SQR mediates therapeutic effects of H2S by targeting mitochondrial electron transport to induce mitochondrial uncoupling

A proof‐of‐concept, Phase 2 clinical trial of the gastrointestinal safety of a hydrogen sulfide‐releasing anti‐inflammatory drug

(2019) John L. Wallace et al.   BRITISH JOURNAL OF PHARMACOLOGY

H+ transport is an integral function of the mitochondrial ADP/ATP carrier

(2019) Ambre M. Bertholet et al.   NATURE

Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler

(2019) Naohide Kanemoto et al.   Nature Communications

Hydrogen Sulfide-Releasing Therapeutics: Translation to the Clinic

(2018) John L. Wallace et al.   ANTIOXIDANTS & REDOX SIGNALING

Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H 2 S Production

(2018) Alban Longchamp et al.   CELL

Control of mitochondrial superoxide production by reverse electron transport at complex I

(2018) Ellen L. Robb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly

(2018) Elizabeth C Hinchy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accumulation of succinate controls activation of adipose tissue thermogenesis

(2018) Evanna L. Mills et al.   NATURE

Regulation of redox balance in cancer and T cells

(2017) Hyewon Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Update on AMPK in Hydrogen Sulfide Pharmacology

(2017) Minjun Wang et al.   Frontiers in Pharmacology

Mitochondrial complex I deactivation is related to superoxide production in acute hypoxia

(2017) Pablo Hernansanz-Agustín et al.   Redox Biology

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan

(2016) Filippo Scialò et al.   Cell Metabolism

A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury

(2016) Edward T. Chouchani et al.   Cell Metabolism

Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits

(2015) Christopher Hine et al.   CELL

The mitochondrial uncoupling protein-2 is a master regulator of both M1 and M2 microglial responses

(2015) Roberta De Simone et al.   JOURNAL OF NEUROCHEMISTRY

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

(2015) John L. Wallace et al.   NATURE REVIEWS DRUG DISCOVERY

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

(2015) R. J. Perry et al.   SCIENCE

Toll-like receptor 2/4 heterodimer mediates inflammatory injury in intracerebral hemorrhage

(2014) Yan-Chun Wang et al.   ANNALS OF NEUROLOGY

CaMKKβ-Dependent Activation of AMP-Activated Protein Kinase Is Critical to Suppressive Effects of Hydrogen Sulfide on Neuroinflammation

(2014) Xiaomei Zhou et al.   ANTIOXIDANTS & REDOX SIGNALING

Adenosine 5′-Monophosphate–Activated Protein Kinase Regulates IL-10–Mediated Anti-Inflammatory Signaling Pathways in Macrophages

(2014) Yanfang Peipei Zhu et al.   JOURNAL OF IMMUNOLOGY

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice

(2014) Hanlin Tao et al.   NATURE MEDICINE

Hydrogen sulfide and cell signaling: Team player or referee?

(2014) J.T. Hancock et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Inflammation in intracerebral hemorrhage: From mechanisms to clinical translation

(2013) Yu Zhou et al.   PROGRESS IN NEUROBIOLOGY

Detoxification of H2S by Differentiated Colonic Epithelial Cells: Implication of the Sulfide Oxidizing Unit and of the Cell Respiratory Capacity

(2012) Sabria Mimoun et al.   ANTIOXIDANTS & REDOX SIGNALING

Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics

(2012) Katalin Módis et al.   FASEB JOURNAL

The Deactive Form of Respiratory Complex I from Mammalian Mitochondria Is a Na+/H+Antiporter

(2012) Philippa G. Roberts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

H2S signalling through protein sulfhydration and beyond

(2012) Bindu D. Paul et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial H2O2 generated from electron transport chain complex I stimulates muscle differentiation

(2011) Seonmin Lee et al.   CELL RESEARCH

Mitochondria and Sulfide: A Very Old Story of Poisoning, Feeding, and Signaling?

(2010) Frédéric Bouillaud et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidation of hydrogen sulfide remains a priority in mammalian cells and causes reverse electron transfer in colonocytes

(2010) Emilie Lagoutte et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Effects of Hydrogen Sulfide-releasing l-DOPA Derivatives on Glial Activation

(2010) Moonhee Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteine-Activated Hydrogen Sulfide (H2S) Donors

(2010) Yu Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY