Review
Hematology
Laura R. Goldberg
Summary: Extracellular vesicles (EVs) play a critical role in modulating hematopoiesis within the bone marrow microenvironment and may be key mediators of HSC aging. Studies have shown their involvement in numerous age-related biologic processes and diseases, influencing both normal and malignant hematopoiesis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cristina Mas-Bargues
Summary: Aging is a complex biological process characterized by the decline in cellular and tissue function. Stem cells and mitochondria play important roles in this process, influencing tissue function and aging. This review discusses the mechanisms through which mitochondria impact stem cell fate decisions and explores potential anti-aging therapies targeting mitochondrial health.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Claudia Morganti, Keisuke Ito
Summary: Mitochondrial dysfunction and stem cell exhaustion are characteristic features of aging, particularly in the hematopoietic system. Understanding the key mechanisms of HSC aging, including mitochondrial ROS production and alterations in metabolism, could lead to the identification of new therapeutic targets to prevent, delay, or reverse aspects of the aging process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Takeshi Fujino, Shuhei Asada, Susumu Goyama, Toshio Kitamura
Summary: This review discusses the causes of hematopoietic stem cell aging, including both intrinsic and extrinsic factors. Epigenetics and inflammation have been found to be involved in the connection between HSC aging, clonality, and oncogenesis. Clarifying the mechanisms of HSC aging has accelerated the development of therapeutic interventions for rejuvenating HSCs.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Makiko Mochizuki-Kashio, Hiroko Shiozaki, Toshio Suda, Ayako Nakamura-Ishizu
Summary: This review highlights the importance of metabolic regulation, including anaerobic metabolism, mitochondrial metabolism, and lysosomal regulation, in determining the cell fate of HSCs and maintaining hematopoietic homeostasis. These mechanisms are essential for the balance of hematopoietic system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Geovanny Genaro Reivan Ortiz, Yasaman Mohammadi, Ahmad Nazari, Mehrnaz Ataeinaeini, Parisa Kazemi, Saman Yasamineh, Bashar Zuhair Talib Al-Naqeeb, Haider Kamil Zaidan, Omid Gholizadeh
Summary: Aging is a biological process that leads to a decrease in the organism's standard of living due to time-related cellular and functional impairments. Recent advances in aging investigation have revealed that the rate of senescence can be regulated through genetic pathways and biological processes. Hematopoietic stem cells (HSCs) maintain blood generation throughout an organism's lifetime but are also affected by the senescence process, resulting in a decline in their capabilities. MicroRNAs (miRNAs) play a crucial role in controlling HSCs and can modulate senescence and age-associated diseases.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Craig Stamp, Julia C. Whitehall, Anna L. M. Smith, David Houghton, Carla Bradshaw, Elizabeth A. Stoll, Alasdair P. Blain, Doug M. Turnbull, Laura C. Greaves
Summary: Reduced levels of complex I protein are associated with increased colonic stem cell proliferation, indicating potential implications for age-related intestinal pathogenesis.
Article
Cell Biology
Ana Branco, Ines Moniz, Jao Ramalho-Santos
Summary: Research has shown that the decline in stem cell function and mitochondria dysfunction are linked, contributing to organismal aging. Targeting mitochondria is seen as a potential intervention to prevent stem cell dysfunction and slow down the aging process.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Matthias Mietsch, Rabea Hinkel
Summary: With the prevalence of cardiovascular diseases, there is an urgent need for new treatment strategies. While stem cell based approaches have shown promise in improving cardiac functions, recent research has highlighted the potential importance of mitochondria in these treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Otto Morris, Heinrich Jasper
Summary: Reactive Oxygen Species (ROS) play critical signaling roles in the intestine, maintaining the regenerative capacity of Intestinal Stem Cells (ISCs). Declines in metabolic adaptations, through aging or pathology, result in reciprocal changes in ISC metabolism and ROS signaling, ultimately leading to aberrant ISC function and loss of tissue homeostasis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Engineering, Environmental
Govinda Bhattarai, Hyun-Jaung Sim, Han-Sol So, Jeong-Chae Lee, Sung-Ho Kook
Summary: Research has mainly focused on the negative impacts of PM2.5 on respiratory, brain, immune, and metabolic diseases, with little knowledge about its effects on hematopoietic stem cell (HSC) fate. This study investigated the effects of atmospherically relevant PM2.5 on newborn hematopoietic stem progenitor cells (HSPCs), revealing increased oxidative stress and inflammasome activation in the lungs and bone marrow of PM2.5-exposed mice.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biology
Leonard Herault, Mathilde Poplineau, Adrien Mazuel, Nadine Platet, Elisabeth Remy, Estelle Duprez
Summary: By analyzing 15,000 young and aged HSC transcriptomes, the study identified 15 groups of HSCs showing rare and new specific abilities that change with age. This established a new reference map of HSC differentiation and revealed a potential mechanism that delays differentiation in aged HSCs, potentially contributing to age-related hematologic diseases.
Article
Genetics & Heredity
Xiangjun Zeng, Xia Li, Mi Shao, Yulin Xu, Wei Shan, Cong Wei, Xiaoqing Li, Limengmeng Wang, Yongxian Hu, Yanmin Zhao, Pengxu Qian, He Huang
Summary: This study identified markers of apoptosis-biased and inflammatory aged HSCs, common differentially expressed genes between young and aged HSCs, and functional enrichment analysis showed involvement in the cell cycle and TNF signaling pathway. The Skp2-induced signaling pathway was found to contribute to rapid transition through G1 phase in aged HSCs, and inflammatory genes in the bone marrow microenvironment were increased in HSC aging. Inflammatory cytokines promoted cellular senescence, but blockade of the inflammatory pathway rejuvenated aged HSC functions and increased B cell output.
FRONTIERS IN GENETICS
(2021)
Article
Cell & Tissue Engineering
Christophe Desterke, Annelise Bennaceur-Griscelli, Ali G. Turhan
Summary: The analysis of single-cell transcriptomes revealed a significant upregulation of EGR1 in aged human lineage-CD34+CD38- cells, associated with dysregulation of the cell cycle and reduced expression of CCND2 during the S phase. EGR1 upregulation in aging hematopoietic stem cells was found to be independent of cell cycle phases and gender. The EGR1 expression trajectory in aging HSC highlighted a signature enriched in hematopoiesis and immune disorders.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Pascal Fichtel, Malte von Bonin, Robert Kuhnert, Kristin Moebus, Martin Bornhaeuser, Manja Wobus
Summary: Aging of the hematopoietic system is characterized by an expansion of hematopoietic stem and progenitor cells (HSPCs) with reduced capacity for engraftment, self-renewal, and lymphoid differentiation, resulting in myeloid-biased hematopoiesis.
The communication between HSPCs and MSCs is mediated by direct cell-cell contacts or extracellular vesicles (EVs) that carry bioactive substances. Aging MSCs secrete fewer miRNAs, but aged MSC-EVs contain higher levels of specific miRNAs such as miR-29a and miR-34a. Young EVs enhance the cell number and viability of HSPCs, while aged MSC-EVs promote the differentiation of HSPCs into erythroid and erythroid-megakaryocytic progenitor cells. The therapeutic relevance of MSC-derived EVs in modulating HSPC characteristics needs further investigation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)