski et al.   ARCHIVES OF DERMATOLOGY

High-ceiling diuretics are associated with an increased risk of basal cell carcinoma in a population-based follow-up study

(2010) Rikje Ruiter et al.   EUROPEAN JOURNAL OF CANCER

The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Peritumoral clefting in basal cell carcinoma: correlation of in vivo reflectance confocal microscopy and routine histology

(2010) Martina Ulrich et al.   JOURNAL OF CUTANEOUS PATHOLOGY

How to diagnose nonpigmented skin tumors: A review of vascular structures seen with dermoscopy

(2010) Iris Zalaudek et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Intralesional agents in the management of cutaneous malignancy: A review

(2010) Laurie M. Good et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Photodynamic therapy for basal cell carcinoma: clinical and pathological determinants of response

(2010) F. Fantini et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Vascular patterns in basal cell carcinoma

(2010) T Micantonio et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Chemoprevention of Nonmelanoma Skin Cancer With Celecoxib: A Randomized, Double-Blind, Placebo-Controlled Trial

(2010) Craig A. Elmets et al.   JNCI-Journal of the National Cancer Institute

Identification of the cell lineage at the origin of basal cell carcinoma

(2010) Khalil Kass Youssef et al.   NATURE CELL BIOLOGY

Photoprotective effects of nicotinamide

(2010) Diona L. Damian   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Observation of Chrysalis Structures With Polarized Dermoscopy

(2009) Ashfaq A. Marghoob et al.   ARCHIVES OF DERMATOLOGY

Topical Imiquimod or Fluorouracil Therapy for Basal and Squamous Cell Carcinoma

(2009) W. Elliot Love et al.   ARCHIVES OF DERMATOLOGY

Towards an integrated view of Wnt signaling in development

(2009) R. van Amerongen et al.   DEVELOPMENT

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

(2009) Barbara Stecca et al.   EMBO JOURNAL

Cloning of the HumanGLI2Promoter

(2009) Sylviane Dennler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Patients with both basal and squamous cell carcinomas are at a lower risk of further basal cell carcinomas than patients with only a basal cell carcinoma

(2009) Sudarshan Ramachandran et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Dermatoscopy of basal cell carcinoma: Morphologic variability of global and local features and accuracy of diagnosis

(2009) Davide Altamura et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Downregulated MicroRNA-200a in Meningiomas Promotes Tumor Growth by Reducing E-Cadherin and Activating the Wnt/ -Catenin Signaling Pathway

(2009) O. Saydam et al.   MOLECULAR AND CELLULAR BIOLOGY

The Efficacy of Facial Skin Cancer Treatment with High-Energy Pulsed Neodymium and Nd:YAG Lasers

(2009) Konstantin Moskalik et al.   PHOTOMEDICINE AND LASER SURGERY

Epidermal Notch signalling: differentiation, cancer and adhesion

(2008) Fiona M Watt et al.   CURRENT OPINION IN CELL BIOLOGY

Hedgehog: functions and mechanisms

(2008) M. Varjosalo et al.   GENES & DEVELOPMENT

Dermatoscopy aids in the diagnosis of the solitary red scaly patch or plaque–features distinguishing superficial basal cell carcinoma, intraepidermal carcinoma, and psoriasis

(2008) Yan Pan et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Basosquamous carcinoma

(2008) Carlos Garcia et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/β-catenin signaling

(2008) Steven Hoseong Yang et al.   NATURE GENETICS

UV Radiation-Induced Immunosuppression Is Greater in Men and Prevented by Topical Nicotinamide

(2007) Diona L. Damian et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY