Article
Engineering, Biomedical
Lin Huang, Wantao Wang, Yiwen Xian, Lei Liu, Jinghao Fan, Hongmei Liu, Zhaomin Zheng, Decheng Wu
Summary: This study reported a rapidly forming injectable chitosan/PEG hydrogel (CSMA-PEGDA-L) that can retard the progression of intervertebral disc (IVD) degeneration. The hydrogel demonstrated strong compressive strength and low cytotoxicity. When implanted on the punctured IVD of rats, it effectively slowed down the degenerative changes.
MATERIALS TODAY BIO
(2023)
Article
Nanoscience & Nanotechnology
Jixing Ye, Ningyuan Liu, Zongxin Li, Liehua Liu, Ming Zheng, Xueping Wen, Nan Wang, Yanqin Xu, Biemin Sun, Qiang Zhou
Summary: In this study, an injectable, hierarchically degradable bioactive scaffold was developed to simulate the natural process of autologous bone repair. The scaffold exhibited superior mechanical properties and promoted cell proliferation and osteogenic differentiation. It provided even and complete repair of bone defects and showed promising potential for bone regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biotechnology & Applied Microbiology
Shuai Chang, Chao Li, Nanfang Xu, Jiedong Wang, Zehao Jing, Hong Cai, Yun Tian, Shaobo Wang, Zhongjun Liu, Xing Wang
Summary: The construction of a tetra-PEG hydrogel with sustained drug release capability has shown promising potential in treating bone defects by promoting stem cell growth and bone regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chengkun Liu, Chang Liu, Zhiyuan Liu, Zhuang Shi, Shihai Liu, Xiaojuan Wang, Xiaoqiang Wang, Fang Huang
Summary: A thermogelling chitosan/glycerophosphate formulation was developed by incorporating dihydrocaffeic acid (DHCA), which significantly enhanced gel-forming capacity and tissue adherence. The thermosensitive hydrogels showed improved hemostasis and reduced blood loss in both in vitro and in vivo models. The results demonstrated the potential of enhancing thermogelling and bioadhesion of chitosan-based hydrogels through noncovalent supramolecular mechanisms.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Fereshteh Kazemi-Aghdam, Vahid Jahed, Maryam Dehghan-Niri, Fariba Ganji, Ebrahim Vasheghani-Farahani
Summary: The study developed an injectable chitosan hydrogel with enhanced mechanical strength and osteoinductivity by synthesizing chitosan-modified halloysite nanotubes and loading bone inducer. The resulting scaffold showed improved biocompatibility and promoted proliferation and differentiation of bone cells, making it a promising candidate for bone regeneration.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Baharak Divband, Marziyeh Aghazadeh, Zahraa Haleem Al-qaim, Mohammad Samiei, Falah H. Hussein, Alireza Shaabani, Shahriar Shahi, Roya Sedghi
Summary: Injectable hydrogels loaded with VEGF and BMP-2 promote proliferation and osteogenic differentiation of DPSCs, showing potential for bone defect treatment.
CARBOHYDRATE POLYMERS
(2021)
Article
Multidisciplinary Sciences
Jiawei Li, Huiming Jiang, Zhongyang Lv, Ziying Sun, Chaoqun Cheng, Guihua Tan, Maochun Wang, Anlong Liu, Heng Sun, Hu Guo, Fufei Chen, Zizheng Liu, Yuxiang Fei, Yuan Liu, Rui Wu, Xingquan Xu, Wenjin Yan, Qing Jiang, Dongquan Shi
Summary: This study proposed a new strategy for cartilage regeneration by hyalinizing fibrocartilage through stabilizing the cytoskeleton. The use of docetaxel was found to inhibit cartilage fibrosis and promote the regeneration of hyaline cartilage.
Review
Pharmacology & Pharmacy
Yevgeniy Kim, Zharylkasyn Zharkinbekov, Kamila Raziyeva, Laura Tabyldiyeva, Kamila Berikova, Dias Zhumagul, Kamila Temirkhanova, Arman Saparov
Summary: Chitosan, a biopolymer derived from chitin, has great potential for tissue regeneration and controlled drug delivery. It possesses qualities such as biocompatibility, low toxicity, and antimicrobial activity, making it attractive for biomedical applications. Chitosan can be fabricated into different structures, including nanoparticles, scaffolds, hydrogels, and membranes, which can be customized for specific outcomes. It has been shown to stimulate tissue regeneration and repair in various tissues and organs, and is an efficient carrier for medications, genes, and bioactive compounds.
Article
Pharmacology & Pharmacy
Mu Hu, Jielai Yang, Jihai Xu
Summary: The new CS/HA/Si-HPMC composite hydrogels, synthesized without the addition of a chemical crosslinking agent, show promising physical and biological properties for cartilage tissue engineering. The proper amount of Si-HPMC in the hydrogels enhances proliferation and deposition of the cartilage extracellular matrix, leading to relatively good in vivo bone regeneration. These hydrogels are potential candidates for tissue compatibility injectable scaffolds aimed at repairing joint cartilage using a tissue-engineered approach.
