Article
Neurosciences
Mohammad Azam Ansari, Takshashila Tripathi, Baskar Venkidasamy, Alan Monziani, Govindasamy Rajakumar, Mohammad N. Alomary, Sami A. Alyahya, Oriane Onimus, Naomi D'souza, Md. Abul Barkat, Ebtesam A. Al-Suhaimi, Ramkumar Samynathan, Muthu Thiruvengadam
Summary: The incidence of neurodegenerative diseases (NDDs) has been increasing, yet available therapies for these diseases are limited. Nanomedicine, especially the use of nanoparticles (NPs), has the potential to improve drug delivery for the treatment of NDDs. Metal-based NPs, polymeric nanogels, and nanocarrier systems are among the promising approaches for therapy. However, more research is needed to introduce these approaches into clinical use.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Nanoscience & Nanotechnology
Shuo Zhang, Yishu Wang, Shuai Zhang, Chengqi Huang, Qiyang Ding, Ji Xia, Daocheng Wu, Wei Gao
Summary: Anesthetic nanomedicines play a crucial role in clinical surgery, improving anesthesia effectiveness and reducing toxic effects. However, research on anesthetic nanomedicines is still limited and requires further exploration and analysis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Geriatrics & Gerontology
Yuto Uchida, Hirohito Kan, Keita Sakurai, Kenichi Oishi, Noriyuki Matsukawa
Summary: The blood-brain barrier plays important roles in maintaining brain homeostasis, protecting the central nervous system, regulating substance exchange, and clearing metabolic waste. It is believed to contribute to preventing and understanding Alzheimer's disease. The development of blood-brain barrier imaging technologies can provide valuable insights and potential interventions for Alzheimer's disease and related dementias.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
David Male, Radka Gromnicova
Summary: This review discusses the ability of nanoparticles with oligonucleotides to enter the brain and modulate gene expression or disease. The size and surface charge of the nanocarrier, as well as the structure of the oligonucleotide and chemical formulation of the nanocarrier, play important roles in determining their efficacy. Successful gene therapy with oligonucleotides in humans has required intrathecal injection, while in animal models, progress has been made with intraventricular or intravenous injection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xiande Wang, Cheng Wu, Shiming Liu, Deqing Peng
Summary: Brain cancer is a highly aggressive cancer with limitations in current treatment strategies. The blood-brain barrier and blood-cerebrospinal fluid barrier pose additional challenges in drug delivery to brain tumors. Dual-targeting strategies have shown promise in enhancing drug delivery efficiency and targeting of tumor cells in brain tumors.
Review
Chemistry, Multidisciplinary
Alireza Poustforoosh, Mohammad Hadi Nematollahi, Hassan Hashemipour, Abbas Pardakhty
Summary: This review discusses the challenges and barriers in drug delivery to the brain, as well as strategies and pathways to overcome the blood-brain barrier. The application of bioconjugated vesicles as nanocarriers for enhancing drug loading into the brain is emphasized.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Pharmacology & Pharmacy
Lili Li, Jiajia Zhang, Xiaoyue Huang, Jingguo Du, Zhiqiang Tu, Haotian Wu, Xu Liu, Mingqing Yuan
Summary: Currently, nanotechnology has been widely used to overcome the challenge of drug delivery across the blood-brain barrier (BBB) and improve the efficacy of therapeutic drugs for central neurological diseases, particularly Alzheimer's disease (AD). Nanocarriers have shown great potential in targeting the delivery of drugs to brain tissue, alleviating the progression of AD. Various nanoparticles and nanomedicine, such as liposomes and self-assembled nanoparticles, have been developed for the treatment and diagnosis of AD.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Pharmacology & Pharmacy
Yu-Chen Lo, Wen-Jen Lin
Summary: The study utilized a peptide-conjugated nano-delivery system to enhance penetration into tumor cells by overcoming the blood brain barrier. NPs conjugated with T7 peptide showed higher accumulation in the brain and lower biodistribution in nontarget tissues. The benefit of T7 peptide as a targeting ligand for NPs across the BBB was elucidated in this study.
Review
Pharmacology & Pharmacy
Xihui Gao, Jinliang Xu, Tingting Yao, Xiaoxiao Liu, Hanchang Zhang, Changyou Zhan
Summary: The blood-brain barrier (BBB) serves as a crucial physiological barrier that restricts the exchange of substances between blood and brain tissues. Peptide decorated nanocarriers have shown promise in overcoming the BBB for diagnosis and therapy of brain diseases. However, challenges related to stability, safety, and immunocompatibility need to be addressed for their clinical translation.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Lin Tang, Yicheng Feng, Sai Gao, Qingchun Mu, Chaoyong Liu
Summary: Glioblastoma (GBM) is a common malignant primary brain tumor with a poor prognosis. The current standard treatment regimen has limited efficacy, and new therapeutic approaches, such as nanotechnologies for overcoming the blood-brain barrier, hold promise for treating GBM.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Luyao Wang, Youyuan Shi, Jingzhen Jiang, Chan Li, Hengrui Zhang, Xinhui Zhang, Tao Jiang, Liang Wang, Yinyan Wang, Lin Feng
Summary: The blood-brain barrier (BBB) poses a significant challenge for drug delivery to brain tumors. Recent research in micro- and nanotechnology has shown that nano drug-targeted delivery technologies have the potential to overcome this challenge. This review provides a detailed understanding of the BBB, summarizes recent research topics on drug delivery carriers for brain tumors, evaluates the effectiveness of targeted therapy, and discusses the challenges and future prospects of developing brain tumor drug delivery systems.
Article
Engineering, Biomedical
Yang Han, Chunhong Gao, Hao Wang, Jiejie Sun, Meng Liang, Ye Feng, Qianqian Liu, Shiyao Fu, Lin Cui, Chunsheng Gao, Yi Li, Yang Yang, Baoshan Sun
Summary: The use of macrophage membrane-coated solid lipid nanoparticles for antioxidant delivery shows promise in delaying the progression of Alzheimer's disease by targeting neuronal mitochondria. This biomimetic nanosystem, capable of crossing the blood-brain barrier and selectively targeting neurons, exhibits favorable therapeutic effects in vitro and in vivo. The synergistic effects of macrophage membranes, RVG29, and TPP contribute to the success of this neuronal mitochondria-targeted delivery system.
BIOACTIVE MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Chang Li, Shenghui Qin, Yu Wen, Wei Zhao, Yijie Huang, Jun Liu
Summary: Exosomes, as nanocarriers, have the potential to be used in personalized/precision radiology due to their low immunogenicity, low toxicity, biocompatibility, and ability to penetrate the blood-brain barrier.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biotechnology & Applied Microbiology
Ruiyi Zhou, Lihong Zhu, Zhaohao Zeng, Rixin Luo, Jiawei Zhang, Rui Guo, Lei Zhang, Qunying Zhang, Wei Bi
Summary: In this study, a brain-targeted nanomedicine was designed for the treatment of Alzheimer's disease. The results showed that the nanomedicine had favorable biocompatibility and could effectively reduce amyloid deposition, improve neuronal damage, and enhance learning and memory capability.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Review
Neurosciences
Hinal Shah, Gajanan Paul, Awesh K. Yadav
Summary: Stroke is one of the leading causes of neurological mortality and morbidity worldwide. Current clinical therapies for stroke have limitations, hence the use of nanocarriers as a promising strategy for treatment and diagnosis.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Environmental Sciences
L. Fei, F. Ali, A. Said, N. Tariq, F. Raziq, N. Ali, U. Arif, M. S. Akhter, A. Rahdar, M. Bilal
Summary: Three types of zinc ferrite nanoparticles were synthesized successfully and characterized for their structure and photocatalytic performance. The results showed that these nanoparticles exhibited excellent photocatalytic properties and could be reused.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Leili Mohammadi, Amin Mohammadpour, Mohammad Reza Hosseini, Ebrahim Shahsavani, Reza Abbasi Rayeni, Mohammad Golaki, Abbas Rahdar, Sadanand Pandey
Summary: This study investigated the photocatalytic degradation of BOD from wastewater using copper oxide nanoparticles. The study found that factors such as UV intensity, pH, time, and copper oxide dose significantly influenced the removal efficiency. The Langmuir isotherm provided the best fit for the experimental data.
ENVIRONMENTAL PROGRESS & SUSTAINABLE ENERGY
(2023)
Article
Chemistry, Applied
Javeria Ayub, Muhammad Usama Saeed, Nazim Hussain, Iqra Zulfiqar, Tahir Mehmood, Hafiz M. N. Iqbal, Muhammad Bilal
Summary: Nanobiocatalysis is a technique that combines biotechnology with nanotechnology to enhance bioprocessing capabilities. Immobilized enzymes improve enzyme activity, stability, and reusability. Recent advancements in nano-biotechnology allow for the incorporation of natural biocatalysts into nanostructures that provide additional properties. The use of nanomaterials as carriers for enzymes has led to the development of stable and active nanobiocatalysts.
TOPICS IN CATALYSIS
(2023)
Article
Environmental Sciences
Marise Silva de Carvalho, Luiz Henrique Sales de Menezes, Adriana Bispo Pimentel, Floriatan Santos Costa, Polyane Cabral Oliveira, Marta Maria Oliveira dos Santos, Iasnaia Maria de Carvalho Tavares, Muhammad Irfan, Muhammad Bilal, Joao Carlos Teixeira Dias, Julieta Rangel de Oliveira, Marcelo Franco
Summary: In this study, a comprehensive investigation was conducted on the production of xylanase by solid-state fermentation using Aspergillus oryzae ATCC 10124. Enzyme production was optimized through statistical designs for both the mixture of waste residues and fermentation parameters. The optimized process resulted in a significant increase (up to 165%) in enzymatic activity. The xylanase produced in this fermentation process exhibited alkaline characteristics and high thermal stability. Moreover, the multienzyme extract obtained directly from the fermentation process showed efficient saccharification capabilities without the need for enzyme purification.
WASTE AND BIOMASS VALORIZATION
(2023)
Article
Biochemistry & Molecular Biology
Veer Singh, Jyoti Singh, Nidhi Singh, Sachchida Nand Rai, Manoj Kumar Verma, Manisha Verma, Vishal Singh, Mahesh Sanjay Chivate, Muhammad Bilal, Vishal Mishra
Summary: In this study, the removal of Cd (II), Pb (II), and Cr (VI) at a concentration of 50 mg/L was investigated using Microbacterium paraoxydans strain VSVM IIT(BHU). X-ray photoelectron spectroscopy and energy dispersive X-ray confirmed the binding of heavy metals on the bacterial cell surface, as well as the reduction of Cr (VI) to Cr (III). The dynamics of heavy metal removal were determined to be a combination of diffusion and transfer control based on the dimensionless values of N-k (9.49 x 10(-3), 9.92 x 10(-3), and 1.23 x 10(-2) for Cr (VI), Cd (II), and Pb (II) ions, respectively). The isolated bacterial strain showed a high removal efficiency for heavy metal ions, with maximum values of 91.62% for Cr (VI), 89.29% for Pb (II), and 83.29% for Cd (II) at 50 mg/L.
Review
Biotechnology & Applied Microbiology
Tehreem Mahmood, Nazim Hussain, Areej Shahbaz, Sikandar Mulla, Hafiz M. N. Iqbal, Muhammad Bilal
Summary: The worldwide depletion of fossil fuel reserves and the associated environmental and health risks are discussed in this study. The need for alternative renewable energy sources, with a focus on algae-based biofuels, is emphasized. Different cultivation systems for algae and various factors affecting biomass yield and biofuel production are outlined. The economic benefits of algae-based biofuels are highlighted.
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2023)
Article
Biophysics
Laura Ferreira, Filipa Mascarenhas-Melo, Sofia Rabaca, Ankita Mathur, Ankur Sharma, Prabhanjan S. Giram, Kiran D. Pawar, Abbas Rahdar, Faisal Raza, Francisco Veiga, Priscila Gava Mazzola, Ana Claudia Paiva-Santos
Summary: The progress in new delivery systems for active ingredients in dermopharmaceutical and cosmetic fields has been boosted by the use of cyclodextrins (CDs) as versatile carriers. CDs are able to form host-guest inclusion complexes with guest active molecules, improving their physicochemical properties. The advantages of CDs in dermopharmaceutical and cosmetic applications include improved solubility and stability of active ingredients, as well as the ability to mask unpleasant odors, making them promising for skin disease treatment and cosmetic formulation improvement.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Chemistry, Medicinal
Anai A. Valencia-Lazcano, Dilawar Hassan, Mehrab Pourmadadi, Amin Shamsabadipour, Razieh Behzadmehr, Abbas Rahdar, Dora I. Medina, Ana M. Diez-Pascual
Summary: This study reviews the applications of 5-Fluorouracil (5-FU) as an anticancer drug for various types of cancers. Different approaches, such as nanoparticles loaded with 5-FU, co-delivery systems with other drugs, have been described to overcome the limitations of 5-FU therapy. This review provides the latest progress on 5-FU-loaded nanocarriers and their potential as an advanced tool for cancer therapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Sepehr Darvishan, Mehrab Pourmadadi, Majid Abdouss, Saeedeh Mazinani, Fatemeh Yazdian, Abbas Rahdar, Ana M. Diez-Pascual
Summary: A novel PAA-based hydrogel coated with ?-alumina modified with PVP was synthesized for the delivery of quercetin to cancer cells. The addition of Al2O3 increased pH-sensitivity, and the use of Span 80 surfactant led to a nano niosomal emulsion that improved stability and retention of quercetin. The microemulsion's physical interactions, crystalline structure, and morphology were analyzed, and drug loading efficiency was significantly improved with the double emulsion method. The developed ?-alumina-PAA/PVP nanoemulsion shows promise as a pH-sensitive drug delivery system.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mahmood Barani, Mohammad Reza Hajinezhad, Farshid Zargari, Sheida Shahraki, Fatemeh Davodabadi, Shekoufeh Mirinejad, Saman Sargazi, Abbas Rahdar, Ana M. Diez-Pascual
Summary: Novel niosomes containing cholesterol, Span (60), Tween (60), and gemcitabine (GEM) were developed and characterized. They showed a nanometric size, controlled drug release, and higher effectiveness in cancer cell lines compared to free GEM. The main mechanism of cell-killing effects was apoptosis, with some cells undergoing necrosis. However, intravenous treatment with niosomal GEM caused severe side effects in rats, while free GEM did not. Molecular dynamics simulations demonstrated the interactions between GEM and niosome components, suggesting their potential as drug carriers with reduced side effects.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Applied
Despina A. Gkika, Athanasios C. Mitropoulos, Petros Kokkinos, Dimitra A. Lambropoulou, Ioannis K. Kalavrouziotis, Dimitrios N. Bikiaris, George Z. Kyzas
Summary: In the past 30 years, global pharmaceutical consumption has tripled. Despite their importance in protecting human life, pharmaceuticals are a significant source of environmental pollution due to their presence in water bodies. Technological approaches are necessary to address this issue, and adsorption methods using Chitosan and its modifications have emerged as an effective solution for removing organic pollutants from water. This review examines the trends in chitosan modifications and their effectiveness in eliminating pharmaceuticals, providing valuable insights for future research.
CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS
(2023)
Article
Engineering, Environmental
Jakub Zdarta, Filip Ciesielczyk, Muhammad Bilal, Katarzyna Jankowska, Karolina Bachosz, Oliwia Degorska, Agnieszka Rybarczyk, Teofil Jesionowski, Anne S. Meyer
Summary: Synthetic hormones are dangerous pollutants that pose risks to the reproductive health of both ecosystems and humans through water, including drinking water. Traditional wastewater treatment methods are not efficient enough. In this study, a new biosystem made of CaSiO3 and laccase was designed and fabricated, and its application for the removal of the synthetic estrogen 17 alpha-ethynylestradiol (EE2) from aqueous systems was demonstrated. The biosystem achieved 100% removal efficiency and showed synergistic degradation through simultaneous adsorption and biocatalytic conversion, with enzymatic conversion dominating.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Mina Sarani, Maryam Roostaee, Mahboubeh Adeli-Sardou, Davood Kalantar-Neyestanaki, Seyed Amin Ayatollahi Mousavi, Azam Amanizadeh, Mahmood Barani, Alireza Amirbeigi
Summary: This study successfully synthesized nano bismuth oxide using green synthesis methods. The nano particles doped with silver and copper demonstrated excellent antibacterial properties and selective cytotoxicity against cancer cells. These findings have important implications for biomedical and therapeutic applications.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Chemistry, Applied
Despina A. Gkika, Georgios Maliaris, Nick Vordos, Athanasios C. Mitropoulos, George Z. Kyzas
Summary: This study explores the challenges faced by laboratories using 3D printing technology, highlighting the relationship between safety and economics in decision-making processes. Qualitative and quantitative methods were used to address the challenges in manufacturing 3D printed biomedical products. The study reveals that labor cost is the most significant parameter impacting the total cost of ownership for 3D printing.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2023)