The early life education of the immune system: Moms, microbes and (missed) opportunities

Neonatal T Cells: A Reinterpretation

(2020) Brian D. Rudd   Annual Review of Immunology

Microbiome Composition in Pediatric Populations from Birth to Adolescence: Impact of Diet and Prebiotic and Probiotic Interventions

(2020) Erin C. Davis et al.   DIGESTIVE DISEASES AND SCIENCES

Viable bacterial colonization is highly limited in the human intestine in utero

(2020) E. Rackaityte et al.   NATURE MEDICINE

Intestinal microbes influence development of thymic lymphocytes in early life

(2020) Maria Ennamorati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Why is COVID‐19 so mild in children?

(2020) Petter Brodin   ACTA PAEDIATRICA

Microbial–host molecular exchange and its functional consequences in early mammalian life

(2020) Stephanie C. Ganal-Vonarburg et al.   SCIENCE

The Interplay Between Reproductive Tract Microbiota and Immunological System in Human Reproduction

(2020) Salwan Al-Nasiry et al.   Frontiers in Immunology

Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973–2016

(2020) Vibeke Andersen et al.   Clinical Epidemiology

AGA Technical Review on the Role of Probiotics in the Management of Gastrointestinal Disorders

(2020) Geoffrey A. Preidis et al.   GASTROENTEROLOGY

Perinatal Interactions between the Microbiome, Immunity, and Neurodevelopment

(2019) Geoffrey N. Pronovost et al.   IMMUNITY

Association between antibiotic treatment during pregnancy and infancy and the development of allergic diseases

(2019) Stefanie Metzler et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult

(2019) Ziad Al Nabhani et al.   IMMUNITY

Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors

(2019) Shirin Moossavi et al.   Cell Host & Microbe

The vaginal microbiome and preterm birth

(2019) Jennifer M. Fettweis et al.   NATURE MEDICINE

Intrauterine Microbiota: Missing, or the Missing Link?

(2019) Helen J. Chen et al.   TRENDS IN NEUROSCIENCES

Perinatal factors affect the gut microbiota up to four years after birth

(2019) Fiona Fouhy et al.   Nature Communications

The good bugs

(2019) Naire Sansotta et al.   CURRENT OPINION IN PEDIATRICS

Human placenta has no microbiome but can contain potential pathogens

(2019) Marcus C. de Goffau et al.   NATURE

Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia

(2019) Mingjing Hu et al.   Nature Communications

Colonization by B. infantis EVC001 modulates enteric inflammation in exclusively breastfed infants

(2019) Bethany M. Henrick et al.   PEDIATRIC RESEARCH

Maturation of the Human Intestinal Immune System Occurs Early in Fetal Development

(2019) Stephanie F. Stras et al.   DEVELOPMENTAL CELL

Decoding human fetal liver haematopoiesis

(2019) Dorin-Mirel Popescu et al.   NATURE

MAIT cells are imprinted by the microbiota in early life and promote tissue repair

(2019) Michael G. Constantinides et al.   SCIENCE

The impact of maternal nutrition on offspring’s risk of non-communicable diseases in adulthood: a systematic review

(2019) Jessie Pullar et al.   Journal of Global Health

Developmental Origin Governs CD8 + T Cell Fate Decisions during Infection

(2018) Norah L. Smith et al.   CELL

Early-Life Antibiotic-Driven Dysbiosis Leads to Dysregulated Vaccine Immune Responses in Mice

(2018) Miriam Anne Lynn et al.   Cell Host & Microbe

Fetal and early life antibiotics exposure and very early onset inflammatory bowel disease: a population-based study

(2018) Anne K Örtqvist et al.   GUT

Hemogenic Endothelial Fate Mapping Reveals Dual Developmental Origin of Mast Cells

(2018) Rebecca Gentek et al.   IMMUNITY

Immune regulation by microbiome metabolites

(2018) Chang H. Kim   IMMUNOLOGY

The influence of probiotics on vaccine responses – A systematic review

(2018) Petra Zimmermann et al.   VACCINE

Initial meconium microbiome in Chinese neonates delivered naturally or by cesarean section

(2018) Yi-Chao Shi et al.   Scientific Reports

Stereotypic Immune System Development in Newborn Children

(2018) Axel Olin et al.   CELL

Antibodies Set Boundaries Limiting Microbial Metabolite Penetration and the Resultant Mammalian Host Response

(2018) Yasuhiro Uchimura et al.   IMMUNITY

Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition

(2018) Marcus Fulde et al.   NATURE

Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors

(2018) Zhiqing Li et al.   IMMUNITY

Commensals Suppress Intestinal Epithelial Cell Retinoic Acid Synthesis to Regulate Interleukin-22 Activity and Prevent Microbial Dysbiosis

(2018) Mayara Grizotte-Lake et al.   IMMUNITY

Temporal development of the gut microbiome in early childhood from the TEDDY study

(2018) Christopher J. Stewart et al.   NATURE

Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity

(2017) Dania Zhivaki et al.   IMMUNITY

Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny

(2017) Tobias R. Kollmann et al.   IMMUNITY

Functional and phenotypic heterogeneity of group 3 innate lymphoid cells

(2017) Felipe Melo-Gonzalez et al.   IMMUNOLOGY

Reduced generation of lung tissue–resident memory T cells during infancy

(2017) Kyra D. Zens et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mode of Delivery and Risk of Celiac Disease: Risk of Celiac Disease and Age at Gluten Introduction Cohort Study

(2017) Elena Lionetti et al.   JOURNAL OF PEDIATRICS

Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2

(2017) Naomi McGovern et al.   NATURE

Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery

(2017) Derrick M Chu et al.   NATURE MEDICINE

First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment

(2017) Simona Saluzzo et al.   Cell Reports

Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo

(2017) Christoph Hirche et al.   Cell Reports

Peripartum Antibiotics Promote Gut Dysbiosis, Loss of Immune Tolerance, and Inflammatory Bowel Disease in Genetically Prone Offspring

(2017) Jun Miyoshi et al.   Cell Reports

Postnatal Innate Immune Development: From Birth to Adulthood

(2017) Anastasia Georgountzou et al.   Frontiers in Immunology

Fetal and adult progenitors give rise to unique populations of CD8+ T cells

(2016) J. Wang et al.   BLOOD

The mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants' life: a systematic review

(2016) Erigene Rutayisire et al.   BMC GASTROENTEROLOGY

Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life

(2016) Meghan A. Koch et al.   CELL

Bacterial Peptidoglycan Traverses the Placenta to Induce Fetal Neuroproliferation and Aberrant Postnatal Behavior

(2016) Jessica Humann et al.   Cell Host & Microbe

Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung

(2016) Ismé M. de Kleer et al.   IMMUNITY

Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens

(2016) Melody Y. Zeng et al.   IMMUNITY

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

Direct TLR-2 Costimulation Unmasks the Proinflammatory Potential of Neonatal CD4+T Cells

(2016) Brian D. Sinnott et al.   JOURNAL OF IMMUNOLOGY

Maternal Antibiotic Treatment Impacts Development of the Neonatal Intestinal Microbiome and Antiviral Immunity

(2016) Gabriela Gonzalez-Perez et al.   JOURNAL OF IMMUNOLOGY

Significant Correlation Between the Infant Gut Microbiome and Rotavirus Vaccine Response in Rural Ghana

(2016) Vanessa C. Harris et al.   JOURNAL OF INFECTIOUS DISEASES

Neonatal colonization of mice with LGG promotes intestinal development and decreases susceptibility to colitis in adulthood

(2016) F Yan et al.   Mucosal Immunology

Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin

(2016) Donghyun Kim et al.   NATURE MEDICINE

The microbiome in early life: implications for health outcomes

(2016) Sabrina Tamburini et al.   NATURE MEDICINE

The maternal microbiota drives early postnatal innate immune development

(2016) M. Gomez de Aguero et al.   SCIENCE

A Critical Look at Prebiotics Within the Dietary Fiber Concept

(2016) Joran Verspreet et al.   Annual Review of Food Science and Technology

Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation

(2016) Katie A. Matatall et al.   Cell Reports

Comparison of placenta samples with contamination controls does not provide evidence for a distinct placenta microbiota

(2016) Abigail P. Lauder et al.   Microbiome

Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid

(2016) Maria Carmen Collado et al.   Scientific Reports

The first wave of B lymphopoiesis develops independently of stem cells in the murine embryo

(2015) Momoko Yoshimoto   Annals of the New York Academy of Sciences

Natural Antibody Repertoires: Development and Functional Role in Inhibiting Allergic Airway Disease

(2015) John F. Kearney et al.   Annual Review of Immunology

I’m Eating for Two: Parental Dietary Effects on Offspring Metabolism

(2015) Oliver J. Rando et al.   CELL

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

(2015) Fredrik Bäckhed et al.   Cell Host & Microbe

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors

(2015) Simon Haas et al.   Cell Stem Cell

MicroRNAs and Their Targets Are Differentially Regulated in Adult and Neonatal Mouse CD8+ T Cells

(2015) E. M. Wissink et al.   GENETICS

A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes

(2015) Tiffany C. Scharschmidt et al.   IMMUNITY

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

Maternal Antibiotic Treatment Protects Offspring from Diabetes Development in Nonobese Diabetic Mice by Generation of Tolerogenic APCs

(2015) Youjia Hu et al.   JOURNAL OF IMMUNOLOGY

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Epidemiology of Viral-associated Acute Lower Respiratory Tract Infection Among Children

(2015) Cheryl Cohen et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

The microbiota regulates type 2 immunity through ROR t+ T cells

(2015) C. Ohnmacht et al.   SCIENCE

Early infancy microbial and metabolic alterations affect risk of childhood asthma

(2015) Marie-Claire Arrieta et al.   Science Translational Medicine

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

(2015) Alison N. Thorburn et al.   Nature Communications

Maternal high-fat diet and obesity compromise fetal hematopoiesis

(2015) Ashley N. Kamimae-Lanning et al.   Molecular Metabolism

Antibiotics in Early Life Alter the Gut Microbiome and Increase Disease Incidence in a Spontaneous Mouse Model of Autoimmune Insulin-Dependent Diabetes

(2015) Sophie Candon et al.   PLoS One

Antepartum Antibiotic Treatment Increases Offspring Susceptibility to Experimental Colitis: A Role of the Gut Microbiota

(2015) Peris Mumbi Munyaka et al.   PLoS One

Sphingolipids from a Symbiotic Microbe Regulate Homeostasis of Host Intestinal Natural Killer T Cells

(2014) Dingding An et al.   CELL

Gut Microbiota Promote Hematopoiesis to Control Bacterial Infection

(2014) Arya Khosravi et al.   Cell Host & Microbe

Immune cells in term and preterm labor

(2014) Nardhy Gomez-Lopez et al.   Cellular & Molecular Immunology

TLR5-Mediated Sensing of Gut Microbiota Is Necessary for Antibody Responses to Seasonal Influenza Vaccination

(2014) Jason Z. Oh et al.   IMMUNITY

GATA binding protein 3+ group 2 innate lymphoid cells are present in cord blood and in higher proportions in male than in female neonates

(2014) Anna Forsberg et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Activated Human Neonatal CD8+ T Cells Are Subject to Immunomodulation by Direct TLR2 or TLR5 Stimulation

(2014) M. McCarron et al.   JOURNAL OF IMMUNOLOGY

Attenuation of Respiratory Syncytial Virus-Induced and RIG-I-Dependent Type I IFN Responses in Human Neonates and Very Young Children

(2014) N. Marr et al.   JOURNAL OF IMMUNOLOGY

Plasmacytoid Dendritic Cells Engagement by Influenza Vaccine as a Surrogate Strategy for Driving T-Helper Type 1 Responses in Human Neonatal Settings

(2014) Xiaoming Zhang et al.   JOURNAL OF INFECTIOUS DISEASES

Invariant natural killer T cells developing in the human fetus accumulate and mature in the small intestine

(2014) L Loh et al.   Mucosal Immunology

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

(2014) Serge A. van de Pavert et al.   NATURE

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Persistent gut microbiota immaturity in malnourished Bangladeshi children

(2014) Sathish Subramanian et al.   NATURE

The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice

(2014) Hitesh S Deshmukh et al.   NATURE MEDICINE

Diet and host–microbial crosstalk in postnatal intestinal immune homeostasis

(2014) Nitya Jain et al.   Nature Reviews Gastroenterology & Hepatology

Stool Microbiota and Vaccine Responses of Infants

(2014) M. N. Huda et al.   PEDIATRICS

Myeloid Derived Suppressor Cells Are Present at High Frequency in Neonates and Suppress In Vitro T Cell Responses

(2014) Ana Gervassi et al.   PLoS One

Antibiotic Treatment of Pregnant Non-Obese Diabetic Mice Leads to Altered Gut Microbiota and Intestinal Immunological Changes in the Offspring

(2014) N. Tormo-Badia et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development

(2014) Edwin Leeansyah et al.   Nature Communications

The stunting syndrome in developing countries

(2014) Andrew J. Prendergast et al.   Paediatrics and International Child Health

Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months

(2013) M. B. Azad et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Intestinal Microbial Diversity during Early-Life Colonization Shapes Long-Term IgE Levels

(2013) Julia Cahenzli et al.   Cell Host & Microbe

Neutrophilic myeloid-derived suppressor cells in cord blood modulate innate and adaptive immune responses

(2013) N. Rieber et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Dynamics of thymus organogenesis and colonization in early human development

(2013) A. M. Farley et al.   DEVELOPMENT

Human Neonatal Naive CD4+ T Cells Have Enhanced Activation-Dependent Signaling Regulated by the MicroRNA miR-181a

(2013) A. C. Palin et al.   JOURNAL OF IMMUNOLOGY

Three Main Factors Define Changes in Fecal Microbiota Associated With Feeding Modality in Infants

(2013) Carolina Gomez-Llorente et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection

(2013) Shokrollah Elahi et al.   NATURE

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

(2013) Jochem H Bernink et al.   NATURE IMMUNOLOGY

Neonatal Plasmacytoid Dendritic Cells (pDCs) Display Subset Variation but Can Elicit Potent Anti-Viral Innate Responses

(2013) Xiaoming Zhang et al.   PLoS One

Memory CD4+CCR5+ T cells are abundantly present in the gut of newborn infants to facilitate mother-to-child transmission of HIV-1

(2012) M. J. Bunders et al.   BLOOD

Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence

(2012) M. Yoshimoto et al.   BLOOD

Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma

(2012) Shannon L Russell et al.   EMBO REPORTS

Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly

(2012) Tobias R. Kollmann et al.   IMMUNITY

Phenotypic Characterization of Leukocytes in Prenatal Human Dermis

(2012) Christopher Schuster et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Uninfected but not unaffected: chronic maternal infections during pregnancy, fetal immunity, and susceptibility to postnatal infections

(2012) Nicolas Dauby et al.   LANCET INFECTIOUS DISEASES

Reciprocal interactions of the intestinal microbiota and immune system

(2012) Craig L. Maynard et al.   NATURE

The role of the gut microbiota in nutrition and health

(2012) Harry J. Flint et al.   Nature Reviews Gastroenterology & Hepatology

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

(2012) T. Olszak et al.   SCIENCE

Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region

(2011) Andrejs Ivanovs et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Exposure to Environmental Microorganisms and Childhood Asthma

(2011) Markus J. Ege et al.   NEW ENGLAND JOURNAL OF MEDICINE

B cell subsets in healthy children: Reference values for evaluation of B cell maturation process in peripheral blood

(2010) Barbara Piątosa et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Chronic Intestinal Helminth Infections Are Associated with Immune Hyporesponsiveness and Induction of a Regulatory Network

(2010) C. A. Figueiredo et al.   INFECTION AND IMMUNITY

Clinical Aspects of Pandemic 2009 Influenza A (H1N1) Virus Infection

(2010)   NEW ENGLAND JOURNAL OF MEDICINE

Early-life determinants of overweight and obesity: a review of systematic reviews

(2010) L. Monasta et al.   Obesity Reviews

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

(2010) M. Vijay-Kumar et al.   SCIENCE

Fetal and Adult Hematopoietic Stem Cells Give Rise to Distinct T Cell Lineages in Humans

(2010) J. E. Mold et al.   SCIENCE

Exclusive breastfeeding and incident atopic dermatitis in childhood: a systematic review and meta-analysis of prospective cohort studies

(2009) Y.W. Yang et al.   BRITISH JOURNAL OF DERMATOLOGY

Developmental plasticity of Th17 and Treg cells

(2009) Yun Kyung Lee et al.   CURRENT OPINION IN IMMUNOLOGY

Perinatal risk factors for early onset of Type 1 diabetes in a 2000-2005 birth cohort

(2009) C. S. Algert et al.   DIABETIC MEDICINE

IL-12 and type I IFN response of neonatal myeloid DC to human CMV infection

(2009) Joelle Renneson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Plasticity of CD4+ T Cell Lineage Differentiation

(2009) Liang Zhou et al.   IMMUNITY

Caesarean delivery and risk of atopy and allergic disesase: meta-analyses

(2008) P. Bager et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Day-care attendance, position in sibship, and early childhood wheezing: A population-based birth cohort study

(2008) Nicolaos C. Nicolaou et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prenatal exposure to a farm environment modifies atopic sensitization at birth

(2008) Markus Johannes Ege et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effect of In Utero and Early-Life Conditions on Adult Health and Disease

(2008) Peter D. Gluckman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero

(2008) J. E. Mold et al.   SCIENCE

Poor immunogenicity of BCG in helminth infected population is associated with increased in vitro TGF-β production

(2008) Daniel Elias et al.   VACCINE