Review
Immunology
Wenxian Wu, Xiumei Luo, Maozhi Ren
Summary: This review analyzes the role of autophagy in antiviral defenses in animals and plants, as well as how viruses evade host immune responses by disrupting and manipulating host autophagy. The review provides novel insights into the role of autophagy in virus-host interactions and offers potential targets for the prevention and control of viral infection in both plants and animals.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Mariko Naito, B. Ross Belvin, Mikio Shoji, Qin Gui, Janina P. Lewis
Summary: The study reported the first mutant in the P. intermedia OMA14 strain, which is severely impaired in its ability to grow with host cells and oxidative stress. Transcriptome analysis revealed that the major deregulated genes are involved in the alkylhydroperoxide reductase system and other related proteins.
Review
Clinical Neurology
Yong-hui Jia, Yu-bo Dong, Hai-yin Jiang, Ai-juan Li
Summary: A meta-analysis suggests that herpes zoster vaccination can decrease the risk of stroke, while antiviral treatment does not. In summary, herpes zoster vaccination can prevent stroke.
FRONTIERS IN NEUROLOGY
(2023)
Review
Microbiology
Krzysztof Grzymajlo
Summary: This review sheds light on the current understanding of the interactions between enteric pathogens, host gut microbiota, and the gastrointestinal tract. It discusses the strengths and limitations of in vitro and in vivo models used in studying Salmonella-host-microbiome interactions, and outlines future challenges and directions.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Asahiro Morishita, Kyoko Oura, Tomoko Tadokoro, Koji Fujita, Joji Tani, Tsutomu Masaki
Summary: The liver is a non-immunological organ involved in metabolic activities, nutrient storage, and detoxification. Resident immune cells in the liver drive immunological reactions and certain microRNAs are associated with the immune response to pathogens, although the exact mechanism of miRNA interference in these interactions remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Gerwyn Morris, Maria Gevezova, Victoria Sarafian, Michael Maes
Summary: The immune-inflammatory response is associated with increased nitro-oxidative stress. Redox-associated mechanisms play a crucial role in modulating various aspects of the immune response. Chronic nitro-oxidative stress can have detrimental effects on immune cells and their functions.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Microbiology
Sajal Deea Shukla, Tibor Valyi-Nagy
Summary: HSV-1 is a human virus that causes lifelong infections and can lead to various diseases, including blindness and central nervous system diseases. Host molecules play important roles in the infection process, including immune response, autophagy, and inflammation. Understanding the interaction between the virus and host molecules is essential for developing effective treatments.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Ajay Kumar, Vivek P. Varma, Kavela Sridhar, Mohd Abdullah, Pallavi Vyas, Muhammed Ashiq Thalappil, Yung-Fu Chang, Syed M. Faisal
Summary: The study identified the domain A(11) of Leptospira immunoglobulin-like protein A (LAV) as playing a crucial role in modulating host immune responses, leading to persistent infection in different hosts.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Microbiology
Hongyan Guo, Heather S. Koehler, Richard D. Dix, Edward S. Mocarski
Summary: HSV1 is a common human pathogen that can cause oral and ocular diseases. Host immune mechanisms and cell death pathways play important roles in controlling HSV1 infection, while the virus has evolved strategies to evade host cell death.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Felix Kwame Amevor, Zhifu Cui, Xiaxia Du, Zifan Ning, Xun Deng, Dan Xu, Gang Shu, Youhao Wu, Xueqing Cao, Wei Shuo, Yaofu Tian, Diyan Li, Yan Wang, Yao Zhang, Xiaohui Du, Qing Zhu, Xue Han, Xiaoling Zhao
Summary: This study investigated the effects of dietary combination of quercetin (Q) and vitamin E (VE) on the intestinal structure and barrier integrity in aged breeder chickens. The results showed that Q+VE had synergistic effects on intestinal morphology, reduced intestinal inflammatory damage, and increased the expression of tight junction proteins and anti-inflammatory genes. Q+VE also protected the small intestine from oxidative damage. These findings suggest that Q+VE can improve intestinal function in aged breeder hens.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Junghwan Lee, Chang-Hwa Song
Summary: Oxidative stress plays a crucial role in innate immunity against pathogens, with ROS directly attacking pathogens, regulating immune signals, inducing autophagy, and activating inflammation. The production of ROS by pathogens not only affects cell death but also the endoplasmic reticulum and mitochondria. The regulation of host defense mechanisms by ROS and the interaction between microbial pathogen-induced ROS and the ER and mitochondria remain unclear.
