标题
The promise of mTOR as a therapeutic target pathway in idiopathic pulmonary fibrosis
作者
关键词
-
出版物
European Respiratory Review
Volume 29, Issue 157, Pages 200269
出版商
European Respiratory Society (ERS)
发表日期
2020-10-16
DOI
10.1183/16000617.0269-2020
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Recent Insights Into SREBP as a Direct Mediator of Kidney Fibrosis via Lipid-Independent Pathways
- (2020) Debra Dorotea et al. Frontiers in Pharmacology
- Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism
- (2019) Rebecca Bertolio et al. Nature Communications
- A randomised, placebo-controlled study of omipalisib (PI3K/mTOR) in idiopathic pulmonary fibrosis
- (2019) Pauline T. Lukey et al. EUROPEAN RESPIRATORY JOURNAL
- Activation of mTORC1/PGC1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium
- (2019) Ross Summer et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1–induced collagen biosynthesis
- (2019) Brintha Selvarajah et al. Science Signaling
- Targeting mTOR for cancer therapy
- (2019) Hui Hua et al. Journal of Hematology & Oncology
- Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases
- (2019) Boris Hinz et al. Nature Reviews Rheumatology
- Glutaminolysis Promotes Collagen Translation and Stability via α-Ketoglutarate–mediated mTOR Activation and Proline Hydroxylation
- (2018) Jing Ge et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Fatty acid synthase is required for profibrotic TGF-β signaling
- (2018) Mi-Yeon Jung et al. FASEB JOURNAL
- A small molecule inhibitor of Rheb selectively targets mTORC1 signaling
- (2018) Sarah J. Mahoney et al. Nature Communications
- Glutaminolysis Epigenetically Regulates Anti-Apoptotic Gene Expression in IPF Fibroblasts
- (2018) Le Bai et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis
- (2018) Hannah V. Woodcock et al. Nature Communications
- Glutaminolysis is required for transforming growth factor-β1–induced myofibroblast differentiation and activation
- (2017) Karen Bernard et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cellular senescence mediates fibrotic pulmonary disease
- (2017) Marissa J. Schafer et al. Nature Communications
- mTORC1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts
- (2016) Yair Romero et al. AGING CELL
- Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF
- (2016) Paul F Mercer et al. THORAX
- Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis
- (2015) Na Xie et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs
- (2015) Cheresa Calhoun et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
- (2015) Remi-Martin Laberge et al. NATURE CELL BIOLOGY
- Differential regulation of mTORC1 by leucine and glutamine
- (2015) J. L. Jewell et al. SCIENCE
- Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2
- (2014) Constantinos Demetriades et al. CELL
- The burden of idiopathic pulmonary fibrosis: An unmet public health need
- (2014) Augustine S. Lee et al. RESPIRATORY MEDICINE
- Strategies for the management of adverse events associated with mTOR inhibitors
- (2014) Bruce Kaplan et al. Transplantation Reviews
- mTOR kinase inhibitors as potential cancer therapeutic drugs
- (2013) Shi-Yong Sun CANCER LETTERS
- Areas of normal pulmonary parenchyma on HRCT exhibit increased FDG PET signal in IPF patients
- (2013) Thida Win et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin
- (2013) S. A. Kang et al. SCIENCE
- The myofibroblast matrix: implications for tissue repair and fibrosis
- (2012) Franco Klingberg et al. JOURNAL OF PATHOLOGY
- Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
- (2012) D. W. Lamming et al. SCIENCE
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- An investigator-driven study of everolimus in surgical lung biopsy confirmed idiopathic pulmonary fibrosis
- (2011) MONIQUE A. MALOUF et al. RESPIROLOGY
- Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
- (2010) Yasemin Sancak et al. CELL
- Phosphoinositide 3-kinase γ plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice
- (2010) Remo C. Russo et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition
- (2010) Calvin K. Yip et al. MOLECULAR CELL
- A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1
- (2009) Jingxiang Huang et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Non-Smad pathways in TGF-β signaling
- (2008) Ying E Zhang CELL RESEARCH
- Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis
- (2008) Hong Xia et al. JOURNAL OF EXPERIMENTAL MEDICINE
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