Review
Immunology
Tracoyia Roach, Laurence Morel
Summary: Immune homeostasis relies on the balance between effector T cells and regulatory T cells. Studies have identified genetic factors that maintain the stability and suppressive function of regulatory T cells, which could potentially be targeted for therapeutic intervention against autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Huanhe Ni, Huanling Zhang, Lin Li, He Huang, Hui Guo, Lin Zhang, Chunwei Li, Jing-Xiao Xu, Cai-Ping Nie, Kui Li, Xiaoshi Zhang, Xiaojun Xia, Jiang Li
Summary: In this study, it was found that increased STING and CCL22 levels, as well as higher levels of FOXP3(+) cells and lower levels of CD8(+) cells in tumor tissues of cervical cancer, predicted poor survival. Activation of STING signaling in cooperation with T cell receptor and other signals promoted iTreg differentiation in both human and murine CD4(+) naive T cells. Additionally, tumor-derived exosomes were found to activate STING signaling in tumor-infiltrated T cells, leading to iTreg expansion.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Cell Biology
Daniel S. Shin, Sneha Ratnapriya, Creel Ng Cashin, Lucy F. Kuhn, Rod A. Rahimi, Robert M. Anthony, James J. Moon
Summary: Self-antigen-specific T cells are regulated through tolerance mechanisms, but tissue injury can disrupt this regulation and trigger autoimmunity. Using mouse models of lung injury, we found that acute injury leads to the expansion of CD4+ regulatory T cells (Tregs) that specifically recognize self-antigen. Conventional CD4+ T cells with the same self-antigen specificity remained unresponsive even after Treg ablation. Therefore, the self-antigen-specific CD4+ T cell repertoire plays a regulatory role in limiting tissue damage and autoimmunity during acute injury.
Review
Immunology
Jorge L. Trujillo-Ochoa, Majid Kazemian, Behdad Afzali
Summary: Regulatory T cells (T-reg cells) are regulated by multiple transcription factors, including FOXP3, which control their differentiation and function. The heterogeneity of T-reg cells arises from the expression of different transcription factors that fine-tune their properties. Understanding the imprinting of T-reg cell identity and function is crucial for understanding autoimmunity and developing new drugs.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Immunology
Lili Huang, Yu Xu, Juemin Fang, Weixing Liu, Jianhua Chen, Zhuqing Liu, Qing Xu
Summary: This study evaluates the changes in the tumor microenvironment (TME) after PD-1 blockade, focusing on the role of Treg cells and the expression of Tim-3. Targeting STAT3 in melanoma models can significantly enhance the response to PD-1 therapy by reducing immunosuppression mediated by Treg cells. These findings support STAT3 as a potential target for improving immunotherapy efficacy in melanoma patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Kathryn A. Knoop, Keely G. McDonald, Chyi-Song Hsieh, Phillip Tarr, Rodney D. Newberry
Summary: Atopic disorders are on the rise in Western societies, characterized by immune responses to environmental triggers. Early life exposure to diet and microbes shapes the intestinal Treg population significantly. Tregs developed early in life play a crucial role in restraining systemic inflammatory responses into adulthood.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Farooq Riaz, Zhihui Huang, Fan Pan
Summary: This review discusses the immune-suppressive mechanisms of Treg cells, the post-translational regulations of Foxp3, and the potential therapeutic targets and strategies to target Tregs in the tumor microenvironment. Pharmacological targeting of enzymes involved in PTMs can significantly influence the PTMs of Foxp3, potentially impacting the progression of cancers and autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Sebastian Dohnke, Stephanie Moehser, Alexey Surnov, Thomas Kurth, Rolf Jessberger, Karsten Kretschmer, Annette I. Garbe
Summary: SWAP-70 plays a crucial role in Treg cell biology and is involved in the regulation of immunological synapse formation and the dynamic reorganization of the actin cytoskeleton. Swap-70(-/-) mice have increased numbers of Treg cells with impaired suppressor function and fail to efficiently suppress osteoclastogenesis and osteoclast function.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lu Bai, Xiaolei Hao, Julia Keith, Yongqiang Feng
Summary: DNA methylation as an epigenetic marker plays a crucial role in regulating the differentiation and function of regulatory T cells. The dynamic regulation of DNA methylation affects various stages of Treg cell lifespan and immunological function. Further research is needed to fully understand the differential DNA methylation and its regulatory role in Treg cell fate and immunological function.
