Mechanisms of Desiccation Tolerance: Themes and Variations in Brine Shrimp, Roundworms, and Tardigrades

Late Embryogenesis Abundant (LEA) proteins confer water stress tolerance to mammalian somatic cells

(2020) M. Czernik et al.   CRYOBIOLOGY

Thermotolerance experiments on active and desiccated states of Ramazzottius varieornatus emphasize that tardigrades are sensitive to high temperatures

(2020) Ricardo Cardoso Neves et al.   Scientific Reports

Cyst viability and stress tolerance upon heat shock protein 70 knockdown in the brine shrimp Artemia franciscana

(2020) Mat Taib Mimi Iryani et al.   CELL STRESS & CHAPERONES

Ultrastructural analysis of the dehydrated tardigrade Hypsibius exemplaris unveils an anhydrobiotic-specific architecture

(2020) Myriam Richaud et al.   Scientific Reports

The synthesis of diapause-specific molecular chaperones in embryos of Artemia franciscana is determined by the quantity and location of heat shock factor 1 (Hsf1)

(2019) Jiabo Tan et al.   CELL STRESS & CHAPERONES

Preferential adsorption to air-water interfaces: a novel cryoprotective mechanism for LEA proteins

(2019) Fanny Yuen et al.   BIOCHEMICAL JOURNAL

Functional assessment of hydrophilic domains of late embryogenesis abundant proteins from distant organisms

(2019) Yingying Liu et al.   Microbial Biotechnology

Structural properties and cellular expression of AfrLEA6, a group 6 late embryogenesis abundant protein from embryos of Artemia franciscana

(2019) Blase M. LeBlanc et al.   CELL STRESS & CHAPERONES

Sequence and expression analysis of HSP70 family genes in Artemia franciscana

(2019) Wisarut Junprung et al.   Scientific Reports

Comparative transcriptomics suggest unique molecular adaptations within tardigrade lineages

(2019) Maria Kamilari et al.   BMC GENOMICS

The Caenorhabditis elegans Transgenic Toolbox

(2019) Jeremy Nance et al.   GENETICS

The tardigrade damage suppressor protein binds to nucleosomes and protects DNA from hydroxyl radicals

(2019) Carolina Chavez et al.   eLife

Differential mechanisms of tolerance to extreme environmental conditions in tardigrades

(2019) Dido Carrero et al.   Scientific Reports

Molecular mechanisms driving transcriptional stress responses

(2018) Anniina Vihervaara et al.   NATURE REVIEWS GENETICS

Stress tolerance in diapausing embryos of Artemia franciscana is dependent on heat shock factor 1 (Hsf1)

(2018) Jiabo Tan et al.   PLoS One

Metabolic shift from glycogen to trehalose promotes lifespan and healthspan inCaenorhabditis elegans

(2018) Yonghak Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cooption of heat shock regulatory system for anhydrobiosis in the sleeping chironomidPolypedilum vanderplanki

(2018) Pavel V. Mazin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An integrative redescription of Hypsibius dujardini (Doyère, 1840), the nominal taxon for Hypsibioidea (Tardigrada: Eutardigrada)

(2018) PIOTR GĄSIOREK et al.   ZOOTAXA

Synergy between the small intrinsically disordered protein Hsp12 and trehalose sustain viability after severe desiccation

(2018) Skylar Xantus Kim et al.   eLife

ArHsp40 and ArHsp40-2 contribute to stress tolerance and longevity inArtemia franciscana, but only ArHsp40 influences diapause entry

(2018) Nathan M. Rowarth et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Post-diapause synthesis of ArHsp40-2, a type 2 J-domain protein from Artemia franciscana, is developmentally regulated and induced by stress

(2018) Nathan M. Rowarth et al.   PLoS One

Role of Intrinsic Disorder in Animal Desiccation Tolerance

(2018) Brett Janis et al.   PROTEOMICS

Small heat shock proteins: Simplicity meets complexity

(2018) Martin Haslbeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural insights into a secretory abundant heat-soluble protein from an anhydrobiotic tardigrade, Ramazzottius varieornatus

(2017) Yohta Fukuda et al.   FEBS LETTERS

Potential functions of LEA proteins from the brine shrimp Artemia franciscana – anhydrobiosis meets bioinformatics

(2017) Brett Janis et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Knockdown of heat shock protein 70 (Hsp70) by RNAi reduces the tolerance of Artemia franciscana nauplii to heat and bacterial infection

(2017) Mat Taib Mimi Iryani et al.   JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY

Tardigrades Use Intrinsically Disordered Proteins to Survive Desiccation

(2017) Thomas C. Boothby et al.   MOLECULAR CELL

Comparative genomics of the tardigrades Hypsibius dujardini and Ramazzottius varieornatus

(2017) Yuki Yoshida et al.   PLOS BIOLOGY

daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival

(2017) Jonathan D Hibshman et al.   eLife

Liposomes with diverse compositions are protected during desiccation by LEA proteins from Artemia franciscana and trehalose

(2016) Daniel S. Moore et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The genome-wide role of HSF-1 in the regulation of gene expression in Caenorhabditis elegans

(2016) Jessica Brunquell et al.   BMC GENOMICS

ArHsp40, a type 1 J-domain protein, is developmentally regulated and stress inducible in post-diapause Artemia franciscana

(2016) Guojian Jiang et al.   CELL STRESS & CHAPERONES

The transcription factor p8 regulates autophagy during diapause embryo formation in Artemia parthenogenetica

(2016) Cheng Lin et al.   CELL STRESS & CHAPERONES

Recovery and reproduction of an Antarctic tardigrade retrieved from a moss sample frozen for over 30 years

(2016) Megumu Tsujimoto et al.   CRYOBIOLOGY

Cryopreservation of lipid bilayers by LEA proteins from Artemia franciscana and trehalose

(2016) Daniel S. Moore et al.   CRYOBIOLOGY

Humidity Sensing in Drosophila

(2016) Anders Enjin et al.   CURRENT BIOLOGY

The structure of the desiccated Richtersius coronifer (Richters, 1903)

(2016) Michaela Czerneková et al.   PROTOPLASMA

Tun formation is not a prerequisite for desiccation tolerance in the marine tidal tardigradeEchiniscoides sigismundi

(2016) Thomas L. Hygum et al.   ZOOLOGICAL JOURNAL OF THE LINNEAN SOCIETY

Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein

(2016) Takuma Hashimoto et al.   Nature Communications

The glyoxylate shunt is essential for desiccation tolerance in C. elegans and budding yeast

(2016) Cihan Erkut et al.   eLife

Stress tolerance during diapause and quiescence of the brine shrimp, Artemia

(2015) Thomas H. MacRae   CELL STRESS & CHAPERONES

Johannes Albertus Schlosser, the first author describing Artemia salina(L.) (Branchiopoda: Anostraca): a biographical sketch

(2015) Mario Engelmann et al.   JOURNAL OF CRUSTACEAN BIOLOGY

The C. elegans dauer larva as a paradigm to study metabolic suppression and desiccation tolerance

(2015) Cihan Erkut et al.   PLANTA

Molecular approaches for improving desiccation tolerance: insights from the brine shrimp Artemia franciscana

(2015) Steven C. Hand et al.   PLANTA

Tolerance to Gamma Radiation in the Tardigrade Hypsibius dujardini from Embryo to Adult Correlate Inversely with Cellular Proliferation

(2015) Eliana Beltrán-Pardo et al.   PLoS One

Novel Mitochondria-Targeted Heat-Soluble Proteins Identified in the Anhydrobiotic Tardigrade Improve Osmotic Tolerance of Human Cells

(2015) Sae Tanaka et al.   PLoS One

Group 1 LEA proteins contribute to the desiccation and freeze tolerance of Artemia franciscana embryos during diapause

(2014) Jantina Toxopeus et al.   CELL STRESS & CHAPERONES

Artemin, a diapause-specific chaperone, contributes to the stress tolerance of Artemia franciscana cysts and influences their release from females

(2014) A. M. King et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Why Can’t Vertebrates Synthesize Trehalose?

(2014) Juan-Carlos Argüelles   JOURNAL OF MOLECULAR EVOLUTION

The Role of Phospholipid Headgroup Composition and Trehalose in the Desiccation Tolerance of Caenorhabditis elegans

(2014) Sawsan E. Abusharkh et al.   LANGMUIR

Group 3 Late Embryogenesis Abundant Proteins from Embryos of Artemia franciscana: Structural Properties and Protective Abilities during Desiccation

(2014) Leaf C. Boswell et al.   PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY

Desiccation Tolerance in the Tardigrade Richtersius coronifer Relies on Muscle Mediated Structural Reorganization

(2014) Kenneth Agerlin Halberg et al.   PLoS One

Towards Decrypting Cryptobiosis—Analyzing Anhydrobiosis in the Tardigrade Milnesium tardigradum Using Transcriptome Sequencing

(2014) Chong Wang et al.   PLoS One

Humidity sensation requires both mechanosensory and thermosensory pathways in Caenorhabditis elegans

(2014) J. Russell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular localization of group 3 LEA proteins in embryos of Artemia franciscana

(2014) Leaf C. Boswell et al.   TISSUE & CELL

Quantification of cellular protein expression and molecular features of group 3 LEA proteins from embryos of Artemia franciscana

(2013) Leaf C. Boswell et al.   CELL STRESS & CHAPERONES

Functional differentiation of small heat shock proteins in diapause-destinedArtemiaembryos

(2013) Allison M. King et al.   FEBS Journal

An abundant LEA protein in the anhydrobiotic midge, PvLEA4, acts as a molecular shield by limiting growth of aggregating protein particles

(2013) Rie Hatanaka et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Improved tolerance to salt and water stress in Drosophila melanogaster cells conferred by late embryogenesis abundant protein

(2013) Matthew R. Marunde et al.   JOURNAL OF INSECT PHYSIOLOGY

Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination

(2013) Daniel J Dickinson et al.   NATURE METHODS

Analysis of DNA Repair and Protection in the Tardigrade Ramazzottius varieornatus and Hypsibius dujardini after Exposure to UVC Radiation

(2013) Daiki D. Horikawa et al.   PLoS One

Molecular Strategies of the Caenorhabditis elegans Dauer Larva to Survive Extreme Desiccation

(2013) Cihan Erkut et al.   PLoS One

Complexity of the heat-soluble LEA proteome in Artemia species

(2012) Alden H. Warner et al.   Comparative Biochemistry and Physiology D-Genomics & Proteomics

RNA interference can be used to disrupt gene function in tardigrades

(2012) Jennifer R. Tenlen et al.   DEVELOPMENT GENES AND EVOLUTION

Identification of the trehalose-6-phosphate synthase (tps) gene in desiccation tolerant and intolerant tardigrades

(2012) Michele Cesari et al.   ITALIAN JOURNAL OF ZOOLOGY

MAPK phosphorylation is implicated in the adaptation to desiccation stress in nematodes

(2012) M. C. Banton et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Heat shock proteins in encysted and anhydrobiotic eutardigrades

(2012) Tiziana Alterio et al.   JOURNAL OF LIMNOLOGY

What can we learn from the toughest animals of the Earth? Water bears (tardigrades) as multicellular model organisms in order to perform scientific preparations for lunar exploration

(2012) Roberto Guidetti et al.   PLANETARY AND SPACE SCIENCE

The Small Heat Shock Protein p26 Aids Development of Encysting Artemia Embryos, Prevents Spontaneous Diapause Termination and Protects against Stress

(2012) Allison M. King et al.   PLoS One

Two Novel Heat-Soluble Protein Families Abundantly Expressed in an Anhydrobiotic Tardigrade

(2012) Ayami Yamaguchi et al.   PLoS One

Late embryogenesis abundant proteins protect human hepatoma cells during acute desiccation

(2012) S. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Survival in extreme environments - on the current knowledge of adaptations in tardigrades

(2011) N. Møbjerg et al.   Acta Physiologica

LEA Proteins During Water Stress: Not Just for Plants Anymore

(2011) Steven C. Hand et al.   Annual Review of Physiology

Mechanisms associated with cellular desiccation tolerance of Artemia encysted embryos from locations around the world

(2011) Steffen Hengherr et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Diverse LEA (late embryogenesis abundant) and LEA-like genes and their responses to hypersaline stress in post-diapause embryonic development of Artemia franciscana

(2011) Gang Wu et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Trehalose Renders the Dauer Larva of Caenorhabditis elegans Resistant to Extreme Desiccation

(2011) Cihan Erkut et al.   CURRENT BIOLOGY

Anhydrobiosis: The Model Worm as a Model?

(2011) David A. Wharton   CURRENT BIOLOGY

Both plant and animal LEA proteins act as kinetic stabilisers of polyglutamine-dependent protein aggregation

(2011) Yun Liu et al.   FEBS LETTERS

cDNA representational difference analysis for identifying transcripts regulated under anhydrobiosis in the tardigrade Milnesium tardigradum

(2011) Markus A. Grohme et al.   JOURNAL OF ZOOLOGICAL SYSTEMATICS AND EVOLUTIONARY RESEARCH

Investigating heat shock proteins of tardigrades in active versus anhydrobiotic state using shotgun proteomics

(2011) Elham Schokraie et al.   JOURNAL OF ZOOLOGICAL SYSTEMATICS AND EVOLUTIONARY RESEARCH

Intrinsically disordered proteins as molecular shields

(2011) Sohini Chakrabortee et al.   Molecular BioSystems

Mechanisms Associated with Cellular Desiccation Tolerance in the Animal Extremophile Artemia