Article
Engineering, Biomedical
Liwen Zheng, Yaxian Liu, Lin Jiang, Xiaoping Wang, Yuqin Chen, Lan Li, Mingyu Song, Hongmei Zhang, Yu Shrike Zhang, Ximu Zhang
Summary: This study proposes a new strategy for pulp regeneration by using hydrogel microspheres incorporated with decellularized dental pulp matrix-derived bioactive factors to simulate a pulp-specific three-dimensional microenvironment. The constructed microspheres exhibit favorable plasticity, biocompatibility, and biological performances, and hDPSCs cultured on the microspheres demonstrate enhanced pulp-formation ability. In vivo experiments show that the microspheres facilitate the regeneration of pulp-like tissue and new dentin. The decellularized pulp matrix-derived bioactive factors mediate the multi-directional differentiation of hDPSCs to regenerate the pulp tissue.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Negin Khaneh Zarrin, Fatemeh Mottaghitalab, Rui L. Reis, Subhas C. Kundu, Mehdi Farokhi
Summary: This study demonstrates the use of injectable hydrogels for treating bone defects, which showed significant enhancement of bone healing in aged rat models. The injectable hydrogels contain thermosensitive nanoparticles, simvastatin acid, and vitamin C, and exhibit good biocompatibility and biodegradability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biotechnology & Applied Microbiology
Jianhua Yang, Xiaoguang Jing, Zimin Wang, Xuejian Liu, Xiaofeng Zhu, Tao Lei, Xu Li, Weimin Guo, Haijun Rao, Mingxue Chen, Kai Luan, Xiang Sui, Yen Wei, Shuyun Liu, Quanyi Guo
Summary: The study comprehensively analyzed the physical properties and cytocompatibility of hydrogels as cell carriers for ADSC transplantation. Rat models of articular cartilage defect were treated with GCS/DF-PEG hydrogel, showing potential for repairing injured cartilage.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Shaowei Pan, Zhaowei Yin, Chen Shi, Haonan Xiu, Guanfu Wu, Yongyuan Heng, Zhangyu Zhu, Jing Zhang, Jianchao Gui, Ziyi Yu, Bin Liang
Summary: The study investigated the enhancement of osteogenic and angiogenic potential of Exosomes through overexpression of exosomal miRNA (microRNA) and the long-term effects of Exos loaded in HMPs (Hydrogel microparticles) on new bone formation. The research demonstrated that miR-29a overexpression inhibited HDAC4 and upregulated RUNX2 and VEGF, enhancing the osteogenic and angiogenic capabilities. The synthesized HMP@Exo system showed good injectability, compatibility, and cell adhesion properties, with sustained release of Agomir-29a-Exos enhancing cell proliferation, migration, osteogenesis, and angiogenesis. Overall, the injectable HMP@Exo system provides an innovative approach for coupling osteogenesis and angiogenesis, promoting fracture healing.
Article
Polymer Science
Naiwen Tan, Maja Sabalic-Schoener, Linh Nguyen, Francesco D'Aiuto
Summary: Injectable biomaterials have great potential in dental tissue regeneration. This study successfully prepared an injectable thermosensitive beta-TCP and chitosan hydrogel, and demonstrated its feasibility and biocompatibility in periodontal tissue regeneration.
Article
Engineering, Biomedical
Jieliang Shen, Ao Chen, Zhengwei Cai, Zhijie Chen, Ruichao Cao, Zongchao Liu, Yuling Li, Jie Hao
Summary: A injectable microsphere (MS@MCL) for local lactate exhaustion was developed by grafting a composite nanozyme on microspheres, achieving a long-term lactate exhaustion effect. The microspheres synthesized by microfluidic technology is beneficial for injection therapy and improving encapsulation efficiency. The MS@MCL showed potential in eliminating oxidative stress, promoting extracellular matrix metabolism and cell survival.
BIOACTIVE MATERIALS
(2022)
Article
Clinical Neurology
Jiankun Wen, Changgui Shi, Lei Yu, Shuang Wang, Yanhai Xi, Xiaojian Ye
WORLD NEUROSURGERY
(2020)
Article
Clinical Neurology
Changgui Shi, Yanhai Xi, Bin Sun, Hailong He, Jiankun Wen, Yushan Ruan, Xiaojian Ye
Summary: This study reported a case of titanium allergy symptoms after ACDF surgery using Zero-P device.
BRITISH JOURNAL OF NEUROSURGERY
(2023)
Article
Cell Biology
Sujun Qiu, Changgui Shi, Arivarasu Natarajan Anbazhagan, Vaskar Das, Vipin Arora, Kc Ranjan, Xin Li, InSug O-Sullivan, Andre van Wijnen, Sudhakar Chintharlapalli, Gina Gott-Velis, Ripper Richard, Fackson Mwale, Masabumi Shibuya, Shaoxiong Min, Hee-Jeong Im
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Review
Clinical Neurology
Bingqian Zhu, Changgui Shi, Chang G. Park, Sirimon Reutrakul
Article
Orthopedics
Bin Sun, Huiqiao Wu, Zeng Xu, Jiajia Lu, Yunhao Wang, Ke Zhang, Xiaoxiang Gao, Xiaolong Shen, Xiao-Dong Wu, Ying Zhang, Xin Gu, Changgui Shi, Wen Yuan
INTERNATIONAL ORTHOPAEDICS
(2020)
Article
Biotechnology & Applied Microbiology
Changgui Shi, Bin Sun, Chao Ma, Huiqiao Wu, Rui Chen, Hailong He, Ying Zhang
Summary: This study compared the effects of SrR and Aln treatment in a mouse model of OI, finding that both had comparable effects on reducing fractures and improving bone mass and strength. SrR may be considered as an option for patients with OI when other medications are not suitable or have evident contraindications in clinical practice.
BIOMED RESEARCH INTERNATIONAL
(2021)
Review
Critical Care Medicine
Changgui Shi, Song Li, Zhinong Wang, Hongliang Shen
Summary: Non-compressible hemorrhage in junctional areas and torso is life-threatening. Different techniques like EAC, AAJT, and REBOA have been used for prehospital control, with EAC being cost-effective and readily available, while AAJT and REBOA requiring more training but showing potential for better hemorrhage management.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Review
Cardiac & Cardiovascular Systems
Bingqian Zhu, You Yin, Changgui Shi, Jindarat Chaiard, Chang G. Park, Xiangfang Chen, Bilgay Izci-Balserak
Summary: Sleep extension can increase total sleep time and show promise for reducing 24 h mean blood pressure among those with pre-hypertension or hypertension. More large-scale studies are needed to examine its long-term effects.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2022)
Article
Engineering, Biomedical
Changgui Shi, Bin Sun, Guoke Tang, Ning Xu, Hailong He, Xiaojian Ye, Guohua Xu, Xin Gu
Summary: For endoscopic surgery treating lumbar foraminal stenosis, using preoperative planning software can reduce puncture-channel establishment time, operation time, and the number of intraoperative fluoroscopic images taken without affecting the clinical outcomes.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2021)
Article
Pharmacology & Pharmacy
Yanhai Xi, Weiheng Wang, Liang Ma, Ning Xu, Changgui Shi, Guohua Xu, Hailong He, Wenming Pan
Summary: A novel nano-carrier with bone targeting, AS-AL-mPEG-PLGA, was successfully prepared to enhance the oral bioavailability, bone targeting, and anti-osteoporotic effect of AS.
Article
Chemistry, Multidisciplinary
Guoke Tang, Liang Zhu, Weiheng Wang, Dongqing Zuo, Changgui Shi, Xiaojie Yu, Rui Chen
Summary: The development of functional double-network hydrogel scaffolds for bone regeneration is of great significance. These hydrogel scaffolds show excellent biocompatibility, biomechanical properties, and bioactivity, and they are capable of on-demand drug release to promote cell proliferation and osteogenic differentiation.
FRONTIERS IN CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Changgui Shi, Bin Sun, Huiqiao Wu, Rongcheng Zhang, Lecheng Wu, Lei Guo, Changwei Li, Yanhai Xi, Wen Yuan, Ying Zhang, Guohua Xu
Summary: This study revealed that dysfunction of caveolae-mediated endocytic T beta RI degradation enhances TGF-beta/Smad signaling in the osteogenesis imperfecta (OI) mouse model. Treatment with a T beta RI kinase inhibitor effectively reduces fractures and improves bone mass and strength in OI, suggesting a new therapeutic strategy for OI.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Anesthesiology
Changgui Shi, Xin Gu, Yanyan Zhou, Bin Sun, Junqiang Qi, Yanhai Xi, Hailong He, Guohua Xu
Summary: The study examined the clinical and radiographic outcomes of percutaneous endoscopic lumbar discectomy (PELD) assisted with sequential selective nerve root block (SNRB) in patients with lumbosacral contiguous double-level disc herniation. The results showed that sequential SNRB from S1 to L5 was an effective approach to guide PELD treatment, resulting in significant improvement in clinical symptoms for patients.
Article
Anesthesiology
Changgui Shi, Ning Xu, Bin Sun, Rui Chen, Hailong He, Guohua Xu, Xiaojian Ye, Xin Gu
Summary: A retrospective study was conducted on 30 patients with diagnostic uncertainty of cervical radiculopathy who underwent PPECFD assisted with SNRB, showing that diagnostic SNRB can effectively help identify the cause of radicular pain. Postoperatively, patients' symptoms significantly improved, and most patients achieved good surgical outcomes.