Article
Immunology
Lauren Van Zeebroeck, Rebeca Arroyo Hornero, Beatriz F. Corte-Real, Ibrahim Hamad, Torsten B. Meissner, Markus Kleinewietfeld
Summary: Tregs are crucial for maintaining immune homeostasis and have potential therapeutic value in various diseases. While current genome editing protocols for Tregs are limited, our rapid and effective method may advance possibilities for Treg-based cellular therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Severine Menoret, Laurent Tesson, Severine Remy, Victor Gourain, Celine Serazin, Claire Usal, Aude Guiffes, Vanessa Chenouard, Laure-Helene Ouisse, Malika Gantier, Jean-Marie Heslan, Cynthia Fourgeux, Jeremie Poschmann, Carole Guillonneau, Ignacio Anegon
Summary: In this study, a Foxp3-EGFP rat transgenic line was created to genetically tag CD4(+) and CD8(+) FOXP3(+) regulatory T cells. CD4(+)EGFP(+) Treg were found to be 5-10 times more frequent than CD8(+)EGFP(+) Treg. RNAseq analysis provided insights into the transcriptome of CD8(+) Treg, allowing for a better understanding of their phenotype and function.
Article
Immunology
Hao Sun, Frederic Lagarrigue, Hsin Wang, Zhichao Fan, Miguel Alejandro Lopez-Ramirez, John T. Chang, Mark H. Ginsberg
Summary: Integrin activation is crucial for lymphocyte trafficking and immune function. RIAM is necessary for conventional T cell integrin activation, but dispensable for regulatory T cell integrin activation and suppressive function. Inhibition of RIAM can prevent spontaneous Tconv cell-mediated autoimmune colitis while maintaining T reg cell trafficking and function.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
Beatriz F. F. Corte-Real, Rebeca Arroyo Hornero, Aleksandra Dyczko, Ibrahim Hamad, Markus Kleinewietfeld
Summary: CSF2RB (CD131) may serve as a potential biomarker for autoimmune diseases in Tregs, with its overexpression potentially being linked to disease development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Hyunju Oh, Jingyao Zhao, Yenkel Grinberg-Bleyer, Thomas S. Postler, Pingzhang Wang, Sung-Gyoo Park, Raul Rabadan, Matthew S. Hayden, Sankar Ghosh
Summary: This study demonstrates the essential role of PDK1 in both T cell activation and Treg cell suppressive activity, with PDK1 regulating Treg cell gene expression and suppressor function primarily through the NF-κB pathway.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Immunology
Yiran Qiu, Shouyu Ke, Jieqiong Chen, Zhizhen Qin, Wenle Zhang, Yaqin Yuan, Dehua Meng, Gang Zhao, Kejin Wu, Bin Li, Dan Li
Summary: This review summarizes the latest findings on the dynamic connections and reciprocal regulations of non-lymphoid Treg cell subsets in the immune escape of tumour cells in solid tumors, providing new insights for the development of next-generation engineered T cell-based immune treatments for solid tumors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Luciana Nichita, Sabina Zurac, Alexandra Bastian, Patricia Stinga, Roxana Nedelcu, Alice Brinzea, Gabriela Turcu, Daniela Ion, Lucia Jilaveanu, Liana Sticlaru, Cristiana Popp, Mirela Cioplea
Article
Oncology
Mirela Cioplea, Costin Caruntu, Sabina Zurac, Alexandra Bastian, Liana Sticlaru, Alexandra Cioroianu, Daniel Boda, Gheorghita Jugulete, Luciana Nichita, Cristiana Popp
Article
Medicine, Research & Experimental
Mihaela Balaban, Roxana Ioana Nedelcu, Gabriela Balmes, Teodora Adela Todorovic, Alice Brinzea, Luciana Nichita, Cristiana Gabriela Popp, Razvan Theodor Andrei, Sabina Andrada Zurac, Daniela Adriana Ion, Gabriela Turcu
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2020)
Article
Medicine, Research & Experimental
Gabriela Turcu, Roxana Ioana Nedelcu, Iulia Teodora Nedelcu, Anastasia Hodorogea, Mihaela Balaban, Alice Brinzea, Luciana Nichita, Cristiana Gabriela Popp, Sabina Andrada Zurac, Razvan Theodor Andrei
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2020)
Review
Oncology
Alexandra Ioana Cioroianu, Patricia Irina Stinga, Liana Sticlaru, Mirela Daniela Cioplea, Luciana Nichita, Cristiana Popp, Florica Staniceanu
ANALYTICAL CELLULAR PATHOLOGY
(2019)
Review
Oncology
Anastasia Hodorogea, Andreea Calinescu, Mihaela Antohe, Mihaela Balaban, Roxana Ioana Nedelcu, Gabriela Turcu, Daniela Adriana Ion, Ioana Anca Badarau, Catalin Mihai Popescu, Raluca Popescu, Cristiana Popp, Mirela Cioplea, Luciana Nichita, Ionela Hulea, Alice Brinzea
ANALYTICAL CELLULAR PATHOLOGY
(2019)
Article
Oncology
Ana Caruntu, Liliana Moraru, Mihai Lupu, Florina Vasilescu, Marius Dumitrescu, Mirela Cioplea, Cristiana Popp, Alexandra Dragusin, Constantin Caruntu, Sabina Zurac
Summary: The study highlights the prognostic significance of tumor-infiltrating CD8(+) lymphocytes at the front of invasion and CD56(+) cells in the intratumor compartment in oral squamous cell carcinoma. A rich immune infiltration with these cells is associated with better patient outcomes, suggesting their potential as independent prognostic tools for personalized therapy in the fight against oral cancer.
Article
Oncology
Sabina Zurac, Luciana Nichita, Bogdan Mateescu, Cristian Mogodici, Alexandra Bastian, Cristiana Popp, Mirela Cioplea, Claudiu Socoliuc, Carolina Constantin, Monica Neagu
Summary: The study analyzed IgG and IgA levels in healthcare workers exposed to COVID-19 patients before and after vaccination, showing similar increases in levels regardless of prior infection. Seroconversion was achieved in all subjects following the second round of vaccination.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Health Care Sciences & Services
Roxana Nedelcu, Alexandra Dobre, Alice Brinzea, Ionela Hulea, Razvan Andrei, Sabina Zurac, Mihaela Balaban, Mihaela Antohe, Lorena Manea, Andreea Calinescu, Anastasia Coman, Florentina Pantelimon, Adina Dobritoiu, Catalin Popescu, Raluca Popescu, Elena Balasescu, Daniela Ion, Gabriela Turcu
Summary: Halo nevi, a type of immunological leukoderma, have unclear etiology and pathogenesis. Studying Sutton nevi can provide valuable insights into the human body's anti-tumor reactions.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Medicine, Research & Experimental
Elena Balasescu, Andreea-Cristina Gheorghe, Andreea Moroianu, Gabriela Turcu, Alice Brinzea, Mihaela Antohe, Anastasia Hodorogea, Lorena Manea, Mihaela Balaban, Razvan Andrei, Ionela Hulea, Cristiana Gabriela Popp, Luciana Nichita, Mirela Daniela Cioplea, Sabina Andrada Zurac, Daniela Adriana Ion, Roxana Ioana Nedelcu
Summary: The immunohistochemical study of squamous-cell carcinoma (cSCC) is crucial for accurate diagnosis and prognosis assessment. This study highlights the potential value of immunohistochemical markers in evaluating the biological behavior of cSCC and optimizing case management.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Meeting Abstract
Pathology
A. Toma, M. Cioplea, L. Sticlaru, G. Turcu, R. I. Nedelcu, A. Brinzea, L. Peter, A. Vilaia, A. I. Savin
Review
Developmental Biology
Alice Brinzea, Roxana Ioana Nedelcu, Daniela Adriana Ion, Gabriela Turcu, Mihaela Antohe, Anastasia Hodorogea, Andreea Calinescu, Daniel Pirici, Raluca Popescu, Catalin Mihai Popescu, Cristiana Gabriela Popp, Luciana Nichita, Mirela Daniela Cioplea, Mariana Cordun, Sabina Andrada Zurac
ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY
(2019)