Article
Immunology
Yang Fang, Yi Yang, Chengcheng Liu
Summary: This study proposes a new method to extract features from phylogenetic profiles for predicting pathogen-host interactions (PHIs). The performance of this approach is better than structure-based and machine learning-based methods, and combining phylogenetic profile features with structure-based methods can be applied to explore PHI and discover new unknown biological relationships.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wenjie Yang, Yang Li, Diana Boraschi
Summary: Plastic pollution is a global problem that poses risks to the environment and human health. Discarded plastic degrades into microplastics (MPs) in the environment, which can interact with microorganisms and biomolecules. These interactions can modify the characteristics of microbes and biomolecules, potentially affecting the immune response and leading to risks to human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Gianluca Pandolfo, Giovanni Genovese, Antonio Bruno, Domenica Campolo, Valeria Tigano, Mariateresa Cristani, Marco Casciaro, Giovanni Pioggia, Sebastiano Gangemi
Summary: The pathophysiology of schizophrenia is still not well understood. Genetic factors and oxidative stress play key roles in its development and progression. Oxidative stress leads to the continuous production of oxidation products, such as AGEs and AOPPs, which interact with their receptors, amplifying the production of reactive oxygen species (ROS) and pro-inflammatory cytokines. In this study, plasma levels of AGEs and AOPPs were found to be significantly higher in schizophrenia patients compared to controls, confirming their involvement in mental disorders. Antioxidant nutraceuticals and a healthy lifestyle could reduce oxidative stress and alleviate schizophrenia symptoms.
PSYCHIATRY RESEARCH
(2022)
Review
Parasitology
Seyed Mostafa Razavi, Mohammad Sajjad Soltan, Kiarash Abbasian, Ali Karami, Saeed Nazifi
Summary: This review article summarizes studies on the oxidative stress caused by Piroplasmida in domestic animals. The findings suggest that piroplasmosis infections result in oxidative stress in the host, and the oxidative injury plays a fundamental role in their pathogenicity. Further research is needed to investigate the specific role of oxidative stress, the use of more sensitive diagnostic biomarkers, and the potential therapeutic role of antioxidant agents in piroplasmosis.
VETERINARY PARASITOLOGY
(2023)
Article
Biodiversity Conservation
Daniele Canestrelli, Roberta Bisconti, Anita Liparoto, Frederic Angelier, Cecile Ribout, Claudio Carere, David Costantini
Article
Physiology
David Costantini, Shelly Masi, Lyna Rachid, Marielle Beltrame, Melanie Rohmer, Sabrina Krief
Summary: This study investigated the impact of dietary antioxidants on oxidative status in chimpanzees. The results showed that a decrease in dietary antioxidants increased oxidative damages, while an increase had no effect. Older and higher-ranking chimpanzees had lower levels of oxidative damage, suggesting individual factors play a role in oxidative status.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Opale Coutant, Cecile Richard-Hansen, Benoit de Thoisy, Jean-Baptiste Decotte, Alice Valentini, Tony Dejean, Regis Vigouroux, Jerome Murienne, Sebastien Brosse
Summary: The study found that aquatic eDNA metabarcoding has the potential to inventory mammals in Neotropical environments, providing additional data for diurnal nonaquatic species and detecting species not found in line transect surveys, such as semi-aquatic, aquatic and nocturnal terrestrial and arboreal species. Although further developments are needed, eDNA can be used as a complement to traditional surveys.
MOLECULAR ECOLOGY RESOURCES
(2021)
Article
Infectious Diseases
Edith Darcissac, Damien Donato, Benoit de Thoisy, Vincent Lacoste, Anne Lavergne
Summary: The study identified various paramyxoviruses in bats from French Guiana and revealed cross-infection of paramyxoviruses among different bat species. The results suggest a wide distribution of paramyxoviruses in Central to South America, highlighting the potential risk of cross-species transmission that warrants further investigation.
INFECTION GENETICS AND EVOLUTION
(2021)
Article
Virology
Sourakhata Tirera, Benoit de Thoisy, Damien Donato, Christiane Bouchier, Vincent Lacoste, Alain Franc, Anne Lavergne
Summary: The study characterized viral diversity in seven neotropical rodent species and explored the impact of environmental disturbance on this diversity. The results showed that viral diversity was greater in pristine habitats, lowest in peri-urban areas, and highest in savannah regions. Phylogenetic analysis highlighted the wide diversity of vertebrate-related viral families and potential transmission risks to humans. The findings provide insights into rodent virus diversity in Amazonia and emphasize the role of habitats and host dietary ecology in driving viral diversity.
Article
Environmental Sciences
Marion Cheron, David Costantini, Frederic Angelier, Cecile Ribout, Francois Brischoux
Summary: This study investigated the impact of AMPA on tadpole embryonic development, finding non-monotonic effects on oxidative status markers and suggesting that oxidative imbalance may lead to reduced hatching success.
Article
Zoology
Roberta Bisconti, Claudio Carere, David Costantini, Anita Liparoto, Andrea Chiocchio, Daniele Canestrelli
Summary: Recent studies have shown that personality and locomotory performance traits are important for dispersal syndromes and can evolve during range expansions and colonization. However, little is known about the effects of island colonization on these traits and how they contribute to colonization. In this study, we investigated the contribution of island colonization triggered by postglacial range expansions to intraspecific variation in personality and locomotory performance traits in the Tyrrhenian tree frog. We found that individuals from the recently colonized island were bolder, while individuals from the main island showed higher jumping and stickiness performance.
Article
Engineering, Environmental
Evgenios Agathokleous, Damia Barcelo, Michael Aschner, Ricardo Antunes Azevedo, Prosun Bhattacharya, David Costantini, G. Christopher Cutler, Alessandra De Marco, Anca Oana Docea, Jose G. Dorea, Stephen O. Duke, Thomas Efferth, Despo Fatta-Kassinos, Vasileios Fotopoulos, Antonio Ginebreda, Raul Narciso C. Guedes, A. . Wallace Hayes, Ivo Iavicoli, Olga-Ioanna Kalantzi, Takayoshi Koike, Demetrios Kouretas, Manish Kumar, Jose E. Manautou, Michael N. Moore, Elena Paoletti, Josep Penuelas, Yolanda Pico, Russel J. Reiter, Ramin Rezaee, Jorg Rinklebe, Teresa Rocha-Santos, Pierre Sicard, Christian Sonne, Christopher Teaf, Aristidis Tsatsakis, Alexander I. . Vardavas, Wenjie Wang, Eddy Y. Zeng, Edward J. Calabrese
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Angela M. Early, Flavia Camponovo, Stephane Pelleau, Gustavo C. Cerqueira, Yassamine Lazrek, Beatrice Volney, Manuela Carrasquilla, Benoit de Thoisy, Caroline O. Buckee, Lauren M. Childs, Lise Musset, Daniel E. Neafsey
Summary: This study investigates the impact of declining infection rates on the investment of Plasmodium falciparum in sexual and asexual growth. Using a mathematical model and analyzing parasite genomes collected over an 18-year period, the study confirms the model's predictions and highlights the wide-ranging selection pressures imposed by public health interventions on basic parasite life history traits.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Physiology
Heiko G. Rodel, Veridiana Jardim, Marylin Rangassamy, Ludivine Jaravel, Daphne Jacquet, Raquel Monclus, Christophe Feron, David Costantini
Summary: It is increasingly recognized that alterations of the cellular oxidative status might be an important cost underlying challenging early life conditions. This study investigated the long-term consequences of early life parameters on the oxidative status in mature mice, and found complex interactions between early life conditions, personality, and oxidative status.
PHYSIOLOGICAL REPORTS
(2022)
Review
Virology
Timothee Bonifay, Paul Le Turnier, Yanouk Epelboin, Luisiane Carvalho, Benoit De Thoisy, Felix Djossou, Jean-Bernard Duchemin, Philippe Dussart, Antoine Enfissi, Anne Lavergne, Remi Mutricy, Mathieu Nacher, Sebastien Rabier, Stanislas Talaga, Antoine Talarmin, Dominique Rousset, Loic Epelboin
Summary: French Guiana (FG), a French overseas territory in South America, is vulnerable to tropical diseases caused by arboviruses. The tropical climate facilitates the breeding and establishment of vectors, making it difficult to control transmission. In recent years, FG has experienced outbreaks of imported arboviruses like Chikungunya and Zika, as well as endemic arboviruses such as dengue, Yellow fever, and Oropouche virus. This article aims to summarize the current knowledge of these arboviruses in FG and discuss the challenges associated with their emergence and reemergence.
Article
Infectious Diseases
Jean-Francois Guegan, Loic Epelboin, Maylis Douine, Paul Le Turnier, Olivier Duron, Lise Musset, Christine Chevillon, Philippe Quenel, Mark Eric Benbow, Benoit de Thoisy
Summary: In response to complex and intersecting public health challenges, there is an increasing demand for inter-and transdisciplinary research. This article presents the experience in French Guiana of conducting research on vector-borne and zoonotic infectious diseases, emphasizing the dissolution of disciplinary boundaries and the importance of local conditions and support from research and medical institutions in promoting inter-and transdisciplinary science. The goal is to improve public health responses in French Guiana and other regions.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Fisheries
Flore Emonnot, Blandine Siegrist, Amandine Bordin, Virginie Dos Reis, Damien Chevallier, Yannick Estevez, Benoit de Thoisy
Summary: Plastic pollution has become a significant environmental issue, as evidenced by the presence of macroplastics and microplastics in stranded animals on the coast of French Guiana. The study suggests that plastic pollution has affected a wide range of marine vertebrates in the region.
LATIN AMERICAN JOURNAL OF AQUATIC RESEARCH
(2023)
Article
Microbiology
Sophie Teullet, Marie-Ka Tilak, Amandine Magdeleine, Roxane Schaub, Nora M. Weyer, Wendy Panaino, Andrea Fuller, W. J. Loughry, Nico L. Avenant, Benoit de Thoisy, Guillaume Borrel, Frederic Delsuc
Summary: The consumption of ants and termites by myrmecophagous mammals is an example of dietary convergence. The gut microbiome of these mammals plays an important role in their dietary adaptation, particularly the digestion of chitinous exoskeletons. By sequencing fecal samples, researchers identified chitin-degrading bacteria in the gut microbiota of myrmecophagous species, highlighting the potential role of these bacteria in their convergent adaptation to ant and termite consumption.
Article
Ecology
Maria Cristina Lorenzi, Franco G. Robles-Guerrero, David Costantini
Summary: Measuring reproductive costs is crucial to understanding sexual conflict and its evolutionary outcomes. In this study, hermaphroditic worms were exposed to different social conditions to measure reproductive costs. It was found that hermaphrodites that invested relatively more in the female function produced fewer eggs but had higher levels of antioxidant protection. This suggests that in the short-term, male competition might be costlier than egg production in terms of regulation of oxidative status.
