Circulating Mitochondrial-Derived Vesicles, Inflammatory Biomarkers and Amino Acids in Older Adults With Physical Frailty and Sarcopenia: A Preliminary BIOSPHERE Multi-Marker Study Using Sequential and Orthogonalized Covariance Selection – Linear Discriminant Analysis

Myopathy reversion in mice after restauration of mitochondrial complex I

(2020) Claudia V Pereira et al.   EMBO Molecular Medicine

Gut microbiota compositional and functional fingerprint in patients with alcohol use disorder and alcohol‐associated liver disease

(2020) Giovanni Addolorato et al.   LIVER INTERNATIONAL

Identification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study

(2020) Riccardo Calvani et al.   Nutrients

Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson’s Disease: Results from the EXosomes in PArkiNson’s Disease (EXPAND) Study

(2020) Anna Picca et al.   Journal of Clinical Medicine

Older Adults with Physical Frailty and Sarcopenia Show Increased Levels of Circulating Small Extracellular Vesicles with a Specific Mitochondrial Signature

(2020) Anna Picca et al.   Cells

Identification of biomarkers for physical frailty and sarcopenia through a new multi-marker approach: results from the BIOSPHERE study

(2020) Riccardo Calvani et al.   GeroScience

SO‐CovSel: A novel method for variable selection in a multiblock framework

(2019) Alessandra Biancolillo et al.   JOURNAL OF CHEMOMETRICS

Mitochondrial-Derived Vesicles as Candidate Biomarkers in Parkinson’s Disease: Rationale, Design and Methods of the EXosomes in PArkiNson Disease (EXPAND) Study

(2019) Anna Picca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inflammatory signatures in older persons with physical frailty and sarcopenia: The frailty “cytokinome” at its core

(2019) Emanuele Marzetti et al.   EXPERIMENTAL GERONTOLOGY

Phosphatidylserine decarboxylase is critical for the maintenance of skeletal muscle mitochondrial integrity and muscle mass

(2019) Ahrathy Selathurai et al.   Molecular Metabolism

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Gut Microbial, Inflammatory and Metabolic Signatures in Older People with Physical Frailty and Sarcopenia: Results from the BIOSPHERE Study

(2019) Anna Picca et al.   Nutrients

Update on mitochondria and muscle aging: all wrong roads lead to sarcopenia

(2018) Anna Picca et al.   BIOLOGICAL CHEMISTRY

Sarcopenia: An Overview on Current Definitions, Diagnosis and Treatment

(2018) Francesco Landi et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Biomarkers for Sarcopenia: Reductionism vs. Complexity

(2018) Riccardo Calvani et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

The “BIOmarkers associated with Sarcopenia and PHysical frailty in EldeRly pErsons” (BIOSPHERE) study: Rationale, design and methods

(2018) Riccardo Calvani et al.   European Journal of Internal Medicine

The risks of biomarker-based epidemiology: Associations of circulating calcium levels with age, mortality, and frailty vary substantially across populations

(2018) Alan A. Cohen et al.   EXPERIMENTAL GERONTOLOGY

Hepatocellular carcinoma is associated with gut microbiota profile and inflammation in nonalcoholic fatty liver disease

(2018) Francesca Romana Ponziani et al.   HEPATOLOGY

Circulating Mitochondrial DNA at the Crossroads of Mitochondrial Dysfunction and Inflammation During Aging and Muscle Wasting Disorders

(2018) Anna Picca et al.   REJUVENATION RESEARCH

The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants

(2018) Emanuele Marzetti et al.   EXPERIMENTAL GERONTOLOGY

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

(2018) Claudio Franceschi et al.   Nature Reviews Endocrinology

A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup

(2018) Jamie N. Justice et al.   GeroScience

Influence of hepatitis C virus eradication with direct-acting antivirals on the gut microbiota in patients with cirrhosis

(2018) Francesca Romana Ponziani et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

A Distinct Pattern of Circulating Amino Acids Characterizes Older Persons with Physical Frailty and Sarcopenia: Results from the BIOSPHERE Study

(2018) Riccardo Calvani et al.   Nutrients

Mitochondrial dynamics signaling is shifted toward fusion in muscles of very old hip-fractured patients: Results from the Sarcopenia in HIp FracTure (SHIFT) exploratory study

(2017) Anna Picca et al.   EXPERIMENTAL GERONTOLOGY

Fueling Inflamm-Aging through Mitochondrial Dysfunction: Mechanisms and Molecular Targets

(2017) Anna Picca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Frailty Status in Older Adults Is Related to Alterations in Indoleamine 2,3-Dioxygenase 1 and Guanosine Triphosphate Cyclohydrolase I Enzymatic Pathways

(2017) Diego Marcos-Pérez et al.   Journal of the American Medical Directors Association

Ethanolamine and Phosphatidylethanolamine: Partners in Health and Disease

(2017) Dhaval Patel et al.   Oxidative Medicine and Cellular Longevity

Association between myocyte quality control signaling and sarcopenia in old hip-fractured patients: Results from the Sarcopenia in HIp FracTure (SHIFT) exploratory study

(2016) Emanuele Marzetti et al.   EXPERIMENTAL GERONTOLOGY

Plasma Biomarkers of Poor Muscle Quality in Older Men and Women from the Baltimore Longitudinal Study of Aging

(2016) Ruin Moaddel et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Tryptophan Predicts the Risk for Future Type 2 Diabetes

(2016) Tianlu Chen et al.   PLoS One

The Emergence of Geroscience as an Interdisciplinary Approach to the Enhancement of Health Span and Life Span

(2016) Felipe Sierra   Cold Spring Harbor Perspectives in Medicine

Phosphatidylethanolamine positively regulates autophagy and longevity

(2015) P Rockenfeller et al.   CELL DEATH AND DIFFERENTIATION

Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function

(2015) Katsuhiko Funai et al.   DIABETES

Biomarkers for physical frailty and sarcopenia: state of the science and future developments

(2015) Riccardo Calvani et al.   Journal of Cachexia Sarcopenia and Muscle

The FNIH Sarcopenia Project: Rationale, Study Description, Conference Recommendations, and Final Estimates

(2014) Stephanie A. Studenski et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Expression of mitochondrial fission and fusion regulatory proteins in skeletal muscle during chronic use and disuse

(2013) Sobia Iqbal et al.   MUSCLE & NERVE

A Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes

(2012) Vincent Soubannier et al.   CURRENT BIOLOGY

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

(2011) Dmitri V. Krysko et al.   TRENDS IN IMMUNOLOGY

Tryptophan metabolism, from nutrition to potential therapeutic applications

(2010) Nathalie Le Floc’h et al.   AMINO ACIDS

CovSel: Variable selection for highly multivariate and multi-response calibration

(2010) J.M. Roger et al.   CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

CC family chemokines directly regulate myoblast responses to skeletal muscle injury

(2008) Linda Yahiaoui et al.   JOURNAL OF PHYSIOLOGY-LONDON

Assessment of PLSDA cross validation

(2008) Johan A. Westerhuis et al.   Metabolomics