Article
Plant Sciences
Diana Pimentel, Rute Amaro, Alexander Erban, Nuria Mauri, Flavio Soares, Cecilia Rego, Jose M. Martinez-Zapater, Axel Mithoefer, Joachim Kopka, Ana Margarida Fortes
Summary: This study analyzed the transcriptome and metabolome of grapevine berries infected with powdery mildew, revealing that while the berries activated defense mechanisms, they were not sufficient to restrict fungal growth. Potential metabolic biomarkers such as gallic, eicosanoic, and docosanoic acids and resveratrol were identified, which can be used to monitor early stages of infection.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Psychiatry
Dorinde Korteling, Marco P. Boks, Ania M. Fiksinski, Ilja N. van Hoek, Jacob A. S. Vorstman, Nanda M. Verhoeven-Duif, Judith J. M. Jans, Janneke R. Zinkstok
Summary: The 22q11.2 deletion syndrome (22q11.2DS) is associated with increased risk of autism spectrum disorders (ASD) and intellectual impairment, potentially due to deficits in early brain development metabolic processes. This study identified a unique metabolic signature for 22q11.2DS and trait-specific metabolomic patterns related to intelligence and ASD within the patients. These findings provide insights into the biological mechanisms underlying the neurodevelopmental phenotype and may contribute to the identification of therapeutic targets for developmental disorders.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Xiaojiao Zheng, Tianlu Chen, Aihua Zhao, Zhangchi Ning, Junliang Kuang, Shouli Wang, Yijun You, Yuqian Bao, Xiaojing Ma, Haoyong Yu, Jian Zhou, Miao Jiang, Mengci Li, Jieyi Wang, Xiaohui Ma, Shuiping Zhou, Yitao Li, Kun Ge, Cynthia Rajani, Guoxiang Xie, Cheng Hu, Yike Guo, Aiping Lu, Weiping Jia, Wei Jia
Summary: The study shows that the association of HCA species with diabetes, the circulating concentration of HCA species is decreased in the context of obesity and diabetes and increased after gastric bypass surgery in humans, and further that serum HCA species are predictive of metabolic outcomes in healthy individuals.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Manqi Zhang, Yasemin Ceyhan, Elena M. Kaftanovskaya, Judy L. Vasquez, Jean Vacher, Filip K. Knop, Lubov Nathanson, Alexander I. Agoulnik, Michael M. Ittmann, Irina U. Agoulnik
Summary: Research has shown that INPP4B signaling can protect mice from diet-induced metabolic dysfunction and help prevent multiple cancers associated with this condition.
COMMUNICATIONS BIOLOGY
(2021)
Review
Cell Biology
Shuangyu Lv, Honggang Wang, Xiaotian Li
Summary: Autophagy is a crucial cellular pathway for maintaining cellular balance, while the interaction between autophagy and the NLRP3 inflammasome plays a significant role in various diseases, especially metabolic disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Rupinder Kaur Sodhi, Raghunath Singh, Yashika Bansal, Mahendra Bishnoi, Ishwar Parhar, Anurag Kuhad, Tomoko Soga
Summary: Neuropsychiatric disorders pose a significant burden on patients and society, often linked to cardio-metabolic comorbidities. TRPA1 channels have emerged as potential therapeutic targets for modulating appetite, lipid metabolism, glucose and insulin homeostasis, and inflammation associated with NPDs.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Genetics & Heredity
Birute Tumiene, Carlos R. Ferreira, Clara D. M. van Karnebeek
Summary: Understanding the genetic architecture of metabolic epilepsies is crucial for clinical practice and further research. This study aimed to identify the scope of metabolic epilepsies and investigate their clinical presentation, diagnostic approaches, and treatments. A total of 600 metabolic epilepsies were identified, many of which are complex and multisystem disorders. Abnormalities in routine laboratory tests and/or metabolic testing can be found in 70% of metabolic epilepsies, though often nonspecific. Specific treatments exist for 18% of metabolic epilepsies, which can significantly improve health outcomes if diagnosed in time.
Review
Nutrition & Dietetics
Slavko Komarnytsky, Charles Wagner, Janelle Gutierrez, Odette M. Shaw
Summary: Recent research shows that berry-derived polymeric substrates that resist human digestion are extensively metabolized in the gastrointestinal tract dominated by microbiota, and have potential to improve gastrointestinal health and metabolic outcomes. The differences in complex carbohydrate fractions and polyphenol classes among berries have been found to affect microbial populations and human metabolome, suggesting the intentional modulation of gut microbiome profiles and risk factors through berry consumption.
CURRENT NUTRITION REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Federica Conte, Juda-El Sam, Dirk J. Lefeber, Robert Passier
Summary: Heart failure (HF) is a progressive chronic disease that affects over 64 million patients worldwide. It can be caused by cardiomyopathies and congenital cardiac defects with monogenic etiology. This systematic review provides a comprehensive overview of inherited metabolic disorders (IMDs) linked to carbohydrate metabolism that present with cardiomyopathies, arrhythmogenic disorders, and/or structural cardiac defects. Through this review, we aim to raise awareness about the cardiac presentations in carbohydrate-linked IMDs and draw attention to carbohydrate-linked pathogenic mechanisms contributing to cardiac complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Hematology
Usua Oyarbide, Genevieve M. Crane, Seth J. Corey
Summary: Neutrophils, the shortest-lived blood cells, require extensive proliferation and differentiation to maintain sufficient numbers and respond quickly to infections. Defects in cellular metabolism resulting from monogenic disorders can lead to congenital neutropenias. Understanding metabolic pathways could identify new strategies for treating neutropenias.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sara Tucci, Khaled Ibrahim Alatibi, Zeinab Wehbe
Summary: This work summarizes recent findings on metabolic flexibility and its implications in diseases such as VLCADD and ACSF3 deficiency, discussing the role of mitochondrial fatty acid metabolism in maintaining energy homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Alessandra Ferrandino, Chiara Pagliarani, Eva Pilar Perez-Alvarez
Summary: Abiotic stresses significantly affect the accumulation of secondary metabolites in grapevine berries and vegetative organs. Transcriptional reprogramming, miRNA, epigenetic marks, and hormonal crosstalk regulate secondary metabolism. miRNAs control the flavonoid biosynthetic pathway through post-transcriptional regulation, while DNA methylation affects the plasticity of different grapevine cultivars. Hormones mediate the accumulation of antioxidants and the defense processes in response to stressors.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Marta Rodrigues, Cristian Forestan, Laura Ravazzolo, Philippe Hugueney, Raymonde Baltenweck, Angela Rasori, Valerio Cardillo, Pietro Carraro, Mario Malagoli, Stefano Brizzolara, Silvia Quaggiotti, Duilio Porro, Franco Meggio, Claudio Bonghi, Fabrizio Battista, Benedetto Ruperti
Summary: This study investigated the metabolic and molecular responses of Sauvignon Blanc berries to DYE treatments. The results showed that DYE treatment increased the levels of aroma precursors and activated specific metabolic and hormonal pathways, reducing oxidative stress in the berries.
Review
Endocrinology & Metabolism
Huizhen Chen, Chunguang Xie, Qiu Chen, Shougang Zhuang
Summary: Recent studies have shown that HDAC11 plays an important role in metabolic disorders, including adipogenesis, lipid metabolism, metabolic inflammation, glucose tolerance, immune responses, and energy consumption.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medical Laboratory Technology
Xin Su, Ye Cheng, Bin Wang
Summary: Dyslipidemia plays a significant role in global health and recent studies have highlighted the critical role of ANGPTL8 in modulating glucose and lipid metabolism, impacting cardio-metabolic disorder diseases.
CLINICA CHIMICA ACTA
(2021)
Article
Nutrition & Dietetics
Katarzyna Kowalska, Radoslaw Dembczynski, Agata Golabek, Mariola Olkowicz, Anna Olejnik
Summary: The study found that polyphenol fractions from lingonberry fruit can reduce intracellular ROS generation and triglyceride content in hypertrophied adipocytes, while regulating key adipokines and alleviating inflammation. Consuming polyphenol-rich lingonberry fruit may help prevent and treat obesity and endothelial dysfunction.
Article
Biochemistry & Molecular Biology
Marta Kus, Klaudia Gorniak, Anna Olejnik, Paulina Skupin-Mrugalska, Izabela Ibragimow, Hanna Piotrowska-Kempisty
Summary: This study evaluated the permeation of perindopril arginine across biological and artificial biomimetic membranes, and found relatively poor permeability. Results from the non-cell-based model demonstrated higher transport of PA.
Article
Food Science & Technology
Jakub Michal Kurek, Joanna Zielinska-Wasielica, Katarzyna Kowalska, Zbigniew Krejpcio, Anna Olejnik
Summary: This study demonstrates the inhibitory effect of stevioside and steviol on adipogenesis and lipogenesis, leading to decreased lipid accumulation. Additionally, they can enhance glucose uptake in insulin-resistant cells and alleviate symptoms of insulin resistance.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Cell Biology
Agata Golabek-Grenda, Anna Olejnik
Summary: This review summarizes the range of available in vitro experimental systems used in endometriotic studies, from simple cell models to complex 3D models. The focus of the research is to understand the relationship between the microenvironment of the ectopic lesions and different stages, phenotypes, and symptoms, and to develop new diagnostic and therapeutic concepts.
CELLULAR SIGNALLING
(2022)
Article
Chemistry, Applied
M. Rudzinska, A. Olejnik, A. Grygier, K. Kowalska, D. Kmiecik, A. Grudniewska, A. Chojnacka, W. G. Ladkowski, G. Maciejewska, R. Przybylski
Summary: This study investigated the thermo-oxidative stability of distigmasterol-modified acylglycerols and compared the products formed during heating with free stigmasterol and stigmasteryl esters. The results showed that the formation of degradation products was influenced by temperature and the chemical structure of lipids. Cytotoxicity and genotoxicity tests confirmed that the modified acylglycerols had no toxic effects on normal human cells.
Article
Nutrition & Dietetics
Przemyslaw Lukasz Kowalczewski, Anna Olejnik, Martyna Natalia Wieczorek, Joanna Zembrzuska, Katarzyna Kowalska, Jacek Lewandowicz, Grazyna Lewandowicz
Summary: More and more literature data show the health benefits of potato juice, but it is not clear which compounds in potato juice are biologically active. This study aimed to determine the antiproliferative effect of digested potato juice and its processing products. The results showed that glycoalkaloids exhibited cytotoxicity against all cell lines studied, while phenolic acids did not show cytotoxicity. There was a correlation between cytotoxic potency and glycoalkaloids content in all potato juice products.
Article
Biotechnology & Applied Microbiology
Adam Grzywaczyk, Wojciech Smulek, Anna Olejnik, Urszula Guzik, Agnieszka Nowak, Ewa Kaczorek
Summary: The large-scale use of nitrofurans poses risks of resistance and toxicity in the environment. This study investigates the impact of saponins from Sapindus mukorossi on the antimicrobial properties of nitrofuran antibiotics. The results demonstrate a synergistic bactericidal effect of saponins with nitrofurantoin or furazolidone, without toxic effects on human colon epithelial cells.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Maria Kasprzak, Magdalena Rudzinska, Wojciech Juzwa, Anna Olejnik
Summary: This study aimed to analyze the anti-proliferative potential and genotoxicity of thermo-oxidatively treated stigmasterol (ST), stigmasteryl linoleate (ST-LA), and oleate (ST-OA) in normal human intestinal cells. The results showed that stigmasteryl esters had a significantly lower potential to affect intestinal cell viability and proliferation than non-esterified ST, regardless of heating. Thermo-oxidative derivatives of ST and ST-LA may evoke harmful gastrointestinal effects due to their high oxidative reactivity towards intestinal cells.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Applied
M. Rudzinska, A. Olejnik, A. Grygier, K. Kowalska, D. Kmiecik, A. Chojnacka, W. Gladkowski, A. Grudniewska, R. Przybylski
Summary: The safety and thermoxidative stability of new diacyl-stigmasterylcarbonoyl-sn-glycerols (DAStGs) with different fatty acids and stigmasterol at different positions were studied. The compounds with stigmasterol at the sn-2 position showed better stability after heating, and the degradation of stigmasterol was lower in compounds with oleic acid compared to palmitic acid. The content of SOPs and the level of dimers had a significant effect on the cytotoxicity of heated DAStGs.
Article
Multidisciplinary Sciences
Agata Golabek-Grenda, Mariusz Kaczmarek, Wojciech Juzwa, Anna Olejnik
Summary: The specific characteristics of endometriotic cells include their ability to evade apoptosis and abnormal response to apoptotic stimuli. Natural resveratrol analogs, such as piceatannol, polydatin, and pterostilbene, show potential in modulating apoptosis in endometriosis. Pterostilbene is the most effective in targeting cell death pathways and increasing apoptotic proportion in endometriotic cells. The study provides valuable insight into the apoptogenic activity of resveratrol and its analogs and highlights the therapeutic potential of pterostilbene in endometriosis.
SCIENTIFIC REPORTS
(2023)
Review
Plant Sciences
Przemyslaw Lukasz Kowalczewski, Anna Olejnik, Stanislaw Switek, Anna Bzducha-Wrobel, Piotr Kubiak, Malgorzata Kujawska, Grazyna Lewandowicz
Summary: Potato juice (PJ) is a by-product of the starch production process, which contains high nutritional value and biological activity that can facilitate the treatment of certain gastrointestinal tract diseases. This manuscript provides an overview of the production of potatoes and accompanying PJ. It describes the handling methods for the by-product and presents novel technologies for PJ processing, emphasizing the separation and hydrolysis of protein. The medical potential of PJ, including its antimicrobial, antioxidant, anti-inflammatory, anticancer, antiobesity, antidiabetic, antihyperlipidemic, and antihypertensive activities, is also reviewed.
CRITICAL REVIEWS IN PLANT SCIENCES
(2022)