(2011) Steffen Hengherr et al.   PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY

Extracellular Matrix Peptides of Artemia Cyst Shell Participate in Protecting Encysted Embryos from Extreme Environments

(2011) Li Dai et al.   PLoS One

Artemin as an Efficient Molecular Chaperone

(2011) S. Shirin Shahangian et al.   PROTEIN JOURNAL

Trehalose extends longevity in the nematode Caenorhabditis elegans

(2010) Yoko Honda et al.   AGING CELL

The structural stability and chaperone activity of artemin, a ferritin homologue from diapause-destined Artemia embryos, depend on different cysteine residues

(2010) Yan Hu et al.   CELL STRESS & CHAPERONES

Antioxidant defences in hydrated and desiccated states of the tardigrade Paramacrobiotus richtersi

(2010) Angela M. Rizzo et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Evidence for multiple group 1 late embryogenesis abundant proteins in encysted embryos of Artemia and their organelles

(2010) Alden H. Warner et al.   JOURNAL OF BIOCHEMISTRY

Water Replacement Hypothesis in Atomic Details: Effect of Trehalose on the Structure of Single Dehydrated POPC Bilayers

(2010) E. A. Golovina et al.   LANGMUIR

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Proteomic Analysis of Tardigrades: Towards a Better Understanding of Molecular Mechanisms by Anhydrobiotic Organisms

(2010) Elham Schokraie et al.   PLoS One

Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1

(2009) Sang-Kyu Park et al.   AGING CELL

Desiccation-Induced Structuralization and Glass Formation of Group 3 Late Embryogenesis Abundant Protein Model Peptides

(2009) Tempei Shimizu et al.   BIOCHEMISTRY

Characterization of a group 1 late embryogenesis abundant protein in encysted embryos of the brine shrimp Artemia franciscana

(2009) Michelle A. Sharon et al.   Biochemistry and Cell Biology

Desiccation Induced Structural Alterations in a 66-Amino Acid Fragment of an Anhydrobiotic Nematode Late Embryogenesis Abundant (LEA) Protein

(2009) Daixi Li et al.   BIOMACROMOLECULES

Tardigrade workbench: comparing stress-related proteins, sequence-similar and functional protein clusters as well as RNA elements in tardigrades

(2009) Frank Förster et al.   BMC GENOMICS

Desiccation survival in an Antarctic nematode: molecular analysis using expressed sequenced tags

(2009) Bishwo N Adhikari et al.   BMC GENOMICS

Stress response in tardigrades: differential gene expression of molecular chaperones

(2009) Andy Reuner et al.   CELL STRESS & CHAPERONES

DNA damage in storage cells of anhydrobiotic tardigrades

(2009) Simon Neumann et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Formation of Diapause Cyst Shell in Brine Shrimp,Artemia parthenogenetica, and Its Resistance Role in Environmental Stresses

(2009) Yu-Lei Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Occurrence of Mitochondria-targeted Late Embryogenesis Abundant (LEA) Gene in Animals Increases Organelle Resistance to Water Stress

(2009) Michael A. Menze et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ametabolic embryos of Artemia franciscana accumulate DNA damage during prolonged anoxia

(2009) A. G. McLennan   JOURNAL OF EXPERIMENTAL BIOLOGY

Survival and DNA degradation in anhydrobiotic tardigrades

(2009) L. Rebecchi et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

High‐Temperature Tolerance in Anhydrobiotic Tardigrades Is Limited by Glass Transition

(2009) S. Hengherr et al.   PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY

Effect of trehalose on protein structure

(2009) Nishant Kumar Jain et al.   PROTEIN SCIENCE

ArHsp21, a developmentally regulated small heat-shock protein synthesized in diapausing embryos ofArtemia franciscana

(2008) Zhijun Qiu et al.   BIOCHEMICAL JOURNAL

Tardigrades survive exposure to space in low Earth orbit

(2008) K. Ingemar Jönsson et al.   CURRENT BIOLOGY

ArHsp22, a developmentally regulated small heat shock protein produced in diapause-destined Artemia embryos, is stress inducible in adults

(2008) Zhijun Qiu et al.   FEBS Journal

Desiccation tolerance in embryonic stages of the tardigrade

(2008) R. O. Schill et al.   JOURNAL OF ZOOLOGY

The Enigmatic LEA Proteins and Other Hydrophilins

(2008) M. Battaglia et al.   PLANT PHYSIOLOGY

Vitrification is essential for anhydrobiosis in an African chironomid,Polypedilum vanderplanki

(2008) Minoru Sakurai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA